Open medicine (Warsaw, Poland)最新文献

{"title":"Commentary on \"Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma\".","authors":"Juan Francisco Peña-Cardelles, José Ernesto Moro-Rodríguez, José Luís Cebrián-Carretero, José Juan Pozo-Kreilinger","doi":"10.1515/med-2022-0431","DOIUrl":"https://doi.org/10.1515/med-2022-0431","url":null,"abstract":"The clinical and pathological value of programmed cell death-ligand 1 (PD-L1) expression in the oral squamous cell carcinoma (OSCC) has originated the research of different studies that try to determine the real relationship between this disease and this immune checkpoint since the latest clinical trials have related possible improvements in the blockade of this immune checkpoint through immunotherapy. Is for that reason that new systematic reviews have tried to explain this relationship. Cui and Su (2020) in the review and meta-analysis “Clinicopathological features of programmed cell death-ligand 1 expression in patients with oral squamous cell carcinoma” aimed to clarify the role of PD-L1 in OSCC [1]. For that, they included a large sample of 1,947 participants from a total of 15 studies. The authors found very interesting results concerning PD-L1 and its correlationwith sex, stages, and human papillomavirus (HPV) infection status, although they have described that there is a controversy between the included studies. However, the results concluded in this study may be confusing due to the large sample size of the studies included in this systematic review and meta-analysis. The authors have used as inclusion criteria only OSCC patients confirmed by histology. However, from the total of 15 studies included, 6 studies (De Meulenaere et al., 2017; Kim et al., 2016; Sato et al., 2019, Upko et al., 2013, Hong et al, 2016; Hong et al., 2019) [2–8] were research carried out exclusively on patients with oropharyngeal squamous cell carcinoma (OPSCC) and another study (Ock et al., 2016) [9] included both oropharyngeal and non-oropharyngeal carcinoma. Therefore, approximately 915 patients of the total 1,947 are OPSCC patients and not OSCC. Nowadays, it is established that OPSCC is different in comparison with OSCC, since the diagnostic, the clinical behaviour, the treatment, and the prognostic are very different, a fact that has already been described in the TNM classification [10]. Besides, this bias has already been found in other systematic reviews in this field [11]. On the other hand, the authors have found a strong relationship between the HPV prevalence and OSCC, obtaining important conclusions concerning the HPV status and the PD-L1 in OSCC. Nevertheless, almost the total sample where the HPV was studied was compounded by OPSCC studies, since other studies have demonstrated the highest prevalence in OPSCC [12], while in the OSCC it is almost not prevalent [13], which is not consistent with the data and outcomes obtained with respect to the HPV status in the Cu and Su meta-analysis. Due to the above-mentioned, we consider that it must have a caution interpretation to OSCC concerning the outcomes obtained by Cu and Su since almost half of the sample are OPSCC participants.","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"227-228"},"PeriodicalIF":2.1,"publicationDate":"2022-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39809879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activation of SphK2 contributes to adipocyte-induced EOC cell proliferation.","authors":"Lan Dai,&nbsp;Chen Wang,&nbsp;Wenjing Wang,&nbsp;Keqi Song,&nbsp;Taiyang Ye,&nbsp;Jie Zhu,&nbsp;Wen Di","doi":"10.1515/med-2022-0422","DOIUrl":"https://doi.org/10.1515/med-2022-0422","url":null,"abstract":"<p><p>Epithelial ovarian cancer (EOC) is the leading cause of deaths due to cancer in women. Adipocytes have been suggested to play a key role in the stimulation of EOC growth. However, the mechanisms underlying the adipocyte-induced EOC proliferation remain undefined. Here, we provide the first evidence that adipocytes induce the activation of sphingosine kinase (SphK) 2 in EOC, which represents a novel pathway that mediates the adipocyte-induced EOC growth. SphK2 inhibition in EOC cells led to a remarkable inhibition of the adipocyte-induced cell proliferation. Moreover, the adipocyte-induced SphK2 activation in EOC cells was extracellular signal-regulated protein kinases (ERK) dependent. Furthermore, silencing SphK2 in EOC significantly inhibited the adipocyte-induced expression of phospho-ERK and c-Myc, two crucial players in EOC growth. Collectively, the current study unraveled a previously unrecognized role of SphK2 in the adipocyte-induced growth-promoting action in EOC, suggesting a novel target for EOC treatment.</p>","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"229-238"},"PeriodicalIF":2.1,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39809880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of crescent score in clinical prognosis of IgA nephropathy.","authors":"Ying Chen,&nbsp;Yiya Yang,&nbsp;Yumei Liang,&nbsp;Manting Liu,&nbsp;Wei Xiao,&nbsp;Xiaofang Hu","doi":"10.1515/med-2022-0414","DOIUrl":"https://doi.org/10.1515/med-2022-0414","url":null,"abstract":"<p><p>The scoring of crescents (Cs) was recently added to the Oxford classification for IgA nephropathy (IgAN). Because of the short-term use of the C score in clinical practice, its validity and applicability need to be verified. We, retrospectively, analyzed the clinicopathological data of 144 primary IgAN patients diagnosed at our hospital from March 2017 to March 2019 and with complete ≥6-month follow-up data. We found that the C score was positively correlated with the Lee's classification in the assessment of renal pathological changes and significantly correlated with increased proteinuria and decreased estimated glomerular filtration rate. Univariate Cox regression analysis showed an association of C formation with IgAN prognosis, and multivariate Cox regression indicated Cs as an independent prognosis factor. The optimal proportion of Cs for prognosis prediction by the receiver operating characteristic curve was 11%. Kaplan-Meier survival curve revealed a significantly decreased renal survival rate in patients with C proportions ≥11%. Further multivariate Cox regression analysis confirmed that the C proportion ≥11% is an independent risk factor for poor prognosis of IgAN patients. Our findings demonstrate that Cs are independently related to the prognosis of patients with IgAN, and the proportion of Cs ≥11% is an independent risk factor for poor outcomes.</p>","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"205-215"},"PeriodicalIF":2.1,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39809876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rationale for using low-molecular weight heparin in the therapy of symptomatic COVID-19 patients.","authors":"Edyta Reichman-Warmusz,&nbsp;Oliwia Warmusz,&nbsp;Romuald Wojnicz","doi":"10.1515/med-2021-0374","DOIUrl":"https://doi.org/10.1515/med-2021-0374","url":null,"abstract":"<p><p>Accumulated evidence suggest that the adverse outcome of severe coronavirus disease 2019 (COVID-19) is closely related to prothrombotic microvascular pathology with a high risk of venous thromboembolism. Furthermore, the first observational studies indicated that adjunct therapy with low-molecular weight heparin (LMWH) was associated with lower mortality in this cohort of patients. However, the timing of starting LMWH and the dose remain controversial in COVID-19 patients. Considering the above, the aim of this study was to reveal the rationale for using LMWH in the therapy of symptomatic COVID-19 patients based on experimental and clinical studies on LMWH in inflammatory settings with special consideration given to randomized trials.</p>","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"216-220"},"PeriodicalIF":2.1,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39809877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of DNM3 is associated with good outcome in colorectal cancer.","authors":"Shao-Ang Cheng,&nbsp;Xin Huang,&nbsp;Liang Jiang,&nbsp;Qi-Lian Liang,&nbsp;Xiao-Cui Hong,&nbsp;Hai-Xia Yang,&nbsp;Ke-Hui Hu,&nbsp;Xing-Bo Luo,&nbsp;Hui-Jie Zhang","doi":"10.1515/med-2022-0420","DOIUrl":"https://doi.org/10.1515/med-2022-0420","url":null,"abstract":"<p><p>The aim of this study is to reveal the potential value of dynamin3 (DNM3) in colorectal cancer (CRC) evaluation of clinical diagnosis and prognosis. A total of 100 tissue samples were collected from 50 patients with stages I-IV, CRC tissues (<i>n</i> = 50) paired with non-cancerous adjacent colorectal tissues (<i>n</i> = 50). The expression levels of DNM3 were detected in 50 cases of CRC tissues and 50 cases of non-cancerous adjacent colorectal tissues by real-time fluorescent quantitative reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemical method (IHC) was conducted to semi-quantify the expression of DNM3 protein. Results showed that the relative expression of DNM3 mRNA in CRC tissues was 0.634-fold of that in non-cancerous adjacent colorectal tissues. The positive rate of DNM3 protein in CRC tissues (42.0%) was much lower than that in non-cancerous adjacent colorectal tissues (66.0%; <i>P</i> < 0.05). The expression level of DNM3 protein in CRC tissues was dependent on tumor size, degree of histological differentiation, and clinical stage (<i>P</i> < 0.05). The expression level of DNM3 mRNA in CRC tissues was significantly correlated with tumor size and pathology classification (<i>P</i> < 0.05). The research shows that detecting the expression of DNM3 helps in analyzing the tumor size, degree of histological differentiation, and clinical stage. Expression of DNM3 may be associated with good outcome in CRC.</p>","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"221-226"},"PeriodicalIF":2.1,"publicationDate":"2022-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39809878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pericentric inversion of chromosome 6 and male fertility problems.","authors":"Haitao Fan,&nbsp;Zhe Liu,&nbsp;Peng Zhan,&nbsp;Guoliang Jia","doi":"10.1515/med-2022-0411","DOIUrl":"https://doi.org/10.1515/med-2022-0411","url":null,"abstract":"<p><p>As a significant chromosomal structural abnormality, chromosomal inversion is closely related to male infertility. For inversion carriers, the interchromosomal effect explains male infertility, but its specific mechanism remains unclear. Additionally, inversion carriers with different chromosomes have different clinical manifestations. Therefore, genetic counseling is difficult in clinical practice. Herein, four male carriers of pericentric inversion in chromosome 6 have been described. Two patients showed asthenospermia, one showed azoospermia, and the wife of the remaining patient had recurrent miscarriages. Through a literature search, the association between the breakpoint of pericentric inversion in chromosome 6 and male fertility problems are also discussed in this study. Overall, important genes related to asthenospermia in chromosome 6p21 were found, which may be related to the clinical phenotype. These results suggest that physicians should focus on the breakpoints of inversion in genetic counseling.</p>","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"191-196"},"PeriodicalIF":2.1,"publicationDate":"2022-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39883078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staple line reinforcement with nebulized cyanoacrylate glue in laparoscopic sleeve gastrectomy: A propensity score-matched study.","authors":"Gennaro Martines,&nbsp;Giovanni Tomasicchio,&nbsp;Arcangelo Picciariello,&nbsp;Rigers Dibra,&nbsp;Giuseppe Trigiante,&nbsp;Giuliano Lantone,&nbsp;Donato Francesco Altomare","doi":"10.1515/med-2022-0426","DOIUrl":"https://doi.org/10.1515/med-2022-0426","url":null,"abstract":"<p><strong>Background: </strong>A dreaded complication of laparoscopic sleeve gastrectomy (LSG) is suture leak. The study aimed to assess the efficacy of the nebulized comonomer Glubran 2^® (<i>N</i>-butyl-cyanoacrylate + metacrylosysolfolane) applied to the LSG staple line.</p><p><strong>Methods: </strong>A propensity-matched comparison analysis was conducted in 125 patients undergoing LSG between 2017 and 2019. Groups included those treated with Glubran^® (group 1, <i>n</i> = 70) and those without Glubran^® treatment (group 2, <i>n</i> = 55).</p><p><strong>Results: </strong>There were differences in the mean body mass index (44.4 vs 43 kg/m²; <i>P</i> < 0.05) between the groups. There was a non-significant increase in the operative time for group 1 compared with group 2 (97 ± 8 vs 93.8 ± 10.7 min; <i>P</i> = 0.07), with a greater amount of estimated blood loss (94.5 mL vs 87.8; <i>P</i> < 0.01). There were more severe complications in group 2 over group 1 cases (8 vs 0%; <i>P</i> < 0.05), although postoperative bleeding did not differ between the two groups (1.4 vs 5.4%). There were no postoperative leaks in group 1 patients, but there were two leaks in group 2 cases with an increased length of hospital stay in patients with a leak.</p><p><strong>Conclusion: </strong>Glubran^® LSG support may reduce leak risk without increasing operating time.</p>","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"197-204"},"PeriodicalIF":2.1,"publicationDate":"2022-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8772997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39883079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Leptin and PCSK9 concentrations are associated with vascular endothelial cytokines in patients with stable coronary heart disease.","authors":"Qiang Wang,&nbsp;Bo Zheng,&nbsp;Peng Chen,&nbsp;Yan Lei","doi":"10.1515/med-2021-0400","DOIUrl":"https://doi.org/10.1515/med-2021-0400","url":null,"abstract":"<p><p>Leptin and proprotein convertase subtilisin kexin 9 (PCSK9) play an important role in regulating blood lipid concentration. Recently, they have been found to show the ability to independently regulate the immune response. Vascular immune response has an important pathological function in the development of coronary heart disease (CHD) and thrombosis. The aim of this study was to explore the relationship between leptin, PCSK9, and vascular endothelial cell related inflammatory factors. First, detailed clinical information were collected and analyzed for 27 patients with stable CHD and corresponding 27 healthy controls. Second, using liquid-phase protein chip technology, leptin, PCSK9, and vascular-related inflammatory factors, such as E-selectin, vascular cell adhesion protein 1 (VCAM-1), intercellular cell adhesion molecule-1 (ICAM-1), interferon-gamma (IFN-γ), and interleukin-17 (IL-17), were detected on the same platform. Finally, the correlation between leptin, PCSK9, and the inflammatory factors was analyzed. Through collecting clinical information of patients, it was suggested that there was a significant positive correlation between leptin and blood lipid level in CHD. Compared with healthy people, the levels of leptin, PCSK9, E-selectin, and ICAM-1 were significantly high in patients with CHD. There was a high positive correlation between leptin and E-selectin, ICAM-1, IFN-γ, and IL-17. Also, a high positive correlation between PCSK9 and E-selectin, IFN-γ, and IL-17 concentrations was observed. In general, leptin and PCSK9 may not only be able to regulate lipid metabolism, but may also be able to regulate inflammation in CHD.</p>","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"185-190"},"PeriodicalIF":2.1,"publicationDate":"2022-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8768505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39866883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there any effect on imprinted genes H19, PEG3, and SNRPN during AOA?","authors":"Rong Liang,&nbsp;Fang Fang,&nbsp;Sen Li,&nbsp;Xi Chen,&nbsp;Xiaohong Zhang,&nbsp;Qun Lu","doi":"10.1515/med-2022-0410","DOIUrl":"https://doi.org/10.1515/med-2022-0410","url":null,"abstract":"<p><p>Assisted oocyte activation (AOA) has been proposed as an effective technique to overcome the problem of impaired fertilization after intracytoplasmic sperm injection (ICSI) but the safety of AOA remains a concern. We aimed to investigate if AOA induces imprinting effects on embryos. We used 13 cleavage embryos, nine blastocysts, and eight placentas from 15 patients. The subjects were divided into six groups by tissue type and with or without AOA. The methylation levels of imprinted genes (H19, paternally expressed gene [PEG3] and small nuclear ribonucleoprotein polypeptide N [SNRPN]) were tested by pyrosequencing. We observed different methylation levels among cleavage embryos. The variability was much more remarkable between cleavage embryos than blastocysts and placenta tissues. The methylation levels were especially higher in SNRPN and lower in the H19 gene in AOA embryos than those without AOA. No significant difference was found either among blastocysts or among placenta tissues regardless of AOA. The methylation levels of the three genes in blastocysts were very similar to those in the placenta. Compared to conventional ICSI, AOA changed imprinting methylation rates at H19 and SNRPN in cleavage embryos but not in the blastocyst stage and placenta. We recommend that blastocyst transfer should be considered for patients undergoing AOA during <i>in vitro</i> fertilization.</p>","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"174-184"},"PeriodicalIF":2.1,"publicationDate":"2022-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39855076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does diabetes affect paraneoplastic thrombocytosis in colorectal cancer?","authors":"Gyorgy Herczeg,&nbsp;Aniko Somogyi,&nbsp;Magdolna Herold,&nbsp;Agnes Fodor,&nbsp;Klara Rosta,&nbsp;Magdolna Dank,&nbsp;Zsolt Lang,&nbsp;Zoltan Herold","doi":"10.1515/med-2021-0407","DOIUrl":"https://doi.org/10.1515/med-2021-0407","url":null,"abstract":"<p><strong>Background: </strong>A large variety of factors can affect colorectal cancer (CRC) survival, including type 2 diabetes mellitus (T2DM) and paraneoplastic thrombocytosis. Although several common factors play a role in their development and platelets are damaged in both diseases, the combined relationship of the three conditions was never investigated previously.</p><p><strong>Methods: </strong>A prospective, real-life observational cohort study was conducted with the inclusion of 108 CRC patients and 166 voluntary non-CRC subjects. Plasma interleukin-6 and thrombopoietin levels were measured.</p><p><strong>Results: </strong>Study participants were divided into cohorts based on the presence of T2DM. Platelet count (<i>p</i> < 0.0500) and interleukin-6 (<i>p</i> < 0.0100) level were significantly higher in the CRC groups. Thrombopoietin level was higher in the T2DM, CRC, and <i>CRC + T2DM</i> groups (<i>p</i> < 0.0500). Analysis of parameter changes over time and survival models revealed that neither platelet count, interleukin-6, nor thrombopoietin levels were affected by T2DM. Death of patients was associated with higher baseline platelet count (<i>p</i> = 0.0042) and interleukin-6 level (<i>p</i> < 0.0001).</p><p><strong>Conclusion: </strong>Although the independent, disease-worsening effect of paraneoplastic thrombocytosis and T2DM is known, the coexistence of the two did not further impair the survival of CRC patients, suggesting that T2DM has no significant effect over paraneoplastic thrombocytosis.</p>","PeriodicalId":520729,"journal":{"name":"Open medicine (Warsaw, Poland)","volume":" ","pages":"160-173"},"PeriodicalIF":2.1,"publicationDate":"2022-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39855075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}