Obstetrics & gynecology science最新文献

{"title":"Body fat distribution and insulin resistance among Korean middle-aged women: a Korean National Health and Nutrition Examination Survey.","authors":"Sae Mi Lee,&nbsp;Ki-Jin Ryu,&nbsp;Serhim Son,&nbsp;Yeon Ju Lee,&nbsp;Hyuntae Park,&nbsp;Tak Kim","doi":"10.5468/ogs.22001","DOIUrl":"https://doi.org/10.5468/ogs.22001","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate menopause-related changes in body fat distribution and their relationship with insulin resistance in middleaged Korean women.</p><p><strong>Methods: </strong>We analyzed women aged 40-60 years using data from the National Health and Nutrition Examination Survey conducted from 2008 to 2011. Body fat was measured using dual-energy X-ray absorptiometry. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR).</p><p><strong>Results: </strong>Among 3,468 participants, menopausal women (n=1,489) had a higher body mass index (BMI) and higher trunk, arm, and head fat percentages than premenopausal women (n=1,979). However, no significant difference was found in the leg fat percentage according to menopausal status. Multivariable regression analysis for HOMA-IR showed that trunk fat percentage, BMI, and waist circumference positively correlated with insulin resistance and leg fat percentage negatively correlated after adjusting for several confounding factors, whereas menopausal status was not associated with HOMAIR.</p><p><strong>Conclusion: </strong>Middle-aged women not only have different body weights and BMI but also have different body fat distributions according to menopausal status. Each fat percentage change in the trunk and leg is differently associated with metabolic health, particularly insulin resistance. To evaluate the metabolic health of middle-aged women, BMI is generally noted; however, body fat distribution, which can be easily assessed using dual-energy X-ray absorptiometry, should also be considered.</p>","PeriodicalId":520726,"journal":{"name":"Obstetrics & gynecology science","volume":" ","pages":"468-476"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/50/ogs-22001.PMC9483664.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40567398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sentinel lymph node biopsy in high-risk endometrial cancer: performance, outcomes, and future avenues.","authors":"Yoo-Na Kim,&nbsp;Young Tae Kim","doi":"10.5468/ogs.22146","DOIUrl":"https://doi.org/10.5468/ogs.22146","url":null,"abstract":"<p><p>Endometrial cancer is the second most common gynecological malignancy worldwide, with an overall favorable prognosis. However, a subgroup of patients has a high risk of recurrence and poor prognosis. This review summarizes recently published articles that examined sentinel lymph node (SLN) biopsy in patients with high-risk endometrial cancer. We focused on the performance and outcomes of SLN biopsy, and examined potential methods for improving the management of this high-risk subset. Few studies have examined the long-term outcomes of SLN in patients with high-risk endometrial cancer. Thus, we reviewed recently published retrospective studies that have adopted statistical techniques, such as inverse probability weighting or propensity score matching, to examine the outcome of SLN biopsy compared to conventional lymphadenectomy. Potential avenues for future research to fine-tune decision making for this patient subgroup were also discussed.</p>","PeriodicalId":520726,"journal":{"name":"Obstetrics & gynecology science","volume":" ","pages":"395-405"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/bb/ogs-22146.PMC9483671.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40577505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of immunohistochemistry of the p53 Staining pattern in high-grade serous ovarian carcinoma.","authors":"Panarat Orachum,&nbsp;Amornrat Temtanakitpaisan,&nbsp;Pilaiwan Kleebkaow,&nbsp;Bandit Chumworathayi,&nbsp;Sanguanchoke Luanratanakorn,&nbsp;Apiwat Aue-Angkul,&nbsp;Yuwadee Itarat","doi":"10.5468/ogs.22102","DOIUrl":"https://doi.org/10.5468/ogs.22102","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prevalence of p53 mutations and associated factors between immunohistochemistry (IHC) and p53 staining patterns among patients with high-grade serous ovarian carcinoma (HGSOC).</p><p><strong>Methods: </strong>This study is a retrospective review. A total of 62 patients with HGSOC underwent surgery at Srinagarind Hospital between January 2016 and December 2020. Histological examination was performed based on a combination of morphology and IHC staining with p53. The p53 immunostaining pattern was interpreted as a missense mutation, nonsense mutation, or a wild-type pattern. Missense (p53 overexpression pattern) and nonsense (null expression p53 pattern) mutations were considered p53 mutations. A wild-type pattern was defined as a p53 non-mutation.</p><p><strong>Results: </strong>p53 mutations were identified in 93.6% of the patients. Subgroup analysis of the p53 mutation group between the p53 overexpression pattern and the p53 null expression pattern in terms of clinicopathological characteristics and initial treatment was performed. Patients with the p53 overexpression pattern had significantly more omental metastases than those with the p53 null expression pattern (87.8% vs. 64.7%, P=0.042). There were no statistically significant differences in median progression-free survival (PFS) (9 vs. 10 months, P=0.813) or median overall survival (OS) (12 vs. 17 months, P=0.526) between the two groups.</p><p><strong>Conclusion: </strong>The prevalence of p53 mutations in HGSOC patients in this study was 93.6%. Omental metastasis is a significant pathological factor in predicting overexpression p53 pattern in HGSC. However, IHC analysis of the p53 staining pattern did not affect OS or PFS among patients with HGSOC.</p>","PeriodicalId":520726,"journal":{"name":"Obstetrics & gynecology science","volume":" ","pages":"459-467"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/a5/ogs-22102.PMC9483669.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40558171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of 'Smartscopy' for the detection of preinvasive cervical lesions during the COVID-19 pandemic: a diagnostic study.","authors":"Thamawoot Phoblap,&nbsp;Amornrat Temtanakitpaisan,&nbsp;Apiwat Aue-Angkul,&nbsp;Pilaiwan Kleebkaow,&nbsp;Bandit Chumworathayi,&nbsp;Sanguanchoke Luanratanakorn,&nbsp;Yuwadee Itarat","doi":"10.5468/ogs.22092","DOIUrl":"https://doi.org/10.5468/ogs.22092","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the performance of \"Smartscopy\" in diagnosing preinvasive cervical lesions among patients with abnormal cervical cancer screening results obtained during the coronavirus disease 2019 (COVID-19) pandemic.</p><p><strong>Methods: </strong>This diagnostic study enrolled non-pregnant women with abnormal cervical cancer screening results obtained at the colposcopy clinic at Srinagarind Hospital (Khon Kaen, Thailand) between September 2020 and March 2021. Two colposcopists independently evaluated the uterine cervix using a smartphone and colposcopy. Cervical biopsies and endocervical curettage were performed in accordance with standard procedures. The diagnostic performance of a smartphone in detecting low-grade squamous intraepithelial lesions or worse plus (LSIL+) and high-grade squamous intraepithelial lesions plus (HSIL+) was assessed.</p><p><strong>Results: </strong>In total, 247 patients were included. There was high agreement between the two colposcopists (κ=0.88; 95% confidence interval [CI], 0.82-0.93). The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the smartphone to detect LSIL+ were 96.6% (95% CI, 91.6-99.1), 12.9% (95% CI, 8.06-19.2), 46.2% (95% CI, 39.7-52.4), 83.3% (95% CI, 62.6-95.3), and 0.49% (95% CI, 0.43-0.55), respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of smartscopy in diagnosing HSIL+ were 67.6% (95% CI, 55.2- 78.5), 85.4% (95% CI, 79.9-90.0), 60.5% (95% CI, 48.6-71.6), 88.9% (95% CI, 83.7-92.9), and 81.0% (95% CI, 0.75-0.85), respectively.</p><p><strong>Conclusion: </strong>Smartscopy demonstrated a remarkable correlation with colposcopy and a high diagnostic performance value for the detection of preinvasive cervical lesions. Therefore, smartscopy may be an alternative tool for detecting abnormal cervical lesions in low to medium medical resource settings. Smartscopy may be applied in telemedicine during the COVID-19 pandemic.</p>","PeriodicalId":520726,"journal":{"name":"Obstetrics & gynecology science","volume":" ","pages":"451-458"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d0/4e/ogs-22092.PMC9483663.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40640011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal maternal alcohol exposure: diagnosis and prevention of fetal alcohol syndrome.","authors":"Young Min Hur,&nbsp;Jiwon Choi,&nbsp;Sunwha Park,&nbsp;Sarah Soyeon Oh,&nbsp;Young Ju Kim","doi":"10.5468/ogs.22123","DOIUrl":"https://doi.org/10.5468/ogs.22123","url":null,"abstract":"<p><p>Fetal alcohol syndrome (FAS) is a developmental and congenital disorder characterized by neurocognitive impairment, structural defects, and growth restriction due to prenatal alcohol exposure. The estimated global prevalence of alcohol use during pregnancy is 9.8%, and the estimated prevalence of FAS in the general population is 14.6 per 10,000 people. In Korea, the estimated prevalence of alcohol use during pregnancy is 16%, and the prevalence of FAS is 18-51 per 10,000 women, which is higher than the global prevalence. Women's alcohol consumption rates have increased, especially in women of childbearing age. This could increase the incidence of FAS, leading to higher medical expenses and burden on society. Alcohol is the single most important teratogen that causes FAS, and there is no safe trimester to drink alcohol and no known safe amount of alcohol consumption during pregnancy. Thus, physicians should assess women's drinking patterns in detail and provide education on FAS to women by understanding its pathophysiology. Moreover, the prevention of FAS requires long-term care with a multidisciplinary approach.</p>","PeriodicalId":520726,"journal":{"name":"Obstetrics & gynecology science","volume":" ","pages":"385-394"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e3/e5/ogs-22123.PMC9483667.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40570358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ritodrine in external cephalic version: is it effective and safe?","authors":"Sin Ae Kim,&nbsp;Eun-Hwan Cha,&nbsp;Kyoung-Chul Chun,&nbsp;Young Ah Kim,&nbsp;Jae-Whoan Koh,&nbsp;Jung Yeol Han,&nbsp;Jong Hee Hwang","doi":"10.5468/ogs.22106","DOIUrl":"https://doi.org/10.5468/ogs.22106","url":null,"abstract":"<p><strong>Objective: </strong>The external cephalic version (ECV) has been shown to lower the likelihood of cesarean section requirements among pregnant women with breech presentations. In the current study, we investigated the effectiveness and safety of ritodrine as a tocolytic for ECV.</p><p><strong>Methods: </strong>A total of 407 pregnant women with breech presentations, who had no contraindications for ECV, were enrolled in this study. Multivariable logistic regression analyses were used to assess the impact of ritodrine use on the safety and efficacy of ECV.</p><p><strong>Results: </strong>The overall success rate was 67.6%, and ritodrine use was associated with significantly higher odds of successful ECV after adjusting for confounders. Moreover, using ritodrine did not increase the risk of adverse effects, including temporary changes in fetal heart rate, need for elective or emergency cesarean section due to fetal distress during ECV, low Apgar scores, and perinatal mortality.</p><p><strong>Conclusion: </strong>Our results suggest that using ritodrine as a tocolytic during ECV may increase the likelihood of ECV success and may not increase adverse perinatal outcomes.</p>","PeriodicalId":520726,"journal":{"name":"Obstetrics & gynecology science","volume":" ","pages":"420-429"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ad/fc/ogs-22106.PMC9483666.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40570359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaginal vault drainage as an effective and feasible alternative in laparoscopic hysterectomy.","authors":"Soohyun Oh,&nbsp;Seung Joo Chon,&nbsp;Seung Ho Lee,&nbsp;Jin Woo Shin","doi":"10.5468/ogs.22083","DOIUrl":"https://doi.org/10.5468/ogs.22083","url":null,"abstract":"<p><strong>Objective: </strong>Infected pelvic hematoma is a serious complication of hysterectomies. Pelvic drainage can help reduce complications. In this study, we evaluated the efficacy and safety of vaginal vault drainage in patients who underwent laparoscopic hysterectomy for benign gynecological diseases.</p><p><strong>Methods: </strong>Patients who underwent laparoscopic hysterectomy and pelvic drain insertion for benign gynecological diseases between January 2008 and December 2015 were enrolled retrospectively in the study. They were grouped according to drain insertion sites, that is, through the abdomen (group 1) and vaginal vault (group 2). The postoperative outcomes were compared between the two groups.</p><p><strong>Results: </strong>A total of 504 women were included. No significant differences were observed in the prevalence of postoperative fever, readmission, and reoperation between the two groups.</p><p><strong>Conclusion: </strong>Given the discomfort associated with holding and removing the abdominal drain, inserting a closed pelvic gravity drain through the vaginal vault appears to be a feasible alternative to an abdominal drain.</p>","PeriodicalId":520726,"journal":{"name":"Obstetrics & gynecology science","volume":" ","pages":"477-482"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/6d/ogs-22083.PMC9483674.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40558172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of a support program on the burden of spouses caring for their partners with breast cancer: a randomized controlled trial.","authors":"Seyedeh-Zeynab Hosseinnejad,&nbsp;Forouzan Elyasi,&nbsp;Seyed-Nouraddin Mousavinasab,&nbsp;Zohreh Shahhosseini","doi":"10.5468/ogs.22080","DOIUrl":"https://doi.org/10.5468/ogs.22080","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine the effect of a support program on burden of spouses caring for their partners with breast cancer.</p><p><strong>Methods: </strong>This randomized controlled trial was conducted among spouses of women with breast cancer undergoing chemotherapy at a referral chemotherapy center in Iran. They were assigned to intervention (n=40) and control (n=40) groups using permuted block randomization. Three small group sessions lasted 45-60 minutes, followed by three telephone-based sessions, lasting 15-20 minutes (twice a week). The intervention sessions included defining stress management strategies in different situations: strengthening creativity, optimism, and management in planning, and defining the role of the caregiver. Primary outcome was care burden, and secondary outcomes were spouses' stress, satisfaction with intervention, and partners' quality of life (QOL). The caregiver burden inventory, depression anxiety stress questionnaire, World Health Organization QOL brief version, and client satisfaction questionnaire were completed before and after the intervention and at a 6-week follow-up.</p><p><strong>Results: </strong>Thirty-eight participants in each group with a mean age of 44.24±9.01 years completed the study. Repeated measures analysis of variance showed a significant difference in the care burden (P<0.05; effect size, 0.70), stress (P<0.05; effect size, 0.64), and women's QOL (P<0.05; effect size, 0.67) before and after the intervention.</p><p><strong>Conclusion: </strong>The results of this study can be used to develop interventions, targeting the care burden and stress of spouses of women with breast cancer undergoing chemotherapy.</p>","PeriodicalId":520726,"journal":{"name":"Obstetrics & gynecology science","volume":" ","pages":"441-450"},"PeriodicalIF":1.9,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/62/c6/ogs-22080.PMC9483673.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40569232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction of Funding information: The incidence and survival of cervical, ovarian, and endometrial cancer in Korea, 1999-2017: Korea Central Cancer Registry.","authors":"Hyeong In Ha,&nbsp;Ha Kyun Chang,&nbsp;Soo Jin Park,&nbsp;Jiwon Lim,&nbsp;Young-Joo Won,&nbsp;Myong Cheol Lim","doi":"10.5468/ogs.21116.e1","DOIUrl":"https://doi.org/10.5468/ogs.21116.e1","url":null,"abstract":"","PeriodicalId":520726,"journal":{"name":"Obstetrics & gynecology science","volume":" ","pages":"384"},"PeriodicalIF":1.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ec/dd/ogs-21116-e1.PMC9304441.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40614895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression in pregnant and postpartum women during COVID-19 pandemic: systematic review and meta-analysis.","authors":"Nicholas Adrianto,&nbsp;Josephine Caesarlia,&nbsp;Fegita Beatrix Pajala","doi":"10.5468/ogs.21265","DOIUrl":"https://doi.org/10.5468/ogs.21265","url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19) emerged as a global pandemic in March 2020 and caused a big crisis, especially the health crisis. Pregnant and postpartum women experienced significant physical, social, and mental changes that put them at higher risk for several conditions during the pandemic. This study aimed to report the prevalence of depression in pregnant and postpartum women during the COVID-19 pandemic. Eligible studies were identified using several databases. Prevalence analysis was conducted using MedCalc ver. 19.5.1. This systematic review and metaanalysis was registered in PROSPERO on July 12, 2021 with registration number CRD42021266976. We included 54 studies with 95.326 participants. The overall prevalence of depression was 32.60% among pregnant and postpartum women during the COVID-19 pandemic. The rate was higher among pregnant women (31.49%) compared to postpartum women (27.64%). The prevalence of depression among pregnant and postpartum women increased during the COVID-19 pandemic.</p>","PeriodicalId":520726,"journal":{"name":"Obstetrics & gynecology science","volume":" ","pages":"287-302"},"PeriodicalIF":1.9,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/59/db/ogs-21265.PMC9304439.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40396724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}