Nephrology (Carlton, Vic.)最新文献

{"title":"Letter to the Editor: Incidence of Malignancy in Post-Donation Living Kidney Donors: A Single-Centre, Retrospective Cohort Study in Japan.","authors":"Abubakar Afzal, Zaib Un Nisa","doi":"10.1111/nep.70134","DOIUrl":"https://doi.org/10.1111/nep.70134","url":null,"abstract":"","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 10","pages":"e70134"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Value of LncRNA NNT-AS1 in CRRT-Treated Patients and Its Regulatory Mechanism in Acute Kidney Injury.","authors":"Shiming Zhang, Xuechun Wang, Ping Ni, Peng Huang, Lili Liang","doi":"10.1111/nep.70120","DOIUrl":"https://doi.org/10.1111/nep.70120","url":null,"abstract":"<p><strong>Aim: </strong>We investigated the prognostic value of lncRNA NNT-AS1 in patients undergoing CRRT and its regulatory mechanism in acute kidney injury.</p><p><strong>Methods: </strong>First, we detected serum levels of NNT-AS1 by RT-qPCR in patients before and after treatment with CRRT. Next, the survival probability between NNT-AS1 levels and prognosis of CRRT-treated patients was explored with Kaplan-Meier (K-M) curve analysis. The potential risk factors were evaluated via Cox regression analysis. Moreover, LPS-induced HK-2 cells were employed to establish an in vitro cellular experimental model. Cell viability and apoptosis rate were measured by Cell Counting Kit-8 (CCK-8) and flow cytometry. The relative mRNA levels of MDA and ROS were detected via RT-qPCR, and the concentration of tumour necrosis factor-α (TNF-α), interleukins-1β (IL-1β), neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule 1 (KIM-1) was detected by ELISA assay. Finally, a dual-luciferase reporter assay was utilised to verify the targeted binding of NNT-AS1 to miR-582-5p.</p><p><strong>Results: </strong>Serum NNT-AS1 levels were significantly reduced following CRRT, and patients with high levels of NNT-AS1 had lower survival probability. NNT-AS1 is a potential risk factor for poor outcomes in patients treated with CRRT. In LPS-induced HK-2 cells, NNT-AS1 knockdown increased cell viability and reduced the apoptosis rate. Also, NNT-AS1 knockdown suppressed the expression of oxidative stress markers, inflammatory factors and markers of renal tubular injury. NNT-AS1 targeted miR-582-5p by dual-luciferase reporter assay.</p><p><strong>Conclusion: </strong>LncRNA NNT-AS1 can serve as a marker of poor prognosis for CRRT treatment as well as participate in AKI by targeting miR-582-5p.</p>","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 10","pages":"e70120"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Multicystic Dysplastic Kidney and the Local Renin-Angiotensin-Aldosterone System: A Pilot Study of a New Biomarker.","authors":"Shingo Ishimori, Shinya Ishiko, Junya Fujimura, Asahi Yamamoto, Shuhei Aoyama, Yuka Kimura, Yuta Inoki, Atsushi Kondo, Tomoko Horinouchi, Tomohiko Yamamura, Nana Sakakibara, China Nagano, Kazumichi Fujioka, Masafumi Oka, Wataru Shimabukuro, Koichi Nakanishi, Kandai Nozu","doi":"10.1111/nep.70132","DOIUrl":"https://doi.org/10.1111/nep.70132","url":null,"abstract":"<p><strong>Aim: </strong>To examine the relationship between children with multicystic dysplastic kidney (MCDK) that persists or spontaneously regresses over time and local renin-angiotensin-aldosterone system (RAAS) activity in children.</p><p><strong>Methods: </strong>We conducted a multicentre, cross-sectional study of patients who were diagnosed with unilateral MCDK or a solitary kidney. The controls were age- and sex-matched children who underwent evaluation for short stature without any clinical kidney symptoms. We evaluated urinary angiotensinogen (AGT) as a biomarker of local RAAS activity, which acts specifically within the kidneys and differs from systemic RAAS.</p><p><strong>Results: </strong>We included 52 children who were divided into the following four groups: 11 children with residual MCDK (MCDK persisted), 11 with regressed MCDK (MCDK spontaneously regressed), 12 with a solitary kidney and 18 were controls. Hypertension was identified in six patients, all of whom were in the residual or regressed MCDK groups. The urinary AGT/creatinine ratio was significantly higher in children in the residual MCDK group than in those in the regressed MCDK, solitary and control groups (p = 0.02, p < 0.01, p < 0.01, respectively). A logistic regression model showed that the only significant independent factor for regression of MCDK was urinary AGT/creatinine (odds ratio: 16.0, p < 0.01).</p><p><strong>Conclusion: </strong>Our data suggest that local RAAS activation could be associated with persistence of MCDK, but causality cannot be inferred because of the cross-sectional study design. Whether RAAS activation in residual MCDK is involved in the pathogenesis of MCDK or AGT is secreted from the MCDK kidney itself remains unknown.</p>","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 10","pages":"e70132"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proliferative Glomerulonephritis With Monoclonal IgG Deposits (PGNMID) Following Completion of MDR-TB Therapy.","authors":"Hari Shankar Meshram, Chandani Bhagat, Rajendra Prasad Mathur, Saurabh Puri, Bhavin Modasiya, Vishal Batheja, Sreenivas Rao Gadireddy","doi":"10.1111/nep.70131","DOIUrl":"https://doi.org/10.1111/nep.70131","url":null,"abstract":"","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 10","pages":"e70131"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil Percentage to Albumin Ratio is Associated With Diabetic Kidney Disease in Community Cohorts: A More In-Depth Insight Incorporating Machine Learning.","authors":"Lu Yi, Xiaoli Wen, Yipeng Gong, Gaosi Xu","doi":"10.1111/nep.70129","DOIUrl":"https://doi.org/10.1111/nep.70129","url":null,"abstract":"<p><strong>Aim: </strong>The study aimed to investigate the relationship between neutrophil-percentage-to-albumin ratio (NPAR) and diabetic kidney disease (DKD), and to evaluate its potential for predicting DKD progression.</p><p><strong>Methods: </strong>This cross-sectional study utilised data from the National Health and Nutrition Examination Survey (NHANES). We employed weighted multivariable logistic regression and restricted cubic splines (RCS) to examine nonlinear relationships between NPAR levels and DKD. Additionally, subgroup analyses were performed to assess heterogeneity across demographic strata. Machine learning (ML) algorithms were employed to develop DKD prediction models and receiver operating characteristic (ROC) curves for each model were plotted on the test set to evaluate predictive performance. Finally, the study applied Shapley Additive Explanations (SHAP) to interpret feature contributions to predictions.</p><p><strong>Results: </strong>A total of 10,526 participants were included. After full covariate adjustment, the continuous variable NPAR was positively associated with the prevalence of DKD (OR = 1.16, 95% CI: 1.11-1.22, p < 0.001). The results of the RCS showed a significant nonlinear trend in the correlation between NPAR and DKD (P-non-linear < 0.0001). Subgroup analysis discovered that NPAR was generally associated with an increased possibility of developing DKD, but the subgroup differences were not statistically significant. Predictive modelling revealed NPAR had a good performance in assessing the risk of DKD incidence.</p><p><strong>Conclusion: </strong>In the general population, high NPAR is positively associated with the development of DKD, and predictive modelling of DKD that includes NPAR has shown excellent performance. These findings provide a rationale for NPAR as a potential non-invasive biomarker for early detection of DKD.</p>","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 10","pages":"e70129"},"PeriodicalIF":1.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145188293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpretability of Home Blood Pressure Measurements in Haemodialysis A Post Hoc Analysis of a Randomised Cross-Over Study.","authors":"Vicki Sandys, Lavleen Bhat, Emer O'Hare, Amy Hudson, Conall M O'Seaghdha, Donal J Sexton","doi":"10.1111/nep.70112","DOIUrl":"10.1111/nep.70112","url":null,"abstract":"<p><strong>Aim: </strong>We aimed to assess patterns of home BP in a maintenance haemodialysis cohort in line with consensus guidelines and determine the agreement with in-centre BP.</p><p><strong>Methods: </strong>A post hoc analysis of a pilot-scale, randomised two-period cross-over study comparing self-monitoring of BP over 4 weeks with usual care in 41 haemodialysis patients. Dialysis systolic BP (SBP) was compared with (i) home SBP averaged over 24 h, (ii) home SBP measurements on non-dialysis days between 6 pm-12 am and 6 am-12 pm.</p><p><strong>Results: </strong>Thirty-three participants with a mean age of 50 ± 14 years provided sufficient blood pressure data. Post-dialysis SBP moderately agreed with home SBP measurements (K = 0.65) when averaged over 2 weeks on non-dialysis days. The limits of agreement and mean bias were minimally different between 2-week averaged home SBP and post-dialysis SBP (mean bias -4.44 mmHg, 95% CI for mean difference between methods -61.63 to 52.59 mmHg), versus 24 h averaged home SBP and post-SBP (mean bias -2.32, limits of agreement -61.63 to 56.98 mmHg). Home SBP measurements were as variable [average real variability (16 ± 6)] as in-centre pre-dialysis SBP average real variability (14 ± 5) and post-SBP average real variability (13 ± 5).</p><p><strong>Conclusion: </strong>This study demonstrates the variability of BP measurement patterns if participants are not limited to measuring BP at a pre-specified frequency. Further studies are needed to assess optimal methods of standardising home BP monitoring in dialysis patients and to evaluate home BP thresholds that can be used as targets in randomised controlled trials.</p><p><strong>Trial registration: </strong>www.</p><p><strong>Clinicaltrials: </strong>gov. NCT03403491.</p>","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 9","pages":"e70112"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive Efficacy of Oxygenation on Contrast-Associated Acute Kidney Injury in Chronic Kidney Disease (stages 3-5) Patients Undergoing Elective Coronary Angiography ± Revascularisation: An Open Label Bicentric Randomised Controlled Trial.","authors":"Inderpreet Singh Bhatia, Tomala Murari, Pavitra Manu Dogra, Ramamoorthy Ananthakrishnan, Gurmanbir Singh Dhillon, Jayaraj Hasvi","doi":"10.1111/nep.70122","DOIUrl":"10.1111/nep.70122","url":null,"abstract":"<p><strong>Aim: </strong>Contrast-associated acute kidney injury (CA-AKI) has higher mortality in coronary artery disease (CAD) with chronic kidney disease (CKD), undergoing coronary angiography ± revascularisation (CAG ± R). We conducted a clinical superiority trial with dichotomous outcomes to evaluate the impact of renal hypoxia mitigation with oxygen therapy (OT) on CA-AKI incidence.</p><p><strong>Methods: </strong>CKD stages 3-5 patients undergoing CAG ± R were assigned to the OT group (OTG) and the control therapy group (CTG). CTG received hydration only, whereas OTG received 2 L/min of pure oxygen in addition to hydration. The primary endpoint was the incidence of CA-AKI at 48 h. Secondary endpoints included patient and renal survival (doubling of serum creatinine or dialysis dependency) at 30 days, as well as intervention complications.</p><p><strong>Results: </strong>Of the 395 patients, 321 patients qualified for the per-protocol analysis (OTG: 160 and CTG: 161). CA-AKI incidence was 5.6%, and OTG observed an effective prevention (1.25% vs. 9.93%, CTG, p = 0.004). Renal and patient survival at 30 days was 100%. Three CTG patients required dialysis and were dialysis-independent at 30 days. The risk of CA-AKI incidence was high among ages > 65 years (p = 0.007), previous acute myocardial infarction (p = 0.02), CKD stage-3 (p = 0.01) and avoidance of OT use (p = 0.02). OTG had a favourable serum creatinine trend (p = 0.05). Absolute risk reduction of CA-AKI with OT was 8.7%, and the number needed to treat was 12. Interventional complications were zero.</p><p><strong>Conclusion: </strong>Oxygen supplementation and saline hydration effectively prevented CA-AKI in CKD stages 3-5 patients undergoing elective CAG ± R. Hence, oxygen therapy should be a standard CA-AKI protective strategy during CAG ± R and radiocontrast-related procedures.</p>","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 9","pages":"e70122"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tubulointerstitial Nephritis Post-Microsporidium Infection in a Combined Liver-Kidney Transplanted Patient: A Case Report.","authors":"Alfonso Gindl-Bracho, Hector O Rivera-Villegas, Norma O Uribe-Uribe, Luis E Morales-Buenrostro, Alejandro Schcolnik-Cabrera","doi":"10.1111/nep.70121","DOIUrl":"https://doi.org/10.1111/nep.70121","url":null,"abstract":"<p><p>Microsporidia are emerging opportunistic pathogens in immunosuppressed individuals, including solid organ transplant recipients. We present a case of tubulointerstitial nephritis (TIN) caused by Microsporidia infection in a 55-year-old male who underwent combined liver-kidney transplantation (CLKT) for metabolic-associated fatty liver disease and end-stage kidney disease. The patient developed diarrhoea, abdominal bloating and acute kidney injury (AKI) 1 month post-transplant. A kidney biopsy revealed granulomatous TIN with 50% interstitial fibrosis and 60% tubular atrophy. Stool examination confirmed Microsporidia infection. Treatment with albendazole over 6months led to gradual renal function recovery. This case highlights the risk of Microsporidia infections in CLKT recipients, presenting as a rare but serious cause of graft dysfunction and AKI. Early diagnosis and treatment, including reduction in immunosuppression and antiparasitic therapy, are essential for improving outcomes in these patients. To our knowledge, this is the first report of Microsporidia infection in a CLKT recipient globally.</p>","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 9","pages":"e70121"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144995111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics, Microbiology and Outcomes of Bloodstream Infections in Patients Undergoing Haemodialysis-An Australian Network Cohort Study.","authors":"Aliya N Bryce, Brett Sobey, Paul Kinsella, Steven Y C Tong, Nigel D Toussaint","doi":"10.1111/nep.70113","DOIUrl":"https://doi.org/10.1111/nep.70113","url":null,"abstract":"<p><strong>Aim: </strong>This study reviewed the morbidity and mortality of bloodstream infections (BSIs) in patients with kidney failure receiving haemodialysis (HD).</p><p><strong>Methods: </strong>We conducted a retrospective cohort study reviewing clinical characteristics, microbiology and outcomes of BSIs in patients receiving HD from 1 December 2017 to 1 December 2023 using data from an integrated network of dialysis sites. Descriptive and regression analyses were conducted, as well as Kaplan-Meier analysis for survival.</p><p><strong>Results: </strong>Of 1461 patients who received HD over the study period, 171 positive blood cultures occurred in 137 patients. Sixty blood cultures (35%) were considered non-significant contaminants, leaving 111 significant BSIs in 97 patients. Patients with BSIs had a median age of 65 years (interquartile range [IQR]: 50-76); 61% were males, with 48% having diabetes mellitus and 57% cardiovascular disease. A high proportion of BSI episodes (66/111, 59%) were determined to be HD access-associated, primarily in patients with central venous catheters (55/111, 50%). The most frequent non-HD access-associated sources were intra-abdominal/biliary (9%) and urinary (8%). Staphylococcus aureus (25%) was the most isolated organism, followed by Staphylococcus epidermis (12%). Polymicrobial BSI occurred in 10% of episodes. Median hospitalisation length was 9 days (IQR: 6-15). Mortality at 90 days was high (24%), and on multivariate analysis was associated with increasing age (odds ratio: 1.06 per year [IQR: 1.01-1.10]).</p><p><strong>Conclusion: </strong>BSIs remain a major issue in patients receiving HD, contributing to prolonged hospitalisations and high mortality rates. HD access-associated BSIs account for a substantial proportion of BSIs and remain a pertinent target for intervention.</p>","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 9","pages":"e70113"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12377933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144986690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymic Stromal Lymphopoietin May Induce Steroid Resistance in Minimal Change Disease.","authors":"Maiko Nakayama, Hitoshi Suzuki, Yusuke Fukao, Yoshihito Nihei, Yusuke Suzuki","doi":"10.1111/nep.70123","DOIUrl":"10.1111/nep.70123","url":null,"abstract":"<p><strong>Aim: </strong>Minimal change disease (MCD) is one of the causes of idiopathic nephrotic syndrome, and 40% of patients have allergic diseases. About 30% of MCD patients become resistant to steroid after a long period of steroid therapy; however, the mechanism of steroid resistance is unclear. Thymic stromal lymphopoietin (TSLP), an epithelial cytokine, is known to be associated with steroid-resistant allergic disease. Experiments using mouse models of asthma suggest that TSLP-mediated phosphorylation of signal transducer and activator of transcription 5 (STAT5) binds to corticosteroid receptors, resulting in steroid resistance. In the present study, we aim to investigate whether TSLP is involved in steroid resistance in patients with MCD.</p><p><strong>Methods: </strong>We compared serum TSLP levels in patients with MCD (n = 26) and healthy controls (n = 13). The cultured podocytes were used to investigate whether TSLP attenuates the podocyte-protective effect of dexamethasone (DEX) and whether the administration of a TSLP-neutralising antibody abolishes TSLP-induced steroid resistance.</p><p><strong>Results: </strong>The level of serum TSLP in patients with MCD was significantly higher than that in healthy controls (p < 0.05). Of note, in patients with MCD, serum TSLP levels significantly elevated at recurrence (p < 0.05). In vitro, DEX protected podocytes from Adriamycin-induced injury. The protective effect of DEX on podocytes was attenuated by co-culture with TSLP (p < 0.01). However, treatment with TSLP neutralising antibody improved TSLP-induced steroid resistance (p < 0.001). We also found that TSLP induces STAT5 activation in podocytes, which is blocked by TSLP-neutralising antibodies.</p><p><strong>Conclusion: </strong>TSLP may be involved in steroid resistance via the STAT5 pathway in podocytes.</p>","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 9","pages":"e70123"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145071627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}