Nephrology (Carlton, Vic.)最新文献

New Insights Into Gender Differences in Sarcopenia Among Haemodialysis Patients Through BMI-FTI Quadrant Analysis. 通过BMI-FTI象限分析血液透析患者肌肉减少症的性别差异。

IF 1.9

Nephrology (Carlton, Vic.) Pub Date : 2025-08-01 DOI: 10.1111/nep.70105

Hiroki Ito, Takefumi Mori

引用次数: 0

Ageing Is Not a Disease: Reconsidering Chronic Kidney Disease Diagnosis in the Elderly. 衰老不是一种疾病：重新考虑老年慢性肾脏疾病的诊断。

IF 1.9

Nephrology (Carlton, Vic.) Pub Date : 2025-08-01 DOI: 10.1111/nep.70101

Diego Moriconi

引用次数: 0

Clarifying Assumptions and Interpretation in a Mendelian Randomisation Study of SHBG and Membranous Nephropathy. 澄清SHBG和膜性肾病的孟德尔随机研究中的假设和解释。

Nephrology (Carlton, Vic.) Pub Date : 2025-07-01 DOI: 10.1111/nep.70099

Masashi Hasebe, Chen-Yang Su

引用次数: 0

Are Your Kidneys Ok? Detect Early to Protect Kidney Health. 你的肾脏还好吗？早期发现，保护肾脏健康。

Nephrology (Carlton, Vic.) Pub Date : 2025-07-01 DOI: 10.1111/nep.70078

Joseph A Vassalotti, Anna Francis, Augusto Cesar Soares Dos Santos, Ricardo Correa-Rotter, Dina Abdellatif, Li-Li Hsiao, Stefanos Roumeliotis, Agnes Haris, Latha A Kumaraswami, Siu-Fai Lui, Alessandro Balducci, Vassilios Liakopoulos

{"title":"Are Your Kidneys Ok? Detect Early to Protect Kidney Health.","authors":"Joseph A Vassalotti, Anna Francis, Augusto Cesar Soares Dos Santos, Ricardo Correa-Rotter, Dina Abdellatif, Li-Li Hsiao, Stefanos Roumeliotis, Agnes Haris, Latha A Kumaraswami, Siu-Fai Lui, Alessandro Balducci, Vassilios Liakopoulos","doi":"10.1111/nep.70078","DOIUrl":"https://doi.org/10.1111/nep.70078","url":null,"abstract":"Early identification of kidney disease can protect kidney health, prevent kidney disease progression and related complications, reduce cardiovascular disease (CVD) risk and decrease mortality. We must ask 'Are your kidneys ok?' using serum creatinine to estimate kidney function and urine albumin to assess for kidney and endothelial damage. Evaluation for causes and risk factors for chronic kidney disease (CKD) includes testing for diabetes and measurement of blood pressure and body mass index. This World Kidney Day, we assert that case-finding in high-risk populations, or even population-level screening, can decrease the burden of kidney disease globally. Early-stage CKD is asymptomatic, simple to test for and recent paradigm-shifting CKD treatments, such as sodium glucose co-transporter-2 inhibitors, dramatically improve outcomes and favour the cost-benefit analysis for screening or case-finding programmes. Despite this, numerous barriers exist, including resource allocation, healthcare funding, healthcare infrastructure and healthcare-professional and population awareness of kidney disease. Coordinated efforts by major kidney non-governmental organisations to prioritise the kidney health agenda for governments and aligning early detection efforts with other current programmes will maximise efficiencies.","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 7","pages":"e70078"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melatonin Protects Against Diabetic Kidney Disease via the SIRT1/NLRP3 Signalling Pathway. 褪黑素通过SIRT1/NLRP3信号通路预防糖尿病肾病

Nephrology (Carlton, Vic.) Pub Date : 2025-07-01 DOI: 10.1111/nep.70073

Yaping Zhang, Yinghui Wang, Jingyan Yang, Gang Liu

{"title":"Melatonin Protects Against Diabetic Kidney Disease via the SIRT1/NLRP3 Signalling Pathway.","authors":"Yaping Zhang, Yinghui Wang, Jingyan Yang, Gang Liu","doi":"10.1111/nep.70073","DOIUrl":"https://doi.org/10.1111/nep.70073","url":null,"abstract":"Aim: Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease. Melatonin, a hormone with anti-oxidative and anti-inflammatory properties, has demonstrated potential in mitigating diabetic complications; however, its specific effects and mechanisms in DKD remain unclear. This study aimed to investigate the protective effects of melatonin on podocyte injury and renal damage in DKD and to elucidate its underlying mechanisms.Methods: In vitro, podocytes were exposed to high glucose (HG) and advanced glycation end products (AGEs) to simulate a diabetic environment. The effects of melatonin on podocyte viability, cytoskeletal organisation, oxidative stress markers (MDA, SOD, CAT, and GSH), and NLRP3 signalling activation were assessed. In vivo, a DKD mouse model was treated with melatonin, and renal function, histopathology, oxidative stress, and inflammation were evaluated. The role of SIRT1 in mediating the effects of melatonin was also investigated.Results: Melatonin improved podocyte viability, alleviated cytoskeletal disorganisation, reduced oxidative stress (decreased MDA, increased SOD, CAT, and GSH), and inhibited activation of the NLRP3 signalling pathway in podocytes and renal tissues. In DKD mice, melatonin reduced proteinuria, improved renal histopathology, and suppressed NLRP3-mediated inflammation. Mechanistically, melatonin upregulated SIRT1 expression, which inhibited NLRP3 activation and downstream inflammatory responses.Conclusion: Melatonin protects against DKD by enhancing podocyte viability, reducing oxidative stress, and suppressing NLRP3-mediated inflammation through SIRT1 upregulation. These findings highlight the potential of melatonin as a therapeutic agent for DKD.","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 7","pages":"e70073"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IgA Nephropathy With Membranoproliferative Pattern and Resistance to Immunosuppressive Therapy in Two Patients With Cofactor I Pathogenic Variant. 2例辅助因子I致病性变异体伴膜增生性IgA肾病及免疫抑制治疗耐药

Nephrology (Carlton, Vic.) Pub Date : 2025-07-01 DOI: 10.1111/nep.70092

Tommaso Mazzierli, Pamela Gallo, Costanza Giuliani, Elisabetta Pelo, Pietro Dattolo, Chiara Somma

引用次数: 0

Coronavirus Disease 2019 Vaccination Booster Effectiveness Based on the 2022 Japanese Dialysis Registry. 基于2022年日本透析登记的2019冠状病毒病疫苗增强效果

Nephrology (Carlton, Vic.) Pub Date : 2025-07-01 DOI: 10.1111/nep.70093

Yuka Sugawara, Masao Iwagami, Yuki Sakurai, Kan Kikuchi, Masaomi Nangaku

{"title":"Coronavirus Disease 2019 Vaccination Booster Effectiveness Based on the 2022 Japanese Dialysis Registry.","authors":"Yuka Sugawara, Masao Iwagami, Yuki Sakurai, Kan Kikuchi, Masaomi Nangaku","doi":"10.1111/nep.70093","DOIUrl":"10.1111/nep.70093","url":null,"abstract":"Aim: To evaluate the effectiveness of the third, fourth, and fifth booster doses (rolled out in December 2021, June 2022, and October 2022, respectively) of the coronavirus disease 2019 (COVID-19) vaccine in Japanese haemodialysis patients during the Omicron era.Methods: We analysed the Japanese Society for Dialysis Therapy Renal Data Registry (JRDR) year-end survey data from 2021 to 2022, which included information on the number of vaccinations and the most recent vaccination and infection months. For each month of 2022, the COVID-19 infection and related mortality risks were calculated by vaccination status, followed by logistic regression analyses to estimate adjusted odds ratios (aORs).Results: Overall, 225 887 patients were analysed, including 13 440 (5.9%), 25 547 (11.3%), 64 242 (28.4%), and 122 658 (54.3%) with ≤ 2, 3, 4, and 5 doses at the end of 2022, respectively. The third dose was significantly correlated with a lower risk of COVID-19 infection in early 2022 (March: aOR 0.53 [0.43-0.64]; April: 0.77 [0.63-0.95]) but was associated with a higher risk during mid-2022, coinciding with the BA.1/2 to BA.5 transition (July: 1.65 [1.39-1.95]; August: 2.37 [2.06-2.71]). The third dose consistently correlated with reduced COVID-19-related mortality. The fourth and fifth doses correlated with lower infection risk and COVID-19-related mortality throughout the period.Conclusion: Among Japanese haemodialysis patients, the third to fifth COVID-19 vaccine doses were associated with reduced infection risk (except in July and August for third doses) and mortality.","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 7","pages":"e70093"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baseline Potassium Levels and Their Association With Electrocardiograph Abnormalities in Hyperkalaemia. 基线钾水平及其与高钾血症心电图异常的关系。

Nephrology (Carlton, Vic.) Pub Date : 2025-07-01 DOI: 10.1111/nep.70100

Takashin Nakayama, Ryunosuke Mitsuno, Tatsuhiko Azegami, Kyosei Nakamura, Shinnosuke Sugihara, Hiroaki Miyauchi, Akira Nakamura, Norifumi Yoshimoto, Akihito Hishikawa, Aika Hagiwara, Kaori Hayashi

{"title":"Baseline Potassium Levels and Their Association With Electrocardiograph Abnormalities in Hyperkalaemia.","authors":"Takashin Nakayama, Ryunosuke Mitsuno, Tatsuhiko Azegami, Kyosei Nakamura, Shinnosuke Sugihara, Hiroaki Miyauchi, Akira Nakamura, Norifumi Yoshimoto, Akihito Hishikawa, Aika Hagiwara, Kaori Hayashi","doi":"10.1111/nep.70100","DOIUrl":"https://doi.org/10.1111/nep.70100","url":null,"abstract":"Background: Hyperkalaemia poses a life-threatening risk due to cardiac arrhythmias. Hyperkalaemic serum potassium (HK) levels are associated with the development of electrocardiograph (ECG) abnormalities, while the potential relationship between baseline serum potassium (BK) levels and these changes remains unclear.Methods: This retrospective cohort study involved outpatients identified with severe hyperkalaemia (serum potassium level ≥ 6.5 mEq/L). BK levels were defined as the average of the three most recent values prior to the severe hyperkalaemia episode. Hyperkalaemia-associated ECG changes were determined by comparison with the recordings taken during normokalaemia.Results: Among 283 patients, the median age was 74 (63-82) years, with 90 patients (31.8%) being female. The median BK and HK levels were 5.0 (4.5-5.3) and 6.8 (6.6-7.1) mEq/L, respectively. The most frequent ECG changes in hyperkalaemia were peaked T waves (35.7%), followed by prolonged PR interval (12.1%), bradycardia (12.0%), widened QRS duration (7.8%), escape rhythm (7.1%), second- or third-degree atrioventricular block (3.5%), and ventricular arrhythmias (0.7%). Logistic regression analyses adjusted for potential confounders demonstrated that both the below-median BK and above-median HK levels were associated with an increased likelihood of developing ECG changes (odds ratio [OR], 4.61; 95% confidence interval [CI], 2.44-8.72 and OR, 2.28; 95% CI, 1.34-3.89, respectively), as was a greater BK-HK level difference (OR, 6.85; 95% CI, 3.68-12.77).Conclusion: BK levels as well as HK levels were significant predictors of ECG abnormalities. Healthcare professionals should place emphasis on the magnitude of potassium increase when managing hyperkalaemia.","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 7","pages":"e70100"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144652070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine Learning Models for Predicting Acute and Chronic Kidney Diseases During the Post-Covid-19 Pandemic. 后covid -19大流行期间预测急性和慢性肾脏疾病的机器学习模型。

Nephrology (Carlton, Vic.) Pub Date : 2025-07-01 DOI: 10.1111/nep.70097

Chen-Yang Su, Masashi Hasebe

引用次数: 0

Three Years Outcome Comparison of Remote Monitoring Versus Conventional Automated Peritoneal Dialysis in Incident APD Patients: A Retrospective Study From Taiwan. 远程监测与传统自动腹膜透析治疗APD的三年疗效比较：来自台湾的回顾性研究。

Nephrology (Carlton, Vic.) Pub Date : 2025-07-01 DOI: 10.1111/nep.70061

Mu-Chi Chung, Tung-Min Yu, Laing-You Wu, Ching-Ching Hsiao, Ya-Wen Chuang, Ming-Ju Wu, Cheng-Hsu Chen, Chi-Jung Chung

{"title":"Three Years Outcome Comparison of Remote Monitoring Versus Conventional Automated Peritoneal Dialysis in Incident APD Patients: A Retrospective Study From Taiwan.","authors":"Mu-Chi Chung, Tung-Min Yu, Laing-You Wu, Ching-Ching Hsiao, Ya-Wen Chuang, Ming-Ju Wu, Cheng-Hsu Chen, Chi-Jung Chung","doi":"10.1111/nep.70061","DOIUrl":"https://doi.org/10.1111/nep.70061","url":null,"abstract":"Aim: The efficacy of the remote monitoring of automated peritoneal dialysis (RM-APD) with Sharesource platform versus conventional APD outcomes in East Asia remains limited.Methods: This study analysed data from incident APD patients at Taichung Veterans General Hospital between 2010 and 2021. Patients were categorised into RM-APD (n = 77, initiated March 2019-Dec 2021) and conventional APD groups (n = 100, initiated Jan 2010-Dec 2017). Follow-up for both groups extended to censoring, studied outcomes, or the end of the observation period (Dec 2018 for conventional APD and Dec 2022 for RM-APD), with a maximum follow-up of 3 years. Outcomes included death, technique survival, peritonitis incidence and hospitalisation rates using Cox proportional hazard models.Results: Among 452 patients undergoing peritoneal dialysis, 177 were included after exclusions. Mean age was 49 years in RM-APD and 46 years in conventional APD groups. After mean follow-up of 2.05 years, no significant differences were found in mortality, technique survival rates, or hospitalisation rates between groups. However, RM-APD showed significantly lower peritonitis incidence compared to conventional APD (HR = 0.39, 95% CI: 0.17-0.90, p < 0.05). The conventional APD group had 3 relapse peritonitis and 2 transfer to HD, while the RM-APD group had none.Conclusions: RM-APD using Sharesource platform significantly reduces peritonitis incidence compared to conventional APD in Taiwan. While mortality and technique survival were similar, improved peritonitis outcomes suggest RM-APD can enhance care quality and safety for incident APD patients in clinical practice. Further prospective studies are warranted to validate these findings.","PeriodicalId":520716,"journal":{"name":"Nephrology (Carlton, Vic.)","volume":"30 7","pages":"e70061"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0