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Battling the two-headed dragon of prostate cancer targeted therapy. 对抗前列腺癌靶向治疗的双头龙。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-04-14 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1745037
Scott Wilkinson, Adam G Sowalsky
{"title":"Battling the two-headed dragon of prostate cancer targeted therapy.","authors":"Scott Wilkinson,&nbsp;Adam G Sowalsky","doi":"10.1080/23723556.2020.1745037","DOIUrl":"https://doi.org/10.1080/23723556.2020.1745037","url":null,"abstract":"<p><p>Neoadjuvant intense androgen deprivation therapy for high-risk localized prostate cancer is an emerging but unproven treatment paradigm that is hoped to delay or prevent disease recurrence. We found that a patient enrolled in a clinical trial harbored two completely independent prostate cancers that responded differently to this therapy.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1745037"},"PeriodicalIF":2.1,"publicationDate":"2020-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1745037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38392171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
S1PR1 and VEGFR2 - a synergy that promotes tumor angiogenesis? S1PR1和VEGFR2 -促进肿瘤血管生成的协同作用?
IF 2.1
Molecular & cellular oncology Pub Date : 2020-04-07 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1746131
Vijay Avin Balaji Ragunathrao, Vigneshwaran Vellingiri, Mumtaz Anwar, Md Zahid Akhter, Dolly Mehta
{"title":"S1PR1 and VEGFR2 - a synergy that promotes tumor angiogenesis?","authors":"Vijay Avin Balaji Ragunathrao,&nbsp;Vigneshwaran Vellingiri,&nbsp;Mumtaz Anwar,&nbsp;Md Zahid Akhter,&nbsp;Dolly Mehta","doi":"10.1080/23723556.2020.1746131","DOIUrl":"https://doi.org/10.1080/23723556.2020.1746131","url":null,"abstract":"<p><p>We have recently uncovered that endothelial cell (EC) S1PR1 controls the effectiveness of VEGFR2 driven tumor angiogenesis. By using tumor ECs, EC-S1PR1<sup>-/-</sup> mice and S1PR1 antagonist, we showed that VEGF-VEGFR2 pathway requires EC-S1PR1-induced signaling to efficiently drive tumor vascularization and growth, indicating combining S1PR1 antagonist with anti-VEGF/VEGFR2 therapy may eradicate resistant tumors.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1746131"},"PeriodicalIF":2.1,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1746131","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38490000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress. prmt1依赖性精氨酸甲基化在细胞对基因毒性应激反应中的双重作用。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-04-07 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1743808
Roberto Giambruno, Tiziana Bonaldi
{"title":"Dual role of PRMT1-dependent arginine methylation in cellular responses to genotoxic stress.","authors":"Roberto Giambruno,&nbsp;Tiziana Bonaldi","doi":"10.1080/23723556.2020.1743808","DOIUrl":"https://doi.org/10.1080/23723556.2020.1743808","url":null,"abstract":"<p><p>We have recently shown that arginine methylation by protein arginine N-methyltransferase 1 (PRMT1) controls the response to cisplatin in ovarian cancer cells. In addition to increased methylation of chromatin proteins that favors senescence-associated secretory phenotype (SASP) activation, our study unraveled global hypo-methylation of RNA-binding proteins, which - we speculate - may promote their phase separation and stress granules formation.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1743808"},"PeriodicalIF":2.1,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1743808","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38392170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Centromere strength: just a sense of proportion. 着丝粒强度:只是一种比例感。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-04-07 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1742063
Marie Dumont, Daniele Fachinetti
{"title":"Centromere strength: just a sense of proportion.","authors":"Marie Dumont,&nbsp;Daniele Fachinetti","doi":"10.1080/23723556.2020.1742063","DOIUrl":"https://doi.org/10.1080/23723556.2020.1742063","url":null,"abstract":"<p><p>The overall structure and composition of human centromeres have been well reported, but how these elements vary between individual chromosomes and influence the chromosome-specific behavior during mitosis remains untested. In our study, we discover the existence of heterogeneity of centromeric DNA features that dictates the chromosome segregation fidelity during mitosis.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1742063"},"PeriodicalIF":2.1,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1742063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38392169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Mechanisms of spindle bipolarity establishment in acentrosomal human cells. 梭形体双极性在人类无核体细胞中建立的机制。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-04-03 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1743899
Kaho Hashimoto, Takumi Chinen, Daiju Kitagawa
{"title":"Mechanisms of spindle bipolarity establishment in acentrosomal human cells.","authors":"Kaho Hashimoto,&nbsp;Takumi Chinen,&nbsp;Daiju Kitagawa","doi":"10.1080/23723556.2020.1743899","DOIUrl":"https://doi.org/10.1080/23723556.2020.1743899","url":null,"abstract":"<p><p>Centrosomes are not absolutely essential for cell division; acentrosomal bipolar spindles can be established in oocytes and centrosome-eliminated somatic cells. However, the detailed mechanisms describing how spindle bipolarity is established without centrosomes are not completely understood. We have recently demonstrated that in acentrosomal human cells, nuclear mitotic apparatus protein (NuMA) assemblies-mediated microtubule asters and EG5 promote spindle bipolarization in early mitosis.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1743899"},"PeriodicalIF":2.1,"publicationDate":"2020-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1743899","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37922197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Cancer neoantigens and immunogenicity: mutation position matters. 癌症新抗原和免疫原性:突变位置问题。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-04-03 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1740071
Aude-Hélène Capietto, Suchit Jhunjhunwala, Lélia Delamarre
{"title":"Cancer neoantigens and immunogenicity: mutation position matters.","authors":"Aude-Hélène Capietto,&nbsp;Suchit Jhunjhunwala,&nbsp;Lélia Delamarre","doi":"10.1080/23723556.2020.1740071","DOIUrl":"https://doi.org/10.1080/23723556.2020.1740071","url":null,"abstract":"<p><p>Cancer mutations can elicit protective immunity. Computational methods are critical for selecting these neoantigens for immunotherapy. While significant progress has been made in the field in predicting peptide presentation, our understanding of which mutated peptide is recognized as foreign by T cells remains limited. We used mouse vaccination studies to examine the features of immunogenic neoantigens and demonstrated that the mutation position is an important criterion for predicting neoantigens.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1740071"},"PeriodicalIF":2.1,"publicationDate":"2020-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1740071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37922195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins. 修复蛋白对不同DNA结构的致突变加工的不同机制。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-04-02 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1743807
Jennifer A McKinney, Guliang Wang, Karen M Vasquez
{"title":"Distinct mechanisms of mutagenic processing of alternative DNA structures by repair proteins.","authors":"Jennifer A McKinney,&nbsp;Guliang Wang,&nbsp;Karen M Vasquez","doi":"10.1080/23723556.2020.1743807","DOIUrl":"https://doi.org/10.1080/23723556.2020.1743807","url":null,"abstract":"<p><p>Repetitive sequences can form a variety of alternative DNA structures (non-B DNA) that can modulate transcription, replication, and repair. However, non-B DNA-forming sequences can also stimulate mutagenesis, and are enriched at mutation hotspots in human cancer genomes. Interestingly, different types of non-B DNA stimulate mutagenesis via distinct repair processing mechanisms.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1743807"},"PeriodicalIF":2.1,"publicationDate":"2020-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1743807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37922196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
An automated tissue-to-diagnosis pipeline using intraoperative stimulated Raman histology and deep learning. 使用术中刺激拉曼组织学和深度学习的自动组织到诊断管道。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-04-01 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1736742
Todd C Hollon, Daniel A Orringer
{"title":"An automated tissue-to-diagnosis pipeline using intraoperative stimulated Raman histology and deep learning.","authors":"Todd C Hollon,&nbsp;Daniel A Orringer","doi":"10.1080/23723556.2020.1736742","DOIUrl":"https://doi.org/10.1080/23723556.2020.1736742","url":null,"abstract":"<p><p>We recently developed and validated a bedside tissue-to-diagnosis pipeline using stimulated Raman histology (SRH), a label-free optical imaging method, and deep convolutional neural networks (CNN) in prospective clinical trial. Our CNN learned a hierarchy of interpretable histologic features found in the most common brain tumors and was able to accurately segment cancerous regions in SRH images.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1736742"},"PeriodicalIF":2.1,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1736742","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37922193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Targeting potassium channels and autophagy to defeat chemoresistance. 以钾通道和自噬为靶点，战胜化疗耐药。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-03-30 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1745038
Giulia Petroni
{"title":"Targeting potassium channels and autophagy to defeat chemoresistance.","authors":"Giulia Petroni","doi":"10.1080/23723556.2020.1745038","DOIUrl":"https://doi.org/10.1080/23723556.2020.1745038","url":null,"abstract":"<p><p>Both autophagy and hERG1 potassium channels have been shown to promote tumor progression and resistance to treatment. Our findings indicate that the antibiotic clarithromycin can target hERG1 and modulate autophagy to promote the death of chemoresistant colorectal cancer cells. Thus, clarithromycin stands out as promising combinatorial partner to improve the efficacy of chemotherapy in patients with colorectal cancer.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1745038"},"PeriodicalIF":2.1,"publicationDate":"2020-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1745038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37922198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation. 没有杀死你的东西会让你更强壮：通过细胞骨架重塑和肌球蛋白II再激活在抗癌治疗中存活下来。
Molecular & cellular oncology Pub Date : 2020-03-26 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1735911
Jose L Orgaz, Victoria Sanz-Moreno
{"title":"What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation.","authors":"Jose L Orgaz, Victoria Sanz-Moreno","doi":"10.1080/23723556.2020.1735911","DOIUrl":"10.1080/23723556.2020.1735911","url":null,"abstract":"<p><p>Myosin II and its regulator Rho-associated coiled-coil containing protein kinase (ROCK) are essential for cell invasion and metastatic dissemination. Our recent findings show that this molecular machinery is also involved in drug resistance in melanoma by playing a dual role: protection of tumor cells from reactive oxygen species (ROS) and DNA damage (intrinsic), and co-option of myeloid and lymphoid populations to establish immunosuppression (extrinsic).</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1735911"},"PeriodicalIF":0.0,"publicationDate":"2020-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37922235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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