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Ser784 phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response. Ser784磷酸化:在DNA损伤反应中VCP功能的临床相关增强剂。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-08-12 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1796179
Jieya Shao
{"title":"Ser<sup>784</sup> phosphorylation: a clinically relevant enhancer of VCP function in the DNA damage response.","authors":"Jieya Shao","doi":"10.1080/23723556.2020.1796179","DOIUrl":"https://doi.org/10.1080/23723556.2020.1796179","url":null,"abstract":"<p><p>Valosin-containing protein (VCP) is essential for proteostasis during many cellular processes. However, it remains uncertain how its diverse functions are selectively regulated. We recently showed that DNA damage-induced Ser<sup>784</sup> phosphorylation specifically increases VCP function for the DNA damage response and significantly influences the survival of chemotherapy-treated breast cancer patients.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1796179"},"PeriodicalIF":2.1,"publicationDate":"2020-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1796179","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Overcoming resistance to immunotherapy by teaching old drugs new tricks. 通过教旧药物新方法来克服免疫疗法的耐药性。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-08-12 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1801088
John M Perry, Linheng Li
{"title":"Overcoming resistance to immunotherapy by teaching old drugs new tricks.","authors":"John M Perry,&nbsp;Linheng Li","doi":"10.1080/23723556.2020.1801088","DOIUrl":"https://doi.org/10.1080/23723556.2020.1801088","url":null,"abstract":"<p><p>Cancer stem cells (CSCs) underlie resistance to therapy. Cancer develops only in the context of failing immunosurveillance, and stem cells occupy immune privileged microenvironments. Recent evidence demonstrates that CSCs borrow immune privilege from their normal counterparts. However, low doses of doxorubicin can target CSCs by restoring anticancer immunity.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1801088"},"PeriodicalIF":2.1,"publicationDate":"2020-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1801088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer. 模拟禁食的饮食和维生素C:用抗衰老策略对抗癌症。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-29 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1791671
Maira Di Tano, Valter D Longo
{"title":"A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer.","authors":"Maira Di Tano,&nbsp;Valter D Longo","doi":"10.1080/23723556.2020.1791671","DOIUrl":"https://doi.org/10.1080/23723556.2020.1791671","url":null,"abstract":"<p><p>In search of anti-aging interventions with differential effects on normal and cancer cells, we show that cycles of a fasting-mimicking diet plus pharmacological doses of vitamin C can be effective in targeting <i>KRAS</i>-mutant cancers. This approach represents a promising strategy able to protect the organism while killing cancer cells.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1791671"},"PeriodicalIF":2.1,"publicationDate":"2020-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1791671","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics. 棕榈酸通过损害自噬体-溶酶体融合和内溶酶体动力学来降低下丘脑神经元的自噬通量。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-25 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1789418
María Paz Hernández-Cáceres, Karina Cereceda, Sergio Hernández, Ying Li, Carla Narro, Patricia Rivera, Patricio Silva, Yenniffer Ávalos, Claudia Jara, Paulina Burgos, Lilian Toledo-Valenzuela, Pablo Lagos, Flavia Cifuentes Araneda, Claudio Perez-Leighton, Cristina Bertocchi, Deborah J Clegg, Alfredo Criollo, Cheril Tapia-Rojas, Patricia V Burgos, Eugenia Morselli
{"title":"Palmitic acid reduces the autophagic flux in hypothalamic neurons by impairing autophagosome-lysosome fusion and endolysosomal dynamics.","authors":"María Paz Hernández-Cáceres,&nbsp;Karina Cereceda,&nbsp;Sergio Hernández,&nbsp;Ying Li,&nbsp;Carla Narro,&nbsp;Patricia Rivera,&nbsp;Patricio Silva,&nbsp;Yenniffer Ávalos,&nbsp;Claudia Jara,&nbsp;Paulina Burgos,&nbsp;Lilian Toledo-Valenzuela,&nbsp;Pablo Lagos,&nbsp;Flavia Cifuentes Araneda,&nbsp;Claudio Perez-Leighton,&nbsp;Cristina Bertocchi,&nbsp;Deborah J Clegg,&nbsp;Alfredo Criollo,&nbsp;Cheril Tapia-Rojas,&nbsp;Patricia V Burgos,&nbsp;Eugenia Morselli","doi":"10.1080/23723556.2020.1789418","DOIUrl":"https://doi.org/10.1080/23723556.2020.1789418","url":null,"abstract":"<p><p>High-fat diet (HFD)-induced obesity is associated with increased cancer risk. Long-term feeding with HFD increases the concentration of the saturated fatty acid palmitic acid (PA) in the hypothalamus. We previously showed that, in hypothalamic neuronal cells, exposure to PA inhibits the autophagic flux, which is the whole autophagic process from the synthesis of the autophagosomes, up to their lysosomal fusion and degradation. However, the mechanism by which PA impairs autophagy in hypothalamic neurons remains unknown. Here, we show that PA-mediated reduction of the autophagic flux is not caused by lysosomal dysfunction, as PA treatment does not impair lysosomal pH or the activity of cathepsin B.Instead, PA dysregulates autophagy by reducing autophagosome-lysosome fusion, which correlates with the swelling of endolysosomal compartments that show areduction in their dynamics. Finally, because lysosomes undergo constant dynamic regulation by the small Rab7 GTPase, we investigated the effect of PA treatment on its activity. Interestingly, we found PA treatment altered the activity of Rab7. Altogether, these results unveil the cellular process by which PA exposure impairs the autophagic flux. As impaired autophagy in hypothalamic neurons promotes obesity, and balanced autophagy is required to inhibit malignant transformation, this could affect tumor initiation, progression, and/or response to therapy of obesity-related cancers.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1789418"},"PeriodicalIF":2.1,"publicationDate":"2020-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1789418","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 21
Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development. Brca1卷曲结构域的突变阻碍了Rad51在DNA上的装载和小鼠的发育。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-20 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1786345
J J Krais, N Johnson
{"title":"<i>Brca1</i> mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development.","authors":"J J Krais,&nbsp;N Johnson","doi":"10.1080/23723556.2020.1786345","DOIUrl":"https://doi.org/10.1080/23723556.2020.1786345","url":null,"abstract":"<p><p>We recently developed a <i>Brca1</i> coiled-coil mutant mouse model (<i>Brca1<sup>CC</sup></i> ). <i>Brca1<sup>CC/CC</sup></i> results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia. <i>Brca1<sup>CC/CC</sup></i> cells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-crossing with <i>Brca1<sup>Δ11</sup></i> generated <i>Brca1</i> <sup>CC/<i>Δ11</i></sup> mice that were developmentally normal.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1786345"},"PeriodicalIF":2.1,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1786345","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stress-induced metastatic niches in breast cancer. 应激诱导的乳腺癌转移龛。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-17 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1780105
Thordur Oskarsson
{"title":"Stress-induced metastatic niches in breast cancer.","authors":"Thordur Oskarsson","doi":"10.1080/23723556.2020.1780105","DOIUrl":"https://doi.org/10.1080/23723556.2020.1780105","url":null,"abstract":"<p><p>Interactions between disseminated cancer cells and the microenvironment in secondary organs are essential for the development of metastasis in most malignancies. Metastasis-initiating cells and their progeny can impose changes in the microenvironment leading to the formation of a metastatic niche that supports malignant growth at secondary sites. Our recent findings indicate that stress responses play a crucial role in generation of metastatic niches in breast cancer by modulating the extracellular matrix and promoting interactions with reactive fibroblasts.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1780105"},"PeriodicalIF":2.1,"publicationDate":"2020-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1780105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The phospho-barcode of RIPK1: complementarity or redundancy? RIPK1的磷酸化条形码:互补还是冗余?
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-16 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1776085
Wenxian Wu, Björn Stork
{"title":"The phospho-barcode of RIPK1: complementarity or redundancy?","authors":"Wenxian Wu,&nbsp;Björn Stork","doi":"10.1080/23723556.2020.1776085","DOIUrl":"https://doi.org/10.1080/23723556.2020.1776085","url":null,"abstract":"ABSTRACT Receptor interacting serine/threonine kinase 1 (RIPK1) is the central mediator of tumor necrosis factor (TNF) signaling. It regulates both pro-survival/pro-inflammatory and cell death pathways. In order to fulfill this complex regulation, RIPK1 is regulated by several post-translational modifications, including ubiquitination, acetylation, and phosphorylation. In our recent work, we show that the unc-51-like autophagy activating kinase 1 (ULK1) phosphorylates RIPK1 at Ser357 and thus blocks TNF-induced cell death.","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1776085"},"PeriodicalIF":2.1,"publicationDate":"2020-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1776085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38391995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HSP70 promotes MLKL polymerization and necroptosis. HSP70促进MLKL聚合和坏死坏死。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-14 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1791561
Andrea N Johnston, Zhigao Wang
{"title":"HSP70 promotes MLKL polymerization and necroptosis.","authors":"Andrea N Johnston,&nbsp;Zhigao Wang","doi":"10.1080/23723556.2020.1791561","DOIUrl":"https://doi.org/10.1080/23723556.2020.1791561","url":null,"abstract":"<p><p>Mixed lineage kinase domain-like protein (MLKL) is the proposed executioner of necroptosis. Our recent findings identify a novel inhibitor necroptosis-blocking compound 1 (NBC1) which specifically conjugates to two cysteines of heat shock protein 70 (HSP70) to block its function. Importantly, HSP70 promotes MLKL polymerization to activate necroptosis.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1791561"},"PeriodicalIF":2.1,"publicationDate":"2020-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1791561","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
SOX6: a double-edged sword for Ewing sarcoma. SOX6:治疗尤文氏肉瘤的双刃剑。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-14 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1783081
Aruna Marchetto, Thomas G P Grünewald
{"title":"SOX6: a double-edged sword for Ewing sarcoma.","authors":"Aruna Marchetto,&nbsp;Thomas G P Grünewald","doi":"10.1080/23723556.2020.1783081","DOIUrl":"https://doi.org/10.1080/23723556.2020.1783081","url":null,"abstract":"<p><p>Developmental pathways play an important role in cancer. We have recently demonstrated that the constitutive activation of the developmental transcription factor SOX6 via the fusion oncoproteinne EWSR1-FLI1 (Ewing sarcoma breakpoint region 1 - Friend leukemia virus integration 1) contributes to the aggressive phenotype of Ewing sarcoma but on another hand provides an opportunity for targeted therapy.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1783081"},"PeriodicalIF":2.1,"publicationDate":"2020-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1783081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Expression patterns and clinical significance of the potential cancer stem cell markers OCT4 and NANOG in colorectal cancer patients. 潜在肿瘤干细胞标志物OCT4和NANOG在结直肠癌患者中的表达模式及临床意义
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-14 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1788366
Raheleh Roudi, Mahboubeh Barodabi, Zahra Madjd, Giandomenico Roviello, Silvia Paola Corona, Mahshid Panahei
{"title":"Expression patterns and clinical significance of the potential cancer stem cell markers OCT4 and NANOG in colorectal cancer patients.","authors":"Raheleh Roudi,&nbsp;Mahboubeh Barodabi,&nbsp;Zahra Madjd,&nbsp;Giandomenico Roviello,&nbsp;Silvia Paola Corona,&nbsp;Mahshid Panahei","doi":"10.1080/23723556.2020.1788366","DOIUrl":"https://doi.org/10.1080/23723556.2020.1788366","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is one of the most important malignancies and causes of cancer-related deaths worldwide. Cancer stem cell markers identification could be helpful to acquire important prognostic information and develop new treatment regimens. This study aimed to evaluate the expression of OCT4 and NANOG in CRC patients and their clinical significance.</p><p><p>Totally 359 CRC samples were stained for OCT4 and NANOG expression using tissue microarray. The correlation between their expression and clinical and pathological features was explored.</p><p><p>The majority of CRC cases showed low-level expression of OCT4 (80%) and NANOG (75%). Lower expression of OCT4 was more often detected in CRC cases with no vascular involvement (<i>P</i> = .01). Also, a trend found between low level of OCT4 expression and absence of distant metastasis or lymph node involvement (<i>P</i> = .07 and <i>P</i> = .09, respectively). Surprisingly, a significant positive correlation was observed between NANOG expression and cellular differentiation (<i>P</i> = .05). Our combined analysis demonstrated that OCT4 <sup>low</sup>/NANOG <sup>low</sup> phenotype has frequently seen in colorectal cancer cases with no vascular invasion (<i>P</i> = .05).</p><p><p>Our observations indicated that higher expression of OCT4 and NANOG can confer malignant and aggressive behavior to CRC. Evaluation of the co-expression of these cancer stem cell markers can serve a new diagnostic and prognostic approach in CRC patients. These findings also suggested that simultaneous expression of OCT4 and NANOG can be considered as a therapeutic marker for targeted therapy of CRC, especially in advanced stages.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1788366"},"PeriodicalIF":2.1,"publicationDate":"2020-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1788366","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
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