{"title":"Brca1卷曲结构域的突变阻碍了Rad51在DNA上的装载和小鼠的发育。","authors":"J J Krais, N Johnson","doi":"10.1080/23723556.2020.1786345","DOIUrl":null,"url":null,"abstract":"<p><p>We recently developed a <i>Brca1</i> coiled-coil mutant mouse model (<i>Brca1<sup>CC</sup></i> ). <i>Brca1<sup>CC/CC</sup></i> results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia. <i>Brca1<sup>CC/CC</sup></i> cells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-crossing with <i>Brca1<sup>Δ11</sup></i> generated <i>Brca1</i> <sup>CC/<i>Δ11</i></sup> mice that were developmentally normal.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1786345"},"PeriodicalIF":0.0000,"publicationDate":"2020-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1786345","citationCount":"0","resultStr":"{\"title\":\"<i>Brca1</i> mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development.\",\"authors\":\"J J Krais, N Johnson\",\"doi\":\"10.1080/23723556.2020.1786345\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We recently developed a <i>Brca1</i> coiled-coil mutant mouse model (<i>Brca1<sup>CC</sup></i> ). <i>Brca1<sup>CC/CC</sup></i> results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia. <i>Brca1<sup>CC/CC</sup></i> cells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-crossing with <i>Brca1<sup>Δ11</sup></i> generated <i>Brca1</i> <sup>CC/<i>Δ11</i></sup> mice that were developmentally normal.</p>\",\"PeriodicalId\":520710,\"journal\":{\"name\":\"Molecular & cellular oncology\",\"volume\":\" \",\"pages\":\"1786345\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-07-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1080/23723556.2020.1786345\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular & cellular oncology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1080/23723556.2020.1786345\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular & cellular oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/23723556.2020.1786345","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}
Brca1 mutations in the coiled-coil domain impede Rad51 loading on DNA and mouse development.
We recently developed a Brca1 coiled-coil mutant mouse model (Brca1CC ). Brca1CC/CC results in embryonic lethality, with a fraction of mice reaching birth but with defects that parallel Fanconi anemia. Brca1CC/CC cells lacked Rad51 foci and were PARP inhibitor sensitive. Strikingly, inter-crossing with Brca1Δ11 generated Brca1CC/Δ11 mice that were developmentally normal.
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