发布求助
文献互助 智能选刊 最新文献

Molecular & cellular oncology最新文献

筛选
英文 中文
Adding to the CASeload: unwarranted p53 signaling induced by Cas9. 增加病例负荷:Cas9诱导的无根据p53信号。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-14 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1789419
Veronica Rendo, Oana M Enache, Uri Ben-David
{"title":"Adding to the CASeload: unwarranted p53 signaling induced by Cas9.","authors":"Veronica Rendo,&nbsp;Oana M Enache,&nbsp;Uri Ben-David","doi":"10.1080/23723556.2020.1789419","DOIUrl":"https://doi.org/10.1080/23723556.2020.1789419","url":null,"abstract":"<p><p>We investigated the genetic and transcriptional changes associated with Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated protein 9 (Cas9) expression in human cancer cell lines. For a subset of cell lines with a wild-type tumor protein TP53 (best known as p53), we detected p53 pathway activation, DNA damage accumulation and emerging p53-inactivating mutations following Cas9 introduction. We discuss the potential implications of our findings in basic and translational research.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1789419"},"PeriodicalIF":2.1,"publicationDate":"2020-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1789419","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say? 癌症中的基因组不稳定性和线粒体稳态:染色质有发言权吗?
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-13 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1771959
Yue Liu, Haojian Li, Susan E Zimmerman, Urbain Weyemi
{"title":"Genomic instability and mitochondrial homeostasis in cancer: does chromatin have a say?","authors":"Yue Liu,&nbsp;Haojian Li,&nbsp;Susan E Zimmerman,&nbsp;Urbain Weyemi","doi":"10.1080/23723556.2020.1771959","DOIUrl":"https://doi.org/10.1080/23723556.2020.1771959","url":null,"abstract":"<p><p>While genomic instability and mitochondrial homeostasis are integral for cancer progression, how these two hallmarks interact remains poorly understood. Here, we reflect on the dialogue between chromatin-based genomic instability and impairment of mitochondrial function and depict the importance of this interaction in cancer progression to metastasis.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1771959"},"PeriodicalIF":2.1,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1771959","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38391994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Oncogenic pathway driven by p85β: upstream signals to activate p110. p85β驱动的致癌途径:上游信号激活p110。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-07-13 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1780900
Ling Rao, Lydia W T Cheung
{"title":"Oncogenic pathway driven by p85β: upstream signals to activate p110.","authors":"Ling Rao,&nbsp;Lydia W T Cheung","doi":"10.1080/23723556.2020.1780900","DOIUrl":"https://doi.org/10.1080/23723556.2020.1780900","url":null,"abstract":"<p><p>The phosphatidylinositol 3-kinase (PI3K), which is composed of the p85 regulatory and p110 catalytic subunits, is known to be downstream of the receptor tyrosine kinase (RTK). Our recent findings revealed that p85β increases the protein level of AXL (an RTK) to activate p110, suggesting bidirectional regulation between PI3K and RTK.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1780900"},"PeriodicalIF":2.1,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1780900","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Translation control can shape TP53-dependent cell fate. 翻译控制可以塑造依赖tp53的细胞命运。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-06-23 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1767483
Dario Rizzotto, Sara Zaccara, Annalisa Rossi, Erik Dassi, Alberto Inga
{"title":"Translation control can shape TP53-dependent cell fate.","authors":"Dario Rizzotto,&nbsp;Sara Zaccara,&nbsp;Annalisa Rossi,&nbsp;Erik Dassi,&nbsp;Alberto Inga","doi":"10.1080/23723556.2020.1767483","DOIUrl":"https://doi.org/10.1080/23723556.2020.1767483","url":null,"abstract":"<p><p>The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30. Sifting through a multi-functional p53-dependent transcriptional output, this translational control can modulate the activation of cell death pathways.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1767483"},"PeriodicalIF":2.1,"publicationDate":"2020-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1767483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38391991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
ARF6 controls RHOB targeting to endosomes regulating cancer cell invasion. ARF6控制RHOB靶向调节癌细胞侵袭的核内体。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-06-23 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1766932
Kossay Zaoui, Harvey Wilmore Smith, Morag Park, Stéphanie Duhamel
{"title":"ARF6 controls RHOB targeting to endosomes regulating cancer cell invasion.","authors":"Kossay Zaoui,&nbsp;Harvey Wilmore Smith,&nbsp;Morag Park,&nbsp;Stéphanie Duhamel","doi":"10.1080/23723556.2020.1766932","DOIUrl":"https://doi.org/10.1080/23723556.2020.1766932","url":null,"abstract":"<p><p>Endocytic trafficking has emerged as an essential mechanism to spatiotemporally coordinate signaling protein complexes that control cytoskeletal dynamics and cell motility. Our study established an unexpected regulatory mechanism whereby ADP ribosylation factors 6 (ARF6) controls the stability and endosomal localization of RAS homologous protein B (RHOB) to regulate cell invasion downstream of the oncogenic receptor tyrosine kinase, MET.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1766932"},"PeriodicalIF":2.1,"publicationDate":"2020-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1766932","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38391992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye. 肾髓质癌的分子特征:更多的是c-MYC。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-06-23 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1777060
Pavlos Msaouel, Cheryl L Walker, Giannicola Genovese, Nizar M Tannir
{"title":"Molecular hallmarks of renal medullary carcinoma: more to c-MYC than meets the eye.","authors":"Pavlos Msaouel,&nbsp;Cheryl L Walker,&nbsp;Giannicola Genovese,&nbsp;Nizar M Tannir","doi":"10.1080/23723556.2020.1777060","DOIUrl":"https://doi.org/10.1080/23723556.2020.1777060","url":null,"abstract":"<p><p>Renal medullary carcinoma (RMC) is a lethal disease that predominantly afflicts young individuals with sickle cell trait. Our recently reported molecular profiling of primary untreated RMC tissues elucidated distinct genomic and immune hallmarks of RMC, and identified MYC-induced replication stress as a targetable vulnerability for this disease.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1777060"},"PeriodicalIF":2.1,"publicationDate":"2020-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1777060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38391998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
PathSTORM: a road to early cancer detection. PathSTORM:早期癌症检测之路。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-06-21 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1776086
Kris Troy, Yang Liu, Sarah J Hainer
{"title":"PathSTORM: a road to early cancer detection.","authors":"Kris Troy,&nbsp;Yang Liu,&nbsp;Sarah J Hainer","doi":"10.1080/23723556.2020.1776086","DOIUrl":"https://doi.org/10.1080/23723556.2020.1776086","url":null,"abstract":"<p><p>Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. Using stochastic optical reconstruction microscopy optimized for pathological tissue (PathSTORM), we uncovered a gradual decompaction of higher-order chromatin folding through progressive stages of carcinogenesis. We demonstrated potential detection of pre-cancerous genomic architecture not easily discernible by conventional pathology.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1776086"},"PeriodicalIF":2.1,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1776086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38391996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EIF2α phosphorylation: a hallmark of both autophagy and immunogenic cell death. EIF2α磷酸化:自噬和免疫原性细胞死亡的标志。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-06-19 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1776570
Juliette Humeau, Lucillia Bezu, Oliver Kepp, Guido Kroemer
{"title":"EIF2α phosphorylation: a hallmark of both autophagy and immunogenic cell death.","authors":"Juliette Humeau,&nbsp;Lucillia Bezu,&nbsp;Oliver Kepp,&nbsp;Guido Kroemer","doi":"10.1080/23723556.2020.1776570","DOIUrl":"https://doi.org/10.1080/23723556.2020.1776570","url":null,"abstract":"<p><p>Different intrinsic and extrinsic stress pathways including endoplasmic reticulum (ER) stress converge on the phosphorylation of eukaryotic translation initiation factor 2A (EIF2A, best known as eIF2α), which characterizes the so-called \"integrated stress response\". This phosphorylation event is important for the induction of autophagy in response to multiple distinct stressors, as well as for the exposure of calreticulin (CALR) as an \"eat me\" signal on the surface of the plasma membrane of stressed cells. Both autophagy and CALR exposure are required for immunogenic cell death, a modality of cellular demise that ignites anticancer and antiviral immune responses. In several different cancer types, eIF2α phosphorylation indicates favorable prognosis, correlating with an enhanced antitumor immune response.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1776570"},"PeriodicalIF":2.1,"publicationDate":"2020-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1776570","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38391997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
The spliceosome as a new therapeutic vulnerability in aggressive prostate cancer. 剪接体作为侵袭性前列腺癌新的治疗易感性。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-06-18 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1778420
Cheng Zou, Dingxiao Zhang
{"title":"The spliceosome as a new therapeutic vulnerability in aggressive prostate cancer.","authors":"Cheng Zou,&nbsp;Dingxiao Zhang","doi":"10.1080/23723556.2020.1778420","DOIUrl":"https://doi.org/10.1080/23723556.2020.1778420","url":null,"abstract":"<p><p>Alternative splicing (AS) analysis across the entire spectrum of human prostate cancer evolution reveals the unexpected findings that intron retention is a hallmark of stemness and tumor aggressiveness, and androgen receptor controls a splicing program distinct from its transcriptional regulation. Importantly, twisted activity of the spliceosome causing abnormal AS landscape represents a therapeutic vulnerability in aggressive prostate cancer.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1778420"},"PeriodicalIF":2.1,"publicationDate":"2020-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1778420","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38394970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
A bidirectional crosstalk between autophagy and TP53 determines the pace of aging. 自噬和TP53之间的双向串扰决定了衰老的速度。
IF 2.1
Molecular & cellular oncology Pub Date : 2020-06-18 eCollection Date: 2020-01-01 DOI: 10.1080/23723556.2020.1769434
Valentina Sica, Guido Kroemer
{"title":"A bidirectional crosstalk between autophagy and TP53 determines the pace of aging.","authors":"Valentina Sica,&nbsp;Guido Kroemer","doi":"10.1080/23723556.2020.1769434","DOIUrl":"https://doi.org/10.1080/23723556.2020.1769434","url":null,"abstract":"<p><p>When the orthologue of tumor suppressor protein p53 (<i>TP53), cep-1</i>, is inactivated in <i>Caenorhabditis elegans</i>, the nematodes manifest an autophagy-dependent increase in lifespan. A recent paper by Yang <i>et al</i>. demonstrates that accelerated aging phenotype of autophagy-deficient mice can be reduced by the knockout (KO) of <i>Trp53</i>. These findings point to a complex bidirectional crosstalk between autophagy and TP53 that has vast implications for the aging process.</p>","PeriodicalId":520710,"journal":{"name":"Molecular & cellular oncology","volume":" ","pages":"1769434"},"PeriodicalIF":2.1,"publicationDate":"2020-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/23723556.2020.1769434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38391993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信