Dario Rizzotto, Sara Zaccara, Annalisa Rossi, Erik Dassi, Alberto Inga
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Translation control can shape TP53-dependent cell fate.
The search for mechanisms underlying different cellular responses to the treatment with Nutlin-3, an MDM2 inhibitor that unleashes p53, revealed a translational control mechanism involving the RNA binding proteins PCBP2 and, particularly, DHX30. Sifting through a multi-functional p53-dependent transcriptional output, this translational control can modulate the activation of cell death pathways.
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