Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society最新文献

{"title":"Normothermic machine perfusion - The juice is definitely worth the squeeze.","authors":"Isaac S Alderete, Qimeng Gao, Nihal Aykun, Andrew S Barbas","doi":"10.1097/LVT.0000000000000670","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000670","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Every last detail-Managing hepatic artery thrombosis and stenosis in a time of organ scarcity.","authors":"Voytek Slowik","doi":"10.1097/LVT.0000000000000672","DOIUrl":"10.1097/LVT.0000000000000672","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and diagnostic biomarkers in liver transplantation: A systematic review and meta-analysis.","authors":"Andrea Camera, Tawhidul Islam, Reza Parvan, Søren Erik Pischke, Gustavo Jose Justo Silva, Kåre-Olav Stensløkken","doi":"10.1097/LVT.0000000000000666","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000666","url":null,"abstract":"<p><p>Liver transplantation (LT) is a therapeutic option for patients suffering from end-stage liver diseases. Recent research has probed the prognostic significance of biomarkers to predict graft function and mortality post-transplant, yet few candidates are recommended in clinical practice. We employed a pipeline that integrates meta-analysis (PRISMA 2020), followed by Kaplan Meier (KM)-based individual patient data (IPD) analysis, aiming to identify potential novel prognostic biomarker panels for LT recipients. Ovid Medline, Embase, and Cochrane databases were searched. Twenty-one prognostic and eight diagnostic studies were eligible, pooling 34922 patients. Single biomarkers sampled at an early stage (≤15 d after LT) were significant associated with graft-related outcomes (HR/OR 0.95 (0.94-0.97)) but did not predict mortality (HR/OR 1.00 (0.97-1.04)) or composite outcomes (HR/OR 1.02 (0.98-1.07)). Biomarkers in combination (GGT/bilirubin ratio, ALT+AST or ALT+AST+bilirubin+INR) predicted composite outcomes (graft failure or mortality, aHR/aOR 4.37 (2.65-7.21)). Biomarkers assessed at late stage (>15) did not show association with mortality (HR/OR 1.02 (1.00-1.04)) or composite outcomes (HR/OR 1.00 (0.99-1.01)). KM-based IPD analysis showed that coagulation factor V combined with ALT predicted graft survival (HR 2.12 (1.44-3.12)), and coagulation factor V+Insulin-like Growth Factor 1 stratified the risk of patient survival (HR 2.97 (1.79-4.91)). Therefore, we were able to compare various scoring systems in predicting graft-related outcomes and mortality followed LT. Additionally, we identified novel combinations of biomarkers that exhibited prognostic value for LT patients. Finally, we demonstrate that combined analytical tools for assessing large clinical datasets effectively evaluate multi-modal markers for risk stratification of early and late outcomes for LT.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Continuous infusion terlipressin for refractory ascites-Key considerations for future trials.","authors":"Penelope Markham","doi":"10.1097/LVT.0000000000000669","DOIUrl":"10.1097/LVT.0000000000000669","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Continuous Infusion terlipressin for refractory ascites-key considerations for future trials.","authors":"Huan Luo, Lei Pu","doi":"10.1097/LVT.0000000000000667","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000667","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Accurately predict the HCC recurrence after liver transplantation.","authors":"Wei Huang, Lixing Huang","doi":"10.1097/LVT.0000000000000657","DOIUrl":"10.1097/LVT.0000000000000657","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The incidence of severe complications in liver donation from living donors: Real-world data in the era of minimally invasive surgery.","authors":"Koichiro Haruki, Jagadeesh Krishnamurthy, Mukesh Kumar Olaniya, Sadhana Shankar, Ashwin Rammohan, Jinsoo Rhu, Tonguc Utku Yilmaz, Takeo Toshima, Daniel Reis Waisberg, Wellington Andraus, Jaewon Lee, Shinya Okumura, Prasanna Gopal, Takanobu Hara, Yuto Sakurai, Ryugen Takahashi, Daniel Zamora-Valdes, Zhe Yang, Robert C Minnee, Mohamed Rela, Subash Gupta, Toru Ikegami, Kwang-Woong Lee","doi":"10.1097/LVT.0000000000000660","DOIUrl":"10.1097/LVT.0000000000000660","url":null,"abstract":"<p><p>Although living liver donor safety is a fundamental principle in living donor liver transplantation, the details of severe complications that require re-operation or intensive care are not well understood. Therefore, in this study, we summarize those events in liver donation and investigate the difference in complication rates between the open and laparoscopic/robotic approaches in the era of minimally invasive surgery (MIS). We collected the case report forms of donor Clavien-Dindo grade IIIb, IV, and V complications between January 2013 and December 2022 from 16 institutions in the Vanguard Multicenter Study of the International Living Donor Liver Transplantation Group. We then analyzed the difference in complication rates between the open and MIS (laparoscopic/robotic) approaches. A total of 10,025 donor hepatectomies were performed across 16 institutions (8,310 by open or hybrid, 1,479 by laparoscopic, and 236 by robotic). Overall, Clavien-Dindo grade IIIb and IV complications were observed in 1.17% and 0.12%, respectively. There was no mortality in the period. The incidence of grade IIIb and IV complications was comparable between open and MIS cases (1.08% vs. 1.57%, p =0.09, 0.14% vs. 0%, p =0.12). The incidence of postoperative bleeding was more frequent in MIS cases ( p <0.01), especially from the IVC ( p =0.05) and abdominal wall ( p <0.01), compared with those in open cases. The overall incidence of severe complications in liver donation was comparable between the open and MIS approaches. The site of postoperative bleeding differed by surgical approach, suggesting the potential need for different care for MIS to reduce the postoperative complications in donor hepatectomy.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabis and liver transplant: We need to chill, man.","authors":"Alexandra Shingina, Seth Waits","doi":"10.1097/LVT.0000000000000662","DOIUrl":"10.1097/LVT.0000000000000662","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creation of a new VA liver transplantation center increased access and retained care within veterans health administration.","authors":"Jessica P E Davis, Suzanne E Robertazzi, Melissa G Kaltenbach, Gary Cutter, Rohit Satoskar, Atoosa Rabiee","doi":"10.1097/LVT.0000000000000661","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000661","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the heart whisper before the liver crashes? NT-proBNP and the Prediction of ACLF.","authors":"Manasa Narasimman, Lisa B VanWagner, Mark Pedersen","doi":"10.1097/LVT.0000000000000663","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000663","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}