Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society最新文献

{"title":"In the vein of silent stasis: Weighing thrombotic risk in living liver donors.","authors":"Umang Arora, Saurav Panda, Robert D McBane, Danielle M Tholey, Matthew R Kappus, Kymberly D Watt","doi":"10.1097/LVT.0000000000000993","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000993","url":null,"abstract":"<p><p>Thrombophilic states in the setting of living donor liver transplantation raises concerns regarding perioperative thromboembolism in the donor, as well as the potential transfer of inherited prothrombotic tendencies through mutated, hepatically synthesised coagulation factors. Screening practices for thrombophilia remain heterogeneous across centers and may result in donor exclusion based on local policies. However, accumulating evidence over the past decade suggests that most prospective donors are asymptomatic, and those with heterozygous inherited thrombophilias-such as Factor V Leiden or Prothrombin G20210A mutation-can safely undergo donation with standard perioperative thromboprophylaxis for recipient and donors. These states are unlikely to be transmitted to the recipient, as extrahepatic synthesis of coagulation proteins contributes to maintaining hemostatic balance. In contrast, donors with a prior history of thromboembolism, high-risk genotypes (e.g., homozygous or compound heterozygous states), or high-risk acquired thrombophilias should generally be excluded owing to an increased risk of thrombotic complications.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Do latent-factor-derived weight trajectories after liver transplantation reflect true biological states or modeling-induced structure?","authors":"Lingyi Meng, Haoyun Zhang","doi":"10.1097/LVT.0000000000000990","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000990","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should parenchymal quality inform resection decisions in non-cirrhotic HCC? a reason to consider transplant, But Not to Wait.","authors":"Dominic Amara, Vatche G Agopian","doi":"10.1097/LVT.0000000000000988","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000988","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply: Do latent-factor-derived weight trajectories after liver transplantation reflect true biological states or modeling-induced structure?","authors":"Alexis Kim, Mohammad Shadab Siddiqui, Anh T Bui","doi":"10.1097/LVT.0000000000000992","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000992","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148890172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Safe use of living donor right liver graft with dual portal veins.","authors":"Sorabh Kapoor","doi":"10.1097/LVT.0000000000000876","DOIUrl":"10.1097/LVT.0000000000000876","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":"E65-E66"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: One size does not fit all-Reconstructing multiple bile ducts in right lobe liver transplantation.","authors":"Sorabh Kapoor","doi":"10.1097/LVT.0000000000000884","DOIUrl":"10.1097/LVT.0000000000000884","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":"E73-E74"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographic and structural variability in liver transplant outreach programs: A national survey of academic centers.","authors":"James L Rogers, Rahul Mohan, Avash Kalra","doi":"10.1097/LVT.0000000000000867","DOIUrl":"10.1097/LVT.0000000000000867","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":"1335-1339"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13480314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147535407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes after liver transplantation using donor grafts with SERPINA1 Z heterozygosity.","authors":"Fredrik Åberg, Maria Semenova, Ville Liukkonen, Jukka Partanen, Kati Hyvärinen, Arno Nordin","doi":"10.1097/LVT.0000000000000878","DOIUrl":"10.1097/LVT.0000000000000878","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":"1340-1342"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13480318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond rejection risk: Identifying ideal candidates for pretransplant immune checkpoint inhibitors for HCC.","authors":"Laia Aceituno, Grainne M O'Kane, Woo Jin Choi, Parissa Tarbizian, Roxana Bucur, Nadia Rukavina, Anudari Zorigtbaatar, Beatriz Mínguez, Arndt Vogel, Gonzalo Sapisochin","doi":"10.1097/LVT.0000000000000829","DOIUrl":"10.1097/LVT.0000000000000829","url":null,"abstract":"<p><p>The role of immune checkpoint inhibitors (ICIs) before liver transplantation (LT) for HCC remains uncertain. In particular, the optimal treatment duration and the potential long-term oncologic benefits remain unclear. Thus, we conducted a systematic review to evaluate outcomes of ICI as bridging or downstaging therapy before LT. Following PRISMA guidelines (PROSPERO CRD1082620), 5 databases were systematically searched up to March 2025. All published studies reporting ICI before LT in HCC were included. Data were synthesized descriptively, and exploratory regression models, including restricted cubic splines, were performed. Thirty-nine studies comprising 261 patients were included. Most were male (87.3%), over 50 years old, and had viral hepatitis as the predominant etiology of their liver disease. ICIs were mainly used for downstaging (84.2%), most frequently using nivolumab (24.5%). The median ICI duration was 63 days (42-105), with a median washout period of 57 days (29-116). Most patients presented with multifocal disease (77.9%) and tumors beyond Milan criteria, with a median largest lesion size of 37.5 mm (9.4-78.5). Macrovascular invasion was present in 15.7%. Posttransplant recurrence occurred in 18.6%. Shorter ICI exposure was significantly associated with a higher risk of recurrence (OR: 0.9; p <0.001). Spline models demonstrated that the benefit of ICI treatment was achieved at 80 days. Paradoxically, patients with BCLC A exhibited higher recurrence risk (OR: 5.2; p =0.01), perhaps underscoring the limitations of conventional staging in candidate selection. Allograft rejection occurred in 23.0% of patients and led to graft failure in 14.7%. Younger age (<50 y) and a shorter washout period (<50 d) were independently associated with an increased risk of recurrence and rejection, respectively. The duration of ICI treatment before LT is a critical factor influencing HCC recurrence risk, with an optimal treatment duration of more than 80 days. Furthermore, a confirmatory washout period of at least 50 days appears to be important to mitigate the risk of rejection.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":"1285-1296"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13480327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the tide recedes: From portal relief to fascial grief.","authors":"Xiaohan Ying, Brett E Fortune","doi":"10.1097/LVT.0000000000000859","DOIUrl":"10.1097/LVT.0000000000000859","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":"1227-1229"},"PeriodicalIF":3.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}