Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society最新文献

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Seeing Through the Machine: Ultrasound Assessment of Hepatic Artery Integrity During Normothermic Machine Perfusion. 透过机器观察:常温机器灌注时肝动脉完整性的超声评估。
Nihal Aykun, Qimeng Gao, Isaac S Alderete, Mohamed M Diab, Andrew S Barbas
{"title":"Seeing Through the Machine: Ultrasound Assessment of Hepatic Artery Integrity During Normothermic Machine Perfusion.","authors":"Nihal Aykun, Qimeng Gao, Isaac S Alderete, Mohamed M Diab, Andrew S Barbas","doi":"10.1097/LVT.0000000000000680","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000680","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative von Willebrand factor is an independent predictive biomarker for posthepatectomy liver failure - a multivariable model with APRI+ALBI. 术前血管性血友病因子是一个独立的预测肝切除术后肝功能衰竭的生物标志物-一个多变量模型与APRI+ALBI。
Yawen Dong, Lindsey A Gregory, Vanja Podrascanin, Jonas Santol, Markus Ammann, David Pereyra, Hubert Hackl, Zhihao Li, Mark J Truty, Susanne G Warner, Rory L Smoot, Thomas Gruenberger, David M Nagorney, Patrick P Starlinger
{"title":"Preoperative von Willebrand factor is an independent predictive biomarker for posthepatectomy liver failure - a multivariable model with APRI+ALBI.","authors":"Yawen Dong, Lindsey A Gregory, Vanja Podrascanin, Jonas Santol, Markus Ammann, David Pereyra, Hubert Hackl, Zhihao Li, Mark J Truty, Susanne G Warner, Rory L Smoot, Thomas Gruenberger, David M Nagorney, Patrick P Starlinger","doi":"10.1097/LVT.0000000000000676","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000676","url":null,"abstract":"<p><strong>Background: </strong>Portal hypertension is a key factor in posthepatectomy liver failure (PHLF). While preoperative liver function tests like APRI+ALBI assess liver function, they only partially reflect portal hypertension severity. Elevated von-Willebrand-factor-antigen (vWF-Ag) indicates endothelial dysregulation and correlates with portal hypertension. Combining vWF-Ag with APRI+ALBI may enhance PHLF prediction.</p><p><strong>Methods: </strong>A total of 534 patients who underwent liver resection at Mayo Clinic Rochester (2020-2024) were analyzed for PHLF incidence, postoperative morbidity, and 90-day mortality. Predictive probability for PHLF was assessed using ROC analysis and validated in an external Austrian cohort of 283 patients (2008-2017). vWF-Ag was then integrated into the existing APRI+ALBI multivariable model.</p><p><strong>Results: </strong>PHLF grade B/C was reported in 56 patients (10.5%). 90-day mortality rate was 0.9% (n=5). Using two cutoffs (182%, 240%), vWF-Ag was found to be an independent predictive factor for PHLF grade B/C that remained statistically significant upon multivariable analysis. The combination of preoperative APRI+ALBI and vWF-Ag increased the positive predictive value to 27.9% for PHLF grade B/C in the APRI+ALBI high and vWF-Ag high group. Incorporation of vWF-Ag into the established APRI+ALBI based multivariable model revealed a superior area under the curve (AUC) of 0.772 for PHLF risk stratification and was successfully validated in an independent cohort (AUC=0.834).</p><p><strong>Conclusion: </strong>The combination of vWF-Ag with APRI+ALBI demonstrates a favorable predictive potential for PHLF risk assessment. We provide two pathways for clinical assessment: 1) a cut-off-based system and 2) a more complex multivariable model that can be calculated in a specifically designed smartphone application.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing outcomes of deceased-donor and living-donor liver transplants in patients with portal vein thrombosis. 门静脉血栓形成患者死供肝与活供肝移植的疗效比较。
Zhihao Li, Owen Jones, Luckshi Rajendran, Laia Aceituno Sierra, Christian T J Magyar, Elmar Jaeckel, Mamatha Bhat, Cynthia Tsien, Les Lilly, Anand Ghanekar, Blayne A Sayed, Markus Selzner, Ian McGilvray, Chaya Shwaartz, Trevor Reichman, Nazia Selzner, Mark Cattral, Gonzalo Sapisochin
{"title":"Comparing outcomes of deceased-donor and living-donor liver transplants in patients with portal vein thrombosis.","authors":"Zhihao Li, Owen Jones, Luckshi Rajendran, Laia Aceituno Sierra, Christian T J Magyar, Elmar Jaeckel, Mamatha Bhat, Cynthia Tsien, Les Lilly, Anand Ghanekar, Blayne A Sayed, Markus Selzner, Ian McGilvray, Chaya Shwaartz, Trevor Reichman, Nazia Selzner, Mark Cattral, Gonzalo Sapisochin","doi":"10.1097/LVT.0000000000000656","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000656","url":null,"abstract":"<p><strong>Background: </strong>Portal vein thrombosis (PVT) complicates liver transplantation (LT) by hindering portal flow restoration. Some centers still consider PVT a contraindication for living-donor LT (LDLT) due to technical challenges compared to deceased-donor LT (DDLT).</p><p><strong>Method: </strong>We retrospectively analyzed adults undergoing LT with main PVT between 2006-2023, excluding tumor thrombi and re-LT. Using 1:1 propensity score matching, we balanced age, MELD score, Yerdel classification, cavernous transformation, and physiological reconstruction methods. The primary endpoint was the 90-day complication rate; secondary endpoints included patient and graft survival.</p><p><strong>Results: </strong>Of 122 patients, 96 were matched (48 LDLT, 48 DDLT). The median age was 57 years (IQR: 50-63), with a median MELD of 18 (IQR:12-25). Common underlying liver diseases were hepatitis C (26%) and alcoholic liver disease (20%). 85% had PVT Yerdel grade I/II, 11% grade III and 3% grade IV, with cavernous transformation present in 17%. Physiological end-to-end portal vein reconstruction was performed in 90% of cases, while 10% received reconstruction with jump grafts. No significant differences were observed between LDLT and DDLT in warm ischemia time (57 vs. 58 min, p=0.3), 90-day major (37.5% vs. 39.6%, p=0.99) or minor complications (47.9% vs. 52.1%, p=0.84), portal vein re-thrombosis (12.5% vs. 10.6%, p=0.99), posttransplant dialysis (4% vs. 8%, p=0.65), or ascites (25% vs. 30%, p=0.77). At 1/3/5 years, patient and graft survival rates were similar between LDLT and DDLT recipients (log-rank p=0.8 and p=0.9, respectively). Cox regression showed posttransplant anticoagulation (with LMWH, FXa inhibitors, VKA) as protective for graft survival (HR 0.3, p=0.005).</p><p><strong>Conclusion: </strong>LDLT can achieve outcomes comparable to DDLT in patients with PVT. PVT should not be considered a contraindication for LDLT in selected patients at experienced centers.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential strategies in porcine liver xenotransplantation: A bridge to allotransplantation and beyond. 猪肝异种移植的潜在策略:通往异体移植的桥梁。
Liaoran Wang, Hidetaka Hara, David Kc Cooper, Yi Wang, Qiang Wei, Xiao Xu
{"title":"Potential strategies in porcine liver xenotransplantation: A bridge to allotransplantation and beyond.","authors":"Liaoran Wang, Hidetaka Hara, David Kc Cooper, Yi Wang, Qiang Wei, Xiao Xu","doi":"10.1097/LVT.0000000000000674","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000674","url":null,"abstract":"<p><p>Advances in both gene editing of organ-source pigs and novel immunosuppressive therapies have substantially propelled the field of heart and kidney xenotransplantation forward, and have helped in overcoming challenges associated with porcine liver transplantation. In this review, the recent experience with porcine liver xenotransplantation in China for both decedents and living patients is discussed. We suggest that porcine liver xenografts play a much greater role in the management of patients with hepatic failure awaiting or following liver allotransplantation. Additionally, we propose that brain-dead human subjects (decedents) be used to validate the efficacy of porcine livers in supporting split or marginal human liver grafts. These developments are expected to lay the groundwork for clinical trials aimed at improving the outcomes of patients with end-stage liver disease, potentially expanding the pool of transplantable organs and providing new therapeutic options for these patients.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatic artery dissection after living-donor liver transplantation requires different management based on the locations and clinical outcomes: A retrospective cohort study. 活体肝移植术后肝动脉夹层需要根据部位和临床结果进行不同的处理:一项回顾性队列研究。
Sung Min Kim, Deok-Bog Moon, Young-In Yoon, Chul-Soo Ahn, Gil-Chun Park, Shin Hwang, Tae-Yong Ha, Dong-Hwan Jung, Gi-Won Song, Ki-Hun Kim, Sung-Gyu Lee, Yong-Pil Cho, Kyoung Won Kim, Seonok Kim
{"title":"Hepatic artery dissection after living-donor liver transplantation requires different management based on the locations and clinical outcomes: A retrospective cohort study.","authors":"Sung Min Kim, Deok-Bog Moon, Young-In Yoon, Chul-Soo Ahn, Gil-Chun Park, Shin Hwang, Tae-Yong Ha, Dong-Hwan Jung, Gi-Won Song, Ki-Hun Kim, Sung-Gyu Lee, Yong-Pil Cho, Kyoung Won Kim, Seonok Kim","doi":"10.1097/LVT.0000000000000675","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000675","url":null,"abstract":"<p><p>HAD is a rare complication of living donor liver transplantation (LDLT) and is associated with hepatic artery thrombosis (HAT). Given its low incidence, the clinical outcomes of HAD are not well established. This study aimed to identify the clinical outcomes of hepatic artery dissection (HAD) according to its location and extent. To achieve this, we retrospectively reviewed adult LDLT recipients at the Asan Medical Center from January 2010 to December 2022. The patients were categorized into three groups: Group 1 (confined to the proper hepatic artery, PHA), Group 2 (common hepatic artery, CHA, extending to PHA), and Group 3 (confined to the CHA). Among the 4,065 LDLT recipients, 114 (2.8%) had HAD. Of these, Group 1 accounted for 47.3% (54/114), whereas Groups 2 for 41.2% (47/114) and Group 3 for 11.4%(13/114), respectively. HAD resolved in 81.6% of the patients (93/114), with a mean resolution time of 104.3 days. Notably, HAT developed in 6.1% of the patients in Group 1 (7 cases). Furthermore, of the 5 cases (4.39%) of graft failure following HAD, 4 cases (7.41%) occurred in Group 1. In conclusion, although HAD presents with severe imaging findings, it generally has a favorable prognosis. However, when HAD involves only PHA, owing to the high risk of HAT, more frequent surveillance and aggressive management are recommended.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of hepatic artery thrombosis and stenosis after pediatric liver transplantation: Variability and agreement in management practices. 儿童肝移植后肝动脉血栓形成和狭窄的处理:管理实践的可变性和一致性。
Weihao Li, Reinoud P H Bokkers, Barbara E Wildhaber, Ana M Calinescu, Alexis Ricoeur, Paolo Marra, Michela Bravi, Domenico Pinelli, Julia Minetto, Marcelo Dip, Sergio Sierre, Martín de Santibañes, Victoria Ardiles, Jimmy Walker Uno, Winita Hardikar, Sue Bates, Lynette Goh, Denise Aldrian, Jonathan Seisenbacher, Georg F Vogel, João Seda Neto, Eduardo Antunes da Fonseca, Carolina Magalhães Costa, Cristina T Ferreira, Luiza S Nader, Marco A Farina, Khaled Z Dajani, Alessandro Parente, David L Bigam, Tingbo Liang, Xueli Bai, Jie Xiang, Lucie Gonsorčíková, Jiří Froněk, Šimon Bohuš, Stéphanie Franchi-Abella, Emmanuel Gonzales, Florent Guérin, Norman Junge, Ulrich Baumann, Nicolas Richter, Steffen Hartleif, Ekkehard Sturm, Muthukumarassamy Rajakannu, Kumar Palaniappan, Mohamed Rela, Arti Pawaria, Haritha Rajakrishnan, Sudhindran Surendran, Mukesh Kumar, Shaleen Agarwal, Subhash Gupta, Sonal Asthana, Mallikarjun Sakpal, Ashritha Avalareddy, Marco Spada, Lidia Monti, Tommaso Alterio, Yusuke Yanagi, Hajime Uchida, Ryuji Komine, Helen Evans, Peter Carr-Boyd, David Duncan, Marek Stefanowicz, Julita Latka-Grot, Adam Koleśnik, Dieter C Broering, Dimitri A Raptis, Kris Ann H Marquez, Vidyadhar Mali, Marion Aw, Marisa Beretta, Francisca Van der Schyff, Jesús Quintero, Maria Mercadal-Hally, Jose Andrés Molino-Gahete, Ane M Andres, Francisco Hernandez-Oliveros, Esteban Frauca Remacha, Thomas Casswall, Carl Jorns, Martin Delle, Girish L Gupte, Khalid Sharif, Simon P McGuirk, Riccardo Superina, Juan Carlos Caicedo, Catalina Jaramillo, Leandra Bitterfeld, Zachary Kastenberg, Amit Shah, Bryanna Domenick, Michael R Acord, George Mazariegos, Kyle Soltys, Joseph DiNorcia, Puja Patel, Sander Florman, Bettina M Buchholz, Uta Herden, Lutz Fischer, Rudi A J O Dierckx, Hermien Hartog, Hubert P J Van der Doef
{"title":"Management of hepatic artery thrombosis and stenosis after pediatric liver transplantation: Variability and agreement in management practices.","authors":"Weihao Li, Reinoud P H Bokkers, Barbara E Wildhaber, Ana M Calinescu, Alexis Ricoeur, Paolo Marra, Michela Bravi, Domenico Pinelli, Julia Minetto, Marcelo Dip, Sergio Sierre, Martín de Santibañes, Victoria Ardiles, Jimmy Walker Uno, Winita Hardikar, Sue Bates, Lynette Goh, Denise Aldrian, Jonathan Seisenbacher, Georg F Vogel, João Seda Neto, Eduardo Antunes da Fonseca, Carolina Magalhães Costa, Cristina T Ferreira, Luiza S Nader, Marco A Farina, Khaled Z Dajani, Alessandro Parente, David L Bigam, Tingbo Liang, Xueli Bai, Jie Xiang, Lucie Gonsorčíková, Jiří Froněk, Šimon Bohuš, Stéphanie Franchi-Abella, Emmanuel Gonzales, Florent Guérin, Norman Junge, Ulrich Baumann, Nicolas Richter, Steffen Hartleif, Ekkehard Sturm, Muthukumarassamy Rajakannu, Kumar Palaniappan, Mohamed Rela, Arti Pawaria, Haritha Rajakrishnan, Sudhindran Surendran, Mukesh Kumar, Shaleen Agarwal, Subhash Gupta, Sonal Asthana, Mallikarjun Sakpal, Ashritha Avalareddy, Marco Spada, Lidia Monti, Tommaso Alterio, Yusuke Yanagi, Hajime Uchida, Ryuji Komine, Helen Evans, Peter Carr-Boyd, David Duncan, Marek Stefanowicz, Julita Latka-Grot, Adam Koleśnik, Dieter C Broering, Dimitri A Raptis, Kris Ann H Marquez, Vidyadhar Mali, Marion Aw, Marisa Beretta, Francisca Van der Schyff, Jesús Quintero, Maria Mercadal-Hally, Jose Andrés Molino-Gahete, Ane M Andres, Francisco Hernandez-Oliveros, Esteban Frauca Remacha, Thomas Casswall, Carl Jorns, Martin Delle, Girish L Gupte, Khalid Sharif, Simon P McGuirk, Riccardo Superina, Juan Carlos Caicedo, Catalina Jaramillo, Leandra Bitterfeld, Zachary Kastenberg, Amit Shah, Bryanna Domenick, Michael R Acord, George Mazariegos, Kyle Soltys, Joseph DiNorcia, Puja Patel, Sander Florman, Bettina M Buchholz, Uta Herden, Lutz Fischer, Rudi A J O Dierckx, Hermien Hartog, Hubert P J Van der Doef","doi":"10.1097/LVT.0000000000000671","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000671","url":null,"abstract":"<p><strong>Background: </strong>Guidelines for managing hepatic artery thrombosis (HAT) and stenosis (HAS) after pediatric liver transplantation (pLT) are lacking, with heterogeneous local practices. This study aims to evaluate management practices for HAT and HAS after pLT.</p><p><strong>Methods: </strong>An online and paper-based survey was sent to 36 international pLT centers. The survey included 36 questions covering center experience, screening protocols, diagnostic criteria, preventive management, post-procedural care, and follow-up. Treatment strategies were explored through hypothetical case scenarios categorized by early (≤14 d after pLT) and late onset complications (>14 d after pLT).</p><p><strong>Results: </strong>Responses from 36 centers showed that 60% applied interrupted sutures and 76% used a surgical loupe during transplantation. Additionally, 89% followed a specific anticoagulation protocol after uncomplicated pLT. All centers initiated Doppler ultrasound (DUS) within 24 hours after pLT, with 60% conducting it daily during the first week. Immediate re-transplantation was preferred for early HAT with pediatric acute liver failure (PALF) (61% vs. 11% for non-PALF, p<0.001), and surgical revascularization was more frequently chosen for non-PALF cases (51% vs. 24% for PALF, p<0.001). Endovascular therapy was selected in 35% of cases for both late HAT and HAS, with conservative management chosen in 51% for late HAT and 61% for late HAS (all p<0.001, compared to early cases).</p><p><strong>Conclusion: </strong>Internationally, there is agreement on the importance of early DUS screening in current management practices. Immediate re-transplantation was preferred for early HAT with PALF, while surgical revascularization was favored for non-PALF cases. Conservative management and endovascular therapy emerged as potential strategies for late-onset cases. This worldwide survey on real-world practice provides a basis for developing and implementing guidelines.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phosphatidylethanol and urinary ethylglucuronide to assess alcohol consumption after liver transplantation. 磷脂酰乙醇和尿乙基葡萄糖醛酸盐评价肝移植术后酒精消耗
Jérôme Dumortier, Olivier Guillaud, Olivier Boillot, François Bailly, Hélène Donnadieu-Rigole, Emma Chambéry, Jérôme Guitton, Antony Citterio-Quentin
{"title":"Phosphatidylethanol and urinary ethylglucuronide to assess alcohol consumption after liver transplantation.","authors":"Jérôme Dumortier, Olivier Guillaud, Olivier Boillot, François Bailly, Hélène Donnadieu-Rigole, Emma Chambéry, Jérôme Guitton, Antony Citterio-Quentin","doi":"10.1097/LVT.0000000000000673","DOIUrl":"10.1097/LVT.0000000000000673","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short- and long-term development of gut microbiota in children after liver transplantation - a prospective observational trial. 肝移植后儿童肠道菌群的短期和长期发展——一项前瞻性观察性试验。
Imeke Goldschmidt, Miriam Kramer, Norman Junge, Niyade Ouro-Djobo, Alina Poets, Margarete Rathert, Robert Geffers, Ulrich Baumann, Björn Hartleben, Kora Dorothea Schulze, Sabrina Woltemate, Marius Vital
{"title":"Short- and long-term development of gut microbiota in children after liver transplantation - a prospective observational trial.","authors":"Imeke Goldschmidt, Miriam Kramer, Norman Junge, Niyade Ouro-Djobo, Alina Poets, Margarete Rathert, Robert Geffers, Ulrich Baumann, Björn Hartleben, Kora Dorothea Schulze, Sabrina Woltemate, Marius Vital","doi":"10.1097/LVT.0000000000000659","DOIUrl":"10.1097/LVT.0000000000000659","url":null,"abstract":"<p><p>In children, little is known on gut microbiota (GM) in end-stage liver disease and its association with graft function after pediatric liver transplantation (pLT). We analyzed GM composition and function in children before pLT, longitudinally post-pLT and in long-term survivors (LT-pLT) in order to assess the impact of disease severity, treatment and pLT on GM and delineate associations with graft and patient health. Fecal samples (FS) of 29 children (17f, age 2.6 [0.2-15.7] years) awaiting pLT were included with longitudinal follow-ups until 12M post-transplant in 18, and compared with 38 LT-pLT (21f, age 11 [2.7-17.7] years, 7.8 [1.0-17.0] years post-pLT) and 94 healthy controls (HC). Samples were analyzed using quantitative 16S rRNA gene analyses combined with shotgun metagenomics (subset of samples). Pre-pLT patients showed reduced alpha-diversities and altered GM composition compared with LT-pLT and HC, associated with disease severity and anti-pruritic treatment with Rifampicin. Dysbiosis increased after pLT and started to recover after 3M. Although bacterial concentrations, alpha diversity and gene richness increased post-pLT, levels remained below those of HC. Abundances of key functions, e.g. the capacity to synthesize butyrate, also remained reduced. Quantitative analyses revealed true extent of differences between patients and HC that were underestimated using relative abundance data. GM diversity and functional capacities correlated negatively with transaminase levels mid- and long-term after pLT. Random Forest analyses based on GM were able to predict hepatocellular damage at high accuracy (AUC: 0.89). We provide comprehensive, quantitative insights into GM composition and function before and after pLT. A link between GM alterations with (long-term) graft health was uncovered providing possible targets to modulate GM function in order to increase graft and patient health.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing donor selection barriers for living donor liver transplantation amongst hispanic and non-hispanic candidates in a large urban center. 在大城市中心比较西班牙裔和非西班牙裔活体肝移植候选人的供体选择障碍。
Christine Tien, Jennifer L Dodge, Dana Toy, Brian Kim, Jeffrey Kahn, Yuri Genyk, Navpreet Kaur, Hyosun H Han
{"title":"Comparing donor selection barriers for living donor liver transplantation amongst hispanic and non-hispanic candidates in a large urban center.","authors":"Christine Tien, Jennifer L Dodge, Dana Toy, Brian Kim, Jeffrey Kahn, Yuri Genyk, Navpreet Kaur, Hyosun H Han","doi":"10.1097/LVT.0000000000000665","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000665","url":null,"abstract":"<p><p>Hispanics represent the largest-growing ethnic group awaiting liver transplantation. Though racial/ethnic barriers to living donor liver transplantation (LDLT) have been described among recipients, little is known about challenges for minority living liver donor (LLD) candidates during donor evaluation. We aimed to characterize LLD candidates and compare donor-related barriers by ethnicity through a single-center retrospective cohort study of all LLD referrals from December 2017-August 2021. Primary outcome was LLD approval with odds ratios (OR) estimated using multivariable logistic regression. Among 1,508 candidates (694 Hispanic, 814 non-Hispanic), 303 (20.1%) failed initial screening; Hispanics were more often screened out for body mass index >35 kg/m2 (73% vs. 55%, p=0.003). Of 1,205 passing screening (533 Hispanic, 672 non-Hispanic), Hispanics were younger (median age 34 [IQR 26-44] vs. 40 [32-51]), more often directed donors (97% vs. 90%), and spouses/first-degree relatives of the recipient (52% vs. 29%, all p<0.001). In the multivariable model adjusted for donor-recipient relationship, Hispanic ethnicity was associated with higher odds of LLD approval (OR 1.48, 95% CI 1.01-2.17, p=0.04). LDLT disparities among Hispanics may involve factors preceding donor evaluation or independent of the donor. Optimizing Hispanic LLD candidacy, establishing a registry of individuals referred for LLD, and conducting multicenter studies are warranted.</p>","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Home-based terlipressin as a therapy for ascites: Increasing evidence for the efficacy of long-term continuous terlipressin infusion in decompensated cirrhosis. 家用特利加压素治疗腹水:越来越多的证据表明长期持续输注特利加压素治疗失代偿肝硬化的疗效。
Marie Sinclair, Adam Testro
{"title":"Home-based terlipressin as a therapy for ascites: Increasing evidence for the efficacy of long-term continuous terlipressin infusion in decompensated cirrhosis.","authors":"Marie Sinclair, Adam Testro","doi":"10.1097/LVT.0000000000000668","DOIUrl":"https://doi.org/10.1097/LVT.0000000000000668","url":null,"abstract":"","PeriodicalId":520704,"journal":{"name":"Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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