{"title":"Comments on parenteral nutrition and extracorporeal membrane oxygenation circuit dysfunction.","authors":"Ju-Tae Sohn","doi":"10.1002/jpen.70065","DOIUrl":"10.1002/jpen.70065","url":null,"abstract":"","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":"505-506"},"PeriodicalIF":4.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146115462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"JPEN Journal Club 97. Splitting studies.","authors":"Ronald L Koretz","doi":"10.1002/jpen.70035","DOIUrl":"10.1002/jpen.70035","url":null,"abstract":"","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":"602-604"},"PeriodicalIF":4.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145531073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dietary indices, gut microbiota, and CKM syndrome: From cross-sectional signals to clinical meaning.","authors":"Andrea Bruni, Mattia Madeo, Eugenio Garofalo","doi":"10.1002/jpen.70079","DOIUrl":"10.1002/jpen.70079","url":null,"abstract":"","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":"499-500"},"PeriodicalIF":4.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ning Li, Jing Chen, Xiuxiu Lu, Wei Li, Dong Qu, Shuang Liu, Lin Wang
{"title":"Performance of different nutrition risk screening tools in predicting malnutrition in critically ill children on mechanical ventilation: A comparison study.","authors":"Ning Li, Jing Chen, Xiuxiu Lu, Wei Li, Dong Qu, Shuang Liu, Lin Wang","doi":"10.1002/jpen.70064","DOIUrl":"10.1002/jpen.70064","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to characterize the distribution of nutrition status and nutrition risk stratification in critically ill children undergoing mechanical ventilation and to evaluate the association of nutrition risk with their clinical outcomes.</p><p><strong>Methods: </strong>This comparison study included 375 critically ill children receiving mechanical ventilation (invasive or noninvasive, duration ≥24 h). Nutrition status at admission was evaluated using body mass index z score, and nutrition risk was assessed via three validated tools: Paediatric Yorkhill Malnutrition Score (PYMS), Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP), and Screening Tool for Risk on Nutritional Status and Growth (STRONGkids). Clinical data were extracted from electronic records.</p><p><strong>Results: </strong>Three hundred seventy-five critically ill children undergoing mechanical ventilation were enrolled (207 boys, 168 girls; median age, 8 [2-26.5] months), with 246 receiving invasive and 129 noninvasive ventilation; 20.6% had moderate-severe malnutrition (59.7% in invasive ventilation). All tools identified >60% at high risk. STRONGkids (area under the curve [AUC], 0.90) and PYMS (AUC, 0.86) better predicted malnutrition than STAMP (AUC, 0.74). STRONGkids (AUC, 0.89) outperformed in mortality prediction. Higher risk correlated with longer ventilation/pediatric intensive care unit stay, higher costs, and worse outcomes (P < 0.05). Multivariate analysis showed malnutrition, clinical diagnosis, and lactate level as independent risk factors and no organ dysfunction, healthy serum prealbumin level, and healthy serum albumin level as protective factors.</p><p><strong>Conclusion: </strong>PYMS and STRONGkids demonstrated high predictive value for moderate-to-severe malnutrition and mortality in children undergoing mechanical ventilation.</p>","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":"507-514"},"PeriodicalIF":4.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13169076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor: Response to Dietary indices, gut microbiota, and CKM syndrome: From cross-sectional signals to clinical meaning.","authors":"Xin Zhang, Hui Qin","doi":"10.1002/jpen.70078","DOIUrl":"https://doi.org/10.1002/jpen.70078","url":null,"abstract":"","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147464624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"JPEN Journal Club 68. Type I errors.","authors":"Ronald L Koretz","doi":"10.1002/jpen.2332","DOIUrl":"https://doi.org/10.1002/jpen.2332","url":null,"abstract":"When I was in training many years ago, it was widely believed that patients with acute pancreatitis (AP) should not be fed too quickly in order to avoid stimulating that organ and creating more inflammation. This article is protected by copyright. All rights reserved.","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":"1736-1738"},"PeriodicalIF":3.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39854344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tribute to Kelly A. Tappenden, PhD, RD, FASPEN, JPEN Editor-in-Chief, 2010-2022.","authors":"Kenneth B Christopher","doi":"10.1002/jpen.2425","DOIUrl":"https://doi.org/10.1002/jpen.2425","url":null,"abstract":"","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":"970-971"},"PeriodicalIF":3.4,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40582847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ping Luo, Xudong Liu, Liya Ma, You Chen, Kun Zhang, Ping Zhou, Yan-Nan Jiang, Ping-Ping Jiang
{"title":"Antenatal corticosteroids affecting enteral feeding and growth of preterm infants: A retrospective cohort study.","authors":"Ping Luo, Xudong Liu, Liya Ma, You Chen, Kun Zhang, Ping Zhou, Yan-Nan Jiang, Ping-Ping Jiang","doi":"10.1002/jpen.2215","DOIUrl":"https://doi.org/10.1002/jpen.2215","url":null,"abstract":"<p><strong>Background: </strong>Treatment of antenatal corticosteroids (ACSs) to women at risk of preterm labor can decrease neonatal mortality and morbidity. However, effect of ACS exposure on enteral feeding and body growth of preterm infants remains elusive.</p><p><strong>Methods: </strong>This retrospective study collected information of eligible singleton infants born between 22<sup>+0</sup> and 36<sup>+6</sup> weeks' gestation from 2017 to 2019. Logistic regression and multivariate linear regression were adopted to examine the associations of the ACS exposure with various outcomes of enteral feeding and growth considering potential confounders. Stratified analysis was performed based on gestational age (GA) (<34 vs ≥34 weeks).</p><p><strong>Results: </strong>Of the 1694 preterm infants included, 1222 (72.1%) were exposed to ACSs. Infants with ACS exposure had a higher incidence of feeding intolerance (odds ratio 1.51; 95% CI, 1.05 to 2.20; P = .03), slower advancement of enteral feeding (β coefficient -0.86; 95% CI, -1.48 to -0.25; P = .01), and lower delta body-weight z-scores (β coefficient-0.13; 95% CI, -0.18 to -0.08; P < .001). Unlike in infants with GA <34 weeks, ACS exposure was associated with slower advancement of enteral feeding, longer time to regain birth weight, and lower delta body-weight z-scores in the ones with GA ≥34 weeks.</p><p><strong>Conclusion: </strong>ACS exposure is associated with poorer enteral feeding process and body growth in our study population, which is more prominent in late preterm infants. A multicenter prospective study and mechanistic studies using animal models are required.</p>","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":"572-582"},"PeriodicalIF":3.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jpen.2215","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39144179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kishore R Iyer, Marion Winkler, Nicole Zubizarreta, Marjorie Nisenholtz, Katie Lucero, Jovana Lubarda
{"title":"Knowledge of chronic intestinal failure among US gastroenterologists: Cause for concern and learning opportunity.","authors":"Kishore R Iyer, Marion Winkler, Nicole Zubizarreta, Marjorie Nisenholtz, Katie Lucero, Jovana Lubarda","doi":"10.1002/jpen.2283","DOIUrl":"https://doi.org/10.1002/jpen.2283","url":null,"abstract":"<p><strong>Background: </strong>Chronic intestinal failure (CIF) is an ultrarare disease, with an estimated national prevalence of ∼25,000 cases. There is a suspicion of widespread lack of expertise in CIF care, but no formal assessment tool or data exist. We developed and validated a knowledge test in CIF and now report our preliminary results from testing CIF knowledge in a cohort of US gastroenterologists.</p><p><strong>Method: </strong>We developed a 20-question knowledge test in CIF, covering four key components of IF. After internal testing, refinement, and revision, we administered the test to a convenience sample of experts and nonexperts in IF. We then deployed the validated test to a cohort of 100 US gastroenterologists.</p><p><strong>Results: </strong>The test had a Cronbach alpha of 0.74, suggesting a reliable test, with a threshold score to discriminate experts and nonexperts of 13.4 (maximum 20) and with a sensitivity of 81.3% and specificity of 86.4%. The overall mean score of 8.2 for the 100 US gastroenterologists was at the level of nonexperts in our convenience sample.</p><p><strong>Conclusion: </strong>The preliminary results of our validated knowledge test in IF among a broad group of US gastroenterologists demonstrate lack of knowledge in IF.</p>","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":"730-733"},"PeriodicalIF":3.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39661595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esther G Neelis, Barbara A E de Koning, Jessie M Hulst, Rodanthi Papadopoulou, Caroline Kerbiriou, Edmond H H M Rings, René M H Wijnen, Ben Nichols, Konstantinos Gerasimidis
{"title":"Gut microbiota and its diet-related activity in children with intestinal failure receiving long-term parenteral nutrition.","authors":"Esther G Neelis, Barbara A E de Koning, Jessie M Hulst, Rodanthi Papadopoulou, Caroline Kerbiriou, Edmond H H M Rings, René M H Wijnen, Ben Nichols, Konstantinos Gerasimidis","doi":"10.1002/jpen.2188","DOIUrl":"https://doi.org/10.1002/jpen.2188","url":null,"abstract":"<p><strong>Background: </strong>This study characterized gut microbiota and its diet-related activity in children with intestinal failure (IF) receiving parenteral nutrition (PN) compared with those of healthy controls (HC) and in relation to disease characteristics.</p><p><strong>Methods: </strong>The fecal microbiota and short-chain fatty acids (SCFAs) were measured in 15 IF patients (n = 68) and 25 HC (n = 25).</p><p><strong>Results: </strong>Patients with IF had a lower bacterial load (P = .003), diversity (P < .001), evenness (P < .001) and richness (P = 0.006) than HC. Patients with surgical IF had lower diversity (P < .039) than those with functional IF. Propionic acid and butyric acid (p < .001) were lower and d-lactate and l-lactate were higher (p < 0.001) in IF patients than in HC. The energy supplied by PN (%PN) was negatively associated with microbiota diversity and SCFA profile. IF patients had more Escherichia-Shigella (P = .006), Cronobacter (P = .001), and Staphylococcus (Operational Taxonomic Unit 14, P < .001) and less Faecalibacterium (P < 0.001) and Ruminococcus 1 and 2 (P < .001). Duration of PN (P = .005), %PN (P = .005), and fiber intake (P = .011) were predictive of microbiota structure. Higher intake of enteral nutrition was associated with microbiota structure and function closer to those of HC.</p><p><strong>Conclusions: </strong>Microbiota composition and its diet-related function are altered in IF, with depletion of beneficial SCFAs and species and supraphysiological increase of potentially harmful pathobionts. The influence of this compositional and functional microbial dysbiosis on patients' outcomes and management warrants further exploration.</p>","PeriodicalId":520701,"journal":{"name":"JPEN. Journal of parenteral and enteral nutrition","volume":" ","pages":"693-708"},"PeriodicalIF":3.4,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1002/jpen.2188","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38977127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}