Infection & chemotherapy最新文献

{"title":"Diagnostic Performance, Stability, and Usability of Self-Collected Combo Swabs and Saliva for Coronavirus Disease 2019 Diagnosis: A Case-Control Study.","authors":"Seong Jin Choi,&nbsp;Jongtak Jung,&nbsp;Eu Suk Kim,&nbsp;Hong Bin Kim,&nbsp;Jeong Su Park,&nbsp;Kyoung Un Park,&nbsp;Hyunju Lee,&nbsp;Eunyoung Lee,&nbsp;Pyoeng Gyun Choe,&nbsp;Ji-Yeon Kim,&nbsp;Eun Joo Lee,&nbsp;Kyoung-Ho Song","doi":"10.3947/ic.2022.0081","DOIUrl":"https://doi.org/10.3947/ic.2022.0081","url":null,"abstract":"<p><strong>Background: </strong>Self-sampling procedures to detect severe acute respiratory syndrome coronavirus 2 is important for patients who have difficulty visiting the hospital and may decrease the burden for health care workers (HCWs). The objective of this study was to evaluate the diagnostic performance, stability and usability of self-collected nasal and oral combo swabs and saliva specimens.</p><p><strong>Materials and methods: </strong>We conducted a case-control study with 50 patients with coronavirus disease 2019 (COVID-19) and 50 healthy volunteers from March, 2021 to June, 2021. We performed real-time reverse-transcription polymerase chain reaction to compare the diagnostic performance of self-collected specimens using positive percent agreements (PPAs).</p><p><strong>Results: </strong>The PPAs between self-collected and HCW-collected specimens were 77.3 - 81.0% and 80.5 -86.7% for the combo swabs and saliva specimens, respectively. The PPAs increased to 88.9 - 89.2% and 81.2 - 82.1% with a cycle threshold value ≤30.</p><p><strong>Conclusion: </strong>The diagnostic performance of self sampling was comparable to that of HCW sampling in patients with high viral loads and may thus assist in the early diagnosis of COVID-19.</p>","PeriodicalId":520645,"journal":{"name":"Infection & chemotherapy","volume":" ","pages":"517-528"},"PeriodicalIF":4.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7c/f0/ic-54-517.PMC9533156.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33487972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evaluation of Surrogate Laboratory Parameters for Predicting the Trend of Viral Loads in Patients with Severe Fever with Thrombocytopenia Syndrome: Cross-Correlation Analysis of Time Series.","authors":"Misun Kim,&nbsp;Hyunjoo Oh,&nbsp;Sang Taek Heo,&nbsp;Sung Wook Song,&nbsp;Keun Hwa Lee,&nbsp;Myeong Jin Kang,&nbsp;Jeong Rae Yoo","doi":"10.3947/ic.2022.0073","DOIUrl":"https://doi.org/10.3947/ic.2022.0073","url":null,"abstract":"<p><strong>Background: </strong>There is a correlation between the severe fever with thrombocytopenia syndrome (SFTS) viral load and disease severity; however, measurement of viral load is difficult in general laboratory and it takes time to obtain a viral load value. Here, the laboratory parameters for predicting the dynamic changes in SFTS viral load were identified. In addition, we tried to evaluate a specific time point for the early determination of clinical deterioration using dynamic change of laboratory parameters.</p><p><strong>Materials and methods: </strong>This observational study included SFTS patients in Korea (2013 - 2020). Cross-correlation analysis at lagged values was used to determine the temporal correlation between the SFTS viral loads and time-series variables. Fifty-eight SFTS patients were included in the non-severe group (NSG) and 11 in the severe group (SG).</p><p><strong>Results: </strong>In the cross-sectional analyses, 10 parameters -white blood cell, absolute neutrophil cell, lymphocyte, platelet, activated partial thromboplastin time (aPTT), C-reactive protein, aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), and creatine phosphokinase (CPK)- were assessed within 30 days from the onset of symptoms; they exhibited three different correlation patterns: (1) positive, (2) positive with a time lag, and (3) negative. A prediction score system was developed for predicting SFTS fatality based on age and six laboratory variables -platelet, aPTT, AST, ALT, LDH, and CPK- in 5 days after the onset of symptoms; this scoring system had 87.5% sensitivity and 86.0% specificity (95% confidence interval: 0.831 - 1.00, <i>P</i> <0.001).</p><p><strong>Conclusion: </strong>Three types of correlation patterns between the dynamic changes in SFTS viral load and laboratory parameters were identified. The dynamic changes in the viral load could be predicted using the dynamic changes in these variables, which can be particularly helpful in clinical settings where viral load tests cannot be performed. Also, the proposed scoring system could provide timely treatment to critical patients by rapidly assessing their clinical course.</p>","PeriodicalId":520645,"journal":{"name":"Infection & chemotherapy","volume":" ","pages":"470-482"},"PeriodicalIF":4.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cb/5a/ic-54-470.PMC9533152.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33488995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Roadmap for the Antimicrobial Usage Monitoring System for Medical Institutions in Korea: a Delphi Study.","authors":"Hyung-Sook Kim,&nbsp;Se Yoon Park,&nbsp;Heun Choi,&nbsp;Ji Young Park,&nbsp;Mi Suk Lee,&nbsp;Byung Wook Eun,&nbsp;Hyukmin Lee,&nbsp;Jun Yong Choi,&nbsp;Hong Bin Kim,&nbsp;Su Jin Jeong,&nbsp;Young Uh,&nbsp;Bongyoung Kim","doi":"10.3947/ic.2022.0107","DOIUrl":"https://doi.org/10.3947/ic.2022.0107","url":null,"abstract":"<p><strong>Background: </strong>It is necessary to develop a roadmap for antimicrobial usage monitoring in order to perform monitoring of antimicrobial use at the national level properly. Therefore, this study aimed to develop a roadmap for establishing surveillance and monitoring of antimicrobial use in medical institutions at the national level.</p><p><strong>Materials and methods: </strong>A modified Delphi study was conducted, including 3 rounds of an online survey and a virtual meeting with 16 expert panels. The survey items were developed based on a literature review of the surveillance systems for antimicrobial use in 12 countries and interviews with experts. The questionnaire was designed to include both the surveillance and benchmarking systems.</p><p><strong>Results: </strong>Regarding the scope of target institutions to be included in the surveillance system, medical institutions for sentinel surveillance had the highest proportion of agreement among the panels (75.0%, 9/12). For the benchmarking system, \"tertiary- and secondary-care hospitals\" were accepted as the scope of target institutions at the current moment. Furthermore, the National Health Insurance claims and prescription data of individual hospitals were considered appropriate data sources for the surveillance system. As for the measures to promote the participation of hospitals in the benchmarking system, \"compensation through the establishment of antimicrobial management fees\" and \"set the participation in the program as a quality evaluation or accreditation index for hospital evaluation\" were accepted.</p><p><strong>Conclusion: </strong>This study provides a roadmap for establishing an antimicrobial use monitoring and benchmarking system for medical institutions at a national level in Korea.</p>","PeriodicalId":520645,"journal":{"name":"Infection & chemotherapy","volume":" ","pages":"483-492"},"PeriodicalIF":4.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/98/1c/ic-54-483.PMC9533154.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33488996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox in HIV Infected Cases: A Summary on Clinical Presentation of 27 Cases.","authors":"Rujittika Mungmunpuntipantip,&nbsp;Viroj Wiwanitkit","doi":"10.3947/ic.2022.0104","DOIUrl":"https://doi.org/10.3947/ic.2022.0104","url":null,"abstract":"Monkeypox emerges as a fresh public health threat in 2022. Acute febrile sickness and vesicular skin problems are the disease's hallmarks [1]. For a very long time, monkeypox has existed throughout Africa. This area has also been impacted by the human immunodeficiency virus (HIV) problem for a long time. It's an interesting discovery that the two diseases coexist. The co-occurrence has been documented in various places. A fascinating scientific topic is the potential coexistence of HIV and monkeypox. Here, the authors conducted a retrospective study with the goal of providing a summary of the data on the clinical manifestation of monkeypox in patients with HIV infection. A basic literature search was conducted using the international database PubMED. The words \"HIV\" and \"monkeypox\" were important. We searched for papers using the keywords \"HIV\" and \"monkeypox\" to discover more information. Retrospective analysis is done on the clinical presentation specifics in published instances. Any reports written in English are included, whereas ones lacking the necessary data are omitted. There are a total of 27 cases of concurrent monkeypox and HIV infection, according to the search [2-6] (Table 1). Of the patients, 24 are men (88.9%). They were all older than thirty. One instance has a history of receiving a smallpox immunization in the past. One syphilis case among all HIV positive cases has been observed (3.7%). All instances tested negative for Hbs antigen HCV antibodies. While hemoglobin and the white blood cell count/differential were within normal limits, 11.1% of patients had thrombocytopenia. Averaging 280.1 + 207.3 cells/mm3, the CD4+ count varied from 20 to 700 cells/mm3. Every antiretroviral medication regimen is the same. The vesicular cutaneous lesion is the primary complaint in each instance. Over 100 skin lesions connected to genital ulcers were present in all HIV-positive individuals. Two cases (7.4%; all had CD4+ counts below 100 cells/mm3) were fatal.","PeriodicalId":520645,"journal":{"name":"Infection & chemotherapy","volume":" ","pages":"549-550"},"PeriodicalIF":4.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/59/f1/ic-54-549.PMC9533167.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40667102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Co-Administration of COVID-19 and Hepatitis B Vaccines, Should Safety Be a Concern?","authors":"Mohammad S Alrashdan,&nbsp;Mohamed El-Kishawi,&nbsp;Sausan Al Kawas","doi":"10.3947/ic.2022.0042","DOIUrl":"https://doi.org/10.3947/ic.2022.0042","url":null,"abstract":"We read with great interest the recent contribution by Choi and Cheong entitled “Should the COVID-19 Vaccine be Administered Simultaneously with Other Vaccines?” [1]. The topic of concomitant administration of coronavirus disease 2019 (COVID-19) and other vaccines has been largely overlooked in literature and hence the available data represent general recommendations and guidelines that need to be carefully applied. The editorial by Choi and Cheong clearly underscores the importance of considering the current health status of the individual to receive the vaccines as well as the specifications of each vaccine to be administered. The authors also overviewed the different protocols currently applied in some countries as well as the World Health Organization recommendations. Apparently, two major concerns are to be addressed about the concomitant administration of COVID-19 and other vaccines: potential adverse reactions and immunogenicity, i.e., safety and efficacy.","PeriodicalId":520645,"journal":{"name":"Infection & chemotherapy","volume":" ","pages":"542-544"},"PeriodicalIF":4.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/18/08/ic-54-542.PMC9533160.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40667106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment for Immune Thrombocytopenia in Coronavirus Disease 2019 (COVID-19) Infection after COVID-19 Vaccination: A Case Report.","authors":"Jun Hee Lee,&nbsp;Sang-Min Oh,&nbsp;Eunyoung Lee,&nbsp;Ji Hwan Bang,&nbsp;Sang-Won Park","doi":"10.3947/ic.2021.0072","DOIUrl":"https://doi.org/10.3947/ic.2021.0072","url":null,"abstract":"Thrombocytopenia is one of the rare signs of both the coronavirus disease 2019 (COVID-19) and COVID-19 vaccination. An 85-year-old man was diagnosed with immune thrombocytopenia and COVID-19, 7 days after COVID-19 vaccination. The patient was successfully treated with a short course of intravenous immunoglobulin and oral corticosteroids.","PeriodicalId":520645,"journal":{"name":"Infection & chemotherapy","volume":" ","pages":"559-562"},"PeriodicalIF":4.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/27/bf/ic-54-559.PMC9533155.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39775060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correspondence on Promoting COVID-19 Healthcare Worker Welfare.","authors":"Tejas C Sekhar,&nbsp;Vibhav S Prabhakar,&nbsp;Divya Srinivasan","doi":"10.3947/ic.2022.0114","DOIUrl":"https://doi.org/10.3947/ic.2022.0114","url":null,"abstract":"The article published by Lee and colleagues presents an important addition to the growing body of literature on severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and explores its effects on healthcare worker satisfaction and safety [1]. In their article, they report an unmet need within the medical field to understand opportunities to improve existing infrastructure and current practices to better address gaps in provisions for healthcare professionals, chiefly pertaining to the coronavirus disease 2019 (COVID-19) pandemic. Elements of ‘effectiveness’ and ‘urgency’ were evaluated in their study with respect to multiple areas of interest including facilities, personnel, and compensation support, among others. Since healthcare workers interface widely across multilayered institutions and their respective hospital or healthcare systems, it is crucial to ensure that outstanding needs are adequately met.","PeriodicalId":520645,"journal":{"name":"Infection & chemotherapy","volume":" ","pages":"551-552"},"PeriodicalIF":4.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/71/36/ic-54-551.PMC9533150.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40667108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Weight is Inversely Associated with Anti-SARS-CoV-2 Antibody Levels after BNT162b2 mRNA Vaccination in Young and Middle Aged Adults.","authors":"Su Youn Nam,&nbsp;Seong Woo Jeon,&nbsp;Deuk Kju Jung,&nbsp;Sung-Jae Heo","doi":"10.3947/ic.2022.0089","DOIUrl":"https://doi.org/10.3947/ic.2022.0089","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to determine factors affecting serum levels of anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies 2 months after coronavirus disease 2019 (COVID-19) vaccination in young and middle aged healthy adults.</p><p><strong>Materials and methods: </strong>Healthcare workers who have no history of SARS-CoV-2 infection, were enrolled at 2 months after second shot of BNT162b2 mRNA COVID-19 vaccine. Antibody immunoglobulin G against the spike protein subunit of SARS-CoV-2 was semi-quantitatively measured using 4 commercial enzyme-linked immunosorbent assay kits. Factors affecting anti-SARS-CoV-2 antibodies levels were investigated.</p><p><strong>Results: </strong>Fifty-one persons (22 - 54 years, male sex; 19.6%) were enrolled and all participants acquired anti-SARS-CoV-2 antibodies in four diagnostic kits. Anti-SARS-CoV-2 antibodies were strongly correlated between diagnostic kits; SG Medical and Genscript (r = 0.942), SG Medical and HB Healthcare (r = 0.903), and HB Healthcare and Genscript (r = 0.868). We investigated factors affecting antibody level using SG medical kit. The median inhibition was 93.1%, and 84.0% of participants showed >90.0% inhibition. Systemic adverse event severity had no association with the anti-SARS-CoV-2 antibodies level. Antibody level was inversely correlated with weight (-0.312, <i>P</i> = 0.027), body mass index (BMI) (r = -0.303, <i>P</i> = 0.032), and body surface area (r = -0.285, <i>P</i> = 0.044). In multivariate analysis, the upper 50% of anti-SARS-CoV-2 antibodies (≥93.1%) was inversely associated with weight (odds ratio [OR]: 0.19; 95% confidence interval [CI]: 0.04 - 0.83 in weight ≥55kg) and BMI (OR: 0.12; 95% CI: 0.03 - 0.61 in BMI ≥22 kg/m²).</p><p><strong>Conclusion: </strong>Anti-SARS-CoV-2 antibody was inversely correlated with weight and BMI, which may be used as a marker to predict immune response of BNT162b2 mRNA vaccination in young and middle aged adults.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT05083026.</p>","PeriodicalId":520645,"journal":{"name":"Infection & chemotherapy","volume":" ","pages":"504-516"},"PeriodicalIF":4.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7f/97/ic-54-504.PMC9533164.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33487971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Transient Effect of Convalescent Plasma Therapy in a Patient with Severe Covonavirus Disease 2019: A Case Report.","authors":"Ae-Rin Baek,&nbsp;Eun Ju Choo,&nbsp;Ji-Yeon Kim,&nbsp;Tae Sun Ha,&nbsp;Sung Woo Park,&nbsp;Hee Bong Shin,&nbsp;Seong Kyu Park,&nbsp;Joo Hyun Park,&nbsp;Tark Kim","doi":"10.3947/ic.2020.0089","DOIUrl":"https://doi.org/10.3947/ic.2020.0089","url":null,"abstract":"<p><p>A 65-year-old male patient with an end-stage renal disease was diagnosed with coronavirus disease 2019 (COVID-19) by reverse transcription polymerase chain reaction. The patient complained of cough, sputum, and respiratory distress that worsened three days ago. The patient required mechanical ventilation and extracorporeal mentrane oxygenation. On day 9, convalescent plasma collected from a 34-year old man who recovered from COVID-19 45 days ago was administered. The patient showed immediate clinical improvement. However, on day 14, the patient's clinical course worsened again. On day 19 and day 24, vancomycin-resistant <i>Enterococcus faecium</i> bacteremia and methicillin-resistant <i>Staphylococcus aureus</i> pneumonia were found. After long-term supportive care, he slowly recovered. He was discharged on day 91 without any oxygen requirement. This case report suggests that convalescent plasma therapy might just provide a short-term relief and that persistent effort for critical care is necessary to save patients from severe COVID-19.</p>","PeriodicalId":520645,"journal":{"name":"Infection & chemotherapy","volume":" ","pages":"553-558"},"PeriodicalIF":4.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d2/b7/ic-54-553.PMC9533158.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40665720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Three Cardiovascular Risk Scores among HIV-Infected Patients in Korea: The Korea HIV/AIDS Cohort Study.","authors":"Ji Yun Bae,&nbsp;Soo Min Kim,&nbsp;Yunsu Choi,&nbsp;Jun Yong Choi,&nbsp;Sang Il Kim,&nbsp;Shin-Woo Kim,&nbsp;Bo Young Park,&nbsp;Bo Youl Choi,&nbsp;Hee Jung Choi","doi":"10.3947/ic.2022.0048","DOIUrl":"https://doi.org/10.3947/ic.2022.0048","url":null,"abstract":"<p><strong>Background: </strong>We investigated cardiovascular disease (CVD), risk factors for CVD, and applicability of the three known CVD risk equations in the Korean human immunodeficiency virus/ Acquired Immune Deficiency Syndrome (HIV/AIDS) cohort.</p><p><strong>Materials and methods: </strong>The study parcitipants were HIV-infected patients in a Korean HIV/AIDS cohort enrolled from 19 hospitals between 2006 and 2017. Data collected at entry to the cohort were analyzed. The 5-year CVD risk in each participant was calculated using three CVD risk equations: reduced CVD prediction model of HIV-specific data collection on adverse effects of anti-HIV drugs (R-DAD), Framingham general CVD risk score (FRS), and Korean Coronary Heart Disease Risk Score (KRS).</p><p><strong>Results: </strong>CVD events were observed in 11 of 586 HIV-infected patients during a 5-year (median) follow-up period. The incidence of CVD was 4.11 per 1,000 person-years. Older age (64 <i>vs.</i> 41 years, <i>P</i> = 0.005) and diabetes mellitus (45.5% <i>vs.</i> 6.4%, <i>P</i> <0.001) were more frequent in patients with CVD. Using R-DAD, FRS, and KRS, 1.9%, 2.4%, and 0.7% of patients, respectively, were considered to have a very high risk (≥10%) of 5-year CVD. The discriminatory capacities of the three prediction models were good, with c-statistic values of 0.829 (<i>P</i> <0.001) for R-DAD, 0.824 (<i>P</i> <0.001) for FRS, and 0.850 (<i>P</i> = 0.001) for KRS.</p><p><strong>Conclusion: </strong>The FRS, R-DAD, and KRS performed well in the Korean HIV/AIDS cohort. A larger cohort and a longer period of follow-up may be necessary to demonstrate the risk factors and develop an independent CVD risk prediction model specific to Korean patients with HIV.</p>","PeriodicalId":520645,"journal":{"name":"Infection & chemotherapy","volume":" ","pages":"409-418"},"PeriodicalIF":4.2,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/9c/ic-54-409.PMC9533153.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40665721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}