Monkeypox in HIV Infected Cases: A Summary on Clinical Presentation of 27 Cases.

Abstract

Monkeypox emerges as a fresh public health threat in 2022. Acute febrile sickness and vesicular skin problems are the disease's hallmarks [1]. For a very long time, monkeypox has existed throughout Africa. This area has also been impacted by the human immunodeficiency virus (HIV) problem for a long time. It's an interesting discovery that the two diseases coexist. The co-occurrence has been documented in various places. A fascinating scientific topic is the potential coexistence of HIV and monkeypox. Here, the authors conducted a retrospective study with the goal of providing a summary of the data on the clinical manifestation of monkeypox in patients with HIV infection. A basic literature search was conducted using the international database PubMED. The words "HIV" and "monkeypox" were important. We searched for papers using the keywords "HIV" and "monkeypox" to discover more information. Retrospective analysis is done on the clinical presentation specifics in published instances. Any reports written in English are included, whereas ones lacking the necessary data are omitted. There are a total of 27 cases of concurrent monkeypox and HIV infection, according to the search [2-6] (Table 1). Of the patients, 24 are men (88.9%). They were all older than thirty. One instance has a history of receiving a smallpox immunization in the past. One syphilis case among all HIV positive cases has been observed (3.7%). All instances tested negative for Hbs antigen HCV antibodies. While hemoglobin and the white blood cell count/differential were within normal limits, 11.1% of patients had thrombocytopenia. Averaging 280.1 + 207.3 cells/mm3, the CD4+ count varied from 20 to 700 cells/mm3. Every antiretroviral medication regimen is the same. The vesicular cutaneous lesion is the primary complaint in each instance. Over 100 skin lesions connected to genital ulcers were present in all HIV-positive individuals. Two cases (7.4%; all had CD4+ counts below 100 cells/mm3) were fatal.