Head and neck pathology最新文献

{"title":"Where to Practice Pathology? Comments from a Personal Journey.","authors":"Jerome B Taxy","doi":"10.1007/s12105-025-01761-7","DOIUrl":"10.1007/s12105-025-01761-7","url":null,"abstract":"<p><p>This article concerns the years I spent in practicing anatomic pathology in various places and the evolution of my opinion that location and specialization are linked. I am going to assume that those of us who practice pathology know how to describe the nature of our duties and responsibilities as well as how we got to that point, whether as generalist or specialist. In addition, we know geographically and institutionally where we presently are. My personal experience and observations, admittedly anecdotal, have been that pathologists commonly practice in one or at the most two locations during the course of a career. The reasons are multifactorial, but my comments here suggest that it need not be a foreordained conclusion that where one starts is where one finishes.</p>","PeriodicalId":520636,"journal":{"name":"Head and neck pathology","volume":"19 1","pages":"68"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106207/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nodal Metastasis in Low Grade Salivary Gland Carcinoma: A Retrospective Analysis of Incidence, Histologic Spectrum and Outcome.","authors":"Bin Xu, Neha Chongtham, Ronald Ghossein, Nora Katabi","doi":"10.1007/s12105-025-01800-3","DOIUrl":"10.1007/s12105-025-01800-3","url":null,"abstract":"<p><strong>Background: </strong>Lymph node metastasis is an adverse pathologic feature that often necessitates post-operative adjuvant radiation therapy or concurrent chemoradiation for salivary gland carcinoma (SGC). While regional metastasis is more common in high grade SGCs, it is rare in low grade (LG) SGCs.</p><p><strong>Methods: </strong>In this retrospective study, we conducted a detailed review of a retrospective cohort of 543 LG-SGCs. Nodal metastasis at presentation and regional recurrence were identified in 7% (n = 38) and 3% (n = 14) of LG-SGCs respectively. The incidence of nodal metastasis varied by tumor histologic subtype, ranging from 0% for epithelial-myoepithelial carcinoma to 10% for polymorphous adenocarcinoma. Compared with LG-SGCs without nodal metastasis, those with regional metastasis were associated with a significantly higher frequency of pT4 disease, larger tumor size, lymphovascular invasion, and perineural invasion. However, clinical outcomes did not differ significantly between the two groups. The 5-year disease-specific survival was 100% and 99% respectively for pN + and pNx/pN0 groups, while the 5-year disease-free survival was 82% and 93% respectively. Among the LG-SGCs that developed regional recurrence to neck lymph nodes, the time between primary resection and recurrent disease ranged from 6 to 233 months (median = 64 months).</p><p><strong>Conclusion: </strong>Nodal metastasis, though rare, occurs in 7% of patients with LG-SGCs at the time of diagnosis and in 3% as a recurrent disease. It is associated with pT4 disease, larger tumor size, perineural and lymphovascular invasion but does not appear to significantly impact clinical outcomes.</p>","PeriodicalId":520636,"journal":{"name":"Head and neck pathology","volume":"19 1","pages":"69"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEK::AFF2-Associated Papillary Squamous Cell Carcinoma of the Sinonasal Tract: Clinicopathologic Characterization of 9 Cases.","authors":"Ye Zhao, Yebin Fu, Wei Wang, Hui Peng, Shuang Wang","doi":"10.1007/s12105-025-01799-7","DOIUrl":"10.1007/s12105-025-01799-7","url":null,"abstract":"<p><strong>Introduction: </strong>DEK::AFF2 fusion-associated carcinoma, a recently recognized entity predominantly localized to the sinonasal tract and skull base, remains diagnostically challenging due to its poorly defined clinicopathological spectrum and epidemiological profile. Despite its deceptively bland histomorphology, this neoplasm is paradoxically linked to aggressive clinical behavior and elevated mortality rates.</p><p><strong>Purpose: </strong>To delineate the clinicopathological and molecular characteristics of DEK::AFF2 fusion-associated carcinomas to elucidate their biological drivers and refine therapeutic strategies.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on some cases initially diagnosed as sinonasal papilloma of various types, with or without dysplasia or associated malignant transformation. DEK::AFF2 fusion was confirmed by DEK break-apart fluorescence in situ hybridization (FISH). Molecular features were assessed using immunohistochemistry (IHC) and in situ hybridization (ISH) to differential diagnosis. Clinical outcomes were analyzed for recurrence and disease-specific mortality.</p><p><strong>Results: </strong>Nine cases with DEK gene rearrangements were identified. The cohort comprised patients aged 51-76 years (median: 59 years), with a male predominance (M:F = 7:2). All cases demonstrated nuclear positivity for p40/p63 and AFF2 (30% ~90% tumor cells), while staining for p16 and Epstein-Barr encoded mRNA (EBER) was uniformly negative by IHC and ISH. Ki-67 index ranges from 5 to 40% with the median at 20%. Local recurrences occurred in 55.6% (5/9) of patients within 10-30 months following initial therapeutic intervention. The disease-specific mortality observed in 22.2% (2/9) of cases.</p><p><strong>Conclusion: </strong>DEK::AFF2 fusion-associated carcinoma is characterized by a clinicopathological dichotomy: bland histological features contrast with aggressive biological behavior and poor prognosis in the nasal cavity, paranasal sinuses, and skull base.</p>","PeriodicalId":520636,"journal":{"name":"Head and neck pathology","volume":"19 1","pages":"66"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Sensitivity PD-L1 Staining Using Clone 73-10 Antibody and Spatial Transcriptomics for Precise Expression Analysis in Non-Tumorous, Intraepithelial Neoplasia, and Squamous Cell Carcinoma of Head and Neck.","authors":"Yuri Noda, Naho Atsumi, Takeo Nakaya, Hiroshi Iwai, Koji Tsuta","doi":"10.1007/s12105-025-01798-8","DOIUrl":"10.1007/s12105-025-01798-8","url":null,"abstract":"<p><strong>Purpose: </strong>While immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis have improved outcomes in head and neck squamous cell carcinoma (HNSCC), eligibility criteria based on immunohistochemistry (IHC) target PD-1 solely. We aimed to evaluate the PD-L1 (CD274) expression using highly sensitive clone 73 - 10 and spatial transcriptomics (ST) analysis to elucidate the role of PD-L1 in HNSCC and thus potentially expand the pool of eligible patients.</p><p><strong>Methods: </strong>Immunohistochemical staining of 73 - 10, CD3, CD4, and CD8 were performed in 94 HNSCC clinical samples along with paired adjacent squamous intraepithelial neoplasm (SIN) and normal oral mucosa (NOM) samples. The 73 - 10 positivity was evaluated using a tumor cell score ≥ 1%, and the results were analyzed against clinicopathological features including CD4⁺ and CD8⁺ tumor-infiltrating lymphocytes (TILs), and clinical outcomes. Furthermore, ST and PD-L1 related pathway analysis was performed in 6 paired HNSCC, SIN and NOM samples.</p><p><strong>Results: </strong>The 73 - 10 detected-PD-L1 positivity was high in HNSCC (79%) compared to SIN (10%) and NOM (3%). 73 - 10⁺ correlated with high CD4⁺ TILs, as well as the independent prognostic factor of OS, DSS, and PFS of HNSCC (all p < 0.05). ST analysis revealed that the upregulated distribution of CD274 correlated with 73 - 10 positivity. Pathway analysis revealed a significant upregulation of CD274 and CD4 in HNSCC compared to SIN and NOM, and HIF-1α and IFN-γ as key regulators of PD-L1 expression in HNSCC.</p><p><strong>Conclusion: </strong>Clone 73 - 10 is a relatively suitable candidate for identifying patients with PD-L1 expression eligible for ICI therapy. It demonstrates high sensitivity in detecting PD-L1 (CD274) in HNSCC, offering immunological and prognostic insights.</p>","PeriodicalId":520636,"journal":{"name":"Head and neck pathology","volume":"19 1","pages":"65"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrasalivary Thymic Carcinoma: A Case Report and Literature Review.","authors":"Michał Kunc,&nbsp;Alexandra Kamieniecki,&nbsp;Grzegorz Walczak,&nbsp;Tomasz Nowicki,&nbsp;Bartosz Wasąg,&nbsp;Bogusław Mikaszewski,&nbsp;Dominik Stodulski,&nbsp;Wojciech Biernat","doi":"10.1007/s12105-021-01394-6","DOIUrl":"https://doi.org/10.1007/s12105-021-01394-6","url":null,"abstract":"<p><p>Ectopic thymic carcinomas are rarely diagnosed in the thyroid gland, let alone in extrathyroid tissues. In the currently available literature, only five cases of extrathyroidal malignancies with thymic differentiation have been reported as arising in the major salivary glands. A 69-year-old female presented with a slow-growing palpable mass in the left parotid gland. Fine needle aspiration biopsy suggested metastatic cancer, whereas core needle biopsy revealed high-grade squamous cell carcinoma. The patient underwent left radical parotidectomy with selective ipsilateral lymph node dissection and subsequent radiation therapy. The surgical specimen was taken for histopathological examination. Microscopically, the tumor resembled thymic carcinoma. It was composed of large nests of squamoid cells with smooth contours, focally with a syncytial growth pattern, and accompanied by abundant lymphocytes with reactive lymphoid follicles. This appearance resembled a micronodular thymic carcinoma with lymphoid hyperplasia. Moreover, the tumor displayed expression of squamous markers (p40 and p63) and markers of thymic carcinoma (CD5 and CD117). Therefore, the final diagnosis of intrasalivary thymic carcinoma was rendered. The molecular analysis including next-generation sequencing demonstrated no variants of the strong, potential, or unknown clinical significance. The patient remains disease-free at 1-year follow-up. In the current case, we comprehensively present a clinical, microscopic, molecular, and radiological picture of CD5-positive squamous cell carcinoma of the parotid. We postulate that similar cases should be designated as intrasalivary thymic carcinoma analogically to similar thyroid tumors. Our case and the limited literature data indicate they should be distinguished from conventional squamous cell carcinoma of major salivary glands due to their rather favorable prognosis.</p>","PeriodicalId":520636,"journal":{"name":"Head and neck pathology","volume":" ","pages":"857-864"},"PeriodicalIF":2.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39646767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whole Exome Sequencing Identifies Somatic Variants in an Oral Composite Hemangioendothelioma Characterized by YAP1-MAML2 Fusion.","authors":"Ioannis G Koutlas,&nbsp;William S Oetting,&nbsp;Gregory M Burns,&nbsp;Rajaram Gopalakrishnan,&nbsp;Cristina R Antonescu","doi":"10.1007/s12105-021-01393-7","DOIUrl":"https://doi.org/10.1007/s12105-021-01393-7","url":null,"abstract":"<p><p>Composite hemangioendothelioma (CHE) is considered a borderline malignant vascular tumor defined by an admixture of distinct vascular neoplastic components. A 21-year-old female is presented herein with a 1 cm painless mandibular vestibular mass of less than a year duration. The infiltrating tumor was characterized by dilated vascular channels lined by endothelial cells with bland ovoid or round nuclei exhibiting, occasionally, hobnail/matchstick-like arrangement. Intravascular cell proliferations with hyaline globular deposits were also present. Additionally, lobular spindle and epithelioid cell aggregates, as well as slit-like spaces exhibiting a retiform or angiosarcomatous morphology were observed. Intracytoplasmic signet-ring or lipoblast-like vacuolization was also noted. Mitotic activity was exceptionally rare. Vascular spaces and the stroma featured lymphocytes and plasma cells. Neoplastic cells were positive for CD31, CD34, D2-40 and ERG, negative for CAMTA1 and synaptophysin, while type IV collagen highlighted the plasmalemma of most vessels and hyaline globules. Fluorescence in situ hybridization revealed gene rearrangements in both YAP1 and MAML2 genes, in keeping with a YAP1-MAML2 fusion. Whole exome sequencing (WES) identified three missense mutations FLT1 [p.R1016G], PIK3CA [p.H1047L], and C11orf42 [p.A304P] and a mitochondrial frameshift insertion MT-ND4 [c.1107_1108insC; p.P370fs]. These WES results suggest that FLT1 and/or PIK3CA variants may contribute to tumor growth/transformation while the MT-ND4 variant may relate to proliferation, angiogenesis and/or inhibition of apoptosis.</p>","PeriodicalId":520636,"journal":{"name":"Head and neck pathology","volume":" ","pages":"849-856"},"PeriodicalIF":2.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424484/pdf/12105_2021_Article_1393.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39723483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adamantinoma-like Ewing Sarcoma of the Nasal Cavity: A Rare Clinical Presentation with Deceptive Histopathologic Features.","authors":"Sunil Pasricha,&nbsp;Saloni Pahwa,&nbsp;Ankush Jajodia,&nbsp;Sumit Goyal,&nbsp;Mudit Agarwal,&nbsp;Ankur Kumar,&nbsp;Gurudutt Gupta,&nbsp;Anila Sharma,&nbsp;Garima Durga,&nbsp;Meenakshi Kamboj,&nbsp;Anurag Mehta","doi":"10.1007/s12105-021-01396-4","DOIUrl":"https://doi.org/10.1007/s12105-021-01396-4","url":null,"abstract":"<p><p>Ewing sarcoma (ES) is a malignant round cell tumour (MRCT) that usually involves bone and soft tissue of young and paediatric populations. ES of the head and neck region is uncommon. Adamantinoma-like Ewing sarcoma (ALES) is a rare variant of ES that shows complex epithelial differentiation on histopathology and immunohistochemistry (IHC). It demonstrates a t(11;22) translocation and EWSR1- FLI1 fusion. Most documented cases of ALES of the head and neck region were initially misdiagnosed as epithelial tumours. We present a rare case of ALES of the nasal cavity in a young female. The patient subsequently underwent chemotherapy and showed an excellent response. Awareness of this entity is important for pathologists and oncologists due to its distinct therapeutic and prognostic implications. We propose performing upfront NKX2.2 and CD99 IHC studies, as well as other lineage specific IHC markers, in any poorly differentiated MRCT of head and neck region.</p>","PeriodicalId":520636,"journal":{"name":"Head and neck pathology","volume":" ","pages":"865-869"},"PeriodicalIF":2.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424420/pdf/12105_2021_Article_1396.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39773788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Squamoglandular Variant of Acinic Cell Carcinoma: A Case Report of a Novel Variant.","authors":"Akeesha A Shah,&nbsp;Raja R Seethala","doi":"10.1007/s12105-021-01399-1","DOIUrl":"https://doi.org/10.1007/s12105-021-01399-1","url":null,"abstract":"<p><p>While salivary gland tumors have considerable plasticity, juxtaposition of the morphologies of two named tumor types is rare. Tumors with both mucoepidermoid and serous acinar components, dubbed \"mucoacinar\" carcinomas were recently characterized, and based on morphologic and molecular features, considered variants of mucoepidermoid carcinoma. Here we describe a unique case of a 59-year-old male with a 0.9 cm right parotid mass with a similar blend of mucoepidermoid-like and acinar elements that instead has a molecular phenotype of acinic cell carcinoma, essentially the reverse of mucoacinar carcinoma. The tumor was fairly well circumscribed with a prominent tumor associated lymphoid response. It consisted of a predominant bland but basaloid squamoid proliferation with scattered pockets of serous acinar differentiation as well as rare mucous cells and tubules. The tumor showed diffuse cytokeratin and DOG1 reactivity as well as p40 expression in the squamoid components. Immunostaining for NR4A3 was diffusely positive, and an NR4A3 rearrangement was noted on fluorescence in situ hybridization, while testing for MAML2 and MSANTD3 rearrangements were negative. Based on these findings, this tumor is best considered a \"squamoglandular variant of acinic cell carcinoma.\" Morphologic and clinical evidence argues against this representing a form of high-grade transformation. While overall bland, the differential diagnosis may include various basaloid tumors in the parotid gland, both primary and metastatic.</p>","PeriodicalId":520636,"journal":{"name":"Head and neck pathology","volume":" ","pages":"870-875"},"PeriodicalIF":2.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424470/pdf/12105_2021_Article_1399.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39697774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clear Cell Odontogenic Carcinoma a Systematic Review.","authors":"Alberto Jose Peraza Labrador, Nestor Ricardo Gonzalez Marin, Luciano Hermios Matos Valdez, Martinez P Valentina, Katman Bear Toledo Sanchez, Karem Annelise Rodriguez Ibazetta, Basterrechea Johan, Abad Villacrez Cesar, John M Wright","doi":"10.1007/s12105-021-01383-9","DOIUrl":"10.1007/s12105-021-01383-9","url":null,"abstract":"<p><p>Clear cell Odontogenic Carcinoma (CCOC) is an uncommon malignant odontogenic tumor (MOT). It is the fifth most common MOT. A systematic review is presented of reported cases, case series and retrospective studies of CCOC, to determine trends in presentation, diagnostic features, treatment, and patient outcome. Searches of detailed databases were carried out to identify papers reporting CCOC. The variables were demographics, patient symptoms, tumor location, histopathological findings, immunohistochemical studies, treatment, follow-up, and recurrence. 117 cases were identified; CCOC was most frequently seen in mature females 65% (n = 76). The total average age was 55.4 with a range from 17 to 89 years, for females 56.4 and males 53.6 years. The mean size was 3.41 cm. The most common location was in the mandibular body 36.2% (n = 42), followed by the anterior mandible 23.3% (n = 27). The most common clinical presentation was a swelling 80.4% (n = 74), and the main symptom was pain 41.3% (n = 31), followed by painless lesion 24% (n = 18). The most common Immunohistochemistry positive expression was CK19, EMA, and CEA, and for special staining periodic acid Shiff (PAS); 97% of cases were treated surgically. The average follow-up was 30.3 months, and recurrence was reported in 52.4% of the cases. Conclusion: CCOC shows a strong predilection for the body and anterior mandible, and females are more frequently affected. CCOCs can be painful and the principle clinical sign is swelling, CCOCs can metastasize, and the prognosis is fair.</p>","PeriodicalId":520636,"journal":{"name":"Head and neck pathology","volume":" ","pages":"838-848"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424403/pdf/12105_2021_Article_1383.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39492739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy and Post-Procedural Complications Associated with Ultrasound-Guided Core Needle Biopsy in the Preoperative Evaluation of Parotid Tumors.","authors":"Monika Jering,&nbsp;Marcel Mayer,&nbsp;Rubens Thölken,&nbsp;Stefan Schiele,&nbsp;Andrea Maccagno,&nbsp;Johannes Zenk","doi":"10.1007/s12105-021-01401-w","DOIUrl":"https://doi.org/10.1007/s12105-021-01401-w","url":null,"abstract":"<p><p>Correct diagnosis of a parotid neoplasm based on histology preoperatively is of utmost importance in order to guide patient management. The aim of this study was to evaluate the diagnostic accuracy of an ultrasound-guided core needle biopsy of a parotid lesion and to describe associated post-procedural complications. A retrospective study was conducted between January 2015 and March 2021 of all patients who were referred to a tertiary care center for evaluation of a parotid lesion and who underwent core needle biopsy due to high-risk features or when malignancy was suspected on clinical examination or ultrasonography. Patient characteristics, histological findings, and post-procedural complications were recorded and evaluated. Among 890 patients referred for evaluation of a parotid lesion, in 138 patients a core needle biopsy was undertaken. On the basis of core needle biopsy findings, 11 lymphomas and 82 non-lymphoma malignancies were diagnosed in the parotid gland. The sensitivity of the core needle biopsy predicting the accurate tumor type was 97.56% (95% CI 91.47-99.70%) and the specificity 94.64% (95% CI 85.13-98.88%). The accuracy for the correct histopathological diagnosis was 93.48% (95% CI 87.98-96.97%). Post-procedural minor complications occurred in 19 patients (13.8%). In conclusion, a core needle biopsy can identify malignancy in the parotid gland with high sensitivity and specificity in a safe manner and therefore guide surgical treatment.</p>","PeriodicalId":520636,"journal":{"name":"Head and neck pathology","volume":" ","pages":"651-656"},"PeriodicalIF":2.1,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39734506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}