European journal of trauma and emergency surgery : official publication of the European Trauma Society最新文献

{"title":"Protective effects of tasimelteon on kidney injury in a traumatic brain injury rat model: a histopathological and immunohistochemical study.","authors":"Adem Milletsever, Halil Asci, Rumeysa Taner, Ozlem Ozmen","doi":"10.1007/s00068-025-02915-6","DOIUrl":"10.1007/s00068-025-02915-6","url":null,"abstract":"","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"241"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12205017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone wax spacers increase induced membrane thickness and promote osteogenesis more than polymethylmethacrylate spacers in the masquelet technique.","authors":"Takushi Nakatani, Hajime Mishima, Sho Totsuka, Ryunosuke Watanabe, Norihito Arai, Yohei Tomaru, Hisashi Sugaya, Tomofumi Nishino, Masashi Yamazaki","doi":"10.1007/s00068-025-02911-w","DOIUrl":"10.1007/s00068-025-02911-w","url":null,"abstract":"<p><strong>Purpose: </strong>The Masquelet technique is a recent novel treatment for severe bone defects. Polymethylmethacrylate (PMMA) has been used as a spacer for bone defects, but the optimal spacer is still unknown. Therefore, this study aimed to histologically evaluate the membranes induced by bone wax and PMMA spacers and compare them with respect to bone formation.</p><p><strong>Methods: </strong>In this study, bone defects were created in the femurs of Sprague-Dawley rats, and bone wax and PMMA spacers were implanted into the defects to histologically evaluate the induced membrane and bone formation after bone grafting.</p><p><strong>Results: </strong>As a result, the induced membrane formed by bone wax spacers was significantly thicker than that formed by PMMA spacers, and the vascular area ratio was significantly higher. In addition, bone wax spacers promoted bone formation more than PMMA spacers.</p><p><strong>Conclusion: </strong>Bone wax spacers promoted induced membrane formation and bone formation by enhancing inflammatory responses more than PMMA spacers.</p>","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"236"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic investigation and comparison of diagnostic methods in implant-related infections and infectious non-unions in trauma surgery- results of a prospective study.","authors":"Robin Otchwemah, Rolf Lefering, Benedikt Marche, Thorsten Tjardes, Andreas Friedrich Wendel, Veronika Weichert, Marcel Dudda, Eva Steinhausen","doi":"10.1007/s00068-025-02900-z","DOIUrl":"10.1007/s00068-025-02900-z","url":null,"abstract":"","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"243"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of chronic pain, chronic opioid use and neuropathic pain in Ukrainian military patients with isolated thoracic injuries sustained during the Russia-Ukraine conflict: a single-centre prospective observational study.","authors":"Ceri Battle, Edward Baker, Dmytro Dmytriiev","doi":"10.1007/s00068-025-02914-7","DOIUrl":"10.1007/s00068-025-02914-7","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to investigate the rate and predictors of (a) chronic pain, (b) chronic opioid use and (c) neuropathic pain in Ukrainian military patients with isolated thoracic injuries sustained during the Russia-Ukraine Conflict.</p><p><strong>Methods: </strong>A prospective, single-centre observational study design was used. Military patients (≥ 16 years old) with isolated thoracic injuries, admitted to a frontline hospital in Ukraine for ≥ 24 h were included. At three-months post-injury, baseline data were collected retrospectively from the participants' hospital records and the Eq. 5D-5 L, PROMIS-PI, and PainDETECT surveys completed with either face to face in the follow-up appointment, or by telephone. Predictors of chronic pain, chronic opioid use and neuropathic pain were investigated using multivariate logistic regression modelling.</p><p><strong>Results: </strong>101 patients were included; 85 (85%) were male, with a median age of 38 (IQR: 33-44). Median number of ribs fractures was six (IQR: 5-8), with 62 (62%) patients sustaining burns to the thorax, and 34 (34%) presenting with one or more thoracic spinal fracture. A total of 61 (61%) of patients reported chronic pain, 55 (55%) reported chronic opioid use and 74 (74%) reported neuropathic pain at three months. Positive predictors for chronic pain at three months post-injury were an increasing hospital length of stay, bilateral rib fractures, thoracic burns and one or more thoracic spinal fracture (all p < 0.05).</p><p><strong>Conclusion: </strong>This study provides an overview of the rate and predictors of chronic pain, chronic opioid use and neuropathic pain at three months, in military patients with isolated thoracic injuries.</p>","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"237"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting traumatic brain injury severity: analysis of the correlation between Glasgow coma scale and abbreviated injury scale.","authors":"Puck Domino Monique Niessen, Pieta Krijnen, Henry Alexander Leijdesdorff, Wilco Cornelis Peul, Inger Birgitta Schipper","doi":"10.1007/s00068-025-02909-4","DOIUrl":"10.1007/s00068-025-02909-4","url":null,"abstract":"<p><strong>Purpose: </strong>Both the Glasgow Coma Scale (GCS) and Abbreviated Injury Scale (AIS) for head injuries quantify traumatic brain injury (TBI) severity. The GCS is based on brain physiology of consciousness, whereas the AIS is an anatomical injury scoring system. This study aimed to describe the correlation of GCS with maximal AIS-Head (maxAIS) and summative AIS-Head (sumAIS) in TBI patients.</p><p><strong>Methods: </strong>Data of 4996 adult TBI patients admitted to two level 1 trauma centers in the Netherlands between 2015 and 2021 were selected from the regional trauma registry. The association of GCS with maxAIS and sumAIS was quantified using Spearman rank correlation coefficients (r_s).</p><p><strong>Results: </strong>For 39% of the patients, the GCS was not documented in the trauma registry. These patients had less severe head injuries than the 3051 patients with documented GCS scores, who were further analyzed. Among those with severe head injuries (AIS-Head ≥ 4), 53% had a GCS score ≥ 13. The GCS showed a weak inverse relationship with both maxAIS and sumAIS (r_s -0.33 and - 0.34, respectively, both p < 0.001).</p><p><strong>Conclusions: </strong>The correlation between physiological alterations (GCS) and anatomical brain damage (AIS) in patients with TBI patients, represented by the GCS and AIS respectively, is weak. Additionally, the GCS appears to underestimate the severity of AIS coded severe TBI. Recognizing this limited correlation is important for valid TBI research.</p>","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"239"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of SCUBE-1, SCUBE-2, caveolin-1, and ischemia biomarker levels in rats following renal ischemia-reperfusion.","authors":"Remzi Can Cakir, Bulent Dinc, Hamit Yaşar Ellidağ, Senay Yildirim, Tahir Turker Kaplan, Omer Celik, Halit Ozgul, Tugrul Cakir","doi":"10.1007/s00068-025-02906-7","DOIUrl":"https://doi.org/10.1007/s00068-025-02906-7","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the histopathological findings and serum levels of ischemia and oxidative stress biomarkers in a rat model of renal ischemia-reperfusion injury.</p><p><strong>Methods: </strong>Fifty-one female Wistar rats were randomly allocated into six groups: ischemia/third day, ischemia/first week, ischemia/second week, and corresponding control groups for each ischemia group. Each ischemia group had 10 rats, and each control group had seven. Ischemia was induced by clamping the left renal hilum for 45 min, followed by reperfusion. Relaparotomy was performed at designated time points, and blood and kidney samples were collected. Control groups underwent laparotomy without ischemia. Serum levels of signal peptide-complement C1r/C1s, Uegf, and Bmp1-epidermal growth factor-like domain-containing protein 1 and 2 (SCUBE-1/2), caveolin-1 (Cav-1), albumin, ischemia-modified albumin (IMA), total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), IMA/albumin ratio (IMAR), creatinine, and blood urea nitrogen were analyzed, and histopathological examinations were undertaken.</p><p><strong>Results: </strong>In the ischemia groups, serum levels of SCUBE-1, IMA, TAS, TOS, creatinine, IMAR, and OSI statistically significantly differed from those in the control groups. Serum Cav-1 levels showed a statistically significant difference between the third-day and first-week groups, whereas no statistically significant difference was observed between the ischemia and control groups in the second-week cohort.</p><p><strong>Conclusion: </strong>Significant differences in ischemia and oxidative stress biomarkers, including SCUBE-1 and Cav-1, were observed. SCUBE-1 and Cav-1 may serve as potential biomarkers for assessing kidney injury, function, and recovery.</p>","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"235"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity influences the biological response to injury: a multi-omics analysis.","authors":"Terry R Schaid, Christopher Erickson, Angelo D'Alessandro, Kirk Hansen, Otto Thielen, William Hallas, Lauren Gallagher, Alexis Cralley, Ian LaCroix, Benjamin Ramser, Benjamin Stocker, Sanchayita Mitra, Preston Stafford, Monica Dzieciatkowska, Christopher Silliman, Mitchell Cohen","doi":"10.1007/s00068-025-02922-7","DOIUrl":"https://doi.org/10.1007/s00068-025-02922-7","url":null,"abstract":"<p><strong>Purpose: </strong>Obesity is a prevalent disease, but its influence on post-injury biology remains unclear. In this study, we aimed to characterize the independent effect of obesity on the proteomic and metabolomic signatures of trauma.</p><p><strong>Methods: </strong>Plasma was obtained on arrival from injured patients at a Level 1 Trauma Center and analyzed with modern mass spectrometry-based proteomics and metabolomics. Samples obtained after start of transfusion were excluded. Patients were stratified by \"obesity\" (body mass index [BMI]≥30 kg/m²) vs. \"no obesity\" (BMI < 30 kg/m²). In sub-group analyses, patients were sub-stratified by Low Injury/Low Shock (ISS < 15, base excess [BE]≥-6mEq/L) and High Injury/High Shock (ISS≥15, BE<-6). Multiple regression was used to adjust the omics data for significant covariates prior to performing ome-wide analyses.</p><p><strong>Results: </strong>There were 183 patients included (48 [26%] with obesity and 135 [74%] without). After covariate-adjustment, multiple proteins and metabolites were correlated with ISS and/or BE and were significantly different from Low Injury/Low Shock to High Injury/High Shock only in patients with obesity. This obesity-specific omics response to injury was characterized by increased inflammation, hypercoagulability, altered nitrogen metabolism, and mitochondrial dysfunction. Patients with obesity also exhibited excessive injury-provoked tissue destruction and organ damage compared to patients without obesity. In injury severity-adjusted analyses, the obesity signature consistently displayed markers of hemolysis, likely reflecting a pre-injury hemolytic propensity.</p><p><strong>Conclusion: </strong>Obesity is independently associated with altered post-injury biology, which likely underlies unique pathology in trauma patients with obesity. Identifying this aberrant response to injury is the first step in developing personalized therapies for this patient population.</p>","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"238"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the silence: communication failures are the leading errors identified in 10-years of trauma morbidity and mortality conferences.","authors":"Severin Gloor, Marcel Quante, Beat Lehmann, Beat Schnüriger","doi":"10.1007/s00068-025-02913-8","DOIUrl":"10.1007/s00068-025-02913-8","url":null,"abstract":"","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"242"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic fractures of the sternum - typical distribution and need for subgroups within AO and OTA classification system?","authors":"Johannes Groh, Florian Kern, Anne Schenderlein, Johannes Krause, Mario Perl, Stefan Schulz-Drost","doi":"10.1007/s00068-025-02910-x","DOIUrl":"10.1007/s00068-025-02910-x","url":null,"abstract":"","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"234"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative study of minimally invasive plate osteosynthesis with t-shaped incision technique and standard volar approach with pronator quadratus preservation in volar plating of distal radius fractures.","authors":"Wei-Chin Chen, Jeng-Wei Lu, Zhi-Hong Zheng, Shiu-Bii Lien, Sui-Lung Su, Hsiu-Ching Hsu, Yi-Jung Ho, Chih-Chien Wang","doi":"10.1007/s00068-025-02908-5","DOIUrl":"https://doi.org/10.1007/s00068-025-02908-5","url":null,"abstract":"","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"233"},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}