{"title":"在掩膜技术中，骨蜡间隔剂比聚甲基丙烯酸甲酯间隔剂更能增加诱导膜厚度，促进成骨。","authors":"Takushi Nakatani, Hajime Mishima, Sho Totsuka, Ryunosuke Watanabe, Norihito Arai, Yohei Tomaru, Hisashi Sugaya, Tomofumi Nishino, Masashi Yamazaki","doi":"10.1007/s00068-025-02911-w","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The Masquelet technique is a recent novel treatment for severe bone defects. Polymethylmethacrylate (PMMA) has been used as a spacer for bone defects, but the optimal spacer is still unknown. Therefore, this study aimed to histologically evaluate the membranes induced by bone wax and PMMA spacers and compare them with respect to bone formation.</p><p><strong>Methods: </strong>In this study, bone defects were created in the femurs of Sprague-Dawley rats, and bone wax and PMMA spacers were implanted into the defects to histologically evaluate the induced membrane and bone formation after bone grafting.</p><p><strong>Results: </strong>As a result, the induced membrane formed by bone wax spacers was significantly thicker than that formed by PMMA spacers, and the vascular area ratio was significantly higher. In addition, bone wax spacers promoted bone formation more than PMMA spacers.</p><p><strong>Conclusion: </strong>Bone wax spacers promoted induced membrane formation and bone formation by enhancing inflammatory responses more than PMMA spacers.</p>","PeriodicalId":520620,"journal":{"name":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","volume":"51 1","pages":"236"},"PeriodicalIF":2.2000,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204891/pdf/","citationCount":"0","resultStr":"{\"title\":\"Bone wax spacers increase induced membrane thickness and promote osteogenesis more than polymethylmethacrylate spacers in the masquelet technique.\",\"authors\":\"Takushi Nakatani, Hajime Mishima, Sho Totsuka, Ryunosuke Watanabe, Norihito Arai, Yohei Tomaru, Hisashi Sugaya, Tomofumi Nishino, Masashi Yamazaki\",\"doi\":\"10.1007/s00068-025-02911-w\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>The Masquelet technique is a recent novel treatment for severe bone defects. Polymethylmethacrylate (PMMA) has been used as a spacer for bone defects, but the optimal spacer is still unknown. Therefore, this study aimed to histologically evaluate the membranes induced by bone wax and PMMA spacers and compare them with respect to bone formation.</p><p><strong>Methods: </strong>In this study, bone defects were created in the femurs of Sprague-Dawley rats, and bone wax and PMMA spacers were implanted into the defects to histologically evaluate the induced membrane and bone formation after bone grafting.</p><p><strong>Results: </strong>As a result, the induced membrane formed by bone wax spacers was significantly thicker than that formed by PMMA spacers, and the vascular area ratio was significantly higher. In addition, bone wax spacers promoted bone formation more than PMMA spacers.</p><p><strong>Conclusion: </strong>Bone wax spacers promoted induced membrane formation and bone formation by enhancing inflammatory responses more than PMMA spacers.</p>\",\"PeriodicalId\":520620,\"journal\":{\"name\":\"European journal of trauma and emergency surgery : official publication of the European Trauma Society\",\"volume\":\"51 1\",\"pages\":\"236\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-06-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12204891/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European journal of trauma and emergency surgery : official publication of the European Trauma Society\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s00068-025-02911-w\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of trauma and emergency surgery : official publication of the European Trauma Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s00068-025-02911-w","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Bone wax spacers increase induced membrane thickness and promote osteogenesis more than polymethylmethacrylate spacers in the masquelet technique.
Purpose: The Masquelet technique is a recent novel treatment for severe bone defects. Polymethylmethacrylate (PMMA) has been used as a spacer for bone defects, but the optimal spacer is still unknown. Therefore, this study aimed to histologically evaluate the membranes induced by bone wax and PMMA spacers and compare them with respect to bone formation.
Methods: In this study, bone defects were created in the femurs of Sprague-Dawley rats, and bone wax and PMMA spacers were implanted into the defects to histologically evaluate the induced membrane and bone formation after bone grafting.
Results: As a result, the induced membrane formed by bone wax spacers was significantly thicker than that formed by PMMA spacers, and the vascular area ratio was significantly higher. In addition, bone wax spacers promoted bone formation more than PMMA spacers.
Conclusion: Bone wax spacers promoted induced membrane formation and bone formation by enhancing inflammatory responses more than PMMA spacers.
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