European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry最新文献

{"title":"A randomised controlled clinical trial comparing pure Portland cement and formocresol pulpotomies followed from 2 to 4 years.","authors":"R Petel,&nbsp;K Ziskind,&nbsp;N Bernfeld,&nbsp;H Suliman,&nbsp;A B Fuks,&nbsp;M Moskovitz","doi":"10.1007/s40368-020-00578-y","DOIUrl":"https://doi.org/10.1007/s40368-020-00578-y","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of the present prospective randomised clinical control trial was to evaluate the long-term clinical and radiographic success rate of pulpotomies in primary molars using pure Portland cement versus formocresol. Pure Portland cement has shown a high rate of success in pulpotomy treatments, with no side effects.</p><p><strong>Methods: </strong>Healthy 3- to 11-year-old children were treated with pulpotomies on primary molars as part of their scheduled dental treatment. Pulp dressing alternated randomly between pure Portland cement and formocresol. Data were analysed at follow-up periods up to 48 months.</p><p><strong>Results: </strong>68 (50%) teeth with pure Portland cement and 68 (50%) teeth with formocresol in 136 healthy children (59 boys and 77 girls) were followed. The overall success rate of the pulpotomies in this study was 95.6%. Pure Portland cement was successful in 100% of the cases (68 out of 68), and formocresol in 91.1% (62 out of 68). No association was found between success and type of tooth or time range from treatment to last follow-up.</p><p><strong>Conclusion: </strong>Based on this study's results, it can be concluded that there is no superiority of one material over the other and pure Portland cement can be used in primary molar pulpotomies.</p>","PeriodicalId":520615,"journal":{"name":"European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry","volume":" ","pages":"547-552"},"PeriodicalIF":2.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40368-020-00578-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38590783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, distribution, characteristics and associated factors of molar-incisor hypo-mineralisation among Libyan schoolchildren: a cross-sectional survey.","authors":"A Arheiam,&nbsp;S Abbas,&nbsp;L Ballo,&nbsp;E Borowis,&nbsp;S Rashwan,&nbsp;M El Tantawi","doi":"10.1007/s40368-020-00594-y","DOIUrl":"https://doi.org/10.1007/s40368-020-00594-y","url":null,"abstract":"<p><strong>Background and aim: </strong>This study aimed to assess the prevalence and clinical status of molar incisor hypomineralisation (MIH) and other enamel defects and associated factors in Libyan children.</p><p><strong>Methods: </strong>A cross-sectional survey of a randomly selected sample of 8- to 10-year-old Libyan school children was conducted in the city of Benghazi, Libya in 2019. The children were assessed for the presence of MIH and enamel defects according to EAPD evaluation criteria. The survey was supplemented by a questionnaire, completed by parents, about potential associated factors occurring before, around and after birth. Association with risk indicators was assessed using chi-square and Mann-Whitney U tests.</p><p><strong>Results: </strong>One thousand forty-seven children returned complete questionnaires and attended the clinical examination, with 87% response rate. MIH was the most common form of enamel defects, affecting 162 (15.5%) children. The average number of MIH affected teeth was 3.54 (SD = 1.82). There were no statistically significant associations between the prevalence of MIH and health or demographic characteristics except for the history of early childhood health problems (P = 0.047).</p><p><strong>Conclusions: </strong>In Libyan children, MIH appeared to be the most prevalent type of enamel defects affecting 15.5% of the participants. Although not statistically significant, MIH appeared to be associated with prenatal, perinatal and post-natal challenges.</p>","PeriodicalId":520615,"journal":{"name":"European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry","volume":" ","pages":"595-601"},"PeriodicalIF":2.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40368-020-00594-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38773747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of different liners on the bond strength of a compomer to primary teeth dentine: in vitro study.","authors":"R Frankenberger,&nbsp;S Nassiri,&nbsp;S Lücker,&nbsp;N N Lygidakis,&nbsp;N Krämer","doi":"10.1007/s40368-020-00601-2","DOIUrl":"https://doi.org/10.1007/s40368-020-00601-2","url":null,"abstract":"<p><strong>Objective: </strong>This in vitro investigation should identify the effect of protective liners on dentine bond strength of a polyacid modified resin composite to dentine of primary teeth.</p><p><strong>Methods: </strong>Forty-two extracted caries-free primary molars were randomly assigned to seven groups (n = 6) and flattened. Six test groups were centrally covered with different protective liners/base materials: Kerr Life (KL), IRM zinc oxide eugenol cement (IRM), Ketac Bond (KB), Vitrebond (VB), Dycal (DY), and mineral trioxide aggregate (MTA). Specimens were bonded with Prime&Bond NT (PB) and restored with Dyract eXtra. The control group (C) did not receive liner pretreatment. After 24-h storage in Aqua dest. (37 °C), specimens were cut and regional microtensile bond strengths of the uncovered areas were tested. Fractography was conducted under a light microscope and further interface/surface analyses were performed under a SEM. Statistical appraisal was carried out using oneway ANOVA (mod. LSD test; p < 0.05).</p><p><strong>Results: </strong>Independent of the distance to the applied liner, all groups exhibited inferior μ-TBS to dentine of primary teeth compared to the control group (p < 0.05). The results were as follows in MPa(SD) ^x:significance level/percentage of adhesive fractures: PB: 34 (10)^A/72%; KL: 23 (25)^B/64%; KB: 15 (12)^C/76%; DY 15 (13)^C/55%; IRM: 14 (10)^C/68%; VB: 12 (10)^C/61%; MTA 12 (10)^C/69%.</p><p><strong>Conclusions: </strong>Protective liners significantly reduced μ-TBS to dentine of primary teeth.</p>","PeriodicalId":520615,"journal":{"name":"European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry","volume":" ","pages":"643-649"},"PeriodicalIF":2.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40368-020-00601-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25330906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of dental caries and its treatment under general anaesthetic on children and their families.","authors":"R Knapp,&nbsp;Z Marshman,&nbsp;F Gilchrist,&nbsp;H Rodd","doi":"10.1007/s40368-020-00591-1","DOIUrl":"https://doi.org/10.1007/s40368-020-00591-1","url":null,"abstract":"<p><strong>Objective: </strong>To assess the impact of dental caries and treatment under general anaesthetic (GA) on the everyday lives of children and their families, using child-reported measures of quality of life (QoL) and oral health-related quality of life (OHRQoL).</p><p><strong>Method: </strong>Participants, aged 5-16 years old having treatment for dental caries under GA, were recruited from new patient clinics at Charles Clifford Dental Hospital, Sheffield. OHRQoL was measured before and 3-months after treatment using the Caries Impacts and Experiences Questionnaire for Children (CARIES-QC). Overall QoL was measured using the Child Health Utility 9D (CHU9D). Parents/caregivers completed the Family Impact Scale (FIS).</p><p><strong>Results: </strong>Eighty five parent-child dyads completed the study. There was statistically significant improvement in OHRQoL (mean interval score difference in CARIES-QC = 4.43, p < 0.001) and QoL (mean score difference in CHU9D = 2.48, p < 0.001) following treatment, with moderate to large effect sizes. There was statistically significant improvement in FIS scores (mean score difference = 5.48, p = 0.03).</p><p><strong>Conclusions: </strong>Treatment under GA was associated with improvement in QoL and OHRQoL as reported by children, and reduced impacts on the family. This work highlights the importance of GA services in reducing the caries-related impacts experienced by children. Further work is needed investigate the impact of clinical, environmental and individual factors.</p>","PeriodicalId":520615,"journal":{"name":"European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry","volume":" ","pages":"567-574"},"PeriodicalIF":2.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40368-020-00591-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38338933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Child maltreatment in Dubai and the Northern United Arab Emirates: dental hygienists and assistants' knowledge.","authors":"R Al Hashmi,&nbsp;I Hussein,&nbsp;M Kowash,&nbsp;R Welbury,&nbsp;M Al-Halabi","doi":"10.1007/s40368-021-00602-9","DOIUrl":"https://doi.org/10.1007/s40368-021-00602-9","url":null,"abstract":"<p><strong>Purpose: </strong>Dental assistants (DAs) and hygienists (DHs) should play an active role in the detection and reporting of child abuse and neglect (CAN). We aimed to investigate CAN knowledge of DAs and DHs in the United Arab Emirates (UAE) and some of the inhibiting factors to the process of CAN reporting.</p><p><strong>Methods: </strong>A cross-sectional study design was utilized. We surveyed 186 DAs and DHs using a previously validated self-administered anonymous CAN knowledge questionnaire. Statistical analysis was performed using χ²-square, Fisher's exact test, t test/Mann-Whitney, and a ROC curve (p < 0.05).</p><p><strong>Results: </strong>Among 186 DAs and DHs surveyed, satisfactory knowledge of CAN was demonstrated by 50.5%. DAs scored a significantly higher score of knowledge compared to DHs (p = 0.03). The most reported CAN referral inhibiting factor was \"being afraid to get in trouble with parents\". The recognition of a child with special needs and parents missing multiple appointments as risk factors for CAN was significantly higher in the DAs compared to DHs (p = 0.04, p = 0.024, respectively). Awareness of local laws was related to CAN knowledge in DAs (p = 0.012) and DHs (p = 0.008).</p><p><strong>Conclusion: </strong>The lack of appropriate knowledge regarding CAN necessitates a clear reporting process and better education for DAs and DHs in the UAE.</p>","PeriodicalId":520615,"journal":{"name":"European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry","volume":" ","pages":"651-658"},"PeriodicalIF":2.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40368-021-00602-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25335711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental acceptance of advanced behaviour management techniques in paediatric dentistry in families with different cultural background.","authors":"L Al Zoubi,&nbsp;J Schmoeckel,&nbsp;M Mustafa Ali,&nbsp;C H Splieth","doi":"10.1007/s40368-021-00607-4","DOIUrl":"https://doi.org/10.1007/s40368-021-00607-4","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the differences of parental acceptance of advanced behaviour management techniques (BMT) in different cultural backgrounds (Germany vs. Jordan).</p><p><strong>Methods: </strong>A convenience sample of 100 parents each of paediatric patients at the University of Greifswald/Germany and Jordan University/Jordan completed a questionnaire to rate their acceptance of four advanced BMT (passive restraint, active restraint, nitrous oxide sedation, and general anaesthesia) using a five-point Likert scale.</p><p><strong>Results: </strong>In both groups, nitrous oxide sedation was the most accepted advanced BMT (mean 3.78 ± 1.34/3.22 ± 1.50, respectively). The least acceptable technique in Germany was passive restraint (2.05 ± 1.18) and in Jordan general anaesthesia (2.11 ± 1.30). The parents in Germany are significantly more accepting of nitrous oxide sedation than are parents in Jordan (p = 0.010), while parents in Jordan are more willing to accept passive restraint (p = 0.001). The acceptance of all advanced BMT increased significantly in both groups when the treatment was urgent.</p><p><strong>Conclusions: </strong>Parental cultural background and the urgency of the treatment affect the acceptance of different BMT. Moreover, the parental attitude to the pharmacological technique has changed, as nitrous oxide sedation generally appears to be the most preferred advanced technique in both groups.</p>","PeriodicalId":520615,"journal":{"name":"European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry","volume":" ","pages":"707-713"},"PeriodicalIF":2.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40368-021-00607-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25518171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure pain threshold of masticatory muscles in children and adolescents with and without intellectual disability: a pilot study.","authors":"C A de Araújo Vitor,&nbsp;A de Oliveira Lira Ortega,&nbsp;A C F M Ferreira,&nbsp;C A-A L da Silva,&nbsp;M H C Gallottini,&nbsp;M T B R Santos","doi":"10.1007/s40368-020-00593-z","DOIUrl":"https://doi.org/10.1007/s40368-020-00593-z","url":null,"abstract":"<p><strong>Purpose: </strong>Pain is considered a stressful experience, related to real or possible tissue damage with emotional, sensory, social and cognitive components. The aim of the study was to evaluate and compare, using a digital algometer, the pressure pain threshold of temporal and masseter muscles of children and adolescents with and without intellectual disability.</p><p><strong>Methods: </strong>A cross-sectional study was conducted. Data regarding gender and age were collected from the caregiver of children and adolescents with and without intellectual disability. The evaluations followed this sequence: pressure pain threshold of the masseter and temporal muscles, evaluation of pain on touch using the visual analog scale and signs and symptoms of Temporomandibular disorder. The χ² test, the Kolgomorov-Smirnov test, Student t test and Mann-Whitney test were performed. The significance level was set at 5%.</p><p><strong>Results: </strong>Two homogeneous groups by gender (P = 0.258) and age (P = 0.727) were evaluated, of which 25 children and adolescents presented intellectual disability and another 25 did not have intellectual disability. No significant difference was observed between groups on the pressure pain threshold of the masseter and temporal muscles, nor pressure average or exam time (P > 0.05). Regarding Temporomandibular dysfunction, no difference in signs or symptoms frequency was found (P > 0.05). However, the range of maximum mouth opening was smaller in the intellectual disability group (P = 0.006).</p><p><strong>Conclusion: </strong>Children and adolescents with intellectual disability and preserved basic functionalities do not present alterations in pain perception when evaluated with computerized pressure algometer and visual analog scale. They present similar threshold of pain to pressure as those reported by normative children and adolescents. These results emphasize the importance to treat these children and adolescents with intellectual disability with respect to their pain threshold.</p>","PeriodicalId":520615,"journal":{"name":"European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry","volume":" ","pages":"587-593"},"PeriodicalIF":2.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40368-020-00593-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38773740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rinsing with water for 1 min after milk formula increases plaque pH.","authors":"S G S Koh,&nbsp;Y F Sim,&nbsp;C J Sim,&nbsp;S Hu,&nbsp;C H L Hong,&nbsp;M S Duggal","doi":"10.1007/s40368-020-00598-8","DOIUrl":"https://doi.org/10.1007/s40368-020-00598-8","url":null,"abstract":"<p><strong>Purpose: </strong>Parents find it challenging to follow recommendations to brush young children after feeds at night despite the increase caries risk. This study compared three clinical recommendations (dilution, rinsing and wiping) on plaque pH after formula consumption.</p><p><strong>Methods: </strong>Eighteen subjects were recruited. The five interventions with 2-week washout between visits included: Rinse with undiluted formula for 30 s (UF); rinse with 50% diluted formula for 30 s (DF); rinse with undiluted formula for 30 s, followed by rinsing with water for 1 minute (UF/R); rinse with undiluted formula for 30 s, followed by wiping (UF/W); rinse with 10% sucrose for 30 s as control (C). Plaque samples were collected at baseline, 2, 5, 10, 20 and 30 min after the intervention and pH measured using the plaque sampling method.</p><p><strong>Results: </strong>UF/R resulted in significantly smaller pH drops at 5, 10 and 20 min compared to UF. It also resulted in higher minimum pH (UF/R: 6.34 ± 0.36 Vs UF: 6.06 ± 0.40, p = 0.02), smaller maximum pH drop (UF/R: 0.63 ± 0.35 Vs UF: 0.90 ± 0.49, p = 0.03), smaller sum of change of hydrogen ion concentration (UF/R: 9.22 × 10^-7 ± 7.8 × 10^-7 Vs UF: 2.30 × 10^-6 ± 2.6 × 10^-6, p = 0.04), and smaller area under the curve (UF/R: 7.70 ± 5.44 Vs UF: 13.44 ± 9.44, p = 0.02). DF and UF/W did not result in any significant pH change compared to UF.</p><p><strong>Conclusions: </strong>Of the three clinical recommendations, only rinsing with water for 1 min after undiluted formula reduced plaque acidogenicity. Teeth wiping with a moist cloth and 50% dilution of infant formula did not have an effect on plaque acidity.</p>","PeriodicalId":520615,"journal":{"name":"European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry","volume":" ","pages":"611-618"},"PeriodicalIF":2.2,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40368-020-00598-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38801613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molar-incisor hypomineralisation in Lebanon: association with prenatal, natal and postnatal factors.","authors":"R Elzein,&nbsp;E Chouery,&nbsp;F Abdel-Sater,&nbsp;R Bacho,&nbsp;F Ayoub","doi":"10.1007/s40368-020-00555-5","DOIUrl":"https://doi.org/10.1007/s40368-020-00555-5","url":null,"abstract":"<p><strong>Background: </strong>Molar-incisor hypomineralisation is an enamel developmental defect highly prevalent in Lebanon. Literature suggests that perinatal conditions and childhood illnesses might be potential aetiological factors for this affection.</p><p><strong>Aims: </strong>This case-control study aimed to investigate the association of MIH with prenatal, natal and postnatal factors amongst 7-9 years Lebanese children and to end up with recommendations to overcome its occurrence.</p><p><strong>Methods: </strong>Self-administered, structured questionnaire including potential etiological factors was distributed to 659 MIH and non-MIH children's parents. The analysis of data was carried out using Statistical Package for Social Sciences Computer Software (SPSS 21.0, Inc., Chicago, IL, USA). For Statistical analysis, Pearson's chi-square, Fischer's exact test and multivariate regression model were used. A p value of less than 0.05 was considered statistically significant.</p><p><strong>Results: </strong>Children whose mothers had consumed food and drinks canned during pregnancy had 2.9 (CI: 1.367 to 6.187) times more likely to have MIH. Those who had history of taking antibiotics had 2.15 (CI: 1.186 to 3.909) times higher odds of MIH than those who did not have while those who had fever episodes during the early childhood years were 2.057 (CI: 1.149 to 3.683) times more likely to develop MIH.</p><p><strong>Conclusion: </strong>During early childhood, careful handling of high fever, greater public awareness regarding misuse of antibiotics and education about bisphenol A and how to avoid it during pregnancy and breastfeeding are recommended to decrease the occurrence of MIH.</p>","PeriodicalId":520615,"journal":{"name":"European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry","volume":" ","pages":"283-290"},"PeriodicalIF":2.2,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40368-020-00555-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40553925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Children's dental anxiety (self and proxy reported) and its association with dental behaviour in a postgraduate dental hospital.","authors":"S AlGharebi,&nbsp;M Al-Halabi,&nbsp;M Kowash,&nbsp;A H Khamis,&nbsp;I Hussein","doi":"10.1007/s40368-020-00533-x","DOIUrl":"https://doi.org/10.1007/s40368-020-00533-x","url":null,"abstract":"","PeriodicalId":520615,"journal":{"name":"European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry","volume":" ","pages":"41"},"PeriodicalIF":2.2,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40368-020-00533-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37919806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}