Digestive diseases (Basel, Switzerland)最新文献

{"title":"The Actual Condition of Chronic Constipation in Real-World Clinical Settings and Its Impact on Various Aspects of Daily Life.","authors":"Mariko Hojo, Tadayuki Oshima, Seiji Futagami, Kimio Isshi, Eikichi Ihara, Yoshiharu Yamaguchi, Noriaki Manabe, Motoyasu Chibai, Kazuhiro Kamada, Atsushi Oshio, Koji Nakada","doi":"10.1159/000550317","DOIUrl":"10.1159/000550317","url":null,"abstract":"<p><p><p>Introduction: Chronic constipation is common, but its characteristics and impact on various aspects of daily life remain unclear. This study examined patient characteristics and assessed how background factors, constipation symptoms, and defecation status impact daily life dissatisfaction, quality of life (QOL), and psychological states.</p><p><strong>Methods: </strong>A multicenter, prospective, observational study on outpatients with moderate to severe chronic constipation was conducted. The Chronic Constipation-Therapeutic Efficacy and Satisfaction Test (CC-TEST) and validated questionnaires such as the Hospital Anxiety and Depression Scale (HADS) and Short Form Health Survey-8 (SF-8) were administered to assess symptoms, defecation status, and daily life. Correlation and multiple regression analyses explored factor relationships.</p><p><strong>Results: </strong>The analysis included 201 participants. Despite treatment, with over half using magnesium oxide, many patients remained dissatisfied. Younger patients and females reported more severe abdominal symptoms, while older patients experienced greater defecation difficulty. All constipation symptoms correlated with daily life dissatisfaction, with abdominal discomfort showing the strongest association. Abdominal symptoms were significantly associated with the Mental Component Summary (MCS) of the SF-8, HADS anxiety, and HADS depression scores. Most defecation status components showed no correlation with SF-8 MCS, HADS anxiety, or HADS depression scores. Multivariate analysis revealed that abdominal symptoms, especially discomfort, significantly impacted daily life dissatisfaction, and reduced SF-8 MCS scores.</p><p><strong>Conclusions: </strong>Many patients with moderate to severe chronic constipation experience long-term symptoms and remain dissatisfied with treatment. Abdominal symptoms such as discomfort and pain significantly affect their daily life, QOL, and psychological well-being. Reducing abdominal symptoms may be crucial for improving treatment outcomes. </p>.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"113-128"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12893745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146169222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Ability of Chinese Visceral Adipose Index for Gastric Intestinal Metaplasia in Korean Adults.","authors":"Sung Keun Park, Yeongu Chung, Chang-Mo Oh, Ju Young Jung","doi":"10.1159/000551835","DOIUrl":"10.1159/000551835","url":null,"abstract":"<p><p><p>Introduction: Gastric intestinal metaplasia (GIM) is a precancerous lesion of gastric cancer. Despite increasing interest for association between obesity and gastric cancer, there is still ongoing controversy for effect of obesity on gastric cancer. Therefore, it is important to discover obesity index with reliable predictability for GIM.</p><p><strong>Methods: </strong>Study participants were 85,986 Koreans who were free of GIM at endoscopy. They were categorized by quartile levels of body mass index (BMI), waist circumference (WC), and Chinese visceral adipose index (CVAI). Cox proportional hazard assumption was used to evaluate hazard ratio (HR) and 95% confidence interval (CI) for incident GIM (adjusted HR [95% CI]) according to quartile levels of BMI, WC, and CVAI for about 8 years of follow-up. Using the time ROC package, ROC and area under curve (AUC) were calculated for each quartile group of BMI, WC, and CVAI at 2, 4, 6, and 8 years.</p><p><strong>Results: </strong>In men, BMI ≥ quartile 3, WC ≥ quartile 2, and CVAI ≥ quartile 2 were more significantly associated with incident GIM, compared with quartile 1 groups (reference). In women, while BMI and WC did not show the significant association with GIM, CVAI was solely associated with the increased risk of GIM. Time-dependent ROC and AUC analyses indicated that CVAI was superior to BMI and WC in predicting GIM among both men and women. The predictive ability of CVAI was more prominent in women than men.</p><p><strong>Conclusion: </strong>CVAI was an effective predictor for GIM, surpassing the predictive ability of BMI and WC. </p>.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"270-279"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13268613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Tea Polyphenols Ameliorate Esophagitis rather than Aspirin in a Non-Randomized Prospective Cohort Study.","authors":"Xue Li, Qian Zhang, Hao Zhang, Peng Li, Shengtao Zhu, Shutian Zhang, Jie Xing","doi":"10.1159/000548588","DOIUrl":"10.1159/000548588","url":null,"abstract":"<p><strong>Introduction: </strong>Green tea polyphenols (GTPs) and aspirin were demonstrated to be novel candidates for cancer chemoprevention. This study aimed to investigate effects of GTPs and aspirin on esophageal diseases.</p><p><strong>Methods: </strong>This non-randomized prospective cohort study recruited participants from October 2010 to September 2011, who self-reported long-term GTPs intake, aspirin intake, and no medicine use in a questionnaire and underwent gastroscopy. Regression was defined as any reversal of process from normal epithelium to esophageal high-grade intraepithelial neoplasia. The primary outcome was regression rates after a 1-year follow-up.</p><p><strong>Results: </strong>A total of 159, 151, 160 participants self-reported GTPs intake, aspirin intake, and no medication, respectively. After 1 year, 78, 81, and 83 participants received follow-up endoscopy in GTPs, aspirin, and control groups, respectively. There was no statistically significant difference in baseline pathology between the final cohort and lost to follow-up group. The average age of participants was 50.11 ± 5.62 years old, consisting of 42 females and 200 males. The regression rates of esophageal precursor diseases were 68%, 55%, and 48% in GTPs, aspirin, and control groups, respectively (p = 0.036). Analyzing esophagitis subgroup, the regression rate of GTPs group (43/69, 62%) was significantly higher than aspirin group (32/67, 48%) and control group (27/70, 39%) (p = 0.019). One person experienced nausea for GTPs (1/159) and one person experienced gastrointestinal bleeding in the aspirin group (1/151).</p><p><strong>Conclusions: </strong>GTPs, rather than aspirin, were associated with esophagitis remission compared with the control group. The benefits of GTPs on esophageal precursor diseases make it a promising health supplement.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145282226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biliary Concentration of Carbohydrate Antigen 19-9 and Cancer Antigen 125, Iron Metabolism Markers, and PIVKA-II Activity in Pancreatobiliary Tumors.","authors":"Paweł B Podgórski, Adam Przybyłkowski, Piotr Nehring, Olga Ciepiela","doi":"10.1159/000549784","DOIUrl":"10.1159/000549784","url":null,"abstract":"<p><strong>Introduction: </strong>Biliary tract cancers (cholangiocarcinoma/gallbladder cancer [CCA/GCA]) and pancreatic cancers (PCs) are one of the most aggressive tumors with poor prognosis, frequently diagnosed at advanced stages. Current diagnostic methods are unsatisfactory. This study evaluated diagnostic yield of selected biliary biomarkers.</p><p><strong>Methods: </strong>A prospective study enrolled 80 patients treated with endoscopic retrograde cholangiopancreatography (ERCP) because of choledocholithiasis (n = 50), CCA/GCA (n = 13), and PC (n = 17). Bile samples collected during ERCP were analyzed with electrochemiluminescence immunoassay for carbohydrate antigen 19-9 (CA19-9), PIVKA-II, osteocalcin, AFP, CA15-3, CEA and ferritin, chemiluminescent immunoassay for cancer antigen 125 (CA125), colorimetric analysis for iron and total iron-binding capacity (TIBC), as well as enzyme-linked immunosorbent assay for hepcidin.</p><p><strong>Results: </strong>Several analyzed biomarkers demonstrated statistically significant differences in bile concentrations between patients with choledocholithiasis and malignant diseases. Particularly notable difference was observed for hepcidin and CA125. The biliary iron concentration and TIBC were inconclusive. PIVKA-II protein was confirmed as a reliable qualitative tumor marker. Attempts to detect osteocalcin, AFP, CA15-3, and CEA in bile failed due to concentrations being below the detectable threshold. No markers differentiated accurately the tumor type (p > 0.05).</p><p><strong>Conclusion: </strong>CA125 and hepcidin as quantitative markers, along with PIVKA-II as a qualitative marker, demonstrate significant potential as biliary markers for distinguishing choledocholithiasis from biliary tract or PCs. Biliary iron, TIBC, and CA19-9 require further investigation to confirm their diagnostic yield.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"73-84"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145746511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Factors for Abnormal Diagnostic Colonoscopy Findings among Pediatric Patients: A Retrospective Cohort Study.","authors":"Kazuki Honjo, Keita Murakami, Junya Arai, Sozaburo Ihara, Hiroyuki Hisada, Dai Kubota, Ken Kurokawa, Yu Miyakawa, Mayo Tsuboi, Yuko Miura, Daisuke Ohki, Hiroya Mizutani, Chihiro Takeuchi, Seiichi Yakabi, Nobumi Suzuki, Hiroto Kinoshita, Yoku Hayakawa, Naomi Kakushima, Nobutake Yamamichi, Yosuke Tsuji, Mitsuhiro Fujishiro","doi":"10.1159/000550784","DOIUrl":"10.1159/000550784","url":null,"abstract":"<p><p><p>Introduction: This study investigated predictive factors associated with abnormal diagnostic findings of pediatric colonoscopies.</p><p><strong>Methods: </strong>This retrospective study reviewed the medical records of children who underwent diagnostic colonoscopies between January 2004 and March 2025 at the University of Tokyo Hospital. The patients were divided into two groups based on the presence or absence of abnormal colonoscopy findings, and patient backgrounds, clinical symptoms, endoscopic findings, and blood test results were compared between the groups.</p><p><strong>Results: </strong>A total of 112 colonoscopies were performed, among which 73 cases were the first procedure for diagnostic. Abnormal macroscopic and/or histopathological findings were identified in 36 cases within the diagnostic group. In the multivariable analysis, family history of inflammatory bowel disease or hereditary polyposis (odds ratio [OR]: 6.1, 95% confidence interval [CI]: [1.13-37.7], p = 0.035), serum hemoglobin (OR 0.68, 95% CI: [0.47-0.79], p = 0.005), and serum C-reactive protein (OR 1.04, 95% CI: [1.00-1.13], p = 0.043) was independent predictors of abnormal pediatric colonoscopy findings. The predictive model using these three factors was accurate, with an area under the receiver operating characteristic (ROC) of 0.737.</p><p><strong>Conclusion: </strong>A detailed preliminary medical history, serum hemoglobin, and serum C-reactive protein may help predict the necessity of pediatric colonoscopy, potentially improving diagnostic efficiency. </p>.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"216-224"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12987662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound Characteristics of Budd-Chiari Syndrome: A Multicenter Analysis.","authors":"Jimmy Daza, Isabella Wiest, Xin Wu Cui, Bo Zhang, Yunhao Chen, Yi Dong, Chiara De Molo, Carla Serra, Nitin Chaubal, Ehsan Safai Zadeh, Christian Görg, Theresa Tscheu, Matthias P Ebert, Andreas Teufel, Christoph F Dietrich","doi":"10.1159/000549007","DOIUrl":"10.1159/000549007","url":null,"abstract":"<p><p><p>Introduction: Budd-Chiari syndrome (BCS) is a rare liver disease defined as an obstruction of the hepatic venous outflow, potentially leading to severe complications like liver failure. BCS can be classified as primary (due to endoluminal venous lesions such as thrombosis) or secondary (due to external compression or invasion of the hepatic veins or inferior vena cava; IVC). While numerous case reports illustrate imaging findings in individual patients, systematic data processing across multiple regions is lacking and establishing consistent ultrasound diagnostic criteria could significantly improve early detection and patient outcomes.</p><p><strong>Methods: </strong>This retrospective multicenter study (2010-2020) included 118 patients from China (n = 59), Germany (n = 26), India (n = 18), and Italy (n = 15). The study used standardized ultrasound protocols, including Doppler and contrast-enhanced ultrasound, to assess hepatic venous outflow and other key findings, such as the presence of hepatic-vein thrombosis, caudate lobe hypertrophy, and collateral circulation.</p><p><strong>Results: </strong>The cohort comprised 118 patients (65 men, 53 women; mean age 46 years). Most cases had a chronic disease course (74%), and primary BCS (n = 96, 81%), related to thrombotic alterations, predominated over secondary BCS, related to compressive masses (n = 7, 6%). Key sonographic features observed included portal vein thrombosis (14%), hepatic-vein thrombosis (70%), caudate lobe enlargement (30%), and collateral venous circulation (83%). Among the geographical differences in symptoms, thrombosis of the IVC was common in Chinese patients (33%), while the confluence area and hepatic veins were more frequently involved in European patients.</p><p><strong>Conclusions: </strong>This study provides the first multicenter analysis of ultrasound characteristics in BCS patients from multiple regions. The findings support ultrasound as an essential tool in the standardized diagnostic process for BCS, particularly for identifying key sonographic features such as hepatic-vein thrombosis and caudate lobe enlargement. These results underscore the importance of standardized ultrasound protocols in BCS to facilitate early diagnosis and improve patient outcomes. </p>.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"192-205"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13076981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147278064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction Effect of <italic>Helicobacter pylori</italic> Infection and Family History of Gastric Cancer on the Detection Age of Significant Gastric Precancerous Conditions.","authors":"Mehmet Akif Yağlı, Sabuhi Mammadov, Bilger Cavus, Asli Ormeci, Filiz Akyuz","doi":"10.1159/000549412","DOIUrl":"10.1159/000549412","url":null,"abstract":"","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"111-112"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145472668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ask the Right Questions: Prompting Strategies Shape Large Language Model Performance on Biliary Tract Cancer Guideline Queries.","authors":"Chengpeng Li, Wei-Wei Jia, Erfan Ghanad, Hui Gao, Schaima Abdelhadi, Christoph Reißfelder, Flavius Șandra-Petrescu, Cui Yang","doi":"10.1159/000551433","DOIUrl":"10.1159/000551433","url":null,"abstract":"<p><strong>Introduction: </strong>This study evaluates how different prompting strategies affect the performance of three advanced large language models (LLMs) (GPT-4o, Claude 3.5 Sonnet, and Llama 3 70b) when answering questions about biliary tract cancer (BTC). We used European Society for Medical Oncology (ESMO) guidelines as our reference standard. The study aimed to assess their accuracy, conciseness, evidence quality, and rates of hallucinations.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis using 40 clinical questions derived from the ESMO BTC guidelines. We tested three prompting strategies: no prompt, short prompt, and long prompt. Two independent senior physicians evaluated the responses for accuracy, conciseness, and evidence quality. Inter-rater reliability, text length of response, model performance, and hallucination rates were analyzed.</p><p><strong>Results: </strong>Prompting strategies significantly influenced LLM performance. Long prompts improved evidence quality and accuracy, especially for GPT-4o and Claude 3.5 Sonnet, while short prompts enhanced conciseness. GPT-4o exhibited superior overall performance, with higher accuracy and conciseness scores, whereas Claude 3.5 Sonnet excelled in evidence quality but generated longer responses. Llama 3 70b showed deficiencies in both accuracy and evidence quality. Hallucination rates were lowest for GPT-4o and Claude 3.5 Sonnet, but nearly 40% of their references were fabricated or misattributed.</p><p><strong>Conclusion: </strong>Prompting strategies substantially affect LLM performance in medical contexts. While GPT-4o and Claude 3.5 Sonnet demonstrate promising potential with proper prompts, the risk of hallucinations necessitates careful cross-verification. Future studies should incorporate real-world clinical scenarios to further evaluate LLM capabilities and limitations.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"298-306"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147795211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-COVID-19 Dyspepsia Is Not Due to Impairment of Duodenal Barrier Function.","authors":"Larissa Gurgel Mota Saraiva, Suliana Mesquita Paula, Dayllanna Stefanny Lopes Lima Feitosa, Maria Klayre Araújo de Sousa, Isabela Caldas Borges, Thiago Andrade Ribeiro, Quésia Reis Lederhos, Rôney Reis de Castro Silva, Marco Antônio de Freitas Clementino, Alexandre Havt, Miguel Angelo Nobre-E-Souza, Marcellus Henrique Loiola Ponte Souza","doi":"10.1159/000550865","DOIUrl":"10.1159/000550865","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with coronavirus disease 2019 (COVID-19) have a higher probability of developing dyspepsia; however, mechanisms are not defined. The study analyzes dyspeptic symptoms during and after COVID-19 and whether mechanisms involved are impaired duodenal barrier function or local inflammatory dysfunction.</p><p><strong>Methods: </strong>Fifty-five patients with COVID-19 were interviewed during hospitalization and 6 months after hospital discharge. Dyspeptic symptoms were assessed using the Rome III questionnaire for functional dyspepsia. Intensity and frequency were assessed using a Likert scale (0-6). Of the recovered patients, 23 underwent upper endoscopy with duodenal biopsies to assess the epithelial barrier function (transepithelial electrical resistance and mucosal fluorescein permeability) and concentration of inflammatory cytokines. These results were compared with those of healthy controls.</p><p><strong>Results: </strong>When comparing dyspeptic symptoms during and after COVID-19, there was an increase in the intensity of postprandial fullness and epigastric pain/burning (during: 5.5 ± 0.5 vs. after: 7.0 ± 0.6, p = 0.009), but not in early satiety. In contrast, when comparing the frequency of dyspeptic symptoms during COVID-19 and after 6 months of hospital discharge, there were no significant differences. In addition, basal transepithelial electrical resistance and duodenal permeability showed no statistical difference when comparing healthy controls and post-COVID-19 patients with or without dyspepsia. Concentration of pro-inflammatory cytokines was not different among the groups.</p><p><strong>Conclusions: </strong>The intensity of dyspeptic symptoms increased in the post-COVID-19 period. Furthermore, this event does not seem to be associated with impaired duodenal epithelial barrier.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"137-146"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146208546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<italic>Helicobacter pylori</italic> Infection Is Associated with Leukoaraiosis without Lesion Location Correlation.","authors":"Pingping Jin, Qiong Yao, Yanyan Zheng, Qiaowen Tong, Hua Ye, Baiqi Hu","doi":"10.1159/000549557","DOIUrl":"10.1159/000549557","url":null,"abstract":"<p><strong>Introduction: </strong>Leukoaraiosis, common focal lesion, is associated with cognitive impairment, gait abnormalities, and depression. Helicobacter pylori is an intragastric pathogen that has been implicated in extraintestinal disease. This study explored the relationship between leukoaraiosis and H. pylori infection, and analyzed the H. pylori infection in different white matter lesion sites.</p><p><strong>Methods: </strong>A total of 350 patients underwent cranial MRI and H. pylori testing. Patients were divided into leukoaraiosis group (n = 149) and non-leukoaraiosis group (n = 201), with basic information collected and leukoaraiosis locations recorded based on FLAIR images in MRI. Basic characteristics were compared between the two groups, and a multivariate logistic regression model was used to identify independent risk factors for leukoaraiosis.</p><p><strong>Results: </strong>Patients with leukoaraiosis were older (p = 0.009) and had a higher proportion of smoking (p = 0.032) and hypertension (p < 0.0001) compared to those without leukoaraiosis. H. pylori infection was more prevalent in the leukoaraiosis group (p < 0.0001). However, the distribution of H. pylori infection across different lesion sites did not differ significantly (p = 0.839).</p><p><strong>Conclusion: </strong>H. pylori infection is associated with leukoaraiosis, possibly through mechanisms such as chronic inflammatory responses, blood-brain barrier damage, and vascular endothelium damage. Nevertheless, no variation in H. pylori infection was observed among different cerebral white matter lesion locations. Future prospective studies are warranted to validate these findings.</p>","PeriodicalId":520605,"journal":{"name":"Digestive diseases (Basel, Switzerland)","volume":" ","pages":"25-32"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}