Diagnostics (Basel, Switzerland)最新文献

{"title":"Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls.","authors":"Nektarios Koufopoulos,&nbsp;Ioannis S Pateras,&nbsp;Alina Roxana Gouloumis,&nbsp;Argyro Ioanna Ieronimaki,&nbsp;Andriani Zacharatou,&nbsp;Aris Spathis,&nbsp;Danai Leventakou,&nbsp;Panagiota Economopoulou,&nbsp;Amanda Psyrri,&nbsp;Nikolaos Arkadopoulos,&nbsp;Ioannis G Panayiotides","doi":"10.3390/diagnostics12112658","DOIUrl":"https://doi.org/10.3390/diagnostics12112658","url":null,"abstract":"<p><p>Invasive lobular carcinoma is the most common special breast carcinoma subtype, with unique morphological (discohesive cells, single-cell files, targetoid pattern) and immunohistochemical (loss of E-cadherin and β-catenin staining) features. Moreover, ILC displays a poor response to neoadjuvant therapy, a different metastatic pattern compared to invasive breast carcinoma of no special type, as well as unique molecular characteristics. In addition to the classic variant of invasive lobular carcinoma, several other well-recognized variants exist, including classic, alveolar, tubulolobular, solid, pleomorphic, signet-ring, and mixed. Furthermore, three novel variants of invasive lobular carcinoma, i.e., with extracellular mucin production, papillary features, and tubular elements, have been described during the last decade. We herewith focus on the unique morphological and immunohistochemical characteristics of these novel varieties of invasive lobular carcinoma, as well as differential diagnostic considerations and potential diagnostic pitfalls, especially when dealing with biopsy specimens.</p>","PeriodicalId":520604,"journal":{"name":"Diagnostics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40457267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Lower False Positive Pulmonary Nodule Detection Approach for Early Lung Cancer Screening.","authors":"Shaohua Zheng,&nbsp;Shaohua Kong,&nbsp;Zihan Huang,&nbsp;Lin Pan,&nbsp;Taidui Zeng,&nbsp;Bin Zheng,&nbsp;Mingjing Yang,&nbsp;Zheng Liu","doi":"10.3390/diagnostics12112660","DOIUrl":"https://doi.org/10.3390/diagnostics12112660","url":null,"abstract":"<p><p>Pulmonary nodule detection with low-dose computed tomography (LDCT) is indispensable in early lung cancer screening. Although existing methods have achieved excellent detection sensitivity, nodule detection still faces challenges such as nodule size variation and uneven distribution, as well as excessive nodule-like false positive candidates in the detection results. We propose a novel two-stage nodule detection (TSND) method. In the first stage, a multi-scale feature detection network (MSFD-Net) is designed to generate nodule candidates. This includes a proposed feature extraction network to learn the multi-scale feature representation of candidates. In the second stage, a candidate scoring network (CS-Net) is built to estimate the score of candidate patches to realize false positive reduction (FPR). Finally, we develop an end-to-end nodule computer-aided detection (CAD) system based on the proposed TSND for LDCT scans. Experimental results on the LUNA16 dataset show that our proposed TSND obtained an excellent average sensitivity of 90.59% at seven predefined false positives (FPs) points: 0.125, 0.25, 0.5, 1, 2, 4, and 8 FPs per scan on the FROC curve introduced in LUNA16. Moreover, comparative experiments indicate that our CS-Net can effectively suppress false positives and improve the detection performance of TSND.</p>","PeriodicalId":520604,"journal":{"name":"Diagnostics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40457268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Magnetic Resonance in Fabry Disease: Morphological, Functional, and Tissue Features.","authors":"Giovanni Donato Aquaro,&nbsp;Carmelo De Gori,&nbsp;Lorenzo Faggioni,&nbsp;Maria Luisa Parisella,&nbsp;Giacomo Aringhieri,&nbsp;Dania Cioni,&nbsp;Riccardo Lencioni,&nbsp;Emanuele Neri","doi":"10.3390/diagnostics12112652","DOIUrl":"https://doi.org/10.3390/diagnostics12112652","url":null,"abstract":"<p><p>Fabry disease (FD) is an X-linked inheritable storage disease caused by a deficiency of alpha-galactosidase causing lysosomal overload of sphingolipids. FD cardiomyopathy is characterized by left ventricular (LV) hypertrophy and should be considered in differential diagnosis with all the other causes of LV hypertrophy. An early diagnosis of FD is very important because the enzyme replacement therapy (ERT) may change the fate of patients by blocking both cardiac and systemic involvement and improving prognosis. Diagnosis may be relatively easy in young patients with the typical signs and symptoms of FD, but in male patients with late onset of disease and in females, diagnosis may be very challenging. Morphological and functional aspects are not specific to FD, which cannot be diagnosed or excluded by echocardiography. Cardiac magnetic resonance (CMR) with tissue characterization capability is an accurate technique for the differential diagnosis of LV hypertrophy. The finding of decreased myocardial T1 value in LV hypertrophy is specific to FD. Late gadolinium enhancement (LGE) is found in the late stage of the disease, but it is useful to predict the cardiac response to ERT and to stratify the prognosis.</p>","PeriodicalId":520604,"journal":{"name":"Diagnostics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40466617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scanning Laser Ophthalmoscopy Retromode Imaging Compared to Fundus Autofluorescence in Detecting Outer Retinal Features in Central Serous Chorioretinopathy.","authors":"Fabrizio Giansanti,&nbsp;Stefano Mercuri,&nbsp;Federica Serino,&nbsp;Tomaso Caporossi,&nbsp;Alfonso Savastano,&nbsp;Clara Rizzo,&nbsp;Francesco Faraldi,&nbsp;Stanislao Rizzo,&nbsp;Daniela Bacherini","doi":"10.3390/diagnostics12112638","DOIUrl":"https://doi.org/10.3390/diagnostics12112638","url":null,"abstract":"<p><p>Central serous chorioretinopathy (CSCR) is a retinal disease characterized by a heterogeneous clinical phenotype, depending on the influence of different factors in its pathogenesis, including the presence of subretinal fluid (SRF), trophism of the retinal pigmented epithelium (RPE) and choroidal hyper-permeability. Our study has the purpose of assessing the ability of scanning laser ophthalmoscopy (SLO) retromode imaging, compared to fundus autofluorescence (FAF), to identify outer retinal features in a cohort of patients with a diagnosis of CSCR. A total of 27 eyes of 21 patients were enrolled in our study. All patients underwent full ophthalmological examination, including fundus retinography, fundus fluorescein angiography, optical coherence tomography (OCT), FAF and SLO retromode imaging. For each patient, the following features were evaluated: SRF, the presence of pigmented epithelium detachment (PED), RPE dystrophy, and RPE atrophy. RPE dystrophy was further characterized according to the appearance in FAF of iso-, hyper- and hypo-autofluorescent dystrophy. The ability to identify each feature was evaluated for FAF and SLO retromode alone, compared to a multimodal imaging approach. FAF identified SRF in 11/14 eyes (78%), PED in 14/19 (74%), RPE dystrophy with iso-autofluorescence in 0/13 (0%), hyper-autofluorescence in 18/19 (95%), hypo-autofluorescence in 20/20 (100%), and RPE atrophy in 7/7 (100%). SLO retromode imaging identified SRF in 13/14 eyes (93%), PED in 15/19 (79%), RPE dystrophy with iso-autofluorescence in 13/13 (100%), hyper-autofluorescence in 13/19 (68%), hypo-autofluorescent in 18/20 (90%), and RPE atrophy in 4/7 (57%). SLO retromode imaging is able to detect retinal and RPE changes in CSCR patients with a higher sensitivity than FAF, while it is not able to identify the depth of lesions or supply qualitative information about RPE cells' health status, meaning that it is less specific. SLO retromode imaging may have a promising role in the assessment of patients with CSCR, but always combined with other imaging modalities such as OCT and FAF.</p>","PeriodicalId":520604,"journal":{"name":"Diagnostics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40678379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational Fluid Dynamics Could Enable Individualized Surgical Treatment of Nasal Obstruction (A Preliminary Study).","authors":"Marek Plášek,&nbsp;Michaela Masárová,&nbsp;Marián Bojko,&nbsp;Pavel Komínek,&nbsp;Petr Matoušek,&nbsp;Martin Formánek","doi":"10.3390/diagnostics12112642","DOIUrl":"https://doi.org/10.3390/diagnostics12112642","url":null,"abstract":"<p><p>Passage of nasal airflow during breathing is crucial in achieving accurate diagnosis and optimal therapy for patients with nasal disorders. Computational fluid dynamics (CFD) is the dominant method for simulating and studying airflow. The present study aimed to create a CFD nasal airflow model to determine the major routes of airflow through the nasal cavity and thus help with individualization of surgical treatment of nasal disorders. The three-dimensional nasal cavity model was based on computed tomography scans of the nasal cavity of an adult patient without nasal breathing problems. The model showed the main routes of airflow in the inferior meatus and inferior part of the common meatus, but also surprisingly in the middle meatus and in the middle part of the common nasal meatus. It indicates that the lower meatus and the lower part of the common meatus should not be the only consideration in case of surgery for nasal obstruction in our patient. CFD surgical planning could enable individualized precise surgical treatment of nasal disorders. It could be beneficial mainly in challenging cases such as patients with persistent nasal obstruction after surgery, patients with empty nose syndrome, and patients with a significant discrepancy between the clinical findings and subjective complaints.</p>","PeriodicalId":520604,"journal":{"name":"Diagnostics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40694544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Framework for Abnormal Risk Classification over Fetal Nuchal Translucency Using Adaptive Stochastic Gradient Descent Algorithm.","authors":"Deepti Verma,&nbsp;Shweta Agrawal,&nbsp;Celestine Iwendi,&nbsp;Bhisham Sharma,&nbsp;Surbhi Bhatia,&nbsp;Shakila Basheer","doi":"10.3390/diagnostics12112643","DOIUrl":"https://doi.org/10.3390/diagnostics12112643","url":null,"abstract":"<p><p>In most maternity hospitals, an ultrasound scan in the mid-trimester is now a standard element of antenatal care. More fetal abnormalities are being detected in scans as technology advances and ability improves. Fetal anomalies are developmental abnormalities in a fetus that arise during pregnancy, birth defects and congenital abnormalities are related terms. Fetal abnormalities have been commonly observed in industrialized countries over the previous few decades. Three out of every 1000 pregnant mothers suffer a fetal anomaly. This research work proposes an Adaptive Stochastic Gradient Descent Algorithm to evaluate the risk of fetal abnormality. Findings of this work suggest that proposed innovative method can successfully classify the anomalies linked with nuchal translucency thickening. Parameters such an accuracy, recall, precision, and F1-score are analyzed. The accuracy achieved through the suggested technique is 98.642.%.</p>","PeriodicalId":520604,"journal":{"name":"Diagnostics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40694546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of Superb Microvascular Imaging in Differentiating Benign and Malignant Breast Tumors: A Systematic Review and Meta-Analysis.","authors":"Jiaping Feng,&nbsp;Jianghao Lu,&nbsp;Chunchun Jin,&nbsp;Yihao Chen,&nbsp;Sihan Chen,&nbsp;Guoqiang Guo,&nbsp;Xuehao Gong","doi":"10.3390/diagnostics12112648","DOIUrl":"https://doi.org/10.3390/diagnostics12112648","url":null,"abstract":"<p><strong>Purpose: </strong>We performed a systematic review and meta-analysis of studies that investigated the diagnostic performance of Superb Microvascular Imaging (SMI) in differentiating between benign and malignant breast tumors.</p><p><strong>Methods: </strong>Studies published between January 2010 and March 2022 were retrieved by online literature search conducted in PubMed, Embase, Cochrane Library, Web of Science, China Biology Medicine Disc, China National Knowledge Infrastructure, Wanfang, and Vip databases. Pooled sensitivity, specificity, and diagnostic odd ratios were calculated using Stata software 15.0. Heterogeneity among the included studies was assessed using <i>I²</i> statistic and Q test. Meta-regression and subgroup analyses were conducted to investigate potential sources of heterogeneity. Influence analysis was conducted to determine the robustness of the pooled conclusions. Deeks' funnel plot asymmetry test was performed to assess publication bias. A summary receiver operating characteristic curve (SROC) was constructed.</p><p><strong>Results: </strong>Twenty-three studies involving 2749 breast lesions were included in our meta-analysis. The pooled sensitivity and specificity were 0.80 (95% confidence interval [CI], 0.77-0.84, inconsistency index [<i>I</i>²] = 28.32%) and 0.84 (95% CI, 0.79-0.88, <i>I</i>² = 89.36%), respectively. The pooled diagnostic odds ratio was 19.95 (95% CI, 14.84-26.82). The area under the SROC (AUC) was 0.85 (95% CI, 0.81-0.87).</p><p><strong>Conclusion: </strong>SMI has a relatively high sensitivity, specificity, and accuracy for differentiating between benign and malignant breast lesions. It represents a promising supplementary technique for the diagnosis of breast neoplasms.</p>","PeriodicalId":520604,"journal":{"name":"Diagnostics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689350/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40694548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Cost-Effectiveness of Computerized Cranial Tomography in Children with Mild Head Trauma.","authors":"Mustafa Çalik,&nbsp;Ayşe Hilal Ersoy,&nbsp;Elif Evrim Ekin,&nbsp;Derya Öztürk,&nbsp;Seda Geylani Güleç","doi":"10.3390/diagnostics12112649","DOIUrl":"https://doi.org/10.3390/diagnostics12112649","url":null,"abstract":"<p><strong>Purpose: </strong>Pediatric head traumas constitute the majority of admissions to emergency departments (ED) due to trauma. This study aims to draw attention to the use of cranial computerized tomography (CT) scans in the evaluation of children with head trauma under the age of 18, and to determine CT scans' usefulness in terms of cost-effectiveness.</p><p><strong>Materials and methods: </strong>Age, gender, mechanism of trauma and Glasgow Coma Scale (GCS), diagnosis, time of admission to hospital, hospitalization and operation, cranial computerized tomography and hospitalization costs of all cases were retrospectively analyzed.</p><p><strong>Results: </strong>A total of 26,412 patients younger than 18 years old who were admitted to the emergency department due to head trauma and who had a cranial tomography were analyzed. They had a mean age of 7.74 ± 5.66 years. In total, 26,363 (99.8%) of these patients had a GCS greater than 14. Out of these patients, only 402 (1.5%) had brain injury revealed by cranial CT, 41 (0.2%) of these patients were operated and 3 of the patients lost their lives. The total cost of patients admitted to the emergency department with a head injury amounts to USD 583,317. Furthermore, 75.78% of this cost comes from negative cranial CTs. A cost analysis according to different age groups did not show a meaningful difference between 0-2 years and 3-5 years (<i>p</i> = 1.000), but there was a meaningful difference for all the other age groups.</p><p><strong>Conclusion: </strong>Our findings show that applying algorithms to predict traumatic brain injury in children with mild head injury rather than scanning all patients with cranial CT will enable more reliable and cost-effective patient care. Current practices should be reviewed to avoid unnecessary radiation exposure and expense in the ED. It is also necessary to inform and educate parents about the risk/benefit ratio of cranial CT scans.</p>","PeriodicalId":520604,"journal":{"name":"Diagnostics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40466615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common, Less Common, and Unexpected Complications after Bariatric Surgery: A Pictorial Essay.","authors":"Francesca Iacobellis,&nbsp;Giuseppina Dell'Aversano Orabona,&nbsp;Antonio Brillantino,&nbsp;Marco Di Serafino,&nbsp;Alessandro Rengo,&nbsp;Paola Crivelli,&nbsp;Luigia Romano,&nbsp;Mariano Scaglione","doi":"10.3390/diagnostics12112637","DOIUrl":"https://doi.org/10.3390/diagnostics12112637","url":null,"abstract":"<p><p>Bariatric surgery has demonstrated a higher rate of success than other nonsurgical treatments in selected patients with obesity; however, like all medical procedures, postoperative complications may occur, ranging between 2 and 10% and, although rare, they can be life threatening. Complications may be unspecific (any surgery-related complications) or specific (linked to the specific surgical procedure) and can be distinguished as common, less common, and unexpected. According to the onset, they may be acute, when occurring in the first 30 days after surgery, or chronic, with a presentation after 30 days from the procedure. The aim of this pictorial essay is to review the radiological aspects of surgical techniques usually performed and the possible complications, in order to make radiologists more confident with the postsurgical anatomy and with the normal and abnormal imaging findings.</p>","PeriodicalId":520604,"journal":{"name":"Diagnostics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40678378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prosthetic Knee Joint Infection Due to <i>Candida lusitaniae:</i> A Diagnostic and Therapeutic Odyssey: A Case Study.","authors":"Vasileios Giovanoulis,&nbsp;Angelo V Vasiliadis,&nbsp;Christos Koutserimpas,&nbsp;George Samonis,&nbsp;Cécile Batailler,&nbsp;Tristan Ferry,&nbsp;Sébastien Lustig","doi":"10.3390/diagnostics12112640","DOIUrl":"https://doi.org/10.3390/diagnostics12112640","url":null,"abstract":"<p><p>Prosthetic joint infections (PJIs) caused by fungi, although relatively rare, represent a major surgery-related complication. An extremely rare fungal PJI, following revised total knee replacement (TKR) caused by <i>Candida lusitaniae</i>, is reported, and a meticulous review of similar cases is provided. A 74-year-old female, who underwent primary total knee arthroplasty 10 years ago and a revision surgery three weeks ago, presented with signs and symptoms of PJI. <i>C. lusitaniae</i> was eventually isolated from the periprosthetic tissue using the MALDI-TOF VitekMS-bioMérieux technique. Multiple strategies for managing this fungal PJI were performed, and finally, the patient was treated successfully with an intramedullary arthrodesis system and proper antifungal treatment, including fluconazole. A multidisciplinary approach is essential for the diagnosis and treatment of such severe infections. In persistent cases and in cases where revision surgery is extremely difficult to perform, arthrodesis seems to be an effective solution for the elimination of the infection. The efficacy of the therapeutic management of fungal PJIs remains unclear. Therefore, more research should be reported, focusing on proper treatment so that the optimal strategy in treating these severe infections may be established.</p>","PeriodicalId":520604,"journal":{"name":"Diagnostics (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":3.6,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9689177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40678381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}