Cancer biomarkers : section A of Disease markers最新文献_第4页

Development and validation of stemness associated LncRNA based prognostic model for lung adenocarcinoma patients. 基于干性相关LncRNA的肺腺癌患者预后模型的建立和验证。

IF 3.1

Cancer biomarkers : section A of Disease markers Pub Date : 2022-01-01 DOI: 10.3233/CBM-200687

Annesha Chatterjee, Seema Khadirnaikar, Sudhanshu Shukla

{"title":"Development and validation of stemness associated LncRNA based prognostic model for lung adenocarcinoma patients.","authors":"Annesha Chatterjee, Seema Khadirnaikar, Sudhanshu Shukla","doi":"10.3233/CBM-200687","DOIUrl":"https://doi.org/10.3233/CBM-200687","url":null,"abstract":"Background: An increasing number of studies are indicating that the stemness phenotype is a critical determinant of the Lung adenocarcinoma (LUAD) patient's response. Thus, it is crucial to identify novel biomarkers for stemness determination.Objective: Here, we aim to develop a robust LncRNAs based prognostic signature with a stemness association for the LUAD patients.Methods: RNA-seq and clinical data were downloaded from the existing database. The data were analysed using Cox regression, KM-plot, GSEA, and T-test.Results: Initially, we used the TCGA dataset to characterize the stemness phenotype in LUAD. The commonly expressed LncRNAs in TCGA and MCTP cohort were then used as input for the Cox-regression analysis. The top three LncRNAs were selected to build a prognostic model, which was the best prognosticator in multivariate analysis with stage and previously published prognosticators. The characterization of poor surviving patients using various analysis showed high stemness properties and low expression of differentiation markers. Furthermore, we validated the prognostic score in an independent MCTP cohort of patients. In the MCTP cohort, prognostic score significantly predicted survival independent of stage and previous prognosticators.Conclusion: Taken together, in this study, we have developed and validated a new prognostic score associated with the stemness phenotype.","PeriodicalId":520578,"journal":{"name":"Cancer biomarkers : section A of Disease markers","volume":" ","pages":"131-142"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39388418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of CD10 and CD15 in colorectal mucinous and signet ring adenocarcinomas and its relation to clinicopathological features and prognosis. CD10和CD15在结直肠黏液腺癌和印戒腺癌中的表达及其与临床病理特征和预后的关系

IF 3.1

Cancer biomarkers : section A of Disease markers Pub Date : 2022-01-01 DOI: 10.3233/CBM-210067

Abd AlRahman Mohammad Foda, Haitham Abdulkarem Alamer, Nadeem Ikram, Hadi Abdulhadi Helali, Fayza Sami Fayad, Sara Waleed Hussian, Khaled Abdelwahab, Tamer Akl, Ziad Emarah, Ahmed M Ramez

{"title":"Expression of CD10 and CD15 in colorectal mucinous and signet ring adenocarcinomas and its relation to clinicopathological features and prognosis.","authors":"Abd AlRahman Mohammad Foda, Haitham Abdulkarem Alamer, Nadeem Ikram, Hadi Abdulhadi Helali, Fayza Sami Fayad, Sara Waleed Hussian, Khaled Abdelwahab, Tamer Akl, Ziad Emarah, Ahmed M Ramez","doi":"10.3233/CBM-210067","DOIUrl":"https://doi.org/10.3233/CBM-210067","url":null,"abstract":"Background: CD10 and CD15 expression has been reported in several tumors. Whether CD10 and CD15 have a role in colorectal mucinous and signet ring adenocarcinoma (MSA) tumorigenesis is not yet known.Objective: We aimed to investigate the role of CD10 and CD15 expression in mucinous colorectal adenoma-carcinoma sequence (ACS) and determine if there is any clinical and prognostic significance associated with their expression.Methods: Seventy-five cases of colorectal MSA, and 9 cases of adenoma samples were collected. Manual TMA blocks were constructed and immunohistochemistry for CD10 and CD15 was done.Results: Compared to adenomas, CD15 expression was significantly higher in MSA (p= 0.002), in contrast to CD10 expression. CD15 positivity was significantly associated with microsatellite stable (MSS) tumors (p= 0.018). The association between CD10 positivity and fungating tumor growth showed marginal significance. Unlike CD10, CD15 positivity showed significant association with overall survival of colorectal MSA patients.Conclusions: CD15 expression seems to have a role in mucinous colorectal ACS, with significant impact on the survival of MSA patients. Further studies are suggested to identify any genetic alterations that may underlie a potential association with disease progression.","PeriodicalId":520578,"journal":{"name":"Cancer biomarkers : section A of Disease markers","volume":" ","pages":"143-150"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39405558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profile of soluble factors in pleural effusions predict prognosis in mesothelioma. 胸膜积液中可溶性因子预测间皮瘤预后。

IF 3.1

Cancer biomarkers : section A of Disease markers Pub Date : 2022-01-01 DOI: 10.3233/CBM-210280

I M Dick, Y C G Lee, H M Cheah, A Miranda, B W S Robinson, J Creaney

{"title":"Profile of soluble factors in pleural effusions predict prognosis in mesothelioma.","authors":"I M Dick, Y C G Lee, H M Cheah, A Miranda, B W S Robinson, J Creaney","doi":"10.3233/CBM-210280","DOIUrl":"https://doi.org/10.3233/CBM-210280","url":null,"abstract":"Background: Pleural mesothelioma is a deadly asbestos induced cancer. Less than 10% of mesothelioma patients survive 5 years post diagnosis. However survival can range from a few months to a number of years. Accurate prediction of survival is important for patients to plan for their remaining life, and for clinicians to determine appropriate therapy. One unusual feature of mesothelioma is that patients frequently present with tumor-associated pleural effusions early in the course of the disease.Objective: To study whether cells and molecules present in pleural effusions provide prognostic information for mesothelioma.Methods: We profiled the cellular constituents and concentrations of 40 cytokines, chemokines and cellular factors (collectively \"soluble factors\") involved in inflammatory and immune signalling pathways in pleural effusion samples from 50 mesothelioma patients.Associations with survival were evaluated by Cox proportional hazards regression methods. Results for the two soluble factors most significantly and independently associated with survival were validated in an independent set of samples (n= 51) using a separate assay system.Results: Survival analysis revealed that IL8, IL2Ra (CD25) and PF4 were independent determinants of a more negative prognosis in mesothelioma patients, independent of other known prognostic factors. Lipocalin2 and IL4 were associated with better prognosis.Conclusions: This study demonstrates that pleural effusions rich in a range of soluble factors are associated with poor prognosis. These findings will enhance our ability to prognosticate outcomes in mesothelioma patients.","PeriodicalId":520578,"journal":{"name":"Cancer biomarkers : section A of Disease markers","volume":" ","pages":"159-169"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/ce/cbm-33-cbm210280.PMC8925107.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39405959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Machine learning algorithm and deep neural networks identified a novel subtype in hepatocellular carcinoma. 机器学习算法和深度神经网络在肝细胞癌中发现了一种新的亚型。

IF 3.1

Cancer biomarkers : section A of Disease markers Pub Date : 2022-01-01 DOI: 10.3233/CBM-220147

Quan Zi, Hanwei Cui, Wei Liang, Qingjia Chi

{"title":"Machine learning algorithm and deep neural networks identified a novel subtype in hepatocellular carcinoma.","authors":"Quan Zi, Hanwei Cui, Wei Liang, Qingjia Chi","doi":"10.3233/CBM-220147","DOIUrl":"https://doi.org/10.3233/CBM-220147","url":null,"abstract":"Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Due to the lack of specific characteristics in the early stage of the disease, patients are usually diagnosed in the advanced stage of disease progression.Objective: This study used machine learning algorithms to identify key genes in the progression of hepatocellular carcinoma and constructed a prediction model to predict the survival risk of HCC patients.Methods: The transcriptome data and clinical information were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). The differential expression analysis and COX proportional-hazards model participated in the identification of survival-related genes. K-Means, Random forests, and LASSO regression are involved in identifying novel subtypes of HCC and screening key genes. The prediction model was constructed by deep neural networks (DNN), and Gene Set Enrichment Analysis (GSEA) reveals the metabolic pathways where key genes are located.Results: Two subtypes were identified with significantly different survival rates (p< 0.0001, AUC = 0.720) and 17 key genes associated with the subtypes. The accuracy rate of the deep neural network prediction model is greater than 93.3%. The GSEA analysis found that the survival-related genes were significantly enriched in hallmark gene sets in the MSigDB database.Conclusions: In this study, we used machine learning algorithms to screen out 17 genes related to the survival risk of HCC patients, and trained a DNN model based on them to predict the survival risk of HCC patients. The genes that make up the model are all key genes that affect the formation and development of cancer.","PeriodicalId":520578,"journal":{"name":"Cancer biomarkers : section A of Disease markers","volume":" ","pages":"305-320"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40487051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prognostic value of Talin-1 in renal cell carcinoma and its association with B7-H3. Talin-1在肾细胞癌中的预后价值及其与B7-H3的关系。

IF 3.1

Cancer biomarkers : section A of Disease markers Pub Date : 2022-01-01 DOI: 10.3233/CBM-220018

Leili Saeednejad Zanjani, Somayeh Vafaei, Maryam Abolhasani, Fahimeh Fattahi, Zahra Madjd

{"title":"Prognostic value of Talin-1 in renal cell carcinoma and its association with B7-H3.","authors":"Leili Saeednejad Zanjani, Somayeh Vafaei, Maryam Abolhasani, Fahimeh Fattahi, Zahra Madjd","doi":"10.3233/CBM-220018","DOIUrl":"https://doi.org/10.3233/CBM-220018","url":null,"abstract":"Methods: Talin-1 protein was demonstrated as a potential prognostic marker in renal cell carcinoma (RCC) using bioinformatics analysis. We, therefore, examined the protein expression levels and prognostic significance of Talin-1 with a clinical follow-up in a total of 269 tissue specimens from three important subtypes of RCC and 30 adjacent normal samples using immunohistochemistry. Then, we used combined analysis with B7-H3 to investigate higher prognostic values.Results: The results showed that high membranous and cytoplasmic expression of Talin-1 was significantly associated with advanced nucleolar grade, microvascular invasion, histological tumor necrosis, and invasion to Gerota's fascia in clear cell RCC (ccRCC). In addition, high membranous and cytoplasmic expression of Talin-1 was found to be associated with significantly poorer disease-specific survival (DSS) and progression-free survival (PFS). Moreover, increased cytoplasmic expression of Talin-1High/B7-H3High compared to the other phenotypes was associated with tumor aggressiveness and progression of the disease, and predicted a worse clinical outcome, which may be an effective biomarker to identify ccRCC patients at high risk of recurrence and metastasis.Conclusions: Collectively, these observations indicate that Talin-1 is an important molecule involved in the spread and progression of ccRCC when expressed particularly in the cytoplasm and may serve as a novel prognostic biomarker in this subtype. Furthermore, a combined analysis of Talin-1/B7-H3 indicated an effective biomarker to predict the progression of disease and prognosis in ccRCC.","PeriodicalId":520578,"journal":{"name":"Cancer biomarkers : section A of Disease markers","volume":" ","pages":"269-292"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33513324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Association of 21-gene recurrence score and locoregional recurrence in early breast cancer patients. 早期乳腺癌患者21基因复发评分与局部复发的关系

IF 3.1

Cancer biomarkers : section A of Disease markers Pub Date : 2022-01-01 DOI: 10.3233/CBM-210274

Yufei Zeng, Weiqi Gao, Xiaosong Chen, Kunwei Shen

{"title":"Association of 21-gene recurrence score and locoregional recurrence in early breast cancer patients.","authors":"Yufei Zeng, Weiqi Gao, Xiaosong Chen, Kunwei Shen","doi":"10.3233/CBM-210274","DOIUrl":"https://doi.org/10.3233/CBM-210274","url":null,"abstract":"Background: The 21-gene recurrence score (RS) assay has been validated to predict the risk of disease-free survival in estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer patients. However, its relation with locoregional recurrence (LRR) risk is unclear.Objective: This study aimed to explore the ability of RS to predict LRR risk.Methods: Consecutive ER-positive, HER2-negative, pT1, pN0-1, and M0 early breast cancer patients were analyzed retrospectively. According to RS, patients were divided into low- (RS < 18), intermediate- (RS 18-30), and high-risk (RS ⩾ 31) groups. The primary endpoint was LRR. Subgroup analysis was conducted according to different nodal statuses and surgery types.Results: A total of 1558 patients were enrolled: 354 (22.7%), 788 (50.6%), and 416 (26.7%) patients in the low-, intermediate-, and high-risk groups, respectively. The median follow-up time was 53 months, and 2, 8, and 14 LRR events were observed in the low-, intermediate-, and high-risk groups, respectively (P= 0.004). Both univariate (P= 0.009) and multivariate (P= 0.010) analyses demonstrated that 21-gene RS was correlated with LRR. Compared to low-risk patients, high-risk patients were at greater risk of LRR (HR 5.75, 95% CI 1.30-25.31, P= 0.021). Among pN0 (P= 0.033), pN1 (P= 0.049) and postmastectomy patients (P= 0.012), 21-gene RS remained predictive of the risk of LRR.Conclusion: The 21-gene RS assay was significantly associated with the risk of LRR in ER-positive, HER2-negative early breast cancer patients. Among patients with different nodal statuses and patients receiving mastectomy, RS remained predictive of the risk of LRR.","PeriodicalId":520578,"journal":{"name":"Cancer biomarkers : section A of Disease markers","volume":" ","pages":"111-118"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40574447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The tumor microenvironment and prognostic role of autophagy- and immune-related genes in bladder cancer. 肿瘤微环境及自噬和免疫相关基因在膀胱癌中的预后作用。

IF 3.1

Cancer biomarkers : section A of Disease markers Pub Date : 2022-01-01 DOI: 10.3233/CBM-220058

Zhenhua Gao, Cheng Chen, Peng Gu, Jianheng Chen, Xiaodong Liu, Jihong Shen

{"title":"The tumor microenvironment and prognostic role of autophagy- and immune-related genes in bladder cancer.","authors":"Zhenhua Gao, Cheng Chen, Peng Gu, Jianheng Chen, Xiaodong Liu, Jihong Shen","doi":"10.3233/CBM-220058","DOIUrl":"https://doi.org/10.3233/CBM-220058","url":null,"abstract":"Background: Autophagy-related genes and immune-related genes contribute significantly to the initiation and prognosis of bladder cancer (BLCA).Objective: We aimed to explore differentially expressed autophagy-related genes (DEARGs) and immune-related genes (DEIRGs) in BLCA to create a prognostic risk assessment model and gain some insights into BLCA's molecular underpinnings.Methods: The prognostic DEARGs and DEIRGs were evaluated for BLCA through The Cancer Genome Atlas (TCGA) database (n= 399) and GSE13507 dataset (n= 165). The BLCA risk model was constructed and verified. The immune score, stromal score, and estimate score in different risk groups were calculated by the ESTIMATE algorithm. Immune infiltration levels were assessed by a single sample gene set enrichment analysis (GSEA) algorithm.Results: In the risk model, AURKA, ACTC1, MYLK, PDGFD, PDGFRA and TNC were significantly associated with the overall survival. The pathways in cancer, T cell receptor signaling pathway and B cell receptor signaling pathway were significantly gathered in the high-risk group. Moreover, the risk score was significantly correlated with infiltrating immune cells, expression of critical immune checkpoints and mismatch repair genes including MSH6, MLH1, and MSH2.Conclusions: In this study, three DEARGs (AURKA, ACTC1, MYLK) and three DEIRGs (PDGFD, PDGFRA, TNC) were demonstrated to be potential prognostic biomarkers for BLCA patients through bioinformatics methods, which might be novel therapeutic targets and prognostic markers for BLCA, in follow up studies, we will combine experiments to verify this.","PeriodicalId":520578,"journal":{"name":"Cancer biomarkers : section A of Disease markers","volume":" ","pages":"293-303"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33513326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Assessment of a panel of miRNAs in serum and pleural fluid for the differential diagnosis of malignant and benign pleural effusion. 血清和胸腔液中一组mirna对恶性和良性胸腔积液鉴别诊断的评估。

IF 3.1

Cancer biomarkers : section A of Disease markers Pub Date : 2022-01-01 DOI: 10.3233/CBM-210090

Li-Rong Zhu, Rong-Xia Yuan, Xian-Bin Xia, Yi Wang, Yu-Min Zhu, Ling Fi, Jian Li

{"title":"Assessment of a panel of miRNAs in serum and pleural fluid for the differential diagnosis of malignant and benign pleural effusion.","authors":"Li-Rong Zhu, Rong-Xia Yuan, Xian-Bin Xia, Yi Wang, Yu-Min Zhu, Ling Fi, Jian Li","doi":"10.3233/CBM-210090","DOIUrl":"https://doi.org/10.3233/CBM-210090","url":null,"abstract":"Background: Differential diagnosis between malignant pleural effusion (MPE) and benign pleural effusion (BPE) remains a clinical challenge.Objective: The aim of the study is to assess the efficacy of the serum and pleural fluid (PF) miRNA panels in distinguishing MPE from BPE.Methods: Fourteen candidate miRNAs which were shown aberrant expression in lung cancer based on previous studies were tested by quantitative real-time PCR (qRT-PCR) in 20 MPE patients and 20 BPE patients. Significantly aberrantly expressed miRNAs were further assessed by qRT-PCR in all patients enrolled in this study. A receiver operating characteristic (ROC) curve was constructed, and the area under the ROC curve (AUC) was calculated to evaluated the diagnostic performance of the miRNAs.Results: miR-21, miR-29c and miR-182 were found to be significantly aberrantly expressed in the serum and PF of MPE patients. The AUCs for the combination of miR-21, miR-29c and miR-182 in serum and PF were 0.832 and 0.89 respectively in distinguishing MPE from infection-associated PE including tuberculous pleurisy and parapneumonia PE, and 0.866 and 0.919 respectively for differentiating MPE from heart failure-associated PE, which were superior to AUC of each individual miRNAs.Conclusions: miR-21, miR-29c and miR-182 in serum and PF could be useful biomarkers for diagnosis of MPE.","PeriodicalId":520578,"journal":{"name":"Cancer biomarkers : section A of Disease markers","volume":" ","pages":"71-82"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3233/CBM-210090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39292356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Endothelial activation and stress index (EASIX) as a predictive biomarker in small cell lung cancer. 内皮细胞激活和应激指数(EASIX)作为小细胞肺癌的预测性生物标志物。

IF 3.1

Cancer biomarkers : section A of Disease markers Pub Date : 2022-01-01 DOI: 10.3233/CBM-220032

Se-Il Go, Sungwoo Park, Myoung Hee Kang, Hoon-Gu Kim, Jung Hun Kang, Jung Hoon Kim, Gyeong-Won Lee

{"title":"Endothelial activation and stress index (EASIX) as a predictive biomarker in small cell lung cancer.","authors":"Se-Il Go, Sungwoo Park, Myoung Hee Kang, Hoon-Gu Kim, Jung Hun Kang, Jung Hoon Kim, Gyeong-Won Lee","doi":"10.3233/CBM-220032","DOIUrl":"https://doi.org/10.3233/CBM-220032","url":null,"abstract":"Background: Endothelial activation and insult may contribute to the aggressive clinical course of small-cell lung cancer (SCLC); however, no predictive biomarker for this pathogenesis has been identified.Objective: To evaluate the clinical impact of the endothelial activation and stress index (EASIX) in SCLC.Methods: In this retrospective study, the EASIX was calculated from measurements of serum lactate dehydrogenase, creatinine, and platelet levels. A total of 264 patients with SCLC treated with platinum-based chemotherapy were stratified into high and low EASIX groups.Results: Complete and objective response rates in the limited-stage (LD) were 19.5% vs. 33.3% (P= 0.050) and 85.4% vs. 97.9% (P= 0.028) in the high and low EASIX groups, respectively. There was no significant difference in the response rate between the two groups in the extensive-stage (ED). The median overall survival was 9.8 vs. 40.5 months in LD (P< 0.001) and 7.2 vs. 11.9 months in ED (P< 0.001) in the high and low EASIX groups, respectively. In multivariate analyses, a high EASIX level was an independent prognostic factor for worse progression-free and overall survival irrespective of stage.Conclusion: EASIX may be a potential predictive biomarker of SCLC.","PeriodicalId":520578,"journal":{"name":"Cancer biomarkers : section A of Disease markers","volume":" ","pages":"217-225"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40369861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Circulating microRNAs: Challenges with their use as liquid biopsy biomarkers. 循环microrna:作为液体活检生物标志物的挑战。

IF 3.1

Cancer biomarkers : section A of Disease markers Pub Date : 2022-01-01 DOI: 10.3233/CBM-210223

Satoko Takizawa, Juntaro Matsuzaki, Takahiro Ochiya

{"title":"Circulating microRNAs: Challenges with their use as liquid biopsy biomarkers.","authors":"Satoko Takizawa, Juntaro Matsuzaki, Takahiro Ochiya","doi":"10.3233/CBM-210223","DOIUrl":"https://doi.org/10.3233/CBM-210223","url":null,"abstract":"Circulating microRNA (miRNA) is a major focus in liquid biopsy studies. The circulating levels of certain miRNAs have been suggested to reflect specific physiological conditions, and several studies have reported their potential use as biomarkers for the detection and prognosis of cancer, as well as for predicting responses to chemotherapy or radiotherapy. Alongside these biomarker studies, research into the effects of specific background factors on circulating miRNA levels is progressing. Indeed, several studies have shown that a number of factors, including blood sample collection and processing methods, as well as subject-specific factors such as age, sex, and other physiological conditions, can affect the normal levels of circulating miRNAs. Unfortunately, the evidence supporting these effects is not yet strong enough to support a definite conclusion and further research is warranted. Here, we summarize the findings of several studies that have addressed these concerns and identify important topics that should be considered when analyzing circulating miRNA levels in liquid biopsy studies.","PeriodicalId":520578,"journal":{"name":"Cancer biomarkers : section A of Disease markers","volume":" ","pages":"1-9"},"PeriodicalIF":3.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/5f/cbm-35-cbm210223.PMC9661319.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40470375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6