Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia最新文献

{"title":"The association between C-reactive protein/albumin ratio and coronary collateral circulation in patients with chronic coronary syndromes and chronic total occlusion.","authors":"Sinan Iscen, Veysel Ozan Tanik, Cagatay Tunca, Suleyman Kayisoglu, Kursat Akbuga, Bulent Ozlek","doi":"10.5507/bp.2026.010","DOIUrl":"https://doi.org/10.5507/bp.2026.010","url":null,"abstract":"<p><strong>Background: </strong>The C-reactive protein-to-albumin ratio (CAR) has recently gained attention as a novel biomarker reflecting both systemic inflammation and nutritional status. Since inflammation plays a critical role in the formation of the coronary collateral circulation (CCC), this study aimed to investigate the association between CAR and the extent of CCC in patients with chronic coronary syndromes (CCS) and chronic total occlusion (CTO).</p><p><strong>Methods: </strong>A total of 123 consecutive patients with CCS and angiographically documented CTO were included. CCC was assessed using the Rentrop classification and patients were divided into two groups: poor CCC (grades 0-1) and good CCC (grades 2-3). Laboratory data including C-reactive protein (CRP), albumin, lipid parameters, renal and liver function tests, glucose, and complete blood count were recorded. CAR was calculated by dividing CRP (mg/L) by albumin (g/dL), and neutrophil-to-lymphocyte ratio (NLR) was also evaluated.</p><p><strong>Results: </strong>Patients with poor CCC had significantly higher CRP, CAR, and NLR levels (P<0.05 for all). In multivariate logistic regression, both CAR (OR=1.200, 95% CI: 1.102-1.394, P<0.001) and NLR were independently associated with poor CCC. ROC analysis showed that CAR had better predictive value (AUC=0.79) than CRP (AUC=0.75, P=0.02) and NLR (AUC=0.67, P=0.03). A CAR cutoff of 2.36 yielded 67% sensitivity and 68% specificity.</p><p><strong>Conclusion: </strong>Elevated CAR is independently associated with impaired CCC in patients with CCS and CTO. CAR may serve as a simple and superior marker over traditional inflammatory indices in assessing collateral vessel development.</p>","PeriodicalId":520569,"journal":{"name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current perspectives on the indications and surveillance of prosthetic arteriovenous grafts for haemodialysis.","authors":"Julia Jarosciakova, Petr Utikal, Petr Bachleda, Jana Janeckova","doi":"10.5507/bp.2026.008","DOIUrl":"https://doi.org/10.5507/bp.2026.008","url":null,"abstract":"<p><p>A prosthetic arteriovenous graft (AVG) represents a type of vascular access for haemodialysis (HD), employing a synthetic conduit that replaces a native vessel and permits repeated cannulation. Due to their associated complications, particularly thrombosis and infection, arteriovenous grafts (AVGs) have long been regarded as a secondary option. Current recommendations advocate an individualized approach to vascular access planning based on patient´s anatomy, life expectancy, anticipated dialysis duration, and personal preferences, leading to a broader and more flexible use of AVGs. Their key advantage is the potential for early initiation of HD, while minimizing the need for central venous catheters. However, a major disadvantage of AVGs is their tendency to develop stenotic lesions, predominantly at the venous anastomosis, which adversely affects graft patency. If left untreated, this may lead to graft thrombosis. Regular evaluation of AVG function is essential for early detection of stenosis and maintenance of graft patency. Despite its widespread use in clinical practice, the role of AVG surveillance in vascular access management remains a subject of considerable debate, as current evidence regarding its effectiveness in preventing thrombosis and prolonging graft patency is inconclusive.</p>","PeriodicalId":520569,"journal":{"name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147694622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative outcomes and graft patency in coronary artery bypass grafting (CABG) after no-touch saphenous vein harvesting: A single-center exploratory study.","authors":"Jakub Konecny, Martin Troubil, Vladimir Svitek, Artur Barshatskyi, Dominik Sabacky, Martin Simek","doi":"10.5507/bp.2026.007","DOIUrl":"https://doi.org/10.5507/bp.2026.007","url":null,"abstract":"<p><strong>Background: </strong>The no-touch (NT) technique for saphenous vein harvesting aims to preserve vascular integrity and improve graft performance in coronary artery bypass grafting (CABG). However, concerns remain regarding wound healing disorders and local complications at the graft harvest site.</p><p><strong>Methods: </strong>This prospective observational comparative study included 60 consecutive patients undergoing CABG, allocated to conventional saphenous vein harvesting (CONV, n=30) or the NT technique (NT, n=30). Group allocation was based on routine clinical practice and surgeon preference, without formal randomization. The primary outcome was the incidence of wound healing disorders and local complications at the harvest site. Secondary outcomes included perioperative parameters, major adverse cardiovascular events (MACE), and venous graft patency assessed by computed tomography coronary angiography one year after surgery.</p><p><strong>Results: </strong>Operative time and aortic cross-clamp time were comparable between groups. Shorter graft harvesting time was observed in the NT group (35 ± 7.5 min vs. 43 ± 9.1 min; P=0.001), along with significantly reduced perioperative blood loss (15 ± 7 mL vs. 40 ± 12.1 mL; P<0.0001). The incidence of subcutaneous hematoma on postoperative day 7 was significantly lower in the NT group (20% vs. 60%; P=0.003). No statistically significant differences were found between groups in wound infection rates, MACE, or venous graft patency at one-year follow-up.</p><p><strong>Conclusion: </strong>The NT technique for saphenous vein harvesting offers relevant perioperative advantages, including shorter harvesting time, reduced blood loss, and fewer early local complications, without adversely affecting operative time, major adverse cardiac events, wound infection, or one-year graft patency.</p>","PeriodicalId":520569,"journal":{"name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147517980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide mapping: Case study on Olomouc and Zlín regions in Czech Republic in 2018-2022.","authors":"Veronika Kralikova, Alena Vondrakova, Tomas Kralik, Karel Macku, Vaclav Svrchokryl, Adriana Gavronova, Lukas Hamerlik","doi":"10.5507/bp.2026.003","DOIUrl":"https://doi.org/10.5507/bp.2026.003","url":null,"abstract":"<p><strong>Background and aims: </strong>Suicide represents a major public health issue influenced by a complex interplay of individual, social, and environmental factors. While suicidological research traditionally focuses on psychological and clinical aspects, spatial dimensions of suicidal behavior remain less explored, particularly in Central Europe. This study presents a geospatial analysis of completed suicides in the Olomouc and Zlín Regions of the Czech Republic between 2018 and 2022, using a unique dataset derived from forensic autopsy records. The primary goal was to demonstrate the potential of spatial processing and interdisciplinary collaboration between forensic medicine and geoinformatics in identifying contextual patterns of suicidal behavior.</p><p><strong>Methods: </strong>A dataset of 585 completed suicides was compiled from forensic autopsy reports, including detailed individual-level characteristics and geolocation data. Spatial analyses were conducted using GIS software, integrating additional layers such as land use, demographic and socioeconomic indicators, and quality of life indices. Both point-level and aggregated data (municipality and administrative district levels) were used to explore correlations and spatial variability.</p><p><strong>Results: </strong>The study confirmed known trends - such as male predominance and the role of alcohol - and identified new spatial relationships, including a negative correlation between blood alcohol concentration and latitude, and between age and distance from residence to suicide location. Spatial analyses were conducted at multiple levels of aggregation and combined with selected socioeconomic and environmental indicators, including quality of life, urban-rural context, and foreclosure (enforcement) rates. The results demonstrate that spatial patterns and correlations between suicide rates and area-based characteristics vary depending on the spatial scale of analysis.</p><p><strong>Conclusion: </strong>The findings illustrate the potential of interdisciplinary collaboration between forensic medicine and geoinformatics and provide an exploratory basis for further research and more context-sensitive suicide prevention approaches.</p>","PeriodicalId":520569,"journal":{"name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147501637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the impact of sleep duration and quality on tear‑film in adults with complementary validation of a mobile healthy‑lifestyle application.","authors":"Aneta Buchtelova, Eliska Mikulaskova, Vojtech Malina, Karla Mothejlova, Milada Luisa Sedivcova, Jan Kaspar, Karel Hana","doi":"10.5507/bp.2026.006","DOIUrl":"https://doi.org/10.5507/bp.2026.006","url":null,"abstract":"<p><strong>Aims: </strong>This study aimed to investigate the relationship between sleep parameters and tear film hydration assessed by tear meniscus height (TMH), and to evaluate the usability of a mobile application for remote behavioral and physiological data collection.</p><p><strong>Methods: </strong>Eighteen healthy adults (mean age 29.6 ± 6.4 years) completed five consecutive days of linked measurements combining objective sleep tracking (using Fitbit Charge 4) and slit-lamp imaging of TMH under standardized conditions. Behavioral data on stress, caffeine intake, and smartphone use were collected via a custom mobile application, whose usability was assessed by the System Usability Scale (SUS).</p><p><strong>Results: </strong>Ninety valid daily records were analyzed. TMH correlated positively with total sleep time (r=0.31, P=0.0033), REM sleep duration (r=0.28, P=0.0066), and sleep quality (r=0.32, P=0.0024). Each additional 30 min of REM sleep increased TMH by approximately 0.014 mm. Short sleepers (<6 h) showed significantly lower TMH (0.121 mm) than normal sleepers (≥6 h; 0.153 mm; P=0.0023). Stress and evening smartphone use were associated with reduced sleep quality and lower TMH. The mobile application achieved excellent usability (SUS = 87 ± 6).</p><p><strong>Conclusions: </strong>Our data indicate that sleep duration and architecture play essential roles in maintaining tear film stability. Behavioral habits that impair sleep continuity may thus directly affect ocular surface physiology. The combined use of wearable sensors and mobile self-reporting represents a practical approach to studying the interaction between sleep and ocular physiology.</p>","PeriodicalId":520569,"journal":{"name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","volume":" ","pages":""},"PeriodicalIF":0.7,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannabidiol-hyaluronic acid combination delivered rectally for attenuating abacterial prostatitis symptoms: Single-arm open-label pilot clinical trial.","authors":"Vladimir Student, Vaclav Repa, Jana Vrbkova, Jan Vacek","doi":"10.5507/bp.2026.002","DOIUrl":"10.5507/bp.2026.002","url":null,"abstract":"<p><strong>Background: </strong>Chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent urological disorder with a significant impact on quality-of-life. This study assessed the effects of rectal administration of dual cannabidiol (CBD)/hyaluronic acid (HA)-based therapy in men with CP/CPPS.</p><p><strong>Methods: </strong>A single-arm, open-label pilot trial on 16 men (24-49 years) with CP/CPPS (NIH Chronic Prostatitis Symptom Index [NIH-CPSI] >10, pain subscore ≥4). The participants self-administered rectal CANNEFF® suppositories containing CBD (100 mg) and HA (6.6 mg) as active ingredients, nightly for 30 days. Outcome measures included changes in NIH-CPSI total score, International Prostate Symptom Score (IPSS), and International Index of Erectile Function (IIEF-5). Safety and tolerability were also assessed.</p><p><strong>Results: </strong>The median baseline NIH-CPSI score was 24.5 points (range 11, 39) decreasing to a median 20.0 (range 2, 26) at day 30 (P=0.003), with a median reduction of 7.0 points (range -20.0, 6.0). Symptom improvement was found in 81.3 % (13/16) of participants. The IPSS total score decreased from a median of 14.0 points (range 4, 32) to a median 12.0 (range 3, 18) (P=0.033), with voiding symptoms showing the largest improvement. The IIEF-5 score increased modestly but without statistical significance. No adverse events were reported.</p><p><strong>Conclusions: </strong>The administration of the suppositories with CBD/HA action demonstrated potential symptom relief in CP/CPPS with a favourable tolerability profile. A more nuanced analysis of NIH-CPSI changes and IPSS and IIEF-5 data suggests a clinically meaningful benefit for most participants.</p>","PeriodicalId":520569,"journal":{"name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","volume":" ","pages":"47-52"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pilot study on the feasibility and initial outcomes of a telerehabilitation system for balance and cognitive training in older adults.","authors":"Milada Luisa Sedivcova, Karla Mothejlova, Karel Hana, Jan Kaspar, Aneta Buchtelova","doi":"10.5507/bp.2025.018","DOIUrl":"10.5507/bp.2025.018","url":null,"abstract":"<p><strong>Aims: </strong>This randomized controlled multicentric pilot study aimed to evaluate the feasibility, safety, and preliminary clinical efficacy of a home-based telerehabilitation system for improving balance and cognitive function in older adults.</p><p><strong>Methods: </strong>The study was conducted in two four-week phases across multiple centres. In Phase A (n=18), participants were randomized into an experimental group (n=10) using a telerehabilitation balance training module (Stability Module) and a control group (n=8) receiving standard kinesiotherapy. In Phase B (n=11), a second cohort was randomized into an experimental group (n=5) receiving combined balance and cognitive training (Stability + ActiveCOG Modules) and a control group (n=6) receiving standard therapy. Outcomes were measured using the Berg Balance Scale (BBS) and Mini Mental State Examination (MMSE). Statistical analysis included paired t-tests, Fisher's exact test, Wilcoxon rank-sum test, and effect size estimation using Cohen's d.</p><p><strong>Results: </strong>In Phase A, both the experimental and control groups showed significant within-group improvements in balance (BBS: P=0.004 and P=0.041, respectively), with no significant difference between groups. In Phase B, the intervention group demonstrated significant within-group improvements in both balance (BBS: P=0.009) and cognitive function (MMSE: P=0.034), while between-group differences did not reach statistical significance (P≥0.05). Effect sizes in Phase B suggested substantial clinical relevance (Cohen's d>1.0).</p><p><strong>Conclusion: </strong>The study confirmed the feasibility and safety of the telerehabilitation system and highlighted its usability in home environments. While preliminary clinical improvements were observed, particularly with combined motor-cognitive training, the small sample size limits definitive conclusions. These findings support the feasibility of larger, longer-term trials to further evaluate clinical efficacy and scalability.</p>","PeriodicalId":520569,"journal":{"name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","volume":" ","pages":"53-61"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostics of olfactory dysfunction in Parkinson's disease - a literature overview and case series.","authors":"Libor Vasina, Nikola Pastorkova, Oleksii Vorobiov, Karla Janouskova, Petra Dytrych, Jiri Hlozek, Sarka Musilova, Jaromir Astl, Richard Holy","doi":"10.5507/bp.2025.021","DOIUrl":"10.5507/bp.2025.021","url":null,"abstract":"<p><p>Olfactory dysfunction is increasingly recognised for its predictive value as an early indicator of a number of degenerative neuropathologies including Parkinson's Disease (PD). In this overview, we cover the relationship between PD and olfactory dysfunction (OD). Prodromal premotor symptoms of PD include sleep disturbances, psychiatric disorders, constipation and OD. The latter can precede motor symptoms by several years and its occurrence is frequent in Parkinson s disease with a prevalence that can range from 45%-90%. Olfactory perception in these cases can be tested using subjective and objective methods. Commonly used psychophysical tests in the Czech Republic include Sniffin' Sticks Tests and the Odorized Marker Test but these may be inaccurate and demanding on patients with cognitive deficits in addition to motor symptoms. For these reasons, objective electrophysiological olfactory tests that depend on olfactory/trigeminal event-related potentials (OERPs/TERPs) for example are more useful. In this paper we describe a series of case reports, demonstrating the importance of comprehensive olfactory examination. The significance of objective electrophysiological olfactory/ trigeminal tests in the diagnosis of PD, is underscored given the rising incidence of this condition and the need for early diagnosis.</p>","PeriodicalId":520569,"journal":{"name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","volume":" ","pages":"8-14"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring acute cellular rejection in lung transplantation: insights from donor-derived cell-free DNA analysis.","authors":"Andrea Zajacova, Majd Alkhouri, Miray Guney, Goncalo Ferrao, David Rezac, Kristyna Vyskocilova, Tereza Kotowski, Alzbeta Dutkova, Eliska Dvorackova, Robert Lischke, Libor Fila, Jan Havlin","doi":"10.5507/bp.2025.016","DOIUrl":"10.5507/bp.2025.016","url":null,"abstract":"<p><strong>Background: </strong>Acute cellular rejection (ACR) is a frequent complication following lung transplantation, yet standardized guidelines for ACR screening remain lacking. This study aimed to compare the current gold standard for ACR evaluation - histological assessment of transbronchial biopsies - with a novel biomarker for allograft monitoring: donor-derived cell-free DNA (dd-cfDNA). Specifically, we investigated whether total cell-free DNA (cfDNA) and both the absolute and percentage values of dd-cfDNA (dd-cfDNA and dd-cfDNA%) could provide valuable insights into detecting ACR and assessing allograft health.</p><p><strong>Methods: </strong>Patients after bilateral lung transplantation between May 2021 and March 2024 were included. Clinically significant ACR cases (ACR+) were defined as samples with histological ACR grade ≥A2 or ACR grade A1 in patients who have received antirejection therapy due to symptoms, CT findings, or lung function decline. Samples with A0 or A1 rejection in clinically stable, untreated patients were classified as controls. Measurements of dd-cfDNA%, dd-cfDNA (cp/mL) and total cfDNA (cp/mL) were obtained at the time of biopsy and compared between cohorts.</p><p><strong>Results: </strong>The median dd-cfDNA concentration was significantly higher in the ACR+ group (61.2 cp/mL, IQR: 38.7-114.1) compared to controls (25.8 cp/mL, IQR: 10.7-65.7; P=0.04). However, no significant differences were observed for dd-cfDNA% and cfDNA.</p><p><strong>Conclusion: </strong>Dd-cfDNA shows promise as a valuable tool for ruling out ACR; however, further research is necessary in order to validate its clinical utility and optimize its implementation. Its negative predictive value supports dd-cfDNA as an effective screening tool for allograft health, nevertheless, further investigation is required.</p>","PeriodicalId":520569,"journal":{"name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","volume":" ","pages":"33-39"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144113282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copeptin as a promising biomarker of cerebrovascular events: A minireview.","authors":"Kamila Smolikova, Pavel Potuznik, Marek Peterka, Jakub Vejskal, Martina Pestova","doi":"10.5507/bp.2025.028","DOIUrl":"10.5507/bp.2025.028","url":null,"abstract":"<p><p>Cerebrovascular events remain a major health issue, and despite significant improvements in diagnosis and treatment in recent years, their high morbidity and mortality mean that increasing attention is now being given to prevention and early prediction. One option for achieving this is to examine various biomarkers. This mini review covers copeptin, a 39-amino-acid glycopeptide, derived from the precursor protein pre-provasopressin. Copeptin shows great potential in the diagnosis and prognosis of diverse diseases, including cerebrovascular events. Compared to arginine vasopressin or cortisol alone, it shows better potential for use in emergency care due to its rapid determination. Understanding the role of copeptin and its clinical applications is essential for advancing patient care and treatment strategies. This mini review presents selected studies on the use of copeptin as a potential biomarker for cerebrovascular events. Its level correlates with the severity of both clinical and radiological impairment after a stroke. A correlation has been demonstrated between copeptin levels and the ability to predict a cerebrovascular event recurrence within 90 days after a transient ischemic attack. This mini review also includes the limits to copeptin, which are influenced by selected vascular risk factors for cerebrovascular events.</p>","PeriodicalId":520569,"journal":{"name":"Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia","volume":" ","pages":"15-19"},"PeriodicalIF":0.7,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}