Annals of behavioral medicine : a publication of the Society of Behavioral Medicine最新文献

{"title":"Developing a skill-based intervention to address social health needs of adolescents and young adults with cancer: an ORBIT Phase 1 Study.","authors":"Kaitlyn M Fladeboe, Alison O'Daffer, Ruth A Engelberg, John M Salsman, Thomas Merluzzi, K Scott Baker, Joyce P Yi-Frazier, Abby R Rosenberg","doi":"10.1093/abm/kaaf012","DOIUrl":"https://doi.org/10.1093/abm/kaaf012","url":null,"abstract":"<p><strong>Background: </strong>Few interventions have improved social health of adolescents and young adults (AYAs) with cancer. Following the obesity-related behavioral intervention trials model, we developed a skill-based social needs module for integration within the Promoting Resilience in Stress Management (PRISM)  behavioral intervention.</p><p><strong>Methods: </strong>The social needs module targeting social relationship coping efficacy included behavioral skills adapted to AYAs. The module was refined through 2 separate pilot studies. For Study 1, AYAs 12-24 years old completed the module and a feedback interview. Rapid assessment process methods assessed acceptability, appropriateness, understandability, and informed content revisions. For Study 2, AYAs completed PRISM plus the social needs module (PRISM + Social Needs) and a feedback interview. Rapid assessment process methods assessed acceptability of program and session length, timing, and format.</p><p><strong>Results: </strong>For Study 1, 6 AYAs completed the initial module focused on identifying and seeking support (mean age = 16 years); most found content acceptable and appropriate (4/6) but suggested adding skills for maintaining social connections and managing cancer-related conversations. Seven AYAs completed the revised module and interview (M = 16 years old); most found content acceptable (6/7) and appropriate (7/7) and suggestions were minimal. For Study 2, 7 AYAs completed the revised full program (M = 16 years old). Most were satisfied with program length (4/7) and duration (7/7); preferred in-person over virtual delivery (6/7); and wanted PRISM + Social Needs early in treatment (5/7).</p><p><strong>Conclusions: </strong>A skill-based social needs module may be acceptable, appropriate, and promising for AYAs. The PRISM + Social Needs intervention may be best delivered in-person and early in treatment, suggesting AYAs value face-to-face connection. Findings inform subsequent proof-of-concept studies.</p>","PeriodicalId":520558,"journal":{"name":"Annals of behavioral medicine : a publication of the Society of Behavioral Medicine","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144251783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Covariation of daily stressors and alcohol use among adults aged 50+ years: differences across stressor characteristics and individual factors.","authors":"Sara E Miller, Jennifer L Maggs, David M Almeida","doi":"10.1093/abm/kaaf041","DOIUrl":"10.1093/abm/kaaf041","url":null,"abstract":"<p><strong>Background: </strong>Several theoretical frameworks suggest connections between stress and alcohol use. However, limited existing literature has focused on older adults, and associations may vary across stressor and individual characteristics.</p><p><strong>Purpose: </strong>The current study extends the stress-drinking literature by assessing the same-day covariation of daily stressors and alcohol use among a national sample of adults aged 50+ years.</p><p><strong>Methods: </strong>Participants (N = 1,035; Mage=61.62 years; range = 50-83) were non-abstaining adults who participated in an 8-day daily diary project in the National Study of Daily Experiences.</p><p><strong>Results: </strong>Multilevel logistic regression analyses revealed no main effects of stressor exposure (OR = 1.07; 95% CI: 0.93, 1.24), stressor quantity (OR = 1.09; 95% CI: 0.98, 1.20), or stressor severity (OR = 1.06; 95% CI: 0.99, 1.14) on likelihood of same-day alcohol consumption. There were differences by stressor domain. Days with non-work stressors were associated with a 13% greater likelihood of alcohol use compared to days without non-work stressors (OR = 1.13; 95% CI = 1.004, 1.27). In contrast, likelihood of alcohol consumption did not differ between days with work stressors compared to days without work stressors (OR = 0.90; 95% CI = 0.71, 1.13). Several between-person factors were found to moderate associations between daily stressors and alcohol use. Specifically, older age, lower educational attainment, and reporting alcohol-related problems strengthened associations between some daily stressor characteristics and likelihood of same-day alcohol use.</p><p><strong>Conclusions: </strong>Study findings suggest individual differences in middle-aged and older adults' drinking on days with daily stressors. Results may inform efforts to provide personalized alcohol use education and intervention to adults aged 50+ years.</p>","PeriodicalId":520558,"journal":{"name":"Annals of behavioral medicine : a publication of the Society of Behavioral Medicine","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144218524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological distress and substance use among transgender and gender diverse adults in the United States: an intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy.","authors":"Rodrigo Aguayo-Romero, Ariel Beccia, Mai-Han Trinh, Sari L Reisner","doi":"10.1093/abm/kaaf022","DOIUrl":"https://doi.org/10.1093/abm/kaaf022","url":null,"abstract":"<p><strong>Background: </strong>Transgender and gender diverse (TGD) populations have high mental and behavioral health morbidity, yet few studies have explored inequities in TGD people at the intersection of multiple identities.</p><p><strong>Purpose: </strong>This study sought to describe inequities in severe psychological distress and substance use by gender/sex, race, and socioeconomic status (SES) in TGD adults.</p><p><strong>Methods: </strong>We conducted an intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA) with 25 443 TGD people in the 2015 US Transgender Survey, nested within 48 intersectional social strata defined by gender/sex, race/ethnicity, and SES. For each outcome, a multilevel intersectional logistic model was fit with the additive effects of gender/sex, race/ethnicity, and SES and adjusting for age, gender expression, and US region.</p><p><strong>Results: </strong>Mean age was 31 years (SD = 13); 35% were transgender women, 30% transgender men, 7% nonbinary assigned-male-at-birth, 29% nonbinary assigned-female-at-birth; 18% BIPOC; and 34% SES below poverty. Stratum-specific predicted outcome probabilities ranged from: 26%-64% severe psychological distress, 21%-36% binge drinking, 19%-37% cannabis use, 7%-12% illicit drug use, and 16%-34% cigarette smoking. Highest probabilities of cannabis and illicit drug use were among transgender women below the poverty line identifying as Biracial/Multiracial (37% and 12%) and Black/African American (34% and 12%), respectively.</p><p><strong>Conclusion: </strong>Findings highlight the nuance of privilege and oppression, heterogeneity in groups that may share one identity, and need for public health and equity efforts.</p>","PeriodicalId":520558,"journal":{"name":"Annals of behavioral medicine : a publication of the Society of Behavioral Medicine","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144228389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Implications of Being \"In it Together\": Relationship Satisfaction and Joint Health Behaviors Predict Better Health and Stronger Concordance Between Partners.","authors":"Stephanie J Wilson,&nbsp;Joshua R Novak","doi":"10.1093/abm/kaab099","DOIUrl":"https://doi.org/10.1093/abm/kaab099","url":null,"abstract":"<p><strong>Background: </strong>Extensive evidence shows that satisfying marriages boost physical health and longevity. A separate literature reveals strong concordance in couples' health, but the relationship processes that contribute to health concordance remain poorly understood.</p><p><strong>Purpose: </strong>The current study examined whether relationship satisfaction and joint health behaviors-the extent to which couples eat, sleep, and exercise together-are associated simultaneously with better health and greater health similarity between partners.</p><p><strong>Methods: </strong>Heterogeneous variance multilevel models were applied to data from 234 married couples (Mage = 46, Range = 20-84) reporting on their relationship satisfaction, joint health behaviors, and four health indicators-health satisfaction, depressive symptoms, comorbidities, and medication use.</p><p><strong>Results: </strong>More satisfied couples engaged in more joint health behaviors than less satisfied counterparts. When joint health behaviors and relationship satisfaction were examined as separate fixed effects, both predicted greater health satisfaction and fewer depressive symptoms. More joint health behaviors were also associated with less medication use. When both were modeled together, only relationship satisfaction predicted depressive symptoms. By contrast, in random effects, joint health behaviors predicted greater similarity in health satisfaction, depressive symptoms, and comorbidities. Relationship satisfaction only predicted more similar depressive symptoms.</p><p><strong>Conclusions: </strong>Although more satisfied couples engaged in more joint health behaviors. relationship satisfaction and joint health behaviors uniquely predicted couples' health quality and concordance, suggesting that distinct mechanisms may drive better health and stronger health resemblance.</p>","PeriodicalId":520558,"journal":{"name":"Annals of behavioral medicine : a publication of the Society of Behavioral Medicine","volume":" ","pages":"1014-1025"},"PeriodicalIF":3.8,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528786/pdf/kaab099.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39933380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioral and Cognitive Outcomes of an Online Weight Loss Program for Men With Low Mood: A Randomized Controlled Trial.","authors":"Ryan J Drew,&nbsp;Philip J Morgan,&nbsp;Clare E Collins,&nbsp;Robin Callister,&nbsp;Frances Kay-Lambkin,&nbsp;Brian J Kelly,&nbsp;Myles D Young","doi":"10.1093/abm/kaab109","DOIUrl":"https://doi.org/10.1093/abm/kaab109","url":null,"abstract":"<p><strong>Background: </strong>Depression and obesity are major health concerns and commonly co-exist, but men rarely seek help for these conditions. SHED-IT: Recharge was a gender-tailored eHealth program for men that generated clinically meaningful improvements in weight and depressive symptoms.</p><p><strong>Purpose: </strong>To evaluate behavioral and psychological outcomes from the SHED-IT: Recharge intervention designed for overweight/obese men with low mood.</p><p><strong>Methods: </strong>Overall, 125 men (18-70 years) with a BMI between 25 and 42 kg/m2 and depressive symptoms (PHQ-9 ≥ 5) were randomly allocated to SHED-IT: Recharge (n = 62) or wait-list control (n = 63) groups. The self-directed program targeted key health behaviors combined with online mental fitness modules based on cognitive behavioral therapy. Behavioral (e.g., physical activity) and psychological outcomes (e.g., cognitive flexibility) were assessed with validated measures at baseline, 3 months (post-test) and 6 months (follow-up). Intention-to-treat linear mixed models examined treatment effects, which were adjusted for covariates, and effect size estimated (Cohen's d).</p><p><strong>Results: </strong>At post-test, intervention men achieved small-to-medium improvements in several health behavior outcomes including moderate-to-vigorous physical activity, light physical activity, sedentary behavior, sleep, energy intake, portion size, and risky alcohol consumption (range, d = 0.3-0.5), when compared with the control group. Intervention effects were also observed for perceived physical self-worth, perceived physical strength, cognitive flexibility, and behavioral activation (range, d = 0.3-0.8). No effects were found for fruit and vegetable intake, or mindful attention. Most effects were maintained at follow-up.</p><p><strong>Conclusions: </strong>This gender-tailored, eHealth program with integrated mental fitness support elicited meaningful improvements in health behaviors and psychological outcomes for men with low mood. Trial Registration: Australian New Zealand Clinical Trials Registry (ACTRN12619001209189).</p>","PeriodicalId":520558,"journal":{"name":"Annals of behavioral medicine : a publication of the Society of Behavioral Medicine","volume":" ","pages":"1026-1041"},"PeriodicalIF":3.8,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39859090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dyadic Investigation of Depressed Affect and Interspousal Behavior in Couples With Chronic Back Pain.","authors":"Kristina M Post,&nbsp;David A Smith,&nbsp;John W Burns,&nbsp;Laura S Porter,&nbsp;Francis J Keefe","doi":"10.1093/abm/kaab100","DOIUrl":"https://doi.org/10.1093/abm/kaab100","url":null,"abstract":"<p><strong>Background: </strong>Depression and marital discord are characteristic not only of individuals with chronic low back pain (ICPs) but also of their spouses.</p><p><strong>Purpose: </strong>We examined actor-partner interdependence models to evaluate associations among depressed affect and criticism and support of partners at the same time point (concurrent effects) and 3 hr later (lagged effects). Fully dyadic models were used to account for both within-person and cross-spouse associations among depressed affect, criticism, and support for ICPs and spouses. We also examined the direction of the relationships (depressed affect predicting behavior and behavior predicting depressed affect) all while controlling for pain intensity, pain behavior, and the prior dependent variable.</p><p><strong>Methods: </strong>ICPs (n = 105) and their spouses completed electronic diary measures of depressed affect and behavior (criticism and support) five times a day for 2 weeks. Hierarchical linear modeling with person-mean centering was used for data analysis.</p><p><strong>Results: </strong>Within the same 3 hr epoch, more depressed affect was related to higher criticism and generally less support. Lagged analyses suggested bidirectional relationships between spouse's own depressed affect and spouse's own criticism of ICPs. Spouse depressed affect was also associated with decreased support received from ICPs. Pain behavior and pain intensity were also related to depressed affect, criticism, and support especially concurrently.</p><p><strong>Conclusions: </strong>Theories and interventions need to address not only ICP depressed affect but also spouse depressed affect, as spouse depressed affect may be a stress generating precursor to criticism and support.</p>","PeriodicalId":520558,"journal":{"name":"Annals of behavioral medicine : a publication of the Society of Behavioral Medicine","volume":" ","pages":"1002-1013"},"PeriodicalIF":3.8,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9528785/pdf/kaab100.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39933384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choice and the Placebo Effect: A Meta-analysis.","authors":"Biya Tang,&nbsp;Kirsten Barnes,&nbsp;Andrew Geers,&nbsp;Evan Livesey,&nbsp;Ben Colagiuri","doi":"10.1093/abm/kaab111","DOIUrl":"https://doi.org/10.1093/abm/kaab111","url":null,"abstract":"<p><strong>Background: </strong>Choice has been proposed as a method of enhancing placebo effects. However, there have been no attempts to systematically evaluate the magnitude, reliability, and moderators of the influence of choice on the placebo effect.</p><p><strong>Purpose: </strong>To estimate the effect size of choice on the placebo effect and identify any moderators of this effect.</p><p><strong>Methods: </strong>Web of Science, PsycINFO, EMBASE, and PubMed were systematically searched from inception to May 2021 for studies comparing placebo treatment with any form of choice over its administration (e.g., type, timing) to placebo treatment without choice, on any health-related outcome. Random-effects meta-analysis was then used to estimate the effect size associated with the influence of choice on the placebo effect. Meta-regression was subsequently employed to determine the moderating effect of factors such as type of choice, frequency of choice, and size of the placebo effect without choice.</p><p><strong>Results: </strong>Fifteen independent studies (N = 1,506) assessing a range of conditions, including pain, discomfort, sleep difficulty, and anxiety, met inclusion criteria. Meta-analysis revealed that choice did significantly enhance the placebo effect (Hedges' g = 0.298). Size of the placebo effect without choice was the only reliable moderator of this effect, whereby a greater effect of choice was associated with smaller placebo effects without choice.</p><p><strong>Conclusions: </strong>Treatment choice can effectively facilitate the placebo effect, but this effect appears more pronounced in contexts where the placebo effect without choice is weaker. Because most evidence to date is experimental, translational studies are needed to test whether providing choice in clinical scenarios where placebo effects are weaker may help boost the placebo effect and thereby improve patient outcomes.</p>","PeriodicalId":520558,"journal":{"name":"Annals of behavioral medicine : a publication of the Society of Behavioral Medicine","volume":" ","pages":"977-988"},"PeriodicalIF":3.8,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39815371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Parents' Health and Social Control Behaviors and Their Adolescent's Self-Efficacy and Health Behaviors: Insights From the Family Life, Activity, Sun, Health, and Eating (FLASHE) survey.","authors":"Monique S Nakamura,&nbsp;Chloe O Huelsnitz,&nbsp;Alexander J Rothman,&nbsp;Jeffry A Simpson","doi":"10.1093/abm/kaab113","DOIUrl":"https://doi.org/10.1093/abm/kaab113","url":null,"abstract":"<p><strong>Background: </strong>Parents can influence their children to live healthier lifestyles by modeling healthy behaviors and/or trying to persuade their children to engage in healthier activities. Adolescents and their parents tend to have similar eating and exercise patterns, but less is known about the simultaneous influence of parent's health behavior and social control on adolescents' self-efficacy and health behaviors, including whether their effect is moderated by parenting style.</p><p><strong>Purpose: </strong>We examine the degree to which parents' social control and health behaviors are associated with their adolescent's self-efficacy and health behaviors, including whether parenting styles moderate these associations.</p><p><strong>Method: </strong>We analyzed data from the Family Life, Activity, Sun, Health, and Eating project.</p><p><strong>Results: </strong>We found that parents' own health behaviors are positively and strongly associated with their adolescent's health behaviors across four domains: fruit/vegetable consumption, junk food consumption, physical activity, and nonacademic screen time. We found positive, moderate-to-strong associations between parents' use of social control and their adolescents' fruit/vegetable and junk food consumption, small negative associations with screen time, and no associations with physical activity. The effects of social control for junk food consumption and screen time, however, depended on parents' own behavior in those domains. Parent responsiveness moderated the relation between parents' social control and their adolescent children's self-efficacy and health behaviors.</p><p><strong>Conclusions: </strong>The health behaviors parents model and their social control efforts are associated with their adolescents' beliefs and behavior. Efforts to leverage parents as sources of influence must consider the context in which influence is enacted.</p>","PeriodicalId":520558,"journal":{"name":"Annals of behavioral medicine : a publication of the Society of Behavioral Medicine","volume":" ","pages":"920-932"},"PeriodicalIF":3.8,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39817284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Hypertensive Men Spy With an Angry Little Eye? Anger Recognition in Men With Essential Hypertension - Cross-sectional and Prospective Findings.","authors":"Alisa Auer,&nbsp;Roland von Känel,&nbsp;Ilona Lang,&nbsp;Livia Thomas,&nbsp;Claudia Zuccarella-Hackl,&nbsp;Cathy Degroote,&nbsp;Angelina Gideon,&nbsp;Roland Wiest,&nbsp;Petra H Wirtz","doi":"10.1093/abm/kaab108","DOIUrl":"https://doi.org/10.1093/abm/kaab108","url":null,"abstract":"<p><strong>Background: </strong>Higher trait anger has inconsistently been associated with hypertension and hypertension development, but social context in terms of recognition of other persons' anger has been neglected in this context.</p><p><strong>Purpose: </strong>Here, we investigated anger recognition of facial affect and trait anger in essential hypertensive and normotensive men in addition to prospective associations with blood pressure (BP) increases.</p><p><strong>Methods: </strong>Baseline assessment comprised a total of 145 participants including 57 essential hypertensive and 65 normotensive men who were otherwise healthy and medication-free. Seventy-two eligible participants additionally completed follow-up assessment 3.1 (±0.08 SEM) years later to analyze BP changes over time. We assessed emotion recognition of facial affect with a paradigm displaying mixed facial affect of two morphed basic emotions including anger, fear, sadness, and happiness. Trait anger was assessed with the Spielberger trait anger scale.</p><p><strong>Results: </strong>Cross-sectionally, we found that with increasing BP, hypertensive men overrated anger displayed in facial expressions of mixed emotions as compared to normotensive men (ps ≤ .019) while there were no differences in trait anger (p = .16). Prospectively, the interaction between mean anger recognition and trait anger independently predicted BP increases from baseline to follow-up (ps ≤ .043), in that overrating displayed anger predicted future BP increases only if trait anger was high.</p><p><strong>Conclusions: </strong>Our findings indicate an anger recognition bias in men with essential hypertension and that overrating displayed anger in combination with higher trait anger seems to predict future BP increases. This might be of clinical relevance for the development and progression of hypertension and cardiovascular disease.</p>","PeriodicalId":520558,"journal":{"name":"Annals of behavioral medicine : a publication of the Society of Behavioral Medicine","volume":" ","pages":"875-889"},"PeriodicalIF":3.8,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40318304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social Genomics of Methamphetamine Use, HIV Viral Load, and Social Adversity.","authors":"Michael J Li,&nbsp;Emily I Richter,&nbsp;Chukwuemeka N Okafor,&nbsp;Mariah M Kalmin,&nbsp;Shareefa Dalvie,&nbsp;Sae Takada,&nbsp;Pamina M Gorbach,&nbsp;Steven J Shoptaw,&nbsp;Steven W Cole","doi":"10.1093/abm/kaab096","DOIUrl":"https://doi.org/10.1093/abm/kaab096","url":null,"abstract":"<p><strong>Background: </strong>Social genomics has demonstrated altered inflammatory and type I interferon (IFN) gene expression among people experiencing chronic social adversity. Adverse social experiences such as discrimination and violence are linked to stimulant misuse and HIV, conditions that dysregulate inflammatory and innate antiviral responses, leading to increased HIV viral replication and risk of chronic diseases.</p><p><strong>Purpose: </strong>We aimed to determine whether methamphetamine (MA) use, unsuppressed HIV viral load (VL) (≥200 c/mL), and experienced intimate partner violence (IPV) (past 12 months) predicted inflammatory and type I IFN gene expression in HIV-positive Black and Latinx men who have sex with men (MSM).</p><p><strong>Methods: </strong>Participants were 147 HIV-positive Black and Latinx MSM recruited from the mSTUDY, a cohort of 561 MSM aged 18-45 in Los Angeles, CA, of whom half are HIV-positive and substance-using. Transcriptomic measures of inflammatory and type I IFN activity were derived from RNA sequencing of peripheral blood mononuclear cells and matched to urine drug tests, VL, and survey data across two time points 12 months apart. Analysis used linear random intercept modeling of MA use, unsuppressed VL, and experienced IPV on inflammatory and type I IFN expression.</p><p><strong>Results: </strong>In adjusted models, MA use predicted 27% upregulated inflammatory and 31% upregulated type I IFN expression; unsuppressed VL predicted 84% upregulated type I IFN but not inflammatory expression; and experienced IPV predicted 31% upregulated inflammatory and 26% upregulated type I IFN expression.</p><p><strong>Conclusions: </strong>In Black and Latinx MSM with HIV, MA use, unsuppressed VL, and experienced IPV predicted upregulated social genomic markers of immune functioning.</p>","PeriodicalId":520558,"journal":{"name":"Annals of behavioral medicine : a publication of the Society of Behavioral Medicine","volume":" ","pages":"900-908"},"PeriodicalIF":3.8,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424866/pdf/kaab096.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33447007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}