Intestinal Failure (New York, N.Y.)最新文献

{"title":"Post-transplant lymphoproliferative disorder following multivisceral transplantation: Incidence, risk factors, and outcomes in an adult UK cohort.","authors":"C Curran, F Kaji, F Lopez, M Polamreddy, A Butler, N Russell, A Santarsieri, C Rutter","doi":"10.1016/j.intf.2025.100350","DOIUrl":"10.1016/j.intf.2025.100350","url":null,"abstract":"<p><strong>Background: </strong>Post transplant lymphoproliferative disorder (PTLD) incidence is highest in patients undergoing intestinal and multivisceral transplantation (MVT). We describe our experience of PTLD in a large cohort of adult MVT patients.</p><p><strong>Materials and methods: </strong>We performed a retrospective cohort study of 163 consecutive patients undergoing intestinal and multivisceral transplantation with alemtuzumab based induction from 2007 to 2024. Clinical data were obtained from patient records. Univariate analyses were performed to assess factors associated with PTLD development.</p><p><strong>Results: </strong>Twenty-nine patients (17.8 %) developed PTLD, of which 28/29 (96.6 %) were EBV associated. Cumulative incidence of PTLD adjusting for competing risk of death was 14.1 %, 19.7 % and 24.9 % at 1, 5, and 10 years, respectively. In those who developed PTLD median time to development of EBV viraemia was 6.6 months. Median initial EBV viral load log was 3.6. EBV serology mismatch between donor/recipient was the only variable significantly associated with PTLD development (OR 7.7, CI 2.9-20.0, P < 0.001). All patients received rituximab monotherapy initially. Of patients who had end of treatment radiological assessment (n = 23), overall response rate to rituximab was 56.5 %.</p><p><strong>Conclusion: </strong>There is a high incidence of PTLD in patients within the first year post intestinal transplant. EBV matching status is a potentially modifiable risk factor for PTLD development.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100350"},"PeriodicalIF":0.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthcare cost of home parenteral nutrition and intestinal transplantation for paediatric chronic intestinal failure in Singapore.","authors":"Fang Kuan Chiou, Ye Xin Koh, Lay Queen Ng, Lynette Goh, Yee Low, Yong Chen, Pui Ling Wai, Zhen Ling Ng, Debra Sudan, Prema Raj Jeyaraj","doi":"10.1016/j.intf.2026.100351","DOIUrl":"10.1016/j.intf.2026.100351","url":null,"abstract":"<p><strong>Background: </strong>Chronic intestinal failure (IF) and long-term parenteral nutrition (PN) impose significant financial burden on patients and the healthcare system. This study aimed to evaluate the healthcare cost of home-PN (HPN) and intestinal transplantation (ITx) at a single-centre.</p><p><strong>Methods: </strong>This was a cost-of-illness evaluation based on retrospective analysis of billing records of patients (0-18 years) receiving HPN in 2016-2025 (excluding hospital-PN). Annual HPN cost was calculated based on average cost during the latest 3 years of HPN. Cost of ITx (since 2022) included index hospitalisation for transplant surgery and all healthcare costs in the first 3 years following ITx (ITx-Y1/Y2/Y3).</p><p><strong>Results: </strong>Out of 35 patients with chronic IF, 11 patients on HPN with dysmotility(n = 6) and short bowel syndrome(n = 5) were included (median PN-duration: 6.5 years), with 4 eventually receiving ITx. Annual cost of HPN for patients who weaned-off HPN(n = 3), versus patients who remained stable on HPN(n = 3), and patients who developed complications from irreversible IF(n = 5) was S$70,227(US$51,638)/year, S$114,359(US$84,088)/year and S$219,510(US$161,404)/year respectively. Comparatively, mean cost of index hospitalisation for ITx was S$226,316(US$166,409). Cost was highest in ITx-Y1 (S$511,905/US$376,401), followed by 66-67 % year-on-year reduction to S$172,178(US$126,601) in ITx-Y2, and S$56,152(US$41,288) in ITx-Y3. Post-transplant lymphoproliferative disorder and cytomegalovirus infection contributed to wide variation in costs in ITx-Y1.</p><p><strong>Conclusions: </strong>Cost of HPN was highest in patients with irreversible IF. While ITx incurred the highest cost in ITx-Y1, there was substantial reduction in cost in the subsequent years, which may potentially be cost-saving in the long-term, as compared to continued HPN for patients with irreversible IF.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100351"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric intestinal failure due to firearm injury: A case series.","authors":"Hiyori Roberts, Yumiko Gely, Michael Carver, Alysse Baudier, Tijani Mohammed, Cassidy Wheeler, Jessica Aya Zagory","doi":"10.1016/j.intf.2025.100348","DOIUrl":"10.1016/j.intf.2025.100348","url":null,"abstract":"<p><strong>Background: </strong>Pediatric short bowel syndrome (SBS) is often secondary to congenital conditions such as malrotation with midgut volvulus, intestinal atresia, gastroschisis, or necrotizing enterocolitis. Traumatic injury secondary to firearms is a less common cause of SBS encountered in the United States. We aim to describe the morbidity affecting four children (ages 9-16 years) with SBS secondary to firearm injury.</p><p><strong>Case reports: </strong>All patients had extensive injury directly to the bowel and/or the intestinal blood supply, requiring parenteral and/or enteral nutrition at discharge. All patients had significant extra-intestinal manifestations, including peripheral neuropathy and biliary strictures, but did not exhibit changes seen with intestinal failure-associated liver disease. Two patients identified issues with food insecurity, reliable transportation, and difficulty adhering to the treatment plan due to low health literacy. All four had ongoing post-traumatic psychological needs. Two patients had encounters with law enforcement after discharge, with one patient requiring physicians advocating for continued treatment with parenteral nutrition while incarcerated.</p><p><strong>Conclusion: </strong>Firearm violence is the leading cause of pediatric death in the United States, but the morbidity endured by survivors, particularly those with SBS, is often not described. In addition to intestinal failure, we highlight this vulnerable population's medical, social, and psychological needs.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100348"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, perceptions and attitudes of pediatric residents and pediatricians in Colombia about intestinal failure.","authors":"Sofía Ortegón Ochoa, Clara Eugenia Plata García, Claudia Marcela Granados Rugeles","doi":"10.1016/j.intf.2025.100346","DOIUrl":"10.1016/j.intf.2025.100346","url":null,"abstract":"<p><strong>Objective: </strong>Intestinal failure is a high-cost pathology with a chronic course in which it is crucial to make an early diagnosis and timely referral to specialized centers in order to improve survival and reduce morbidity and mortality. The present study evaluated knowledge, attitudes, and perceptions about this diagnosis in health personnel who may be involved in the initial care of these children.</p><p><strong>Methods: </strong>This is a descriptive observational, cross-sectional, survey-type study with a non-probabilistic snowball sampling that took pediatrics residents and pediatricians in Colombia as the study population. The information was collected between July 2023 and March 2024.</p><p><strong>Results: </strong>There are shortcomings regarding the knowledge, diagnosis, management and complications of pediatric intestinal failure with a slightly higher proportion of correct concepts in pediatric residents. In both groups, the attitudes they take when facing a patient with this diagnosis are similar and in addition, both perceive that this pathology has an impact at the institutional, local and regional level.</p><p><strong>Conclusions: </strong>The present study shows that, despite being nationally recognized by health professionals, intestinal failure requires effective strategies to train pediatricians and pediatric residents. It is essential that they understand this pathology, the challenges involved in its management, and the importance of timely referral to multidisciplinary care centers to improve the prognosis and quality of life of both patients and their families.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100346"},"PeriodicalIF":0.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal preservation using a tailored luminal solution and aeration: A small animal study.","authors":"Jasmine Bagge, Arvind Manikantan Padma, Anna Casselbrant, Edina Sehic, Mats Hellström, Mihai Oltean","doi":"10.1016/j.intf.2025.100345","DOIUrl":"10.1016/j.intf.2025.100345","url":null,"abstract":"<p><strong>Background: </strong>Oxygenation during organ preservation has been suggested to enhance outcomes after transplantation, however, data is scarce regarding the intestine. We compared static cold storage (SCS) with two alternative approaches: a luminal polyethylene glycol solution enriched with glutamine and arginine (PEG-GAs), and the same luminal PEG solution combined with air insufflation.</p><p><strong>Methods: </strong>Small intestines of Sprague-Dawley rats were perfused in-situ with cold IGL-1, then divided into 3 segments: group 1 maintained in SCS, group 2 receiving additional luminal PEG-GAs and group 3 receiving luminal PEG-GAs and additional air insufflation. Samples were taken after eight, fourteen and 24 h of cold storage and analysed with western blot and histological assessment using light microscopy, immunofluorescence.</p><p><strong>Results: </strong>Intestinal grafts in groups 2 and 3 exhibited a consistent trend towards lower histological injury scores at all time points compared to group 1. Goblet cell depletion occurred more rapidly in group 1; zonula occludens-1 decreased rapidly in group 1 but was maintained for at least 14 h in groups 2 and 3. Tissue expression of several other tight junction (claudin 3 och 4, occludin, tricellulin) proteins also varied, suggesting a gradually compromised epithelial integrity in group 1 relative to the other two groups. Higher levels of caspase 3 expression were noted in group 1 at all time-points.</p><p><strong>Conclusion: </strong>The current results confirm that extensive tissue and molecular alterations ensue within eight hours of intestinal SCS. This study did not demonstrate significant advantages of additional air insufflation in the preservation solution over luminal preservation alone.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100345"},"PeriodicalIF":0.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The changing landscape of intestinal transplantation: Insights from the first quarter of the 21st century of Eurotransplant experience.","authors":"Mando D Filipe, Marit Kalisvaart, Manuel Maglione, Axel Jens, Stipislav Jadrijevic, Jan Willem Haveman, Andreas Pascher, Jacques Pirenne","doi":"10.1016/j.intf.2025.100349","DOIUrl":"10.1016/j.intf.2025.100349","url":null,"abstract":"<p><strong>Background: </strong>Intestinal transplantation (ITx) remains one of the most complex procedures in solid organ transplantation. This study analyzes 25 years of Eurotransplant data to evaluate trends, outcomes, and prognostic factors.</p><p><strong>Methods: </strong>Retrospective analysis of all intestinal transplant candidates and recipients within Eurotransplant (2000-2024) was performed. Survival analysis used Kaplan-Meier curves and Cox regression models. Primary outcomes included transplantation rates, waitlist mortality, and post-transplant overall survival.</p><p><strong>Results: </strong>Among 303 patients, 215 received transplants and 88 remained non-transplanted. Transplanted patients were younger (37.7 ± 16.0 vs 42.3 ± 16.3 years, p = 0.030). Isolated intestinal transplantation comprised 46.0 % of procedures, while combinations with other organs accounted for 54.0 %. Cumulative transplantation incidence reached 70 % at four years, with significantly higher rates for liver-inclusive procedures (95 % vs 85 %, p = 0.00041). Waitlist mortality reached 40 % at four years, with trends toward higher mortality in adults versus pediatric patients. Post-transplant overall survival showed better univariate outcomes for transplants without liver components (HR=0.61, p = 0.034), though this difference disappeared after multivariable adjustment. Transplant year was independently associated with worse survival (HR=1.062, p = 0.005), reflecting changing selection criteria as non-transplant management improved. Annual transplant volume declined from 17 procedures (2007-2010) to 4 in 2023, despite stable donor reporting.</p><p><strong>Conclusions: </strong>Despite declining volumes, Eurotransplant ITx provides life-saving treatment with 70 % transplantation rates and outcomes comparable to international registries. The paradoxical survival trends reflect the field's success in expanding indications to more complex patients as parenteral nutrition advances. Strategic approaches including program consolidation and enhanced donor utilization could further optimize this essential therapeutic option for irreversible intestinal failure.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100349"},"PeriodicalIF":0.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of non-oncologic metastasis: Keep calm and check the veins.","authors":"Imane Habbal, Francisca Joly, Raphael Bacquet, Eric Le Bihan, Flore de Castelbajac","doi":"10.1016/j.intf.2025.100342","DOIUrl":"https://doi.org/10.1016/j.intf.2025.100342","url":null,"abstract":"<p><p>We report the case of a 57-year-old patient with short bowel syndrome and chronic intestinal failure secondary to multiple resections for Crohn's disease, requiring parenteral nutrition (PN) since 1997. During an annual follow-up, the patient reported difficulties with his central venous access. Computed tomography (CT) revealed pseudo-sclerotic lesions of the T1-T3 vertebrae, suggestive of metastatic disease. Further imaging showed severe stenosis of the superior vena cava related to chronic thrombosis of the central venous line. Endovascular dilatation of the stenosed vein led to complete resolution of the lesions. This phenomenon, known as \"vanishing bone metastases\" (VBM), results from contrast reflux into collateral venous pathways, and can mimic bone metastases. Lack of recognition of this rare but significant radiological artifact may lead to unnecessary invasive procedures. Awareness of VBM is crucial, especially in patients on long-term PR who are at high risk of thrombosis, to prevent misdiagnosis and improve patient care.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100342"},"PeriodicalIF":0.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refeeding syndrome: Applicability of ASPEN criteria in patients with intestinal failure.","authors":"Héctor Solar, Mariana Laura Ortega, Lucía Blengini, Camila Cáceres, Gabriel Gondolesi","doi":"10.1016/j.intf.2025.100341","DOIUrl":"10.1016/j.intf.2025.100341","url":null,"abstract":"<p><strong>Background: </strong>Refeeding syndrome (RS) is defined as the reduction in serum levels of phosphorus, potassium, magnesium and/or thiamine, associated with the initiation of nutritional intake in patients with prolonged periods of low intake. In patients with intestinal failure (IF), risk factors for RS may be present. The aims of our study were to determine how many IF patients were at risk of RS, to determine how many of them developed RS and the accuracy of ASPEN risk criteria.</p><p><strong>Material and methods: </strong>A retrospective, observational, cross-sectional study was conducted. From January 2020 to July 2024 adult patients with IF diagnosis who started parenteral nutrition were included. The variables analyzed were sex, age, percentage of weight loss, BMI, pathophysiological classification of the IF, and serum values of potassium, magnesium, and phosphorus. Risk was classified as none, significant or moderate and the development as none, mild, moderate or severe.</p><p><strong>Results: </strong>A total of 86 adult patients were included, 20.9 % had no risk criteria for RS, 2.3 % had moderate risk, and 76.7 % had significant risk. Fifty percent of patients with no risk criteria and 54.4 % of patients who did have risk criteria developed RS. In 63.0 % IF patients it was mild, 26.1 % moderate and severe in 10.9 %. According to the pathophysiological classification of IF, there were no differences between the groups (p > 0.9).</p><p><strong>Conclusion: </strong>In this cohort of IF patients, 53.5 % developed RS. ASPEN criteria did not predict the development of 50 %. Sensitivity was 0.8 and specificity 0.23.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100341"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of vedolizumab in pediatric intestinal transplant rejection.","authors":"Shahira Ghobrial, Dimitrios Moris, Carolina Rumbo, Stuart S Kaufman, Gabriel Gondolesi, Dong Hyang Kwon, Yoshinori Takeda, Nada Yazigi, Udeme D Ekong, Thomas M Fishbein, Cal S Matsumoto, Alexander Kroemer, Khalid Khan","doi":"10.1016/j.intf.2025.100340","DOIUrl":"10.1016/j.intf.2025.100340","url":null,"abstract":"<p><strong>Background: </strong>Blockade of α4β7 integrin cell adhesion receptors on activated lymphocytes with the monoclonal antibody vedolizumab (VDZ) is efficacious in treatment of inflammatory bowel disease and most probably intestinal graft versus host disease (GVHD) after stem cell transplantation. Recently, there have been reports indicating that VDZ may be similarly effective in the treatment of acute rejection after intestinal transplantation (ITx). Herein, we report 3 additional cases.</p><p><strong>Case presentation: </strong>Mucosal recovery was achieved in 2 of the 3 patients, within 6 days after the first VDZ dose in one and with early restoration of enteral nutrition in the other. There was no response to VDZ in the third case. Complications potentially attributable to VDZ included graft pneumatosis and late-onset histoplasmosis.</p><p><strong>Conclusions: </strong>These cases describe both benefits and limitations of VDZ in ITx. They also suggest that VDZ may be useful in post-ITx rejection prophylaxis and for the treatment of intestinal GVHD.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100340"},"PeriodicalIF":0.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proof of principle study for the development of the world's smallest long-term short bowel syndrome pig model using microminipigs.","authors":"Hironori Kudo, Ryoma Endo, Eiji Kobayashi, Yuto Yamazaki, Motoshi Wada","doi":"10.1016/j.intf.2025.100344","DOIUrl":"10.1016/j.intf.2025.100344","url":null,"abstract":"<p><strong>Background: </strong>This study describes the development of a long-term short bowel syndrome (SBS) model that does not require parenteral nutrition (PN) using Microminipigs (MMP), the smallest experimental pigs, with an adult weight of ≤ 30 kg.</p><p><strong>Methods: </strong>Two MMPs were used to establish an SBS model. A 70 % small bowel resection was performed at 6 months of age (body weight, 5 kg), followed by an 85 % resection 4 months later. Untreated MMPs served as controls. Postoperative clinical conditions, weight, blood, and stool samples were monitored longitudinally. Nine months after the initial surgery, the animals were euthanized for organ collection and histological assessments.</p><p><strong>Results: </strong>Both treated MMPs remained in good general condition and continued to gain weight postoperatively. Plasma citrulline levels decreased after the second surgery, reflecting a reduced intestinal epithelial mass. At 7 months postoperatively (13 months of age), fecal fat was graded as 2 + in both treated MMPs, whereas the 38-month-old control showed a grade of 0. Histologically, jejunal villi were shorter, and goblet cells were smaller and fewer in the treated MMPs. Colonic crypts were taller in the treated MMPs, with no signs of inflammation or fibrosis in any tissue. Histological examination of the liver revealed no changes in fatty acid levels or fibrosis.</p><p><strong>Conclusions: </strong>The MMP SBS model demonstrated prolonged survival and maintained good health for nearly 9 months without PN, which is a significantly longer period than that reported in previous models. This model offers a practical and physiologically relevant platform for future translational and reverse translational studies on intestinal adaptation.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100344"},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}