Intestinal Failure (New York, N.Y.)最新文献

{"title":"Physical function, physical activity, muscle strength, and body composition: Clinical practice recommendations in pediatric intestinal failure and transplantation-position statement of the International Intestinal Rehabilitation and Transplant Association Allied Health Committee.","authors":"Catherine Patterson, Stephanie So, Dianna Yanchis, Taru Palsa, Jemma Mears, Dorsa Fathianpour, Sydney Dempster, Bianca Bondi, Esther Neelis, Christina Belza","doi":"10.1016/j.intf.2026.100366","DOIUrl":"10.1016/j.intf.2026.100366","url":null,"abstract":"<p><strong>Background: </strong>Pediatric survival rates in intestinal failure (IF) and transplant (ITx) have improved over time. However, surgery and prolonged hospitalization can impact motor function and levels of physical activity (PA), which is an essential health behaviour for physical, social, and mental health. This position paper provides clinical recommendations to optimize PA, strength, and exercise in children with IF and ITx.</p><p><strong>Methods: </strong>A working group of the IIRTA Allied Health committee conducted a literature review, identifying relevant articles between 2000 and 2023. Key recommendations were based on scientific evidence and expert-informed opinion.</p><p><strong>Results: </strong>Research indicates children with IF have altered body composition and lower physical function, PA, and muscle strength compared to healthy peers. They also have a higher prevalence of motor delays and an increased risk of sarcopenia pre-and post-ITx. Although exercise can potentially improve these outcomes, parents report unique barriers to PA including central lines and medical appliances. Key recommendations include:1) Early intervention with rehabilitation specialists in hospital and on discharge to the community.2) Education related to PA guidelines including aerobic intensity and strengthening activities.3) Provision of individualized exercise plans with communication and support in school/community settings.4) Ongoing screening at out-patient visits to monitor body composition, strength, and PA and address potential barriers and safety issues.5) Prioritizing multi-center research on PA benefits and effective interventions.</p><p><strong>Conclusions: </strong>This position paper offers actionable steps to optimize physical function, PA, and exercise, and highlights the need for research on exercise efficacy, safety, and intervention in this population.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"10 ","pages":"100366"},"PeriodicalIF":0.0,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13051960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of plasma aluminum on neurocognitive outcomes at early school age in children with intestinal failure.","authors":"Camille Maltais-Bilodeau, Rivka Green, Glenda Courtney-Martin, Daniela Gattini, Christina Belza, Anna Gold, Yaron Avitzur","doi":"10.1016/j.intf.2026.100365","DOIUrl":"10.1016/j.intf.2026.100365","url":null,"abstract":"<p><strong>Background: </strong>Aluminum (AL) is a known contaminant in parenteral nutrition (PN) and is associated with bone disease, and neurotoxicity. We aimed to evaluate the association between plasma AL concentration and neurocognitive outcomes at early school age, in children with intestinal failure (IF) receiving long-term PN.</p><p><strong>Methods: </strong>This retrospective cohort study included children diagnosed with IF before 2 years of age, with at least one measurement of plasma AL who completed a neuropsychological assessment between 4 and 8 years. Spearman correlation coefficient was used to explore the association between AL concentrations and neurocognitive scores.</p><p><strong>Results: </strong>Nineteen patients (12 males, median gestational age of 35 weeks) were included. The median number of PN years was 9.5 (IQR 7.4-11.8). Median and peak AL concentrations were 363 nmol/L (IQR 233-580) and 832 nmol/L (IQR 491.5-1361.5), respectively. Mean age at assessment was 6.32 + /-0.92 years. The mean full-scale intelligence quotient (FSIQ) was 95.8 + /-13.8. There was a moderate, inverse correlation between mean AL concentration before age three (- 0.56, p = 0.020) and FSIQ. For other domains, the strongest association was found between visual memory and the mean AL concentration before assessment (-0.67, p = 0.006).</p><p><strong>Conclusions: </strong>Higher plasma AL concentrations in children at early school age with IF were modestly associated with lower IQ and visual memory scores. Plasma AL monitoring allows early detection of abnormal plasma concentration, minimization of AL in PN and potentially prevention of neurotoxicity in young children with IF.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"10 ","pages":"100365"},"PeriodicalIF":0.0,"publicationDate":"2026-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12995869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147489209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teduglutide use in haemodialysis-dependent renal failure from secondary hyperoxaluria in short bowel syndrome and type 3 intestinal failure - A case report.","authors":"Elizabeth Sl Low, Brooke Chapman, Darren Wong","doi":"10.1016/j.intf.2026.100364","DOIUrl":"10.1016/j.intf.2026.100364","url":null,"abstract":"<p><strong>Background: </strong>Renal impairment is common in patients receiving long-term home parenteral nutrition (HPN) for short bowel syndrome-associated intestinal failure (SBS-IF). While glucagon-like peptide-2 (GLP-2) analogues like teduglutide are effective in reducing parenteral support (PS) requirements, data on their use in advanced stage chronic kidney disease (CKD) or haemodialysis are scarce.</p><p><strong>Case report: </strong>We describe a 66-year-old female with SBS-IF on HPN, complicated by hyperoxaluria and nephrocalcinosis contributing to stage 4 CKD. Initial renally-adjusted teduglutide dosing (0.025 mg/kg/day) enabled enteral autonomy, but was interrupted by intercurrent illness. As a result of progressive renal dysfunction, the patient was commenced on haemodialysis. Teduglutide was introduced post-dialysis at full dose (0.05 mg/kg), resulting in a sustained 36 % reduction in weekly PS requirements without adverse effects, despite recurrent sepsis.</p><p><strong>Conclusion: </strong>This case demonstrates a clinically significant teduglutide response in a haemodialysis-dependent SBS-IF patient, supporting post-dialysis dosing as a feasible strategy in this HPN cohort.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"10 ","pages":"100364"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12993407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147483098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional intake and growth in children with intestinal failure: An exploratory cross-sectional study.","authors":"Naoko Inamura, Miyuki Takeda, Manami Sasaki, Yumi Nishikawa, Chihiro Tanaka, Mikiko Fuda, Tsuyoshi Sakurai, Ryo Ando, Megumi Nakamura, Hironori Kudo, Ryoichi Nagatomi, Motoshi Wada","doi":"10.1016/j.intf.2026.100363","DOIUrl":"10.1016/j.intf.2026.100363","url":null,"abstract":"<p><strong>Objective: </strong>Studies investigating growth impairment (GI) in children with intestinal failure (IF) have seldom reported its associated factors. We hypothesized that a deficient nutritional intake would affect GI in children with IF.</p><p><strong>Methods: </strong>Nineteen patients (2-16 years old) who underwent home-based parenteral nutrition (PN) management at our institution, were divided into patients with or without GI (GI+/GI-). GI was defined as a height-for-age z-score (HAZ) ≤ -2. We performed between-group comparisons of HAZ in the intestinal rehabilitation program (IRP)/nutrition support team (NST) introduction time, PN dependency, residual small intestine length (RSIL), nutritional intake (calorie, protein, lipids, and carbohydrates), caloric intake ratio, and nutrient intake as a percentage of the recommended intake.</p><p><strong>Results: </strong>Six patients were in the GI+ group. PN dependency was significantly higher in the GI+ group (GI+, 109.8 %; GI < median, 61.7 %, P = 0.036). RSIL did not differ significantly between the groups (50 cm vs. 45 cm, P = 0.879). In the GI+ group, the caloric percentage of lipids was significantly lower (11.9 % vs. 17.5 %, P = 0.002), but that for carbohydrates was significantly higher (76.8 % vs. 66.8 %, P = 0.002), while lipid sufficiency was significantly lower (37.5 % vs. 89.6 %, respectively; P < 0.001). Protein intake in the GI+ group was significantly lower; however, the corresponding sufficiency was > 100 % in both groups (136.5 % vs. 209.2 %, P = 0.005).</p><p><strong>Conclusion: </strong>For children with IF, a low intake ratio of proteins and lipids relative to energy requirement and required nutrient levels may inhibit adequate growth.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"10 ","pages":"100363"},"PeriodicalIF":0.0,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147291701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporating solitary supplementary prescribing practice into an Advanced Practitioner role: The experience of a dietetic-based Advanced Practitioner in intestinal failure.","authors":"Maria Barrett, Antje Teubner, Ashley Bond, Simon Lal","doi":"10.1016/j.intf.2026.100361","DOIUrl":"10.1016/j.intf.2026.100361","url":null,"abstract":"<p><strong>Background: </strong>A new role within an intestinal failure unit was devised, which involved training a dietitian to undertake the role of an Advanced Practitioner working within the medical team. In the United Kingdom, dietitians can only undertake supplementary prescribing qualifications, and this study evaluates the safety and effectiveness of this type of prescribing practice in an intestinal failure Advanced Practitioner role.</p><p><strong>Materials and methods: </strong>All adult inpatients with types 2 and 3 intestinal failure were included. An appropriate clinical management plan was agreed by the multidisciplinary team and a medical and surgical consultant reviewed the prescriptions made, including the clinical indication and rationale. Descriptive statistical analysis was used and data presented as means (+/- standard deviation) for continuous variables and percentages for categorical variables.</p><p><strong>Results: </strong>A total of 1030 prescription episodes were made by the supplementary prescriber in the 6-month study period. Of these episodes, 96.2 % (<i>n</i> = 991) related to parenteral or intravenous fluid prescriptions; 13.6 % (<i>n</i> = 135) of which related to a combination of parenteral support and intravenous fluid prescriptions and 0.2 % (<i>n</i> = 2) of these episodes were for resuscitation purposes. No prescription amendments were required following a weekly review by the medical or surgical consultant.</p><p><strong>Conclusion: </strong>This study demonstrates that a dietetic-based Advanced Practitioner in a busy intestinal failure unit effectively and safely incorporated supplementary prescribing into their role. Supplementary prescribing was used to initiate a range of prescriptions, as part of a clinical management plan, and all were deemed to be the optimal prescription choice for the indication identified.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"10 ","pages":"100361"},"PeriodicalIF":0.0,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148348589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Paragonix LIVERguard® donor organ transport system for static hypothermic preservation of a multivisceral allograft.","authors":"Carolyn Smullin, Caitlin Thornley, Valeria Ripa, Brandon Pearson, Jonathan Jou, Robert S Venick, Vatche Agopian, Fady Kaldas, Samer Ebaid, Douglas G Farmer","doi":"10.1016/j.intf.2026.100362","DOIUrl":"10.1016/j.intf.2026.100362","url":null,"abstract":"<p><strong>Background: </strong>Intestine transplants are highly sensitive to ischemia-reperfusion injury (IRI). Static cold storage (SCS) is the standard for multivisceral (MVT) allograft preservation but carries known risks. While several devices have been developed for liver, lung, and heart graft preservation, there are no systems validated specifically for MVT grafts. We report the first use of the Paragonix LIVERguard® Donor Liver Transport System for hypothermic static preservation of a donation after brain death (DBD) MVT allograft, transported approximately 1363 miles.</p><p><strong>Methods: </strong>The Paragonix LIVERguard® was used to preserve a pediatric MVT graft during long-distance transport between the donor and recipient hospitals. We collected donor and recipient characteristics, ischemia intervals, lab markers of IRI, vasopressor duration, intensive care unit (ICU) and hospital length of stay, and time to enteral feeding.</p><p><strong>Results: </strong>The graft included liver, stomach, pancreas, spleen, small intestine, and colon. Cold ischemia time (CIT) was 6.8 h. The device maintained a mean temperature of 4.5°C (range: 3.8-5.2°C). Endoscopy showed no evidence of rejection. There was rapid normalization of both enzymatic injury markers (AST/ALT) and metabolic markers (lactate). Enteral feeding began on POD 13 and advanced to the goal. She was discharged home on POD 103.</p><p><strong>Conclusion: </strong>This case represents the first reported use of the Paragonix LIVERguard® for MVT graft preservation and transport. The device maintained a narrow temperature range over a 6.8-hour CIT and more than 1300 miles of travel. Relative to historical institutional experience, the case demonstrated lower peak biochemical markers and faster normalization of graft function. These findings support further investigation into whether preservation strategies that maintain tighter thermal control may influence early graft recovery in MVT.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"10 ","pages":"100362"},"PeriodicalIF":0.0,"publicationDate":"2026-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148348273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiota-oriented strategies to mitigate parenteral nutrition-related complications in intestinal failure: A narrative review.","authors":"Shurui Zhong, Fengbiao Guo, Qiyi Chen, Shaoyi Zhang","doi":"10.1016/j.intf.2026.100355","DOIUrl":"10.1016/j.intf.2026.100355","url":null,"abstract":"<p><strong>Background: </strong>Parenteral nutrition (PN) is essential for patients with intestinal failure (IF) but is associated with complications such as dysbiosis, small intestinal bacterial overgrowth, catheter-related infections, and intestinal failure-associated liver disease (IFALD). Growing evidence indicates that gut microbiota alterations contribute to the pathogenesis of these complications, supporting microbiota-oriented interventions as potential adjunctive therapies.</p><p><strong>Methods: </strong><b>Data sources:</b> A structured literature search was conducted in PubMed, Web of Science, and Scopus from inception to December 2025.<b>Study eligibility criteria:</b> Clinical trials, observational studies, mechanistic studies, and relevant reviews evaluating gut microbiota features or microbiome-targeted interventions in IF or PN-dependent populations were included.<b>Participants:</b> Pediatric and adult patients with intestinal failure or short bowel syndrome, as well as relevant animal models.<b>Interventions:</b> Microbiota-oriented strategies, including probiotics, prebiotics, synbiotics, antibiotics, and fecal microbiota transplantation (FMT).<b>Statistical analysis:</b> Due to substantial heterogeneity in study design, interventions, and outcomes, meta-analysis was not performed; findings were synthesized qualitatively.</p><p><strong>Results: </strong>PN dependence was consistently associated with reduced microbial diversity, enrichment of Proteobacteria and Lactobacillaceae, and depletion of obligate anaerobes and short-chain fatty acid-producing taxa. Microbiota-oriented interventions demonstrated biological plausibility and microbiome modulation in selected studies; however, clinical benefits were variable and generally modest. Safety concerns, limited microbial engraftment, small sample sizes, and patient heterogeneity limited generalizability.</p><p><strong>Conclusion: </strong>Gut microbiota dysbiosis plays a contributory role in PN-related complications of IF. Microbiota-oriented interventions are promising but remain unproven, underscoring the need for well-designed, stratified clinical studies to define efficacy, safety, and responsive patient subgroups.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"10 ","pages":"100355"},"PeriodicalIF":0.0,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148348284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term medical nutrition therapy improves the outcome of an abdominal tuberculosis patient with intestinal failure, severe malnutrition, and high-risk refeeding syndrome: A case report.","authors":"Dini Diwayani Novitasari, Yosua Yan Kristian, Riza Maulana Nasution","doi":"10.1016/j.intf.2026.100354","DOIUrl":"10.1016/j.intf.2026.100354","url":null,"abstract":"<p><strong>Background: </strong>Abdominal tuberculosis (TB) complicated with enterocutaneous fistula (ECF) carries a high mortality rate of up to 20 %, which further increases in the presence of malnutrition. This case report discusses a long-term medical nutrition therapy (MNT) approach in managing a complex case of abdominal TB with intestinal failure in a resource-limited setting.</p><p><strong>Case report: </strong>A 19-year-old female presented with a severe case of abdominal TB complicated by multiple high-output ECFs, severe malnutrition, and high-risk refeeding syndrome. Long-term MNT was tailored according to the patient's physiological changes to meet nutritional requirements and support recovery, alongside multiple surgical interventions and hospital admissions.</p><p><strong>Conclusion: </strong>We highlighted the importance of a multidisciplinary approach, including the underemphasized role of long-term MNT, in optimizing clinical outcomes of complicated abdominal TB, particularly within developing countries.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100354"},"PeriodicalIF":0.0,"publicationDate":"2026-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intestinal failure in kaposiform hemangioendothelioma successfully resolved with medical therapy and nearly fat-free oral feeding: A novel case report.","authors":"Tierra L Mosher, Eduardo J Contijoch, Jordan Bui, Joyce Teng, Michael R Jeng, Shweta S Namjoshi","doi":"10.1016/j.intf.2025.100347","DOIUrl":"10.1016/j.intf.2025.100347","url":null,"abstract":"<p><strong>Background: </strong>Kaposiform hemangioendothelioma and kaposiform lymphangiomatosis (KHE/KLA) are rare, non-malignant lymphovascular anomalies often complicated by Kasabach-Merritt phenomenon (KMP). Morbidity and mortality are high. There are no prior reports of the dietary management in these disorders.</p><p><strong>Case report: </strong>A 2-month-old female presented with hemorrhagic ascites, abdominal compartment syndrome, and severe KMP secondary to extensive retroperitoneal and intestinal KHE/KLA. Following emergent surgical management for abdominal decompression and diverting ileostomy, medical and nutritional therapy with steroids, vincristine, sirolimus, and parenteral nutrition were employed for management. After maintaining a near fat-free enteral diet supplemented with intravenous lipid therapy in the outpatient setting, she underwent successful ileostomy takedown 18 months after initial diagnosis without the need for intestinal resection and maintenance of adequate growth.</p><p><strong>Conclusion: </strong>This case underscores the value of clinical and pathology-guided diagnosis, coordinated medical therapy, and dietary fat restriction for achieving intestinal autonomy and preserving bowel length in intra-abdominal KHE/KLA.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100347"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case series of selenium insufficiency among infants with intestinal failure.","authors":"Darren Bodkin, Alisha Hemani, Jessica Miller, Jennifer Fraysur, Erica Fuchs","doi":"10.1016/j.intf.2026.100352","DOIUrl":"10.1016/j.intf.2026.100352","url":null,"abstract":"<p><strong>Background: </strong>Selenium (Se) is an essential trace element incorporated into 'selenoenzymes' that are necessary for immune, thyroid and antioxidant responses. Infants with intestinal failure (IF) require prolonged administration of parenteral nutrition (PN). This report presents a series of infants with IF who demonstrate biochemical Se deficiency despite PN supplementation, which normalized following dose escalation.</p><p><strong>Case series: </strong>Patient 1 was born at 25 weeks' gestation, birthweight 870 g, with intestinal malrotation and colonic atresia. Patient 2 was born at 28 weeks' gestation, birthweight 1130 g, with multiple congenital anomalies. Patient 3 was born at 34 weeks' gestation, birthweight 3030 g with gastroschisis and midgut volvulus requiring significant bowel resection. Their serum Se levels ranged from 56 to 93 (reference range 100-340 µg/L) prior to dose changes.</p><p><strong>Conclusion: </strong>Preterm birth, bowel resection and intestinal failure are risk factors for Se deficiency. High quality studies of PN Se supplementation in preterm infants with IF are needed to determine the optimal dose for this high-risk population.</p>","PeriodicalId":520517,"journal":{"name":"Intestinal Failure (New York, N.Y.)","volume":"9 ","pages":"100352"},"PeriodicalIF":0.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}