Case series of selenium insufficiency among infants with intestinal failure.

Intestinal Failure (New York, N.Y.) Pub Date : 2026-01-12 eCollection Date: 2026-01-01 DOI:10.1016/j.intf.2026.100352

Darren Bodkin, Alisha Hemani, Jessica Miller, Jennifer Fraysur, Erica Fuchs

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Abstract

Background: Selenium (Se) is an essential trace element incorporated into 'selenoenzymes' that are necessary for immune, thyroid and antioxidant responses. Infants with intestinal failure (IF) require prolonged administration of parenteral nutrition (PN). This report presents a series of infants with IF who demonstrate biochemical Se deficiency despite PN supplementation, which normalized following dose escalation.

Case series: Patient 1 was born at 25 weeks' gestation, birthweight 870 g, with intestinal malrotation and colonic atresia. Patient 2 was born at 28 weeks' gestation, birthweight 1130 g, with multiple congenital anomalies. Patient 3 was born at 34 weeks' gestation, birthweight 3030 g with gastroschisis and midgut volvulus requiring significant bowel resection. Their serum Se levels ranged from 56 to 93 (reference range 100-340 µg/L) prior to dose changes.

Conclusion: Preterm birth, bowel resection and intestinal failure are risk factors for Se deficiency. High quality studies of PN Se supplementation in preterm infants with IF are needed to determine the optimal dose for this high-risk population.

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肠衰竭患儿硒缺乏的病例系列分析。

背景：硒（Se）是一种必需的微量元素，被纳入“硒酶”，是免疫、甲状腺和抗氧化反应所必需的。患有肠衰竭（IF）的婴儿需要长期给予肠外营养（PN）。本报告介绍了一系列IF婴儿，尽管补充PN，但仍表现出生化硒缺乏，并在剂量增加后恢复正常。病例系列：患者1，孕25周出生，出生体重870 g，肠道旋转不良，结肠闭锁。患者2孕28周出生，出生体重1130 g，患有多发性先天性异常。患者3在妊娠34周出生，出生体重3030 g，伴有胃裂和中肠扭转，需要进行肠切除术。在剂量变化前，他们的血清硒水平为56 ~ 93（参考范围100 ~ 340 µg/L）。结论：早产、肠切除术和肠功能衰竭是硒缺乏的危险因素。需要对IF早产儿补充PN - Se进行高质量的研究，以确定这一高危人群的最佳剂量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Intestinal Failure (New York, N.Y.)

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