The American Journal of Gastroenterology最新文献

Unresolved Challenges in MAFLD-ACLF Risk Stratification: A Critical Appraisal. MAFLD-ACLF风险分层中未解决的挑战：一项关键评估。

The American Journal of Gastroenterology Pub Date : 2025-06-16 DOI: 10.14309/ajg.0000000000003548

Renu Sah,Ankita Mathur,Venkata Dileep Kumar Veldi

引用次数: 0

Trends in Underrepresented Fellows in Gastroenterology. 未被充分代表的胃肠病学研究员的趋势。

The American Journal of Gastroenterology Pub Date : 2025-06-16 DOI: 10.14309/ajg.0000000000003596

Judy Daboul,Gavisha Waidyaratne,Sean G Kelly,Jacob Skeans,Jianing Ma,Jing Peng,Lindsay A Sobotka

引用次数: 0

Dissatisfaction and Barriers in Electronic Health Record Use for Inflammatory Bowel Disease Patients: A Nationwide Survey of Major IBD Centers. 炎性肠病患者电子健康记录使用的不满意和障碍：主要IBD中心的全国调查

The American Journal of Gastroenterology Pub Date : 2025-06-16 DOI: 10.14309/ajg.0000000000003598

Hasan Saleh,Sara Horst,Jami Kinnucan

引用次数: 0

Effect of 3-day linaclotide administration to reduce the PEG volume for colonoscopy bowel preparation: A multicenter, noninferiority, randomized controlled trial. 利那洛肽给药3天对减少结肠镜肠道准备中PEG体积的影响：一项多中心、非劣效性、随机对照试验。

The American Journal of Gastroenterology Pub Date : 2025-05-27 DOI: 10.14309/ajg.0000000000003557

Peng Pan,Huixin Chen,Tongchang Wang,Kaijun Liu,Biguang Tuo,Rong Wang,Hongyu Fu,Chunmeng Jiang,Lisha Chen,Qiu Zhao,Wen Wang,Weigang Chen,Qiang Guo,Weichang Chen,Yanqing Li,Zibin Tian,Zhijie Feng,Shaoqi Yang,Yi Fan,Fujuan Luan,Youxiang Chen,Zhaoshen Li,Yu Bai

{"title":"Effect of 3-day linaclotide administration to reduce the PEG volume for colonoscopy bowel preparation: A multicenter, noninferiority, randomized controlled trial.","authors":"Peng Pan,Huixin Chen,Tongchang Wang,Kaijun Liu,Biguang Tuo,Rong Wang,Hongyu Fu,Chunmeng Jiang,Lisha Chen,Qiu Zhao,Wen Wang,Weigang Chen,Qiang Guo,Weichang Chen,Yanqing Li,Zibin Tian,Zhijie Feng,Shaoqi Yang,Yi Fan,Fujuan Luan,Youxiang Chen,Zhaoshen Li,Yu Bai","doi":"10.14309/ajg.0000000000003557","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003557","url":null,"abstract":"OBJECTIVESSeveral studies have investigated the role of linaclotide in bowel preparation; however, dosage and timing still warrant further exploration.METHODSThis non-inferiority randomized controlled study was performed in sixteen medical centers. The eligible subjects were randomly assigned to three groups: the Lct + 3 L PEG group (Group A), the 3 L PEG group (Group B), or the Lct + 2 L PEG group (Group C). The primary outcome was the adequate bowel preparation rate based on the Boston Bowel Preparation Scale. Safety was assessed based on the incidence of adverse reactions.RESULTSA total of 1607 eligible subjects were enrolled, and 1545 colonoscopy videos were uploaded. In the intention-to-treat analysis, the results of the non-inferiority test indicated that the adequate bowel preparation rate in Group C (87.58%, 95% CI: 85.08 to 90.62%) was neither inferior to that of Group A (88.79%, 95% CI: 86.11 to 91.46%) nor Group B (83.99%, 95% CI: 80.88 to 87.09%). The overall incidence of adverse reactions in Group A was higher than that in Group C (13.64% vs 8.19%, P = 0.012). There were no significant differences in polyp detection rate (P = 0.089), adenoma detection rate (P = 0.776), and bowel preparation completion rate (P = 0.052).CONCLUSIONSThe adequate bowel preparation rate of the combination of 3-day linaclotide and 2 L PEG was neither inferior to the combination of 3-day linaclotide and 3 L PEG nor 3 L PEG alone in the average-risk population.","PeriodicalId":520099,"journal":{"name":"The American Journal of Gastroenterology","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Listening Beyond the Symptoms: Existential Needs and Identity in Older Adults With Inflammatory Bowel Disease. 症状之外的倾听：老年炎症性肠病患者的存在需求和身份认同。

The American Journal of Gastroenterology Pub Date : 2025-05-27 DOI: 10.14309/ajg.0000000000003514

Partha Pal

引用次数: 0

Overlap of esophageal disorders of gut-brain interactions (E-DGBIs) and GERD is highly prevalent in patients with refractory reflux symptoms. 在有难治性反流症状的患者中，肠脑相互作用食道疾病（E-DGBIs）和胃食管反流的重叠非常普遍。

The American Journal of Gastroenterology Pub Date : 2025-05-22 DOI: 10.14309/ajg.0000000000003542

Federico Caldart,Charlotte Gabriel,Blandine Vauquelin,Pauline Rivière,Arthur Berger,Frank Zerbib

{"title":"Overlap of esophageal disorders of gut-brain interactions (E-DGBIs) and GERD is highly prevalent in patients with refractory reflux symptoms.","authors":"Federico Caldart,Charlotte Gabriel,Blandine Vauquelin,Pauline Rivière,Arthur Berger,Frank Zerbib","doi":"10.14309/ajg.0000000000003542","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003542","url":null,"abstract":"BACKGROUNDEsophageal disorders of gut-brain interaction (E-DGBIs) are highly prevalent in patients with unproven gastro-esophageal reflux disease (GERD) who do not respond to proton pump inhibitors (PPIs). The aim of this study was to determine the prevalence and characteristics of confirmed refractory GERD and E-DGBIs in consecutive patients with refractory reflux symptoms.PATIENTS AND METHODSPatients with typical refractory reflux symptoms were prospectively enrolled. Data on age, gender, primary symptoms, pH and pH-impedance monitoring data, presence of esophageal motor disorders and endoscopy results were collected. Patients were classified as unproven and proven GERD, e-DGBI alone, refractory GERD and overlap between GERD and E-DGBI. Questionnaires were obtained for reflux symptoms, presence of other DGBIs, levels of anxiety and depression and on visceral sensitivity.RESULTSA total of 119 patients were included. Among 46 proven GERD patients, 13 (28%) had isolated refractory GERD and 33 (72%) had an overlap of GERD and E-DGBIs. Among unproven GERD group, 23 (31.5%) had GERD and 50 (68.5%) had an E-DGBI. Functional dyspepsia (70.6%) and irritable bowel syndrome (33.6%) were highly prevalent.No difference was found in symptom presentation, anxiety, depression and visceral sensitivity scores. A higher acid exposure time and number of reflux episodes were found in patients with confirmed refractory GERD compared to overlap E-DGBI-GERD group.CONCLUSIONE-DGBIs are highly prevalent in patients with proven GERD and refractory reflux symptoms. Studies with outcome data are needed to determine whether patients with overlapping E-DGBIs and GERD should be identified with pH-impedance monitoring on PPI therapy before an interventional treatment option is considered.","PeriodicalId":520099,"journal":{"name":"The American Journal of Gastroenterology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144114218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence in Gastroenterology Education: DeepSeek Passes the Gastroenterology Board Examination and Outperforms Legacy ChatGPT Models. 胃肠病学教育中的人工智能：DeepSeek通过胃肠病学委员会考试并优于传统ChatGPT模型。

The American Journal of Gastroenterology Pub Date : 2025-05-20 DOI: 10.14309/ajg.0000000000003552

Andrew F Ibrahim,Pojsakorn Danpanichkul,Alexander Hayek,Edwin Paul,Annmarie Farag,Masab Mansoor,Charat Thongprayoon,Wisit Cheungpasitporn,Mohamed O Othman

引用次数: 0

The Role of Patient-Reported Outcomes in Cirrhosis. 肝硬化患者报告结果的作用。

The American Journal of Gastroenterology Pub Date : 2025-05-20 DOI: 10.14309/ajg.0000000000003551

Archita P Desai,Alexander N Scherer,Marina Serper

引用次数: 0

Think out of the box - A rare case of intestinal polyarterites nodosa. 跳出常规思维——一例罕见的肠多动脉结节。

The American Journal of Gastroenterology Pub Date : 2025-05-20 DOI: 10.14309/ajg.0000000000003555

A Toppeta,D Gridavilla,A Dell'Era,G Maconi

引用次数: 0

13C-Spirulina Gastric Emptying Breath Test Normative Values in Healthy Children- A Multicenter Study with Comparison to Symptomatic Children. 13c -螺旋藻胃排空呼吸试验在健康儿童中的正常值——一项与有症状儿童比较的多中心研究

The American Journal of Gastroenterology Pub Date : 2025-05-16 DOI: 10.14309/ajg.0000000000003545

Katja Karrento,Bruno P Chumpitazi,Liyun Zhang,Pippa Simpson,Robert J Shulman

{"title":"13C-Spirulina Gastric Emptying Breath Test Normative Values in Healthy Children- A Multicenter Study with Comparison to Symptomatic Children.","authors":"Katja Karrento,Bruno P Chumpitazi,Liyun Zhang,Pippa Simpson,Robert J Shulman","doi":"10.14309/ajg.0000000000003545","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003545","url":null,"abstract":"BACKGROUNDDiagnosing pediatric gastroparesis presents a significant challenge due to lack of normative data in children. We aimed to determine normative values for gastric emptying using the non-radioactive 13C-Spirulina gastric emptying breath test (13C-GEBT) in a large cohort of healthy children (HC) and examine differences compared to children with gastroparesis-like symptoms (GLS).METHODS301 HC ages 7-18 years completed the 13C-GEBT with 10 different breath samples x 4 hours. 13CO2 excretion rate (kPCD) was determined by change in 13CO2/12CO2. Outcome variables included: kPCD at 10 time points, peak (maximum) kPCD, time to peak (Tmax) kPCD, and area under curve (AUC) of 13CO2 excretion, along with breath test half emptying time (BT t ½). Results were compared to 13C-GEBT data from peri- and post-pubertal patients 11-18 years of age with GLS.RESULTS216 HC, 51·4% female, completed the test meal within the allotted time. Females vs. males had lower peak kPCD (p=0·003), longer Tmax (p=0·04), lower AUC (p<0·001), and longer BT_t½ (p<0·0001). Peak kPCD (p=0·01, p<0·001) and AUC (p=0·012, p<0·001) were higher in pre- vs peri- and post-pubertal children. BT_t½ and Tmax were shorter in HC vs. GLS (p<0·001, p<0·0001, respectively), consistent with faster gastric emptying in HC. Normative reference values based on 5th percentile kPCD and Tmax were established for peri- and post-pubertal females. An algorithm incorporating key variables demonstrated 80.8% sensitivity for diagnosis of gastroparesis.CONCLUSIONSThis study demonstrates sex and pubertal differences in gastric emptying in children and provides the first reference values for female children.","PeriodicalId":520099,"journal":{"name":"The American Journal of Gastroenterology","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0