The American Journal of Gastroenterology最新文献

Participation and Yield in Multiple Rounds of Colorectal Cancer Screening based on Fecal Immunochemical Test: A Systematic Review and Meta-Analysis. 基于粪便免疫化学检验的多轮结直肠癌筛查的参与度和收益率：系统回顾与元分析》。

The American Journal of Gastroenterology Pub Date : 2024-09-27 DOI: 10.14309/ajg.0000000000003107

Yueyang Zhou,Na Li,Jiahui Luo,Yuqing Chen,Yuelun Zhang,Min Dai,Hongda Chen

{"title":"Participation and Yield in Multiple Rounds of Colorectal Cancer Screening based on Fecal Immunochemical Test: A Systematic Review and Meta-Analysis.","authors":"Yueyang Zhou,Na Li,Jiahui Luo,Yuqing Chen,Yuelun Zhang,Min Dai,Hongda Chen","doi":"10.14309/ajg.0000000000003107","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003107","url":null,"abstract":"BACKGROUND AND AIMSThe evidence on the cumulative participation and yield in multiple rounds of colorectal cancer (CRC) screening based on fecal immunochemical test is sparse. We aimed to assess the trends in participation and detection for advanced colorectal neoplasm under different screening intervals in multi-round FIT-based CRC screening by synthesizing the current available evidence.METHODSPubMed, Embase, and Cochrane were retrieved from January 1, 2002 to April 16, 2024 for potential eligible studies and then we synthesized participation and advanced colorectal neoplasm detection rates for each screening round, along with their respective 95% confidence intervals.RESULTS19 studies involving a total of 2,296,071 individuals were included. As screening rounds increased, participation exhibited a gradual consistent increase, reaching 78.45% and 74.97% for annual and biennial screening strategies. For annual screening, the cumulative detection rates for 3 rounds were 1.38% (95% CI: 1.18-1.63%), 1.95% (95% CI: 1.72-2.21%), and 2.50% (95% CI: 2.29-2.72%), respectively. For biennial screening, the cumulative detection rates for 4 rounds were 2.22% (95% CI: 1.22-3.22%), 3.44% (95% CI: 2.06-4.82%), 4.26% (95% CI: 2.70-5.83%), and 5.10% (95% CI: 3.28-7.29%), respectively. Notably, the per-round detection rate of advanced colorectal neoplasms declined yet as the screening progressed.CONCLUSIONIn population-based CRC screening programs, the participation exhibited a slow upward trend for both screening strategies, but the incremental benefits in CRC detection gradually diminished. Tailored strategies, such as extending intervals for individuals with multiple negative FIT results, might optimize effectiveness and cost-efficiency in population-based CRC screening.","PeriodicalId":520099,"journal":{"name":"The American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142328831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health state utility is substantially reduced with an increasing burden of patient-reported symptoms in eosinophilic esophagitis. 随着嗜酸性粒细胞食管炎患者报告症状的增加，健康状态效用也会大大降低。

The American Journal of Gastroenterology Pub Date : 2024-09-27 DOI: 10.14309/ajg.0000000000003106

Cary C Cotton,Mousumi Biswas,Evan S Dellon

引用次数: 0

Addressing Additional Limitations in the Study on Small Intestine Cancer Risk in Patients With Inflammatory Bowel Disease. 解决炎症性肠病患者小肠癌风险研究中的其他局限性。

The American Journal of Gastroenterology Pub Date : 2024-09-27 DOI: 10.14309/ajg.0000000000003053

Ching-Pin Lin,Poi Kuo,James Cheng-Chung Wei

引用次数: 0

Small Bowel Microbiome Profiles in Overweight and Obese Humans. 超重和肥胖人群的小肠微生物组图谱

The American Journal of Gastroenterology Pub Date : 2024-09-26 DOI: 10.14309/ajg.0000000000003071

Liqi Li

引用次数: 0

Request for Clarification on Sample Size Calculation and Statistical Analysis. 要求澄清样本量计算和统计分析。

The American Journal of Gastroenterology Pub Date : 2024-09-26 DOI: 10.14309/ajg.0000000000003063

Mohammed El-Dallal,Rajan Lamichhane,Ahmed Sherif,Wesam Frandah

引用次数: 0

Worldwide Prevalence and Description of Cyclic Vomiting Syndrome According to the Results of the Rome Foundation Global Epidemiology Study. 根据罗马基金会全球流行病学研究结果得出的周期性呕吐综合征的全球患病率和描述。

The American Journal of Gastroenterology Pub Date : 2024-09-25 DOI: 10.14309/ajg.0000000000003105

Arantzazu Izagirre,Cristina Sarasqueta,Joel Flores-Arriaga,María C Aso,María Pérez,Jan Tack,I-Hsuan Huang,Ami D Sperber,Olafur S Palsson,Shrikant I Bangdiwala,Mauro D'Amato,Ángel Lanas,Beatriz Lobo,Carmen Alonso-Cotoner,Javier Santos,Luis Bujanda

{"title":"Worldwide Prevalence and Description of Cyclic Vomiting Syndrome According to the Results of the Rome Foundation Global Epidemiology Study.","authors":"Arantzazu Izagirre,Cristina Sarasqueta,Joel Flores-Arriaga,María C Aso,María Pérez,Jan Tack,I-Hsuan Huang,Ami D Sperber,Olafur S Palsson,Shrikant I Bangdiwala,Mauro D'Amato,Ángel Lanas,Beatriz Lobo,Carmen Alonso-Cotoner,Javier Santos,Luis Bujanda","doi":"10.14309/ajg.0000000000003105","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003105","url":null,"abstract":"BACKGROUND AIMSCyclic vomiting syndrome (CVS) is a disorder of gut-brain interaction (DGBI) of unknown origin. This study aimed to evaluate the global prevalence of this disorder and its associated factors.METHODSData were collected from nationwide Internet surveys in 26 countries, with subjects evenly distributed by age, sex and country. The survey included the Rome IV questionnaire as well as an extensive supplemental questionnaire to evaluate additional factors.RESULTS54,127 participants completed the questionnaire (51% male, mean age 44.3 years). The pooled prevalence of CVS was 0.3% (95% CI 0.3-0.4%; n=187), highest in Brazil (1%, 95% CI 0.6-1.5), and lowest in Japan and Germany (with no subject who fulfilled the criteria for CVS). The mean age of participants with CVS was 36.7 years (standard deviation 13.5) and it was more common in females (56.7% vs 43.5%). Factors independently associated with this syndrome were female sex (OR 1.52, 95% CI 1.13-2.03), young age (OR 2.57, 95% CI 1.34-4.94, for people between the ages of 18 and 39 years, compared to those older than 65 years), depression (OR 3.14, 95% CI 2.05-4.82, p<0.001) and anxiety (OR 1.79, 95% CI 1.15-2.78, p<0.001). Individuals with CVS had impaired quality of life (QoL) (PROMIS-10 score: physical QoL mean, 12.9 vs 15.5, p<0.001; mental QoL mean 12.3 vs 14.4, p<0.001) compared to others.CONCLUSIONSCVS is a relatively common disorder that has a negative impact on quality of life. It is important to raise awareness on this syndrome to avoid underdiagnosis and improve clinical practice.","PeriodicalId":520099,"journal":{"name":"The American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Diet in Inflammatory Bowel Disease Onset, Disease Management, and Surgical Optimization. 饮食在炎症性肠病发病、疾病管理和手术优化中的作用。

The American Journal of Gastroenterology Pub Date : 2024-09-19 DOI: 10.14309/ajg.0000000000003085

Kelly Issokson,Dale Young Lee,Andres J Yarur,James D Lewis,David L Suskind

引用次数: 0

Comparative efficacy and safety of Potassium-Competitive Acid Blocker (P-CAB) based dual, triple and quadruple regimens for first line H. pylori infection treatment: A systematic review and network meta-analysis. 基于钾竞争性酸阻滞剂（P-CAB）的双联、三联和四联方案治疗幽门螺杆菌感染一线疗程的疗效和安全性比较：系统综述和网络荟萃分析。

The American Journal of Gastroenterology Pub Date : 2024-09-19 DOI: 10.14309/ajg.0000000000003084

Theodore Rokkas,Konstantinos Ekmektzoglou,Yaron Niv,David Y Graham

{"title":"Comparative efficacy and safety of Potassium-Competitive Acid Blocker (P-CAB) based dual, triple and quadruple regimens for first line H. pylori infection treatment: A systematic review and network meta-analysis.","authors":"Theodore Rokkas,Konstantinos Ekmektzoglou,Yaron Niv,David Y Graham","doi":"10.14309/ajg.0000000000003084","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003084","url":null,"abstract":"BACKGROUND AIMSIn the last few years numerous new P-CAB based RCTs concerning first-line regimens for H. pylori infection treatment from various countries have been published. However, no NWM exists which examines the comparative efficacy and safety of P-CAB based dual, triple and quadruple treatments and therefore, in this network meta-analysis (NWM) we examined this matter comparing efficacy and safety of these P-CAB based regimens.METHODSDatabases were searched for identification, screening, eligibility and inclusion of relevant randomized controlled trials (RCTs). Extracted data were entered into a Bayesian NWM and the ranking order for each regimen was evaluated by means of surfaces under cumulative ranking area (SUCRA) values.RESULTSTwenty-five eligible RCTs were included with 7,605 patients randomized to 6 first line regimens, i.e. PCAB-DUAL, PCAB-TRIPLE, PCAB-QUADRUPLE, PPI-DUAL, PPI-TRIPLE, and PPI- QUADRUPLE. The SUCRA values (%) for these 6 regimens were 92.7, 62.5, 33.9, 75.1, 19.4 and 16.3 respectively. The comparative effectiveness ranking showed that PCAB-DUAL regimen ranked first for efficacy and last for adverse effects and had the best profile for integrated efficacy-safety.CONCLUSIONSIn this NWM concerning the comparative efficacy and safety of P-CAB based dual, triple and quadruple regimens for first line H. pylori infection treatment, the overall results showed that PCAB based dual treatment ranked first for efficacy with the best-integrated efficacy-safety profile. This is of importance, since the dual regimens overcome the crucial issue of clarithromycin resistance. Consequently, these findings are expected to be useful in helping clinical decision-making and future guidelines.","PeriodicalId":520099,"journal":{"name":"The American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142273467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Guidelines in Practice: Alcohol-Associated Liver Disease. 实践指南：酒精相关性肝病。

The American Journal of Gastroenterology Pub Date : 2024-09-12 DOI: 10.14309/ajg.0000000000003047

Ashwani K Singal,Loretta Jophlin,Vijay H Shah

引用次数: 0

A Stool DNA-Based SDC2 Methylation Test for the Early Detection of Colorectal Cancer in an Asymptomatic, High-Risk Population: A Multicenter Prospective Randomized Trial. 基于粪便 DNA 的 SDC2 甲基化检验用于无症状高危人群结直肠癌的早期检测：多中心前瞻性随机试验》。

The American Journal of Gastroenterology Pub Date : 2024-08-21 DOI: 10.14309/ajg.0000000000003044

Chang Woo Kim,Hyunjin Kim,Hyoung Rae Kim,Daeyeon David Won,Woo Jung Nam,Byung Soh Min,Tae Jeong Oh,Sungwhan An,Suk-Hwan Lee

{"title":"A Stool DNA-Based SDC2 Methylation Test for the Early Detection of Colorectal Cancer in an Asymptomatic, High-Risk Population: A Multicenter Prospective Randomized Trial.","authors":"Chang Woo Kim,Hyunjin Kim,Hyoung Rae Kim,Daeyeon David Won,Woo Jung Nam,Byung Soh Min,Tae Jeong Oh,Sungwhan An,Suk-Hwan Lee","doi":"10.14309/ajg.0000000000003044","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003044","url":null,"abstract":"INTRODUCTIONNoninvasive stool DNA-based methylation testing has emerged as an effective strategy for the early colorectal cancer (CRC) detection. Syndecan-2 (SDC2) methylation frequently occurs in all stages of CRC; therefore, the aim of this study was to evaluate the clinical performance of a stool DNA-based SDC2 methylation test for detecting CRC in asymptomatic or high-risk CRC populations.METHODSThis multicenter prospective study was conducted to determine the clinical performance of the SDC2 methylation test on stool DNA using real-time polymerase chain reaction. Stool samples were collected from asymptomatic individuals before colonoscopy, and the test results were independently analyzed through comparison with colonoscopic findings and pathological outcomes as reference standards.RESULTSOf the 1,124 evaluable participants, 20 had CRC, 73 had advanced adenomatous polyps (≥1.0 cm), 469 had nonadvanced adenomatous polyps (<1.0 cm), 178 had non-neoplastic polyps, and 384 had negative colonoscopy results. The stool SDC2 methylation test had a sensitivity and specificity of 95.0% and 81.5%, respectively, for detecting CRC, while the sensitivity for detecting advanced adenomatous polyps and CRC was 58.1%. The rate of adenoma detection increased with polyp size (P < 0.01), and sensitivity was not associated with CRC stage (P = 0.864).DISCUSSIONThe stool DNA-based SDC2 methylation test attained a high sensitivity for CRC detection in an asymptomatic high-risk population. Further large-scale clinical studies are required to validate the clinical utility of this test as a population-based CRC screening tool.","PeriodicalId":520099,"journal":{"name":"The American Journal of Gastroenterology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142261423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0