EJNMMI reports最新文献

{"title":"Enhancing the diagnostic capacity of [¹⁸F]PSMA-1007 PET/MRI in primary prostate cancer staging with artificial intelligence and semi-quantitative DCE: an exploratory study.","authors":"Philip Alexander Glemser, Martin Freitag, Balint Kovacs, Nils Netzer, Antonia Dimitrakopoulou-Strauss, Uwe Haberkorn, Klaus Maier-Hein, Constantin Schwab, Stefan Duensing, Bettina Beuthien-Baumann, Heinz-Peter Schlemmer, David Bonekamp, Frederik Giesel, Christos Sachpekidis","doi":"10.1186/s41824-024-00225-5","DOIUrl":"10.1186/s41824-024-00225-5","url":null,"abstract":"<p><strong>Background: </strong>To investigate the ability of artificial intelligence (AI)-based and semi-quantitative dynamic contrast enhanced (DCE) multiparametric MRI (mpMRI), performed within [¹⁸F]-PSMA-1007 PET/MRI, in differentiating benign from malignant prostate tissues in patients with primary prostate cancer (PC).</p><p><strong>Results: </strong>A total of seven patients underwent whole-body [¹⁸F]-PSMA-1007 PET/MRI examinations including a pelvic mpMRI protocol with T2w, diffusion weighted imaging (DWI) and DCE image series. Conventional analysis included visual reading of PET/MRI images and Prostate Imaging Reporting & Data System (PI-RADS) scoring of the prostate. On the prostate level, we performed manual segmentations for time-intensity curve parameter formation and semi-quantitative analysis based on DCE segmentation data of PC-suspicious lesions. Moreover, we applied a recently introduced deep learning (DL) pipeline previously trained on 1010 independent MRI examinations with systematic biopsy-enhanced histopathological targeted biopsy lesion ground truth in order to perform AI-based lesion detection, prostate segmentation and derivation of a deep learning PI-RADS score. DICE coefficients between manual and automatic DL-acquired segmentations were compared. On patient-based analysis, PET/MRI revealed PC-suspicious lesions in the prostate gland in 6/7 patients (Gleason Score-GS ≥ 7b) that were histologically confirmed. Four of these patients also showed lymph node metastases, while two of them had bone metastases. One patient with GS 6 showed no PC-suspicious lesions. Based on DCE segmentations, a distinction between PC-suspicious and normal appearing tissue was feasible with the parameters fitted maximum contrast ratio (FMCR) and wash-in-slope. DICE coefficients (manual vs. deep learning) were comparable with literature values at a mean of 0.44. Further, the DL pipeline could identify the intraprostatic PC-suspicious lesions in all six patients with clinically significant PC.</p><p><strong>Conclusion: </strong>Firstly, semi-quantitative DCE analysis based on manual segmentations of time-intensity curves was able to distinguish benign from malignant tissues. Moreover, DL analysis of the MRI data could detect clinically significant PC in all cases, demonstrating the feasibility of AI-supported approaches in increasing diagnostic certainty of PSMA-radioligand PET/MRI.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"8 1","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142606489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the evolution of PET/MR research: a bibliometric analysis of publication trends, leading contributors, and conceptual frameworks (2011-2023).","authors":"Jiajin Li, Chuntao Ye, Shihong Li, Guangwu Lin","doi":"10.1186/s41824-024-00224-6","DOIUrl":"10.1186/s41824-024-00224-6","url":null,"abstract":"<p><strong>Background: </strong>Positron emission tomography-magnetic resonance imaging (PET/MR) is a cutting-edge hybrid imaging technology with the potential to revolutionize medical diagnosis. This bibliometric study aims to map the research landscape of PET/MR by analyzing a curated set of Web of Science Core Collection documents from 2011 to 2023.</p><p><strong>Methods: </strong>We conducted a bibliometric analysis to map the research landscape of PET/MR, leveraging a curated dataset of 3,600 documents retrieved from the Web of Science Core Collection spanning the period from 2011 to 2023. We employed quantitative methods to assess the quantity and distribution of PET/MR studies, including patterns of change, research status, and directions. Additionally, we utilized VOSviewer software to conduct keyword co-occurrence analysis, explore collaborative networks among authors and institutions, and identify influential journals in the field.</p><p><strong>Results: </strong>Results: The analysis reveals several key insights: (1) a significant increase in the number of PET/MR publications over the past 12 years, highlighting the growing interest and activity in this field; (2) the United States and Germany as the leading countries in terms of research output and collaboration, with a growing presence of other countries such as China; (3) the Journal of Nuclear Medicine and the European Journal of Nuclear Medicine and Molecular Imaging as the most influential journals in the field; (4) a shift in research focus from imaging techniques to clinical applications, with an increasing emphasis on prostate cancer, PSMA, and FDG imaging.</p><p><strong>Conclusions: </strong>This study provides a comprehensive overview of PET/MR research, identifying prominent trends, key researchers, and influential works. Based on these findings, we propose recommendations for future research directions in this rapidly evolving field.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"8 1","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11527865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142560013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous segmentation and classification of ^99mTc-DMSA renal scintigraphic images with a deep learning approach.","authors":"Jiayi Wang, Mingyan Wu, Xiemei Ruan, Jiaying Zhang, Zhengguo Chen, Yihui Zhai, Hong Xu, Ha Wu, Jeff L Zhang","doi":"10.1186/s41824-024-00223-7","DOIUrl":"10.1186/s41824-024-00223-7","url":null,"abstract":"<p><strong>Background: </strong>^99mTc-DMSA scan plays an important role in assessing functional abnormalities in kidneys. As a promising network for deep learning (DL), Mask R-CNN has the capability of simultaneously segmenting and classifying objects in images. In this study, we tested the feasibility and accuracy of Mask R-CNN in diagnosing acute pyelonephritis (APN) and segmenting kidneys in ^99mTc-DMSA scintigraphic images. Two hundred and sixty patients with suspected APN were recruited for DMSA scan, of which 358 kidneys were diagnosed as APN. Of the recruited patients, 210 were randomly selected for training and validating Mask R-CNN, and the other 50 patients' images were used for model testing. Accuracy of the results was assessed by comparing against references from human experts.</p><p><strong>Results: </strong>In the validation phase, the trained model provided segmentation masks with intersection over union (mask IoU, for segmentation accuracy) of 86.6%, and classifications with mean average precision at the bounding box IoU ≥ 50% (mAP₅₀, for classification accuracy) of 86.2%. In testing with the 50 independent patients, mask IoU of the model's segmentation was 90.3%±2.2%, and in classifying the kidneys for APN, the trained model showed accuracy of 89.0%, sensitivity of 84.8% and specificity of 97.0%. In identifying patients with any APN kidney, 3 out of 50 patients were mis-diagnosed, achieving accuracy of 94.0%.</p><p><strong>Conclusions: </strong>Mask R-CNN, designed to perform both segmentation and classification for images, showed much promise in analyzing ^99mTc-DMSA images for both accurate diagnosis of APN and kidney segmentation.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"8 1","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative assessment of kidney split function and mean transit time in healthy patients using dynamic ¹⁸F-FDG PET/MRI studies with denoising and deconvolution methods making use of Legendre polynomials.","authors":"Michel Destine, Alain Seret","doi":"10.1186/s41824-024-00221-9","DOIUrl":"https://doi.org/10.1186/s41824-024-00221-9","url":null,"abstract":"<p><strong>Purpose: </strong>Our objective was to assess a deconvolution and denoising technique based on Legendre polynomials compared to matrix deconvolution on dynamic ¹⁸F-FDG renography of healthy patients.</p><p><strong>Method: </strong>The study was carried out and compared to the data of 24 healthy patients from a published study who underwent examinations with ^99mTc-MAG3 planar scintigraphy and ¹⁸F-FDG PET/MRI. Due to corruption issues in some data used in the published article, post-publication measurements were provided. We have been warned that post-publication data were treated differently. The smoothing method switched from Bezier to Savitzky-Golay and the deconvolution from matrix-based (with Tikhonov Regularization) to Richardson-Lucy. A comparison of the split function and mean transit times of the published and post-publication data against our method based on Legendre polynomials was performed.</p><p><strong>Results: </strong>For split function, we only observed a good agreement between the processing methods for the ^99mTc-MAG₃ and the post-published data. No correlation was found between the split functions obtained on the ^99mTc-MAG₃ and the ¹⁸F-FDG, contrary to the published study. However, all calculated split function values for ¹⁸F-FDG and ^99mTc-MAG₃ were within the established normal range. For the mean transit time, the correlation was moderate with published data and very good with the post-publication measurements for both ^99mTc-MAG₃ and ¹⁸F-FDG. Bias of the Bland-Altman analysis of the mean transit times for ^99mTc-MAG₃ versus ¹⁸F-FDG was 1.1 min (SD 1.7 min) for the published data, - 0.11 min (SD 1.9 min) for the post-publication results and .05 min (SD 1.9 min) for our method.</p><p><strong>Conclusions: </strong>The processing methods used in the original publication and in the post-publication work were quite complex and required adaptation of the fitting parameters for each individual and each type of examination. Our method did not require any specific adjustment; the same unmodified and fully automated algorithm was successfully applied to all data.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"8 1","pages":"33"},"PeriodicalIF":0.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of pretreatment PET parameters in inoperable, node-positive NSCLC patients with poor prognostic factors undergoing hypofractionated radiotherapy: a single-institution retrospective study.","authors":"Annemarie Barbara Zinn, Saskia Kenndoff, Adrien Holzgreve, Lukas Käsmann, Julian Elias Guggenberger, Svenja Hering, Sina Mansoorian, Nina-Sophie Schmidt-Hegemann, Niels Reinmuth, Amanda Tufman, Julien Dinkel, Farkhad Manapov, Claus Belka, Chukwuka Eze","doi":"10.1186/s41824-024-00220-w","DOIUrl":"https://doi.org/10.1186/s41824-024-00220-w","url":null,"abstract":"<p><strong>Background: </strong>Node-positive non-small cell lung cancers (NSCLCs) present a challenge for treatment decisions, particularly in patients ineligible for concurrent chemoradiotherapy (CRT) due to poor performance status and compromised lung function. We aimed to investigate the prognostic value of pretreatment positron emission tomography (PET) parameters in high-risk patients undergoing hypofractionated radiotherapy.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on 42 consecutive patients with inoperable node-positive NSCLC, who underwent hypofractionated radiotherapy between 2014 and 2021 at a single institution. Clinical, treatment-related, and [¹⁸F]FDG PET-based parameters were correlated with progression-free survival (PFS) and overall survival (OS). Median dichotomisation was performed to establish risk groups. Statistical analyses included univariable and multivariable Cox regression and Kaplan-Meier survival analyses.</p><p><strong>Results: </strong>After a median follow-up of 47.1 months (range: 0.5-101.7), the median PFS and OS were 11.5 months (95% CI: 7.4-22.0), and 24.3 months (95% CI: 14.1-31.8). In univariable Cox regression analysis, significant predictors of PFS included receipt of salvage systemic treatment (p=0.007), SUVmax (p=0.032), and tMTV (p=0.038). Similarly, ECOG-PS (p=0.014), Histology (p=0.046), and tMTV (p=0.028) were significant predictors of OS. Multivariable Cox regression analysis (MVA) identified SUVmax as a significant predictor for PFS [HR: 2.29 (95% CI: 1.02-5.15); p=0.044]. For OS, ECOG-PS remained a significant prognosticator [HR: 3.53 (95% CI: 1.49-8.39); p=0.004], and tMTV approached significance [HR: 2.24 (95% CI: 0.95-5.26); p=0.065]. Furthermore, the high tMTV group exhibited a median PFS of 5.3 months [95% CI: 2.8-10.4], while the low tMTV group had a PFS of 15.2 months [95% CI: 10.1-33.5] (p=0.038, log-rank test). Median OS was 33.5 months [95% CI: 18.3-56.8] for tMTV ≤ 36.6 ml vs. 14.1 months [95% CI: 8.1-27.2] for tMTV > 36.6 ml (p=0.028, log-rank test).</p><p><strong>Conclusion: </strong>Pretreatment PET parameters, especially tMTV, hold promise as prognostic indicators in NSCLC patients undergoing hypofractionated radiotherapy. The study highlights the potential of PET metrics as biomarkers for patient stratification.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"8 1","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11458843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discordant cardiac inflammation between ¹⁸F-FDG PET and CMR in patients with cardiac sarcoidosis.","authors":"Erika Hutt, Maria P Vega Brizneda, Christine L Jellis, Manuel L Ribeiro Neto, Wael A Jaber, Paul C Cremer","doi":"10.1186/s41824-024-00218-4","DOIUrl":"10.1186/s41824-024-00218-4","url":null,"abstract":"<p><p>Current diagnostic criteria for cardiac sarcoidosis (CS) rely on non-invasive imaging tools including positron emission tomography (PET-CT) and cardiac magnetic resonance (CMR). The aim of this study was to assess the prevalence of discordant myocardial inflammation between PET-CT and CMR in patients with known cardiac sarcoidosis. We retrospectively identified patients with both ¹⁸F-FDG PET-CT and CMR who had histology-proven sarcoidosis (N = 148). Among these 25 (17%) had abnormal ¹⁸F-FDG metabolism with normal tissue characterization by CMR. Of these, 13 (9%) had the studies concomitantly within 180 days (median 5 days, IQR 1-31). During median follow up of 7 years, 3 (23%) deaths were documented. Although prospective studies are required to address the best imaging approach for cardiac inflammation, our observation that some patients with CS have evidence of disease activity on PET-CT, but not on limited CMR without mapping suggests that a negative limited CMR may not fully exclude CS.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"8 1","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Clinical value of semiquantitative parameters in ⁶⁸GaDOTANOC PET/CT in treatment and diagnostics of cranial meningioma in a singlecenter retrospective analysis.","authors":"Friedrich Weitzer, Susanne Stanzel, Elisabeth Plhak, Reingard Maria Aigner","doi":"10.1186/s41824-024-00222-8","DOIUrl":"https://doi.org/10.1186/s41824-024-00222-8","url":null,"abstract":"","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"8 1","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142336053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[¹⁸F]AlF-PSMA-11 PET in diagnosing prostate cancer: a head-to-head comparison with [⁶⁸Ga]Ga-PSMA-11 PET and an exploration of dual-phase scanning.","authors":"Xiao Li, Mingming Yu, Jian Yang, Danni Li, Rou Li, Juanli Mao, Changjing Zuo, Zeying Liang, Qiang Li, Chao Cheng","doi":"10.1186/s41824-024-00217-5","DOIUrl":"10.1186/s41824-024-00217-5","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the physiological distribution and tumour detection ability of [¹⁸F]AlF-PSMA-11 positron emission tomography (PET) dual-phase scans in patients with prostate cancer (PCa).</p><p><strong>Methods: </strong>As a retrospective study, clinical and PET data of PCa patients who underwent dual-phase [¹⁸F]AlF-PSMA-11 PET of routine scan (45-50 min) and delayed scan (120 min) from November 2020 to June 2021 were collected, and physiological and pathological regions of interest were quantified to determine the time-dependent maximum standardized uptake value (SUV_max) of [¹⁸F]AlF-PSMA-11. Part of the above subjects who underwent [⁶⁸Ga]Ga-PSMA-11 PET in the following 6 months were included in a head-to-head comparison. The difference with a p-value < 0.05 was defined as statistical significance. Diagnosis accuracy of primary and metastatic lesions was measured referring to the surgical findings, pathology, and follow-up imaging.</p><p><strong>Results: </strong>[⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]AlF-PSMA-11 were of the comparable uptake in glands in head, but the latter was of a significant lower distribution in liver and spleen. For the 25 patients initially diagnosed with prostate cancer and 3 patients with biochemical recurrence after radical surgery, the SUV_max of the primary lesions, lacrimal glands, parotid glands and submandibular glands was higher at 120 min compared to that at 45-50 min, but not a significant difference. SUV_max of the liver, spleen and bladder decreased significantly at 120 min, but the bladder SUV_max remained higher than that of primary lesions. SUV_max of the kidneys and centrum was the same in dual-phase scans. For the 31 primary lesions detected in [¹⁸F]AlF-PSMA-11 PET, both the SUV_max of the two phases kept the positive correlation with PSA, Gleason score and initial risk stratification. For the 39 distant metastatic lesions, 94.87% accuracy of routine scan and 100% accuracy of delayed scan were acquired, and 7.14% patients (2/28) benefited from the dual-phase [¹⁸F]AlF-PSMA-11 scans that revealed novel information on metastatic lesions compared to the routine scan.</p><p><strong>Conclusion: </strong>[¹⁸F]AlF-PSMA-11 PET expanded the time window and further decreased metabolic background of [⁶⁸Ga]Ga-PSMA-11 PET. The dual-phase scan of [¹⁸F]AlF-PSMA-11 PET can benefit prostate cancer diagnosis via providing more PSMA-specific information.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"8 1","pages":"28"},"PeriodicalIF":0.0,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11381491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D dynamic diuretic renal scintigraphy using a hybrid whole body CZT SPECT/CT camera protocol in the evaluation of acute ureteric obstruction caused by ureteric stone.","authors":"Miguel Ochoa-Figueroa, Klara Borbely, Diana Hasselqvist, Fredrik Askling, Tobias Lööw, Firas Aljabery, Veronica Sanchez-Rodriguez","doi":"10.1186/s41824-024-00213-9","DOIUrl":"10.1186/s41824-024-00213-9","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the performance of dynamic 3D diuretic renal scintigraphy using a hybrid whole body CZT SPECT/CT for the evaluation of acute ureteric obstruction in patients with urinary stone disease.</p><p><strong>Methods: </strong>20 patients who presented to the Emergency Department with acute renal colic due to urinary stone disease confirmed by means of CT were prospectively included. Three observers evaluated and graded hydronephrosis, hydroureter, perirenal stranding, and thickening of the renal fascia from the CT as well as the renal scintigraphy curves from the dynamic SPECT study. The normalized residual activity from dynamic SPECT was analysed at 16 min in all patients and at 20 min in suspected obstruction.</p><p><strong>Results: </strong>Renal scintigraphy curves showed a sensitivity of 100%, specificity of 93%, PPV 83% and a NPV 100% for obstruction, while normalized residual activity showed a sensitivity of 100%, specificity of 73%, PPV 56% and a NPV 100%. All patients presented at least 2 secondary signs of obstruction on the CT, showing a PPV of only 25% for obstruction.</p><p><strong>Conclusion: </strong>Dynamic 3D diuretic renal scintigraphy CZT SPECT/CT provides valuable functional and anatomical information from one single examination. The combination of pathological renogram curves and high normalized residual activity values provide the most valuable imaging information to determine the presence of acute ureteric obstruction. The secondary signs of obstruction observed on CT are not specific and should not be used to confirm or discard obstruction in patients with urinary stone disease.</p><p><strong>Trial registration: </strong>ISRCTN15338358. Registration date 03/01/2024. Retrospectively registered. https://www.isrctn.com/ISRCTN15338358?q=miguel%20ochoa%20figueroa&filters=&sort=&offset=1&totalResults=2&page=1&pageSize=10.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"8 1","pages":"27"},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11366731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measure of ⁹⁰Y-glass microspheres residue post-TARE using PET/CT and potential impact on tumor absorbed dose in comparison ^99mTc-MAA SPECT/CT dosimetry.","authors":"Sarah Boughdad, Rafael Duran, John O Prior, Michael da Mota, Mélanie Mendes De Carvalho, Julien Costes, Maria Firsova, Silvano Gnesin, Niklaus Schaefer","doi":"10.1186/s41824-024-00214-8","DOIUrl":"10.1186/s41824-024-00214-8","url":null,"abstract":"<p><strong>Background: </strong>Transarterial radio-embolization (TARE) became a routine procedure for non-resectable liver tumor mainly hepatocellular carcinoma (HCC). Personalized dosimetry to the index lesion increased tumor response rate. However, there is no requirement to measure the precise activity injected during TARE. We measured ⁹⁰Y-glass microspheres residue (⁹⁰Y-Res) in the application system after TARE and assessed its potential impact on the tumor absorbed dose (AD) previously planned with ^99mTc MAA SPECT/CT.</p><p><strong>Methods: </strong>We measured ⁹⁰Y-Res using PET/CT in all patients that underwent TARE using ⁹⁰Y-glass-microspheres for non-resectable liver tumors over one year.</p><p><strong>Results: </strong>⁹⁰Y-Res was measured in 34 patients (HCC n = 22) with 61 injections, 93.1 ± 94.6 MBq [2-437] that was 4.8 ± 3.5% [0.2-13.7] in comparison to the activity measured in the sealed TheraSphere™ vial (ρ = 0.697; p < 0.001).</p><p><strong>Conclusion: </strong>We reported an average of 5% ⁹⁰Y-Res using PET/CT after TARE with the strongest association to the activity in the TheraSphere™ vial. Therefore, when a high ⁹⁰Y-Res is suspected on the survey meter, a ⁹⁰Y-PET/CT scan of ⁹⁰Y-Res might be useful as a first step to estimate if the target lesion received the recommended AD, especially in HCC patients with borderline tumor dosimetry on the pre-treatment ^99mTc-MAA SPECT/CT.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"8 1","pages":"26"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11345342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}