EJNMMI reports最新文献

{"title":"The role of Choline-PET/CT in patients with recurrent prostate cancer and a negative PSMA-PET/CT.","authors":"Nasir Gözlügöl, Wolfram A Bosbach, Mohamed Shelan, Hasan Sari, Arion Bucher, Irene A Burger, Klaus Strobel, Ali Afshar-Oromieh","doi":"10.1186/s41824-026-00289-5","DOIUrl":"10.1186/s41824-026-00289-5","url":null,"abstract":"<p><p>AIM: The sensitivity of PSMA-PET/CT for the detection of recurrent prostate cancer (rPC) is good at low PSA values and rapidly rises to > 80% in patients with PSA > 1.5 ng/mL. Currently, there are no general rules on how to manage PSMA-PET-negative patients with rPC and PSA levels at which a pathological PSMA-PET must be considered very likely. The aim of this evaluation was to assess the value of a choline-PET/CT in such a clinical context. MATERIALS AND METHODS: We conducted a retrospective analysis incorporating data from 01/2017–09/2023 from two Swiss institutions. Eligible patients included those with rPC following radical prostatectomy (RP) who had a negative or equivocal [6 8 Ga]Ga-PSMA-11 or [1 8 F]F-PSMA-1007 PET/CT despite a PSA level ≥1.5 ng/mL, and were subsequently referred for [18F]F-Fluorocholine-PET/CT within two months. Two experienced nuclear medicine physicians reviewed both scans (choline and PSMA-PET/CTs) in a blinded consensus read. RESULTS: Eleven patients met all inclusion criteria. The median PSA level was 2.8 ng/mL (range: 1.7–16.0). Following [18F]F-Fluorocholine-PET/CT 6 out of 11 patients (54.5%) demonstrated pathologic choline positive findings indicative of rPC: 4 patients with local recurrence, 1 with distant metastasis only, and 1 with concomitant pelvic lymph node and distant metastases. CONCLUSION: More than 50% of patients with a negative or equivocal PSMA-PET/CT showed pathologic [18F]F-Fluorocholine-PET/CT. These results indicate that [18F]F-Fluorocholine-PET/CT may serve as a valuable complementary imaging modality in patients with rPC after RP who present with a negative PSMA-PET/CT at PSA levels ≥1.5 ng/mL. </p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":"6"},"PeriodicalIF":1.7,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146230427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of urinary bladder activity from [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]PSMA-1007 in patients with prostate cancer undergoing PSMA-ligand PET/CT.","authors":"Korbinian Krieger, Paul Cumming, Ian Leigh Alberts, Axel Oliver Rominger, Ali Afshar-Oromieh","doi":"10.1186/s41824-026-00286-8","DOIUrl":"10.1186/s41824-026-00286-8","url":null,"abstract":"<p><p>AIM: PET/CT with radiolabelled PSMA-ligands has become the mainstay of diagnostic imaging for prostate cancer. The several available PSMA tracers differ modestly with respect to their avidity for lesions, but show distinct patterns of off-target uptake and routes of excretion. We sought to compare urinary bladder activity from [68Ga]Ga-PSMA-11 and [18F]PSMA-1007 with regard to their differing renal elimination, which can interfere in the detection of perivesical lesions. MATERIALS AND METHODS: We retrospectively compared urine activity in patients undergoing PET/CT after injection of either [68Ga]Ga-PSMA-11 patients in combination with hydration and diuresis (n = 132) or [18F]PSMA-1007 patients without hydration and diuresis (n = 100). Furthermore, we compared urinary bladder uptake from [18F]PSMA-1007 with lesional uptake in locally recurrent prostate cancer and locoregional lymph node metastasis, and performed an exploratory analysis of urine activity from [18F]PSMA-1007 relative to patient characteristics. RESULTS: Urine activity from [68Ga]Ga-PSMA-11 was normally distributed, being lowest in acquisitions 90 min p.i. with oral hydration and a single dose of furosemide injected 60 min after the tracer. In contrast, urine activity from [18F]PSMA-1007 followed an exponential distribution in the population, with approximately one quarter of cases exceeding an SUVmean threshold of 7. Urine activity of [18F]PSMA-1007 exceeded the uptake in prostate cancer lesions in more than 20% of patients. CONCLUSIONS: Urinary uptake from [18F]PSMA-1007 was in the range of that seen in [68Ga]Ga-PSMA-11 patients with hydration and diuretics. Some 25% of the [18F]PSMA-1007 cases showed problematic urinary uptake, which would potentially eclipse the uptake in prostate cancer lesions. </p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":"5"},"PeriodicalIF":1.7,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12901750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146184059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injection method alters diagnostic confidence and quantitative metrics in [¹⁸F]fluorocholine PET/CT for parathyroid adenoma localization.","authors":"Mette Rode, Hanne Reilev Møller, Peymaneh Abadi, Henriette Juel Nissen, Paw Christian Holdgaard","doi":"10.1186/s41824-026-00285-9","DOIUrl":"10.1186/s41824-026-00285-9","url":null,"abstract":"<p><p>BACKGROUND: Studies evaluating [18F]fluorocholine PET/CT for parathyroid adenoma localisation fail to report the injection method used. At our department, manual injection method (MIM) was initially used, before converting to an automated injection system (AIS). Afterwards, physicians observed increased retention of the radiotracer within the veins leading from the injection site, which had not been as present previously. The aim of this study was to evaluate whether the injection method had a clinical impact. METHODS: The study compared two groups consisting of 60 patients, where the injection method was the only difference. Two physicians, blinded to injection method, evaluated if retention was present and interpretation was jeopardised. Quantitative measures were determined based on the original diagnostic confidence scores (DCS) for each suspected lesion, as these were compared between patient groups. Additionally, the maximum standardised uptake values (SUVmax) were measured for the suspected lesions along with the thyroid and salivary glands as a physiological reference point. Comparisons of the quantitative parameters were also performed between patients with or without retention. RESULTS: There was significant more occurrence of retention in AIS-group (83.3%) than MIM group (36.7%), (p < 0.00001). Retention did not influence the interpretation of any patient. A significant difference of DCS was observed, as 18% of lesions in the AIS-group had a low score, compared to only 1% in the MIM-group (p < 0.001). SUVmax was significantly lower in the AIS-group than the MIM-group for the reported adenomas (10.1 vs. 11.8, p = 0.008). In addition, SUVmax in the AIS-group was significantly lower in both the thyroid (4.6 vs. 5.2, p = 0.023) and salivary glands (10.8 vs. 12.4, p < 0.001). Comparison between patients with and without retention revealed similar differences in DCS and SUVmax for adenomas. CONCLUSION: The AIS is associated with a significant higher presence of retention, low diagnostic confidence and overall lower SUVmax, which indicates an aspect of clinical impact. It could potentially lead to a parathyroid adenoma being missed or classified as normal parathyroid tissue. Thus, manual injection method might be the method of choice, to ensure the most optimal clinical outcome. </p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":"3"},"PeriodicalIF":1.7,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146128554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics associated with abnormal dynamic flow in patients with severe obesity undergoing PET myocardial perfusion imaging.","authors":"Vikas Sunder, Larisa G Tereshchenko, Bryan Abadie, Abhayjit Singh, Wael Jaber","doi":"10.1186/s41824-025-00278-0","DOIUrl":"10.1186/s41824-025-00278-0","url":null,"abstract":"<p><strong>Purpose: </strong>To study dynamic flow data in patients with severe obesity undergoing PET myocardial perfusion imaging given that certain dynamic flow parameters are associated with adverse cardiovascular outcomes and can carry prognostic significance.</p><p><strong>Methods: </strong>Cross-sectional study of patients with severe obesity (BMI ≥ 35 kg/m2) who underwent Rb82 stress/rest PET myocardial perfusion imaging(MPI) in 2022-2023. Absolute myocardial blood flow(MBF) in mL/g/min was computed from the dynamic rest and stress images. MFR was calculated as the ratio of stress to rest MBF. Global MFR < 1.7 was considered significantly reduced and a rest MBF > 1.1 mL/g/min was considered elevated. Linear regression was used to investigate an association of patient characteristics with MBF.</p><p><strong>Results: </strong>Out of 123 patients, 78(63.4%) were male, 38% had reduced MFR, and 30% had an increased rest MBF, whereas 18% had both reduced MFR and increased rest MBF. After adjusting for age and BMI, there was a statistically significant difference in mean rest MBF in female (1.04 mL/g/min; 95%CI 0.96-1.12) versus male (0.85 mL/g/min; 95%CI 0.79-0.91) patients(P = 0.0004). There was a significant association between female sex and rest MBF > 1.1(P = 0.031). Adjusted for sex and BMI, linear regression analysis showed older age was associated with decreasing MFR by 0.14 (95% CI 0.06-0.22) per 10 years of age (P = 0.001).</p><p><strong>Conclusion: </strong>In a sample of patients with severe obesity undergoing Rb82 PET, there is a high prevalence of reduced MFR and increased rest MBF. Increasing age and female sex are associated with adverse physiologic alterations based on dynamic flow data within this at-risk patient population.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":"2"},"PeriodicalIF":0.0,"publicationDate":"2026-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12855704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calvarial intraosseous common venous malformation (hemangioma) diagnosed on technetium-99m labeled RBC scintigraphy: a case report and review of the literature.","authors":"Stephen J Sozio, William Y Raynor, Murray C Becker, Dhruv Patel, Jeffrey S Kempf","doi":"10.1186/s41824-025-00276-2","DOIUrl":"10.1186/s41824-025-00276-2","url":null,"abstract":"<p><strong>Background: </strong>Common venous malformations (\"hemangiomas\") are slow-growing, non-aggressive tumors consisting of small and large caliber vascular channels which can be found throughout the body, including within the musculoskeletal system. In cases where these masses do not present with the typical hallmark X-Ray, CT, or MRI findings, Technetium-99 m labeled Red Blood Cell (RBC) scintigraphy may be performed to confirm the diagnosis.</p><p><strong>Methods: </strong>A retrospective chart review was performed of a single patient with an indeterminate lesion of the calvarium. Relevant clinical history and imaging findings were reviewed. Current literature regarding the use of technetium-99 m labeled RBC scintigraphy in the diagnosis of intraosseous hemangiomas was also reviewed.</p><p><strong>Case discussion: </strong>A 25-year-old female initially presented to a neurologist in 2016 for new onset of seizures and intermittent panic attacks, at which time a non-contrast MRI Brain was obtained, revealing a T2 hyperintense and mildly T1 hyperintense mass within the occipital bone, which was suspected to represent an intraosseous hemangioma. She underwent a repeat non-contrast MRI Brain examination 8 years later for headaches, which found an increase in size of the calvarial lesion from 1.6 cm to 2.4 cm. While this lesion was still suspected to represent an intraosseous hemangioma, Technetium-99 m labeled RBC scintigraphy was performed as a confirmatory examination, which revealed normal initial blood flow but abnormal pooling of tagged RBCs within the lesion, thus compatible with a calvarial intraosseous hemangioma.</p><p><strong>Conclusion: </strong>Technetium-99 m labeled RBC scintigraphy can be an effective problem-solving tool in the diagnosis of intraosseous hemangiomas, and may be considered as a confirmatory examination or when results of conventional imaging techniques are felt to be indeterminate, and thus avoiding histologic correlation.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":" ","pages":"4"},"PeriodicalIF":0.0,"publicationDate":"2026-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12855661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146042242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of enduring benefit of sequential PRRT in malignant insulinoma.","authors":"Cristina-An Wang Zhang, Natacha Driessens, Magdalena Mileva, Amélie Deleporte, Patrick Flamen, Ioannis Karfis","doi":"10.1186/s41824-025-00282-4","DOIUrl":"10.1186/s41824-025-00282-4","url":null,"abstract":"<p><p>We report the case of a 62-year-old woman diagnosed in 2015 with de novo metastatic malignant insulinoma. She presented severe hypoglycemia and was initially treated with somatostatin analogs, chemotherapy (capecitabine-temozolomide), and diazoxide, but none of these controlled the symptoms. Peptide receptor radionuclide therapy (PRRT) with [177Lu]Lu-DOTATATE was initiated in 2016, resulting in marked clinical and radiological responses after four cycles. Due to recurrence, two subsequent PRRT treatments were administered in 2021 and 2024, each consisting of two cycles, leading to significant improvements in symptoms and imaging findings. To date, the patient has undergone eight PRRT cycles with sustained biochemical and morphological responses, long-term glycemic control, and excellent tolerance. This case illustrates the long-term efficacy of sequential PRRT retreatment in refractory functional pancreatic neuroendocrine tumors (pNETs).</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"10 1","pages":"1"},"PeriodicalIF":1.7,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12827842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced attenuation correction in FDG-PET/CT with respiratory mismatch correction.","authors":"Yoshiyuki Kitamura, Takuro Isoda, Motohiro Sando, Masaoki Kusunoki, Kazufumi Kikuchi, Shingo Baba, Kousei Ishigami","doi":"10.1186/s41824-025-00279-z","DOIUrl":"10.1186/s41824-025-00279-z","url":null,"abstract":"<p><strong>Background: </strong>In positron emission tomography/computed tomography (PET/CT), CT is typically used for attenuation correction during the creation and reconstruction of PET images. Respiratory motion can cause artifacts due to misalignment of PET images, known as respiratory misalignment artifacts (RMA), which occur in up to 30% of lesion-based evaluations, often necessitating rescans of both PET and CT. A new method for reconstructing PET/CT artifacts caused by respiratory motion, termed 'Enhanced AC' (EAC) (GE HealthCare, USA), was developed to improve RMA. To evaluate the effectiveness of EAC, radiologists' visual assessment using a misalignment score is appropriate regardless of the presence or absence of target lesions. This study aimed to assess the usefulness of EAC based on radiologist evaluations.</p><p><strong>Methods: </strong>Consecutive F-18 fluorodeoxyglucose (FDG) PET/CT cases imaged at our hospital between July and August 2024 were included. Two radiologists independently assessed the deviation of FDG-PET/CT images from all cases imaged conventionally. Cases identified by either radiologist as misaligned were designated as the misalignment case group and used for evaluating EAC. A 5-point scoring system was established for the misalignment score. To evaluate the effect of EAC, PET coronal section images from the misalignment case group before EAC adaptation (pre-images) and the EAC-reconstructed images (EAC images) were displayed side by side. Five radiologists independently evaluated both images using a misalignment score.</p><p><strong>Results: </strong>Fifty-four patients (male/female = 36/18, average age 64.1 ± 15.0 years, median 66.5 years) were identified as the misalignment case group. The average misalignment scores from the five radiologists for the pre-images were 3.5, 3.4, 3.3, 3.1, and 3.1, respectively, whereas the scores for the EAC images were significantly lower (p < 0.01) across all radiologists: 2.1, 2.4, 2.5, 2.2, and 1.9, respectively.</p><p><strong>Conclusions: </strong>EAC is an effective and practical method for reducing RMA in selected cases. This method can be easily tailored to individual patients and does not require a large, deep-learning dataset, making it suitable for routine diagnostics.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"9 1","pages":"43"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12753605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics-based machine learning models for predicting genomic alterations in metastatic prostate cancer using PSMA PET imaging: a pilot study.","authors":"Anna Scavuzzo, Giovanni Pasini, Osvaldo G Perez, Miguel A Jimenez Rios, Marina Arenas Hernández, Roberto Pedrero-Piedras, Maria Delia Pérez Montiel, Nora Sobrevilla Moreno, Giorgio Russo, Alessandro Stefano","doi":"10.1186/s41824-025-00280-6","DOIUrl":"10.1186/s41824-025-00280-6","url":null,"abstract":"<p><strong>Background and objective: </strong>Genomic characterization of metastatic prostate cancer (mPCa) plays a pivotal role in guiding precision oncology. This study aimed to evaluate the feasibility of combining radiomics and clinical data within a machine learning (ML) framework to non-invasively predict key genomic mutations in patients with mPCa undergoing PSMA PET imaging.</p><p><strong>Methods: </strong>A retrospective cohort of 14 mPCa patients who underwent [¹⁸ F]PSMA-1007 PET/CT was analysed. Prostate and metastatic lesions were segmented, and radiomics features were extracted. Somatic genomic alterations were obtained from formalin-fixed paraffin-embedded tissue samples using FoundationOne CDx testing. Six ML algorithms - Discriminant Analysis, Support Vector Machines, K-Nearest Neighbours, Neural Networks, Random Forest, and Boosting - were trained using a 5-times repeated pipeline with 80/20 train/test split, LASSO feature selection, and 5-fold cross-validation. Model performance was assessed using accuracy, AUC, sensitivity, specificity, precision, and F-score.</p><p><strong>Key findings: </strong>Fourteen patients with mPCa were included, and 46 lesions were analysed. Genomic alterations included mutations in TP53, TMPRSS2, PTEN, BRCA1/2, ATM, and others. Owing to data limitations, mutations other than TP53, TMPRSS2, and PTEN were grouped into a composite \"OTHER\" category. The best-performing clinical-radiomics ML models achieved AUCs of 91.11% (TP53), 84.44% (TMPRSS2), 80.00% (PTEN), and 77.78% (OTHER). Selected feature stability was consistent across repeated runs.</p><p><strong>Conclusions and clinical implications: </strong>Clinical-radiomics ML models based on PSMA PET imaging show promising accuracy in predicting actionable genomic alterations in mPCa. These findings support further investigation into radiogenomics modelling as a complementary, non-invasive tool to inform molecular profiling and treatment stratification.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"9 1","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12753601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative [¹⁸F]FDOPA PET/CT for the characterization of biochemical phenotypes in paraganglioma and pheochromocytoma.","authors":"Paul Dahlmann, Meike Onkes, Sophie Kunte, Matthias K Auer, Ulrike Disko, Katharina Wang, Christian Lottspeich, Isabel Stüfchen, Júnia R O L Schweizer, Nabeel Mansour, Matthias Brendel, Christine Schmid-Tannwald, Alessa Fischer, Svenja Nölting, Christoph J Auernhammer, Martin Reincke, Martin Bidlingmaier, Rudolf A Werner, Matthias Kroiss, Friederike Völter","doi":"10.1186/s41824-025-00275-3","DOIUrl":"10.1186/s41824-025-00275-3","url":null,"abstract":"<p><strong>Aim/introduction: </strong>[¹⁸F]FDOPA PET/CT is one of the most frequently used functional imaging modalities for the diagnosis of pheochromocytoma and paraganglioma (PPGL). The biochemical secretion type of PPGL is crucial for patient management, being linked to varying aggressiveness and metastatic risk. The aim of this study is to compare the biochemical phenotype and secretion with uptake intensity and tumour volume on [¹⁸F]FDOPA PET/CT.</p><p><strong>Methods: </strong>All patients with sympathetic PPGL undergoing [¹⁸F]FDOPA PET/CT and laboratory analysis at first diagnosis at LMU University Hospital between 03/2012 and 11/2023 were included. Metabolic tumour volume (MTV), SUVmax, SUVmean and total lesion uptake (TLU) were compared to biochemical secretion using Rho-Spearman's correlation and linear regression correcting for age, gender and secretion type. Biochemical phenotypes were compared with Mann-Whitney-U-test, ROC analysis was used to test the diagnostic discriminative power of radioligand uptake.</p><p><strong>Results: </strong>71 of 74 PPGL were [¹⁸F]DOPA-positive. TLU and MTV showed a moderate to strong correlation with plasma and urinary normetanephrines (R = 0.68-0.82, p < 0.001), plasma 3-methoxytyramine (R = 0.50, p = 0.003) and urinary metanephrines (R = 0.69-0.80, p < 0.001). Regression analysis revealed a significant relationship between biochemical secretion and TLU (r² = 0.45-0.52, p < 0.001). Compared to adrenergic PPGL, noradrenergic PPGL demonstrated an increased radioligand uptake (p < 0.001). ROC analysis identified thresholds for SUVmax ( > 12.1) and SUVmean ( > 6.95) that moderately distinguished both phenotypes (AUC = 0.75-0.76).</p><p><strong>Conclusion: </strong>Radioligand uptake on [¹⁸F ]FDOPA PET/CT is associated with the biochemical phenotype of PPGL. This finding may facilitate the metabolic profiling of patients with suspected impaired or delayed laboratory results. Normetanephrine concentrations in plasma and 24-hour urine may be employed as predictive markers of MTV and TLU.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":"9 1","pages":"40"},"PeriodicalIF":0.0,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12640888/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145591006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18 F-PSMA PET/CT reveals occult pericardial inflammation.","authors":"Antonios Dimosthenis Kalkinis, Christos Koutserimpas, Nikolaos-Achilleas Arkoudis, Dimitrios Bafaloukos, George Samonis, Constantinos D Anagnostopoulos","doi":"10.1186/s41824-025-00277-1","DOIUrl":"10.1186/s41824-025-00277-1","url":null,"abstract":"<p><p>18F-PSMA PET/CT is widely utilized for the detection and staging of prostate cancer due to its high affinity for prostate-specific membrane antigen (PSMA), which is overexpressed in malignant prostate tissue. PSMA ligands have also been shown to accumulate in non-prostatic tissues under certain pathological conditions, including inflammation. We report a case of inci dentally detected subclinical pericardial inflammation in a patient undergoing prostate cancer staging with 18F-PSMA PET/CT imaging. A 61-year-old male with histologically confir med, organ-confined prostate adenocarcinoma (Gleason score 7, Grade Group 2) underwent 18F-PSMA PET/CT clinically indicated for staging prior to radical prostatectomy. While no evidence of metastatic disease was found, the scan revealed mildly increased PSMA uptake along the pericardium with a small associated effusion. The patie nt had no clinical signs or symptoms of pericarditis, and comprehensive cardiac, infectious, and rheumatologic workup was unremarkable. Conservative management was pursued, and follow-up demonstrated resolution of the effusion with no clinical sequelae. Th is case illustrates that 18F-PSMA PET/CT, although performed for prostate cancer staging, may incidentally detect findings such as subclinical pericardial inflammation, emphasizing the importance of careful evaluation of extra-prostatic uptake. Further res earch is warranted to explore its potential role in identifying subclinical inflammatory conditions beyond oncology.</p>","PeriodicalId":519909,"journal":{"name":"EJNMMI reports","volume":" ","pages":"41"},"PeriodicalIF":1.7,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12715068/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145567052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}