Translational exercise biomedicine最新文献

Why the dominance of East Africans in distance running? a narrative review 东非人为何在长跑运动中独占鳌头？

Translational exercise biomedicine Pub Date : 2024-08-08 DOI: 10.1515/teb-2024-0018

G. Grivas, Vincent O. Onywera, L. A. Marco-Contreras, Shaun Sutehall, B. Muñiz-Pardos

{"title":"Why the dominance of East Africans in distance running? a narrative review","authors":"G. Grivas, Vincent O. Onywera, L. A. Marco-Contreras, Shaun Sutehall, B. Muñiz-Pardos","doi":"10.1515/teb-2024-0018","DOIUrl":"https://doi.org/10.1515/teb-2024-0018","url":null,"abstract":"\u0000 \u0000 \u0000 Runners from East Africa including Kenya, Ethiopia and Uganda have dominated middle- and long-distance running events, for almost six decades. This narrative review examines and updates current understanding of the factors explaining the dominance of East Africans in distance running from a holistic perspective.\u0000 \u0000 \u0000 \u0000 The dominance of East African distance runners has puzzled researchers, with various factors proposed to explain their unparalleled success. Four key elements emerge: 1) biomechanical and physiological attributes, 2) training characteristics, 3) psychological motivations, and 4) African diet. Runners from East Africa often exhibit ectomorphic somatotypes, characterized by lean body compositions which lead them to an extraordinary biomechanical and metabolic efficiency. Their sociocultural lifestyle, training regimens beginning at a young age with aerobic activities, seem crucial, as well as moderate volume, high-intensity workouts at altitudes ranging from 2,000 to 3,000 m. Psychological factors, including a strong motivation to succeed driven by aspirations for socioeconomic improvement and a rich tradition of running excellence, also contribute significantly. A multifactorial explanation considering these factors, without a clear genetic influence, is nowadays the strongest argument to explain the East African phenomenon.\u0000 \u0000 \u0000 \u0000 To unravel the mystery behind the supremacy of East African runners, it is imperative to consider these multifaceted factors. The predominantly rural lifestyle of the East African population underscores the importance of aligning modern lifestyles with the evolutionary past of Homo sapiens, where physical activity was integral to daily life. Further research is required to explain this phenomenon, with a focus on genetics.\u0000","PeriodicalId":519893,"journal":{"name":"Translational exercise biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141926927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A unique pseudo-eligibility analysis of longitudinal laboratory performance data from a transgender female competitive cyclist 对一名变性女自行车竞技运动员的纵向实验室成绩数据进行独特的伪资格分析

Translational exercise biomedicine Pub Date : 2024-07-29 DOI: 10.1515/teb-2024-0017

Blair R. Hamilton, Ke Hu, F. Guppy, Y. Pitsiladis

{"title":"A unique pseudo-eligibility analysis of longitudinal laboratory performance data from a transgender female competitive cyclist","authors":"Blair R. Hamilton, Ke Hu, F. Guppy, Y. Pitsiladis","doi":"10.1515/teb-2024-0017","DOIUrl":"https://doi.org/10.1515/teb-2024-0017","url":null,"abstract":"\u0000 \u0000 \u0000 The Union Cycliste Internationale has deemed transgender female athlete’s ineligible for the female category due to concerns about performance advantages. We conducted a follow-up analysis on laboratory-based performance indicators of sports performance using data from a longitudinally assessed transgender woman athlete undergoing gender-affirming hormone therapy (GAHT).\u0000 \u0000 \u0000 \u0000 We evaluated laboratory performance indicators in transgender and cisgender women athletes using dual-energy X-ray absorptiometry scanning, handgrip strength measurement, jump testing, and cardiopulmonary exercise. Additionally, we assessed a transgender sub-elite cyclist before and after undergoing GAHT.\u0000 \u0000 \u0000 \u0000 After one year of GAHT, the transgender athlete showed declines in handgrip strength (7–13 %), countermovement jump (23–29 %), and V̇O2max (15–30 %). After 3 months, several performance indicators (absolute handgrip, peak power, relative peak power, average power, relative average power, V̇O2max and relative V̇O2max) were above the mean of cisgender female athletes, while others (Relative handgrip, countermovement jump and relative countermovement jump) were below. Similar trends were observed at 6 months and 1 year.\u0000 \u0000 \u0000 \u0000 This hypothetical analysis, although with limited evidence, suggests the transgender athlete could compete equitably in elite cycling events within the female category after one year of GAHT. Adjustments based on competition data would ensure fairness. Further analysis after an additional 12 months is recommended to assess the impact of 2 years of GAHT. An outright ineligibility for the female category for transgender women athletes would hinder a true assessment of performance fairness.\u0000","PeriodicalId":519893,"journal":{"name":"Translational exercise biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141796766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caveolin-3 regulates slow oxidative myofiber formation in female mice Caveolin-3调节雌性小鼠缓慢氧化肌纤维的形成

Translational exercise biomedicine Pub Date : 2024-07-26 DOI: 10.1515/teb-2024-0004

Xinyuan Zhang, Xiaoyang Shi, Jinjie Li, Guangning Kou

{"title":"Caveolin-3 regulates slow oxidative myofiber formation in female mice","authors":"Xinyuan Zhang, Xiaoyang Shi, Jinjie Li, Guangning Kou","doi":"10.1515/teb-2024-0004","DOIUrl":"https://doi.org/10.1515/teb-2024-0004","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000 Caveolin-3 (Cav-3) plays a pivotal role in maintaining skeletal muscle mass and function. Mutations or deletions of Cav-3 can result in the development of various forms of myopathy, which affect the integrity and repair capacity of muscle fiber membranes. However, the potential effect of Cav-3 on myofiber type composition remains unclear.\u0000 \u0000 \u0000 \u0000 To investigate the effect of Cav-3 on muscle strength and running capacity, we examined the grip force test and the low/high-speed running test. Oxidative and glycolytic myofiber-related genes, proteins, and skeletal muscle fiber composition were measured to determine the role of the Cav-3 in oxidative myofiber formation.\u0000 \u0000 \u0000 \u0000 We report the impact of Cav-3 on enhancing muscle endurance performance in female mice, and the discovery of a new physiological function to increase the proportion of slow-twitch oxidative muscle fiber by analyzing the gastrocnemius and soleus. Skeletal muscle-specific ablation of Cav-3 in female mice increased oxidative myofiber-related gene expression and type I oxidative myofiber composition, with resultant improvements in endurance performance. In male mice, the absence of Cav-3 in skeletal muscle reduced in the expression of glycolytic fiber-related genes and proteins.\u0000 \u0000 \u0000 \u0000 This study identified Cav-3 as a regulator of slow-twitch oxidative muscle fiber formation acting on female mice, which may provide a potential target for improving muscle oxidative function.\u0000","PeriodicalId":519893,"journal":{"name":"Translational exercise biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141799535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the Olympic and Paralympic games 奥运会和残奥会之外

Translational exercise biomedicine Pub Date : 2024-07-26 DOI: 10.1515/teb-2024-0023

Fabio Pigozzi

引用次数: 0

Gender equality policy of the Olympic Movement in Chinese sport governing bodies: the case of elite volleyball 中国体育管理机构的奥林匹克运动性别平等政策：以精英排球为例

Translational exercise biomedicine Pub Date : 2024-07-25 DOI: 10.1515/teb-2024-0007

Xingmeng Ava Huang, Patrick Wing Chung Lau

{"title":"Gender equality policy of the Olympic Movement in Chinese sport governing bodies: the case of elite volleyball","authors":"Xingmeng Ava Huang, Patrick Wing Chung Lau","doi":"10.1515/teb-2024-0007","DOIUrl":"https://doi.org/10.1515/teb-2024-0007","url":null,"abstract":"\u0000 \u0000 \u0000 This research based on the theoretical framework of globalisation focuses on the development of gender equality policy in the Olympic Movement and the implementation of IOC’s gender equality policy in the context of Chinese elite volleyball.\u0000 \u0000 \u0000 \u0000 In addition to documentary analysis, 17 semi-structured interviews were conducted with key insiders within Chinese elite volleyball system to provide a comprehensive understanding of the IOC’s gender equality policy implementation. The analysis involved perspectives of athletes’ participation, coaching positions, and leadership roles according to three main elements of the IOC’s gender equality policy.\u0000 \u0000 \u0000 \u0000 The findings demonstrated that the responses of Chinese elite volleyball to IOC’s gender equality policy are participative, conflictual, and passive in terms of the gender balance of athletes’ participation, coaches’ positions, and the representation of leadership roles respectively.\u0000 \u0000 \u0000 \u0000 IOC recommended subordinated stakeholders including NOCs to implement gender equality policy. The attitude of Chinese elite volleyball governing body towards gender equality is generally positive. However, IOC’s gender equality policy is not consistently transferred at national level. Policy might be implemented with symbolic measure in China without monitoring system. Referees should be included in policy contents in addition to athletes, coaches and leaders. In addition, since IOC’s gender equality policy and statistics have been keeping updated, further results with respect to the case of volleyball should be demonstrated in future research.\u0000","PeriodicalId":519893,"journal":{"name":"Translational exercise biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141804377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Are calves trainable? Low-intensity calf muscle training with or without blood flow restriction: a randomized controlled trial 小腿可以训练吗？有无血流限制的低强度小腿肌肉训练：随机对照试验

Translational exercise biomedicine Pub Date : 2024-07-25 DOI: 10.1515/teb-2024-0015

S. Gavanda, Matthias Eisenkolb, Steffen Held, S. Geisler, S. Gehlert

{"title":"Are calves trainable? Low-intensity calf muscle training with or without blood flow restriction: a randomized controlled trial","authors":"S. Gavanda, Matthias Eisenkolb, Steffen Held, S. Geisler, S. Gehlert","doi":"10.1515/teb-2024-0015","DOIUrl":"https://doi.org/10.1515/teb-2024-0015","url":null,"abstract":"\u0000 \u0000 \u0000 Whether low-load resistance training (RT) without muscle failure, with or without blood flow restriction (BFR), is sufficient to increase strength and muscle growth of calf muscles in trained individuals is still unclear. This study aimed to compare the effects of low-intensity BFR RT vs. traditional low-intensity RT (noBFR) with moderate training volume on strength and circumference.\u0000 \u0000 \u0000 \u0000 We designed a parallel, randomized controlled trial including 36 RT-trained participants (BFR: 7 females, 32.9 ± 8.8 years, 11 males, 28.4 ± 3.6 years; noBFR; 8 females, 29.6 ± 3.4 years; 10 males, 28.6 ± 4.9 years) who underwent eight weeks of twice-weekly low-load RT with 16 weekly RT sets (30 % of one-repetition maximum [1RM]). RT consisted of bilateral calf raises and seated unilateral calf raises, each conducted with 4 sets (30, 15, 15, 15 repetitions not to failure) of either BFR or noBFR. Outcome measures included calf circumference (CC), leg stiffness (LS), and various strength tests (seated and standing calf raise 1RM, isokinetic strength of plantar- and dorsiflexion).\u0000 \u0000 \u0000 \u0000 There were no significant interactions or group effects for most measures. Both groups showed significant improvements in seated calf raise strength (p=0.046, η\u0000 2\u0000 p=0.17). Pairwise comparisons indicated moderate to large effect sizes for strength improvements (standardized mean differences: 0.35–1.11), but no changes in calf circumference were observed in either group.\u0000 \u0000 \u0000 \u0000 Low-load RT with and without BFR are useful to increase strength without necessarily affecting hypertrophy. Low-intensity BFR training did not confer additional benefits over traditional low-intensity RT for calf muscle strength or circumference, questioning its general advantage under such conditions.\u0000","PeriodicalId":519893,"journal":{"name":"Translational exercise biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practical steps to develop a transcriptomic test for blood doping 开发血液兴奋剂转录组检测的实用步骤

Translational exercise biomedicine Pub Date : 2024-07-22 DOI: 10.1515/teb-2024-0010

Shaun Sutehall, F. Malinsky, Sven Voss, Neil Chester, Xioa Xu, Y. Pitsiladis

引用次数: 1

Associations of strength indices and cycling economy in young adults 青壮年力量指数与骑行经济性的关系

Translational exercise biomedicine Pub Date : 2024-07-22 DOI: 10.1515/teb-2024-0008

J. Feuerbacher, Moritz Schumann

{"title":"Associations of strength indices and cycling economy in young adults","authors":"J. Feuerbacher, Moritz Schumann","doi":"10.1515/teb-2024-0008","DOIUrl":"https://doi.org/10.1515/teb-2024-0008","url":null,"abstract":"\u0000 \u0000 \u0000 Cycling economy is associated with muscle strength in athletes. However, the relationship between strength capacity (i.e. maximal and explosive strength) and cycling economy in previously untrained but healthy individuals remains unclear. Therefore, this study aimed to assess the associations between cycling economy and strength performance in a population of recreationally active but untrained healthy individuals.\u0000 \u0000 \u0000 \u0000 A total of 155 recreationally active individuals (95 males and 60 females) were included. Strength capacity was assessed through an incremental one-repetition maximum test, from which the one-repetition maximum, mean propulsive velocity, and mean propulsive power were derived as strength indices. Cycling economy was assessed using a step protocol on a cycle ergometer and gross oxygen cost and caloric unit cost were determined at submaximal intensities.\u0000 \u0000 \u0000 \u0000 Marginal R2 ranged between 0.013 and 0.062 for the gross oxygen cost and between 0.022 and 0.103 for the gross caloric unit cost, respectively. Greater cycling economy is related to higher strength levels. However, the relationship is relatively weak, explaining only 1.3–6.2 % of the variance in gross oxygen cost and 2.2–10.3 % of the variance in gross caloric unit cost.\u0000 \u0000 \u0000 \u0000 Greater cycling economy in recreationally active males and females is related to higher strength levels (i.e. one-repetition maximum, mean propulsive velocity, mean propulsive power).\u0000","PeriodicalId":519893,"journal":{"name":"Translational exercise biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolomic and proteomic applications to exercise biomedicine. 代谢组学和蛋白质组学在运动生物医学中的应用。

Translational exercise biomedicine Pub Date : 2024-03-21 eCollection Date: 2024-05-01 DOI: 10.1515/teb-2024-2006

Daniel J Wilkinson, Hannah Crossland, Philip J Atherton

{"title":"Metabolomic and proteomic applications to exercise biomedicine.","authors":"Daniel J Wilkinson, Hannah Crossland, Philip J Atherton","doi":"10.1515/teb-2024-2006","DOIUrl":"https://doi.org/10.1515/teb-2024-2006","url":null,"abstract":"Objectives: 'OMICs encapsulates study of scaled data acquisition, at the levels of DNA, RNA, protein, and metabolite species. The broad objectives of OMICs in biomedical exercise research are multifarious, but commonly relate to biomarker development and understanding features of exercise adaptation in health, ageing and metabolic diseases.Methods: This field is one of exponential technical (i.e., depth of feature coverage) and scientific (i.e., in health, metabolic conditions and ageing, multi-OMICs) progress adopting targeted and untargeted approaches.Results: Key findings in exercise biomedicine have led to the identification of OMIC features linking to heritability or adaptive responses to exercise e.g., the forging of GWAS/proteome/metabolome links to cardiovascular fitness and metabolic health adaptations. The recent addition of stable isotope tracing to proteomics ('dynamic proteomics') and metabolomics ('fluxomics') represents the next phase of state-of-the-art in 'OMICS.Conclusions: These methods overcome limitations associated with point-in-time 'OMICs and can be achieved using substrate-specific tracers or deuterium oxide (D2O), depending on the question; these methods could help identify how individual protein turnover and metabolite flux may explain exercise responses. We contend application of these methods will shed new light in translational exercise biomedicine.","PeriodicalId":519893,"journal":{"name":"Translational exercise biomedicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11036890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140862270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0