P Aravindhmozhi, Tanuj Moses Lamech, Charankumar Swamikkannu, Anila Abraham Kurien, Natarajan Gopalakrishnan
{"title":"Rifampicin-associated intravascular haemolysis causing acute kidney injury.","authors":"P Aravindhmozhi, Tanuj Moses Lamech, Charankumar Swamikkannu, Anila Abraham Kurien, Natarajan Gopalakrishnan","doi":"10.25259/NMJI_1479_2024","DOIUrl":"10.25259/NMJI_1479_2024","url":null,"abstract":"<p><p>Drug-induced acute kidney injury (AKI) is a rare adverse effect of rifampicin, and is mostly related to acute tubular necrosis and acute interstitial nephritis. We report a sputum- positive, isoniazid mono-resistant, pulmonary tuberculosis patient who had a history of anti-tuberculous therapy (ATT) intake 30 years ago. The patient developed AKI requiring dialysis when he restarted the ATT recently. A renal biopsy was consistent with pigment-cast nephropathy secondary to rifampicin-induced intravascular haemolysis. Rifampicin was stopped, and the patient underwent a total of four dialysis sessions and subsequently recovered.</p>","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"38 2","pages":"92-93"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Progress towards Clinical Pig Organ Xenotransplantation.","authors":"David Kc Cooper","doi":"10.25259/NMJI_348_2025","DOIUrl":"https://doi.org/10.25259/NMJI_348_2025","url":null,"abstract":"","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"38 2","pages":"65-68"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Two lady doctors, a vicereine, and a princess: The women behind four historic medical colleges in India.","authors":"Siuli Mitra, Reena George","doi":"10.25259/NMJI_582_2024","DOIUrl":"10.25259/NMJI_582_2024","url":null,"abstract":"<p><p>We introduce the stories of the lives of four women founders of four Indian medical colleges: Dr Edith Brown who founded the North Indian Medical School for Christian Women, Ludhiana (present-day Christian Medical College, Ludhiana); Lady Winifred Hardinge, after whom the Lady Hardinge Medical College, Delhi was named; Dr Ida Sophia Scudder who founded the Christian Medical College, Vellore; and Rajkumari Amrit Kaur, the cabinet minister responsible for the creation of the All India Institute of Medical Sciences, New Delhi. We highlight events and people in their lives crucial to the creation of the four institutions that have had a transformative impact on Indian medical education particularly for women. We observed that very diverse backgrounds and early lives prepared these four women for a mission that in its impact was very similar.</p>","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"38 2","pages":"119-123"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endobronchial ultrasound guided transbronchial needle aspiration leading to cardiac empyema and tamponade by Prevotella oris.","authors":"Damla Ernur, Volkan Hanci, Salýha Ýldem Kaya","doi":"10.25259/NMJI_570_2022","DOIUrl":"10.25259/NMJI_570_2022","url":null,"abstract":"<p><p>Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TNBA) is widely recommended for the diagnosis of mediastinal lymphadenopathy of malignant and non-malignant aetiology. EBUS-TBNA is preferred over mediastinoscopy as it has a better diagnostic accuracy and safety, is cost-effective and less invasive. Major complications of EBUS-TBNA include bleeding, mediastinitis, pneumonia, mediastinal abscess, empyema, lung abscess, pericarditis, pneumothorax, and rarely pericardial tamponade. We report a patient who developed pericardial empyema and tamponade due to Prevotella oris following EBUS-TBNA.</p>","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"38 1","pages":"12-13"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Isolated heart block in snake bite: Recurrent syncope as presenting symptom.","authors":"B Sharan Kumar","doi":"10.25259/NMJI_1047_2023","DOIUrl":"https://doi.org/10.25259/NMJI_1047_2023","url":null,"abstract":"","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"38 1","pages":"58"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rapid diagnosis of disseminated Mycobacterium avium complex infection mimicking metastatic malignancy using metagenomic next-generation sequencing.","authors":"Yan Liu, Jie Wang, Yonglan Pu, Shenjie Tang","doi":"10.25259/NMJI_872_2022","DOIUrl":"10.25259/NMJI_872_2022","url":null,"abstract":"<p><p>Disseminated non-tuberculous mycobacteria (NTM) disease, which is mainly found in immunocompromised individuals, is a rare and severe infection whose diagnosis poses a challenge to clinicians. We present a patient with disseminated NTM infection mistaken for metastatic malignancy in an otherwise healthy patient and the tortuous diagnostic process. Metagenomic next-generation sequencing (mNGS) played a critical role in the diagnosis. Further screening for anti-interferon-γ antibodies revealed that the patient had a potential immunodeficiency.</p>","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"38 1","pages":"16-17"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Status of Liver Transplantation in India.","authors":"Parmanand Tiwari, Samiran Nundy","doi":"10.25259/NMJI_528_2024","DOIUrl":"10.25259/NMJI_528_2024","url":null,"abstract":"<p><p>Background The passage of the Transplantation of Human Organs Act in 1994 banned the unethical trade in human kidneys and recognized heart beating brain death as a form of death. This enabled liver transplantation to be performed in India. We briefly recount the history of the Act's passage and describe, in some detail, the present status of the procedure. Methods We sent a questionnaire regarding liver transplant services via email to 400 members of the Liver Transplant Society of India requesting them to provide details on liver transplantation at their centres up to 2022. We received information on 3069 of 3920 transplants that had been performed in 2022. Results There were 183 registered centres who had performed a total of 3920 liver transplants, placing India in third position behind the USA (n=9528) and China (n=6053) while it performed the largest number of living donor liver transplants (n=3183) in the world. The most common indication for liver transplantation was non-alcoholic steatohepatitis (NASH)-related cirrhosis (20%). Our teams published 2449 PubMed indexed research papers and 384 foreign trainees came from 52 countries for training in liver transplantation. The concerns were the small numbers of deceased organ donation, the dominance of the private sector (96.7%), corruption in the form of kickbacks and false declarations of relationship and gender imbalance with only 22% women recipients receiving organs from men while 68% women donated their livers to men. Conclusion Liver transplantation has saved the lives of many Indians, made a major impact on Indian healthcare overall, and increased its reputation worldwide. There are problems which we hope will be tackled by increasing societal awareness.</p>","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"38 1","pages":"30-34"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence and antimicrobial resistance pattern of Burkholderia cepacia at a tertiary care teaching hospital.","authors":"Naimikaben Patel, Chaitali Dabhi, Rupal Patel, Suman Singh","doi":"10.25259/NMJI_498_2022","DOIUrl":"10.25259/NMJI_498_2022","url":null,"abstract":"<p><p>Background Burkholderia cepacia (B. cepacia) is the fourth most common pathogenic non-fermenting gram-negative bacilli isolated from clinical samples in hospitalized patients. It is an emerging opportunistic pathogen causing a wide range of infections in immunocompromised and hospitalized patients. Methods We did a retrospective observational study at Shree Krishna Hospital, Karamsad after approval by the Institutional Ethics Committee to determine the prevalence and antimicrobial resistance pattern of B. cepacia from January 2015 to November 2020. Clinical specimens of all the indoor and outdoor patients of all age groups, from whom B. cepacia was isolated, were included in the study. Identification and antimicrobial susceptibility testing of isolates were done by the Vitek 2 Compact system as per the Clinical and Laboratory Standards Institute (CLSI) guidelines. Results Ninety-one (0.54%) B. cepacia were isolated out of 16 840 organisms from 45 743 specimens received during the duration of the study. These were isolated most commonly from patients in the 0-20 years age group (31%) followed by those 41-60 years of age (20%). Also it was isolated more often in males than females. Blood and body fluids (57%) were the most common specimens from which B. cepacia was isolated followed by respiratory specimens (18%), urine (14%), and pus (11%). B. cepacia antimicrobial resistance was seen more commonly to ticarcillin-clavulanate (72%) followed by levofloxacin (34%), trimethoprim- sulphamethoxazole (30%), ceftazidime (30%), minocycline (21%) and meropenem (14%). Conclusion The prevalence of B. cepacia was low. B. cepacia has been identified as an important pathogen in bloodstream infections. It is important to know the antimicrobial resistance pattern of B. cepacia for better management of patients.</p>","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"38 1","pages":"9-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of hepatitis B and C virus infections among Buddhist tribes of Kaza health block, Lahaul and Spiti district of Himachal Pradesh.","authors":"Rajesh Sharma, Anmol Gupta, Neetu Sharma, Amit Sachdeva, Deepesh Barall, Vishal Bodh, Dikshant Sharma, Brij Sharma","doi":"10.25259/NMJI_1042_2022","DOIUrl":"10.25259/NMJI_1042_2022","url":null,"abstract":"<p><p>Background Infection of hepatitis B virus (HBV) and/ or hepatitis C virus (HCV) is a global public health concern. We aimed to estimate the prevalence of viral hepatitis B and C in the Buddhist tribal area of Kaza health block in Lahaul and Spiti district in Himachal Pradesh, India, and to identify the determinants. Methods The study was conducted by the departments of Gastroenterology, Community Medicine and Microbiology, Indira Gandhi Medical College, Shimla between June 2015 and October 2017. Using a two-stage sampling method, 4231 participants in 40 clusters were enrolled. For each subject, a pre-tested interview schedule was administered, and blood was tested for hepatitis B surface antigen (HBsAg) and antibodies to HCV (anti-HCV). Those samples which tested positive for HBsAg were further tested for hepatitis B core antigen (HBeAg) and antibody to HBeAg (anti-HBe). Results Among the 4231 participants, HBsAg and anti-HCV were detected in 961 (22.7%) and 33 (0.9%), respectively, including 6 (0.1%) who tested positive for both. HBsAg positivity was not associated with religion (p=0.07), caste (p=0.16), level of education (p=0.58) or marital status (p=0.73). Of all the participants, 588 (13.9%) reported a history of HBV vaccination. Of those who were HBsAg positive (961), 21.6% were positive for HBeAg and 58.3% were positive for anti-HBe. Conclusion The prevalence of HBV infection in the Kaza health block was high, and no specific associations were identified. Interventions such as public health education and universal childhood immunization at birth may help reduce the high rate of transmission of HBV in this population.</p>","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"38 1","pages":"5-8"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"District Residency Programme: Experience of a pharmacology resident.","authors":"Varun Santhosh, Atiya R Faruqui","doi":"10.25259/NMJI_867_2023","DOIUrl":"https://doi.org/10.25259/NMJI_867_2023","url":null,"abstract":"","PeriodicalId":519891,"journal":{"name":"The National medical journal of India","volume":"38 1","pages":"22"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}