Gut microbes reports最新文献_第5页

Using in vitro gastrointestinal (GI) tract digestive products to investigate fermentation dynamics of Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12, and Escherichia coli. 利用体外胃肠道消化产物研究鼠李糖乳杆菌GG、动物双歧杆菌亚种的发酵动力学。乳酸杆菌BB-12和大肠杆菌。

Gut microbes reports Pub Date : 2026-01-26 eCollection Date: 2026-01-01 DOI: 10.1080/29933935.2026.2620183

He Lyu, Saartje Hernalsteens, Qijun Zheng, Aibing Yu, Xiao Dong Chen

{"title":"Using in vitro gastrointestinal (GI) tract digestive products to investigate fermentation dynamics of Lactobacillus rhamnosus GG, Bifidobacterium animalis subsp. lactis BB-12, and Escherichia coli.","authors":"He Lyu, Saartje Hernalsteens, Qijun Zheng, Aibing Yu, Xiao Dong Chen","doi":"10.1080/29933935.2026.2620183","DOIUrl":"10.1080/29933935.2026.2620183","url":null,"abstract":"Gastrointestinal digestion shapes nutrient availability and microbial substrates in early life, yet how milk digestion products regulate probiotic-pathogen dynamics remains unclear. Using in vitro digestion products of human milk (HM), infant formula (IF), and control milk (CM), we evaluated the fermentation responses of Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis subsp. lactis BB-12 (BB-12), and Escherichia coli (E. coli) in static reactors (ST) and peristalsis-mimicking soft elastic tubular reactors (SETR). HM-derived residues selectively enhanced probiotic activity by increasing reducing-sugar utilization, acidification (ΔpH), and overall metabolic output by 110% (LGG) and 130% (BB-12), while suppressing E. coli growth by 28%. In the absence of digestive products, LGG and BB-12 declined by 0.99 and 3.19 log units, whereas E. coli increased by 0.33 log. Mechanical compression in SETR further boosted BB-12 metabolic output by 23% compared with ST. These results demonstrate that infant milk digestion products differentially regulate microbial strategies. We acknowledge that this simplified three-strain model does not capture full gut community complexity, and broader consortia studies are needed for future validation.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"3 1","pages":"2620183"},"PeriodicalIF":0.0,"publicationDate":"2026-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12938877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

Gut microbes reports Pub Date : 2026-01-26 eCollection Date: 2026-01-01 DOI: 10.1080/29933935.2026.2622177

引用次数: 0

Distinguishing the significance of blood microbes in epithelial ovarian cancer. 区分血液微生物在上皮性卵巢癌中的意义。

Gut microbes reports Pub Date : 2026-01-01 Epub Date: 2026-02-02 DOI: 10.1080/29933935.2026.2623562

Diane E Mahoney, Prabhakar Chalise, Dong Pei, Rachel Griffard-Smith, Trisha Home, Harsh B Pathak, Shahid Umar, Andrew K Godwin

{"title":"Distinguishing the significance of blood microbes in epithelial ovarian cancer.","authors":"Diane E Mahoney, Prabhakar Chalise, Dong Pei, Rachel Griffard-Smith, Trisha Home, Harsh B Pathak, Shahid Umar, Andrew K Godwin","doi":"10.1080/29933935.2026.2623562","DOIUrl":"10.1080/29933935.2026.2623562","url":null,"abstract":"The human microbiome has generated growing interest in epithelial ovarian cancer (EOC) research, yet investigations of the blood microbiome remain sparse. This study explored plasma microbial signatures unique to EOC. We accessed 180 age/race/ethnicity-matched archival plasma samples from women with (1) EOC; (2) commonly diagnosed non-EOC solid tumors in women; (3) benign gynecologic conditions; and (4) age/race/ethnicity-matched controls. The microbial profiles of the plasma specimens were assessed using an amplicon-based sequencing method that targets the 16S rRNA gene in the bacterial genome. A stringent bioinformatic pipeline was applied to filter out suspicious bacterial contaminants at the genus level. Bioinformatic decontamination analysis removed 225 high-risk bacterial contaminants. The remaining 339 high-confidence bacteria were included in the final analysis for differential abundances in the plasma between the study groups. Women with EOC, which were primarily of the high-grade serous ovarian carcinoma histologic subtype, had significantly distinct differential abundances of the genera Brevibacterium (p < 0.001), Chloronema (p < 0.001), Facklamia (p < 0.001), Sutterella (p < 0.001), and Zymomonas (p < 0.001) when compared to the other study groups. These results suggest that plasma EOC-associated bacteria could be further exploited in follow-up studies to validate clinical applicability in disease screening, diagnostics, and risk stratification.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12922691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between the infant gut microbiota and the living environment. 婴儿肠道微生物群与生活环境之间的关系。

Gut microbes reports Pub Date : 2025-12-31 eCollection Date: 2026-01-01 DOI: 10.1080/29933935.2025.2603823

Brandon Hickman, Anne Salonen, Kaija-Leena Kolho, Willem M De Vos, Katri Korpela

{"title":"Associations between the infant gut microbiota and the living environment.","authors":"Brandon Hickman, Anne Salonen, Kaija-Leena Kolho, Willem M De Vos, Katri Korpela","doi":"10.1080/29933935.2025.2603823","DOIUrl":"10.1080/29933935.2025.2603823","url":null,"abstract":"The human gut microbiota is central to the health and development of the host, and the early-life microbiota is affected by a range of factors that can alter the infant's development for years to come. The role of the external, natural environment in shaping the gut microbiota is still largely unknown. We examined how the environment surrounding the home postnatally is associated with the infant gut microbiota in the first 2 y of life. The study utilized 16 s rRNA data from 893 children's fecal samples from the longitudinal birth cohort HELMi. We show that the environment has a minimal overall association with microbiota development (R2 < 1%). Air quality explained the greatest degree of variation in microbiota composition, while only forests, agriculture and inland wetlands near the home had any significant association with bacterial genera. The results suggest that the infant gut microbiota is not strongly dependent on the external natural environment, and that the impact of the environment is mostly due to exposure to air pollution that may affect the host's immune system and indirectly the gut microbiota.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"3 1","pages":"2603823"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12938875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased intestinal Lactobacillus abundance in post-pancreatectomy steatotic liver disease is associated with altered bile acid metabolism and FXR-FGF19 pathway suppression. 胰腺切除术后脂肪变性肝病患者肠道乳酸杆菌丰度增加与胆汁酸代谢改变和FXR-FGF19通路抑制相关。

Gut microbes reports Pub Date : 2025-12-27 eCollection Date: 2026-01-01 DOI: 10.1080/29933935.2025.2607927

Kohta Iguchi, Natsumi Seki, Yuki Sugiura, Rae Maeda, Kenzo Nakano, Takayuki Kawai, Yukihiro Okuda, Ryo Kamimura, Yoichiro Uchida, Akihiro Hamasaki, Kojiro Taura, Hiroaki Terajima

{"title":"Increased intestinal Lactobacillus abundance in post-pancreatectomy steatotic liver disease is associated with altered bile acid metabolism and FXR-FGF19 pathway suppression.","authors":"Kohta Iguchi, Natsumi Seki, Yuki Sugiura, Rae Maeda, Kenzo Nakano, Takayuki Kawai, Yukihiro Okuda, Ryo Kamimura, Yoichiro Uchida, Akihiro Hamasaki, Kojiro Taura, Hiroaki Terajima","doi":"10.1080/29933935.2025.2607927","DOIUrl":"10.1080/29933935.2025.2607927","url":null,"abstract":"Steatotic liver disease, a common metabolic disorder characterized by hepatic fat accumulation, is frequently associated with altered bile acid metabolism. Post-pancreatectomy steatotic liver disease (PPSLD) develops in approximately 37% of patients undergoing pancreaticoduodenectomy and can progress to steatohepatitis, liver failure, or death. Here, we investigated microbial, bile acid, and metabolic features associated with PPSLD across two clinical cohorts. Patients with PPSLD exhibited a consistent increase in facultative anaerobes, particularly Lactobacillus species, together with an increased predicted capacity for bile acid deconjugation. This microbial profile was associated with higher circulating levels of deconjugated bile acids and a biochemical pattern suggestive of attenuated intestinal FXR-FGF19 signaling and increased hepatic bile acid synthesis. In addition, patients with PPSLD exhibited lower plasma choline and carnitine levels, indicating reduced availability of nutrients essential for phospholipid and fatty acid metabolism. These findings suggest that microbial dysbiosis, bile acid dysregulation, and postoperative nutrient limitations are associated with the PPSLD phenotype, in addition to pancreatic exocrine insufficiency. This study identifies integrated microbial and metabolic alterations associated with PPSLD. While causal relationships cannot be inferred from these observational data, our results may inform future investigations into therapeutic strategies aimed at maintaining metabolic and microbial homeostasis in post-pancreatectomy patients.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"3 1","pages":"2607927"},"PeriodicalIF":0.0,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12938879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity-associated gut microbiome influences diet-induced metabolic and cognitive outcomes in older adults. 肥胖相关的肠道微生物组影响老年人饮食诱导的代谢和认知结果。

Gut microbes reports Pub Date : 2025-12-25 eCollection Date: 2026-01-01 DOI: 10.1080/29933935.2025.2605879

Cole Patoine, Julia Sheffler, Trinity Sims, Viviana Gutierrez, Gwoncheol Park, Moses Mayonu, Bo Wang, Ravinder Nagpal

{"title":"Obesity-associated gut microbiome influences diet-induced metabolic and cognitive outcomes in older adults.","authors":"Cole Patoine, Julia Sheffler, Trinity Sims, Viviana Gutierrez, Gwoncheol Park, Moses Mayonu, Bo Wang, Ravinder Nagpal","doi":"10.1080/29933935.2025.2605879","DOIUrl":"10.1080/29933935.2025.2605879","url":null,"abstract":"Obesity in older adults is a known risk factor for Alzheimer's disease and related dementias, potentially driven by metabolic dysfunction, inflammation and gut dysbiosis. The gut-brain axis, influenced by diet and the gut microbiome, is increasingly recognized as a contributor to neurodegeneration. In this sub-analysis of a 10-week randomized dietary education intervention (NCT06121986), we examined how obesity modulates gut microbiome, metabolome, and cognitive responses in 31 adults aged 55-85, with or without mild cognitive impairment. Participants received education on either a Mediterranean Diet or a Modified Mediterranean-Ketogenic Diet. Analyses were stratified by baseline obesity (BMI ≥30 kg/m²). Individuals with obesity exhibited lower microbial alpha-diversity, higher Bacteroides, and lower Akkermansia and Christensenellaceae_R-7_group, along with poorer memory and executive function. Only in the obese group did fat loss correlate with improvements in episodic memory and cognitive flexibility. In contrast, increased fat mass was associated with improved memory in non-obese participants. Gains in skeletal muscle mass predicted cognitive improvement in adults aged ≥73. Changes in gut (acetate, propionate, lactate) and plasma (acetate, pyruvate, citric acid) metabolites were linked to cognitive and body composition outcomes. These exploratory findings highlight the gut-muscle-brain axis as a modifiable target to enhance cognitive health in aging populations.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"3 1","pages":"2605879"},"PeriodicalIF":0.0,"publicationDate":"2025-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12938881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The gut microbiome in early pregnancy is associated with the severity of nausea and vomiting: a nested case‒control study. 妊娠早期的肠道微生物群与恶心和呕吐的严重程度有关：一项巢式病例对照研究。

Gut microbes reports Pub Date : 2025-12-22 eCollection Date: 2026-01-01 DOI: 10.1080/29933935.2025.2603861

Clàudia González-Valdivia, Bangzhuo Tong, Sanna Hjalmarsson, Unnur Guðnadóttir, Nicole Wagner, Lars Engstrand, Ina Schuppe-Koistinen, Emma Fransson, Stefanie Prast-Nielsen, Nele Brusselaers, Luisa W Hugerth

{"title":"The gut microbiome in early pregnancy is associated with the severity of nausea and vomiting: a nested case‒control study.","authors":"Clàudia González-Valdivia, Bangzhuo Tong, Sanna Hjalmarsson, Unnur Guðnadóttir, Nicole Wagner, Lars Engstrand, Ina Schuppe-Koistinen, Emma Fransson, Stefanie Prast-Nielsen, Nele Brusselaers, Luisa W Hugerth","doi":"10.1080/29933935.2025.2603861","DOIUrl":"10.1080/29933935.2025.2603861","url":null,"abstract":"Approximately 70% of all pregnancies are affected by nausea and vomiting (NVP), yet the mechanisms controlling this phenomenon are not well known. Pregnancy hormones explain a large part of this effect, mostly through human chorionic gonadotropin and fetal production of GDF15, a hormone active in the brain stem. Still, there is a wide variation in the severity of symptoms, ranging from no nausea to severe vomiting requiring hospitalization (hyperemesis gravidarum). Here, we present a nested case‒control study within the large SweMaMi cohort, wherein 337 participants with severe NVP in early pregnancy were matched 1-to-1 with moderate and mild NVP, respectively. Subjects with more severe nausea had lower richness and diversity in their fecal microbiomes. Several taxa were significantly associated with NVP score, where the most extreme are a negative correlation with Lactobacillaceae and positive correlations with Bifidobacterium dentium and Puniceicoccaceae. Finally, higher NVP score was associated with a higher abundance of bacteria encoding for the neuroactive pathways of glutamine degradation, inositol synthesis, and lactate production. In conclusion, the gut microbiota was strongly associated with NVP. Further studies with direct interventions capable of restoring the early-pregnancy gut microbiome could open up new approaches for dealing with the most common symptom of early pregnancy.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"3 1","pages":"2603861"},"PeriodicalIF":0.0,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12938880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enterococcus faecalis impairs IGSF9-dependent C1q degradation to accelerate MAFLD-HCC progression. 粪肠球菌损害igsf9依赖性C1q降解，加速MAFLD-HCC进展。

Gut microbes reports Pub Date : 2025-12-18 eCollection Date: 2026-01-01 DOI: 10.1080/29933935.2025.2600896

Qiuyu Jiang, Jiale Li, Shengdi Wu, Li Zhang, Ling Dong, Shuqiang Weng, Wenqing Tang, She Chen

{"title":"Enterococcus faecalis impairs IGSF9-dependent C1q degradation to accelerate MAFLD-HCC progression.","authors":"Qiuyu Jiang, Jiale Li, Shengdi Wu, Li Zhang, Ling Dong, Shuqiang Weng, Wenqing Tang, She Chen","doi":"10.1080/29933935.2025.2600896","DOIUrl":"10.1080/29933935.2025.2600896","url":null,"abstract":"The global increase in metabolic associated fatty liver disease (MAFLD)-related hepatocellular carcinoma (HCC) necessitates urgent investigation of its underlying mechanisms. Our study reveals that high fat diet (HFD)-induced gut dysbiosis enriches Enterococcus faecalis, a potential carcinogenic bacterium. Mechanistically, which suppresses hepatic IGSF9 expression, exacerbating liver injury (elevated ALT/AST/ALP), steatosis, fibrosis, and HCC susceptibility. Clinically, reduced hepatic IGSF9 correlates with poor prognosis, particularly in MAFLD-HCC patients. Mechanistically, IGSF9 binds C1QC and E3 ubiquitin ligases (NEDD4/UBE3A) to promote C1QC ubiquitination and degradation; IGSF9 deficiency leads to pathogenic C1q accumulation, accelerating MAFLD progression. Importantly, early interventions targeting this axis - including Bifidobacterium pseudolongum supplementation, overexpressing IGSF9, and C1q neutralization - effectively prevented MAFLD-HCC progression in preclinical models. These findings provide preliminary evidence that the E. faecalis/IGSF9/C1q axis could be involved in MAFLD-HCC, with IGSF9 may serve as both a prognostic biomarker and therapeutic target, which worth further exploration in future studies.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"3 1","pages":"2600896"},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12938874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogen-rich water attenuates radiation-induced oral mucositis in mice via antioxidant and gut microbiota-stabilizing effects: a longitudinal study. 富氢水通过抗氧化和肠道菌群稳定作用减轻辐射引起的小鼠口腔黏膜炎：一项纵向研究。

Gut microbes reports Pub Date : 2025-12-10 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2595392

Zixin Lan, Junyang Chen, Shanwei Lan, Ning Li, Bo Yang, Jin Hou, Xiaojun Yang

{"title":"Hydrogen-rich water attenuates radiation-induced oral mucositis in mice via antioxidant and gut microbiota-stabilizing effects: a longitudinal study.","authors":"Zixin Lan, Junyang Chen, Shanwei Lan, Ning Li, Bo Yang, Jin Hou, Xiaojun Yang","doi":"10.1080/29933935.2025.2595392","DOIUrl":"10.1080/29933935.2025.2595392","url":null,"abstract":"Radiation-induced oral mucositis (RIOM) frequently complicates head and neck radiotherapy, leading to severe pain, compromised nutrition, and often requiring treatment modifications. Although craniofacial-only irradiation is confined to the head and neck region, it can still disrupt gut homeostasis. Mice subjected to head and neck irradiation developed marked epithelial damage in both the oral and intestinal mucosa, as evidenced by pronounced RIOM and diminished barrier integrity. Histological examination revealed substantial mucosal thinning and leukocyte infiltration in the tongue, along with reduced occludin and ZO-1 expression in colonic tissues. Supplementation with hydrogen-rich water (HW) markedly decreased the severity of oral lesions and preserved epithelial thickness, while restoring the expression of tight junction proteins in the colon. Fecal 16S rRNA sequencing showed that radiation alone provoked expansions of Streptococcus and Helicobacter, coupled with a decline in short-chain fatty acid-producing families (Lachnospiraceae, Ruminococcaceae). In contrast, HW supplementation partially reversed these microbial shifts, which correlated with reduced oral inflammatory markers. Collectively, these findings underscore an oral-gut axis whereby HW fosters mucosal healing through microbiome stabilization and decreased inflammatory stress, suggesting that HW as a promising adjunct for managing head and neck irradiation-related complications.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"2 1","pages":"2595392"},"PeriodicalIF":0.0,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12940104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut microbes reports Pub Date : 2025-12-09 eCollection Date: 2025-01-01 DOI: 10.1080/29933935.2025.2591561

Takeshi Yasuda, Tomohisa Takagi, Yuji Naito, Ryo Inoue, Katsura Mizushima, Kouhei Asaeda, Hikaru Hashimoto, Hiroaki Kitae, Kazuhiko Uchiyama, Norihiro Ouchi, Atsuo Adachi, Tadaaki Kamitani, Satoaki Matoba, Yoshito Itoh

{"title":"Sarcopenia-related gut microbiota in the elderly: Insights from the longevity region of Kyotango and its nutritional associations.","authors":"Takeshi Yasuda, Tomohisa Takagi, Yuji Naito, Ryo Inoue, Katsura Mizushima, Kouhei Asaeda, Hikaru Hashimoto, Hiroaki Kitae, Kazuhiko Uchiyama, Norihiro Ouchi, Atsuo Adachi, Tadaaki Kamitani, Satoaki Matoba, Yoshito Itoh","doi":"10.1080/29933935.2025.2591561","DOIUrl":"10.1080/29933935.2025.2591561","url":null,"abstract":"Sarcopenia is influenced by the gut microbiota and dietary habits; however, the underlying mechanisms remain elusive. This study investigated the gut microbiota composition of elderly individuals in a healthy longevity region and examined its association with sarcopenia and dietary habits. Fecal metagenomic analysis was used to identify gut microbiota taxonomy. Sarcopenia was diagnosed on the basis of grip strength, gait speed, and muscle volume. Japanese dietary habits were assessed using a brief-type self-administered diet history questionnaire. A total of 318 elderly individuals from Kyotango were recruited, 5.7% of whom were diagnosed with sarcopenia. Individuals with sarcopenia exhibited a lower abundance of a genus belonging to the family Lachnospiraceae, and a higher abundance of Megasphera. Several butyrate-producing bacteria, including Lachnospira and Coprococcus showed a positive correlation with sarcopenia related factors, whereas Dorea and Streptococcus were negatively correlated. Hierarchical cluster analysis revealed that these beneficial genera were also positively associated with the frequent intake of traditional Japanese dietary components. These findings suggest that the observed microbial and dietary associations may provide a mechanistic basis for potential protective effects against sarcopenia. Our findings suggest that butyrate-producing bacteria associated with Japanese dietary patterns play a protective role against sarcopenia.","PeriodicalId":519879,"journal":{"name":"Gut microbes reports","volume":"2 1","pages":"2591561"},"PeriodicalIF":0.0,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12940105/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147577408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0