Revista de Gastroenterologia de Mexico最新文献

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Reflexiones metodológicas sobre «Resultados funcionales posteriores a rectopexia ventral con malla en 50 pacientes con obstrucción defecatoria y/o incontinencia fecal» 关于“50名有排便阻塞和/或大便失禁的患者的带网腹直肠切除后的功能结果”的方法学思考
IF 2
Revista de Gastroenterologia de Mexico Pub Date : 2026-07-01 Epub Date: 2026-06-10 DOI: 10.1016/j.rgmx.2026.04.001
R. Zayas-Borquez, O. Santes
{"title":"Reflexiones metodológicas sobre «Resultados funcionales posteriores a rectopexia ventral con malla en 50 pacientes con obstrucción defecatoria y/o incontinencia fecal»","authors":"R. Zayas-Borquez, O. Santes","doi":"10.1016/j.rgmx.2026.04.001","DOIUrl":"10.1016/j.rgmx.2026.04.001","url":null,"abstract":"","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":"91 3","pages":"Pages 461-462"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respuesta a Therán-León, JS, «Análisis crítico del modelo predictivo de recurrencia en cáncer de colon derecho: hacia un reporte conforme a TRIPOD+AI y validación externa multicéntrica» 对Theran - Leon, JS的答复,“右结肠癌复发预测模型的关键分析:根据TRIPOD+AI报告和多中心外部验证”
IF 2
Revista de Gastroenterologia de Mexico Pub Date : 2026-07-01 Epub Date: 2026-09-02 DOI: 10.1016/j.rgmx.2026.06.003
R. Zayas-Bórquez, J. Canto-Losa, E. Posadas-Trujillo, N. Salgado-Nesme, O. Santes
{"title":"Respuesta a Therán-León, JS, «Análisis crítico del modelo predictivo de recurrencia en cáncer de colon derecho: hacia un reporte conforme a TRIPOD+AI y validación externa multicéntrica»","authors":"R. Zayas-Bórquez, J. Canto-Losa, E. Posadas-Trujillo, N. Salgado-Nesme, O. Santes","doi":"10.1016/j.rgmx.2026.06.003","DOIUrl":"10.1016/j.rgmx.2026.06.003","url":null,"abstract":"","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":"91 3","pages":"Pages 465-466"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EndoFLIP® en la evaluación funcional del tracto gastrointestinal: estado actual y perspectivas clínicas EndoFLIP®在胃肠道功能评估中的应用:现状和临床前景
IF 2
Revista de Gastroenterologia de Mexico Pub Date : 2026-07-01 Epub Date: 2026-08-11 DOI: 10.1016/j.rgmx.2026.07.001
L.R. Valdovinos-García, E.C. Morel-Cerda, M.F. Vela, J.M. Remes-Troche
{"title":"EndoFLIP® en la evaluación funcional del tracto gastrointestinal: estado actual y perspectivas clínicas","authors":"L.R. Valdovinos-García,&nbsp;E.C. Morel-Cerda,&nbsp;M.F. Vela,&nbsp;J.M. Remes-Troche","doi":"10.1016/j.rgmx.2026.07.001","DOIUrl":"10.1016/j.rgmx.2026.07.001","url":null,"abstract":"<div><div>Endoluminal functional lumen imaging probe (EndoFLIP®) is a device that uses high-resolution impedance planimetry to measure the cross-sectional area of the gastrointestinal tract along an axial plane. It enables the biomechanical properties of the gastrointestinal wall and the functional dynamics of the sphincters to be evaluated. Its clinical indications include the assessment of nonobstructive esophageal dysphagia and the preoperative and postoperative evaluation of antireflux surgery and achalasia, as well as its application in gastroparesis and fecal incontinence. Recent evidence suggests that EndoFLIP® may serve as a screening tool for the detection of esophageal motility disorders during endoscopy in patients with nonobstructive dysphagia and appears to predict response to therapies aimed at reducing pyloric sphincter resistance in gastroparesis.</div></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":"91 3","pages":"Pages 378-392"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sarcopenia, composición corporal y fatiga: ¿existe una conexión en los pacientes con enfermedad inflamatoria intestinal? 肉芽肿、身体组成和疲劳:炎症性肠病患者之间有联系吗?
IF 2
Revista de Gastroenterologia de Mexico Pub Date : 2026-07-01 Epub Date: 2026-02-03 DOI: 10.1016/j.rgmx.2025.11.004
M.S. Martins, G.J. Santos, C.J. Almeida, P.C. Duran, G. Couto, T.C. Morais, G.O. Santana, R. Rocha
{"title":"Sarcopenia, composición corporal y fatiga: ¿existe una conexión en los pacientes con enfermedad inflamatoria intestinal?","authors":"M.S. Martins,&nbsp;G.J. Santos,&nbsp;C.J. Almeida,&nbsp;P.C. Duran,&nbsp;G. Couto,&nbsp;T.C. Morais,&nbsp;G.O. Santana,&nbsp;R. Rocha","doi":"10.1016/j.rgmx.2025.11.004","DOIUrl":"10.1016/j.rgmx.2025.11.004","url":null,"abstract":"<div><h3>Introduction and aim</h3><div>The development and exacerbation of fatigue in patients with inflammatory bowel disease (IBD) have not been widely studied. Our aim was to evaluate the association of sarcopenia, anthropometric parameters, and body composition with fatigue, in patients with IBD.</div></div><div><h3>Methods</h3><div>The Inflammatory Bowel Disease-Fatigue questionnaire was applied to assess fatigue. Body mass index (BMI) was calculated, and body composition was evaluated through Biodynamics® tetrapolar bioimpedance.</div></div><div><h3>Results</h3><div>In 106 patients with IBD, the prevalence of fatigue was 83%, regardless of disease activity (<em>P</em>&gt;.05). Patients who were employed (86.4 vs 61.1%; <em>P</em>=.011), presented with ulcerative colitis (UC) (58 vs 22.2%; <em>P</em>=.006), or with Crohn's disease (CD) diagnosed between 17 and 40 years of age (73 vs 42.9%; <em>P</em>=.045), had a greater prevalence of fatigue. There was no statistically significant association between fatigue and sarcopenia or fatigue and body composition (<em>P</em>&gt;.05). The regression analysis indicated no risk of fatigue for low weight, overweight, lean mass, or phase angle, or for sarcopenia criteria, hand grip strength, or gait speed (<em>P</em>&gt;.05).</div></div><div><h3>Conclusions</h3><div>The prevalence of fatigue was high in patients with IBD, predominantly in adults, even in the disease remission phase, especially in patients with UC and CD (the latter diagnosed between 17 and 40 years of age). Body composition was not associated with fatigue.</div></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":"91 3","pages":"Pages 334-343"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Posicionamiento de la Asociación Mexicana de Gastroenterología sobre detección y referencia oportuna del cáncer gastrointestinal (esófago, estómago y colon) en la atención primaria 墨西哥胃肠病学协会关于在初级保健中发现和及时转诊胃肠癌(食道、胃癌和结肠癌)的立场
IF 2
Revista de Gastroenterologia de Mexico Pub Date : 2026-07-01 Epub Date: 2026-08-11 DOI: 10.1016/j.rgmx.2026.06.005
J.M. Remes-Troche, A.D. Cano-Contreras, A. Noble-Lugo, L.R. Valdovinos-García, L. Moreira, A. Alfaro-Goldaracena, M.C. Díaz-Romero, A. Hernández-Guerrero, O.V. Hernández-Mondragón, F.D. Huitzil-Meléndez, Y.A. Leal, A.M. León-Takahashi, M.C. Manzano-Robleda, J. Melchor-Ruan, A. Noguez-Ramos, V. Rosas-Camargo, E. Ruiz-García, O.E. Trujillo-Benavides, J.A. Velarde-Ruiz Velasco, L.E. Zamora-Nava, A. Espinosa-Schoelly
{"title":"Posicionamiento de la Asociación Mexicana de Gastroenterología sobre detección y referencia oportuna del cáncer gastrointestinal (esófago, estómago y colon) en la atención primaria","authors":"J.M. Remes-Troche,&nbsp;A.D. Cano-Contreras,&nbsp;A. Noble-Lugo,&nbsp;L.R. Valdovinos-García,&nbsp;L. Moreira,&nbsp;A. Alfaro-Goldaracena,&nbsp;M.C. Díaz-Romero,&nbsp;A. Hernández-Guerrero,&nbsp;O.V. Hernández-Mondragón,&nbsp;F.D. Huitzil-Meléndez,&nbsp;Y.A. Leal,&nbsp;A.M. León-Takahashi,&nbsp;M.C. Manzano-Robleda,&nbsp;J. Melchor-Ruan,&nbsp;A. Noguez-Ramos,&nbsp;V. Rosas-Camargo,&nbsp;E. Ruiz-García,&nbsp;O.E. Trujillo-Benavides,&nbsp;J.A. Velarde-Ruiz Velasco,&nbsp;L.E. Zamora-Nava,&nbsp;A. Espinosa-Schoelly","doi":"10.1016/j.rgmx.2026.06.005","DOIUrl":"10.1016/j.rgmx.2026.06.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Gastrointestinal cancer, particularly esophageal, gastric, or colon cancer, is a significant cause of morbidity and mortality in Mexico. There are substantial delays in the early identification and timely referral of primary care patients, resulting in more advanced-stage diagnoses and poorer clinical outcomes. Our aim was to issue a position statement from the <em>Asociación Mexicana de Gastroenterología</em> (AMG) to guide primary care physicians in the identification of alarm features, risk stratification, and timely referral of patients with suspected gastrointestinal cancer.</div></div><div><h3>Methods</h3><div>A multidisciplinary group of 20 specialists in the fields of gastroenterology, oncology, endoscopy, epidemiology, and public health, from both public and private institutions, developed the position statement through a structured consensus process. Clinical statements were drafted and voted on, they were organized by cancer type (esophageal, gastric, and colorectal), and three clinical algorithms were designed to support decision-making in primary care.</div></div><div><h3>Results</h3><div>Thirteen statements were issued on alarm features, risk factors, recommended diagnostic studies, and risk-stratified referral pathways (urgent, priority, and elective). The role of upper endoscopy and high-quality colonoscopy as diagnostic procedures of choice was emphasized, clearly distinguishing them from population-based screening strategies.</div></div><div><h3>Conclusions</h3><div>This position statement provides a practical, evidence-based, expert consensus-informed guide, adapted to the Mexican healthcare setting, whose aim is to implement prevention strategies, reduce diagnostic delays, improve early detection, and optimize the referral of primary care patients with suspected gastrointestinal cancer.</div></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":"91 3","pages":"Pages 410-427"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
El extracto etanólico de hojas de Senecio biafrae mitiga la disrupción de citoqueratinas e histoarquitectura inducida por cloruro de mercurio en ratas Wistar adultas 在成年Wistar大鼠中,双酚a叶乙醇提取物可减轻氯化汞引起的细胞角蛋白破坏和组织结构
IF 2
Revista de Gastroenterologia de Mexico Pub Date : 2026-07-01 Epub Date: 2026-05-19 DOI: 10.1016/j.rgmx.2025.12.012
D.O. Adeyemi, A.O. Ibitoye
{"title":"El extracto etanólico de hojas de Senecio biafrae mitiga la disrupción de citoqueratinas e histoarquitectura inducida por cloruro de mercurio en ratas Wistar adultas","authors":"D.O. Adeyemi,&nbsp;A.O. Ibitoye","doi":"10.1016/j.rgmx.2025.12.012","DOIUrl":"10.1016/j.rgmx.2025.12.012","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Exposure to mercuric chloride (HgCl<sub>2</sub>) causes liver damage by disrupting the hepatic architecture, increasing oxidative stress, and altering cytokeratin integrity, resulting in hepatocyte fragility and impaired function. The present study evaluated the effects of <em>Senecio biafrae</em> leaf ethanol extract (SBLEE) on HgCl<sub>2</sub> induced liver injury and cytoskeletal integrity.</div></div><div><h3>Materials and methods</h3><div>Forty-two adult Wistar rats were divided into seven groups. The control group was given distilled water, whereas the other groups were given 4<!--> <!-->mg/kg of mercuric chloride, orally, for 21 days, followed by either immediate sacrifice or a recovery period, and treatment with silymarin or various doses of SBLEE (300, 400, and 600<!--> <!-->mg/kg) for 21 days.</div></div><div><h3>Results</h3><div>The histologic, immunohistochemical, and biochemical studies showed that HgCl<sub>2</sub> significantly disrupted the hepatic architecture and cytokeratin networks, increased oxidative stress, and altered liver enzyme levels. Treatment with SBLEE restored cytokeratin integrity, reduced oxidative stress, and normalized the liver biomarkers, with results comparable to those of the silymarin and control groups.</div></div><div><h3>Conclusion</h3><div>Our findings suggest that <em>Senecio biafrae</em> leaves have cytoprotective properties that help stabilize the hepatic cytoskeleton and preserve liver function after toxic injury.</div></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":"91 3","pages":"Pages 353-366"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Singulto intratable como manifestación inicial de acalasia: reporte de caso 作为白血球病早期表现的难以治疗的奇点:病例报告
IF 2
Revista de Gastroenterologia de Mexico Pub Date : 2026-07-01 Epub Date: 2026-06-10 DOI: 10.1016/j.rgmx.2026.03.012
C.I. Zubia-Nevárez, M. Herrera-Sato, J.S. Arenas-Martínez, D.I. Carmona-Guerrero, G.M. Torres-Villalobos, E. Coss-Adame
{"title":"Singulto intratable como manifestación inicial de acalasia: reporte de caso","authors":"C.I. Zubia-Nevárez,&nbsp;M. Herrera-Sato,&nbsp;J.S. Arenas-Martínez,&nbsp;D.I. Carmona-Guerrero,&nbsp;G.M. Torres-Villalobos,&nbsp;E. Coss-Adame","doi":"10.1016/j.rgmx.2026.03.012","DOIUrl":"10.1016/j.rgmx.2026.03.012","url":null,"abstract":"<div><h3>Background</h3><div>Intractable hiccups pose a clinical challenge due to their diverse etiologies and lack of standard treatment. While associated with esophageal conditions, hiccups rarely occur in achalasia.</div></div><div><h3>Case report</h3><div>A 65-year-old man presented with intractable hiccups, heartburn, and regurgitation for 7<!--> <!-->years and progressive dysphagia and weight loss for 2<!--> <!-->years. He was unrelieved by Nissen fundoplication for suspected gastroesophageal reflux disease (GERD), performed with no previous assessment of esophageal motility. Two years later, high-resolution impedance manometry (HRIM) revealed type<!--> <!-->I achalasia. The patient underwent a Heller myotomy, with revision of the fundoplication, resulting in complete resolution of dysphagia, regurgitation, and hiccups.</div></div><div><h3>Conclusion</h3><div>This case underscores the rare association of hiccups with achalasia, as well as the importance of manometric assessment in cases of atypical symptoms and dysphagia, and the efficacy of surgical intervention in refractory cases.</div></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":"91 3","pages":"Pages 448-451"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reporte de caso de daño hepático inducido por suplemento nutricional a base de kombucha 以康普茶为基础的膳食补充剂引起肝脏损伤的案例报告
IF 2
Revista de Gastroenterologia de Mexico Pub Date : 2026-07-01 Epub Date: 2026-04-24 DOI: 10.1016/j.rgmx.2025.11.007
D.A. Belmontes-Gutiérrez, P.A. Moreno-Velazco, L.I. Gurza-Morales
{"title":"Reporte de caso de daño hepático inducido por suplemento nutricional a base de kombucha","authors":"D.A. Belmontes-Gutiérrez,&nbsp;P.A. Moreno-Velazco,&nbsp;L.I. Gurza-Morales","doi":"10.1016/j.rgmx.2025.11.007","DOIUrl":"10.1016/j.rgmx.2025.11.007","url":null,"abstract":"","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":"91 3","pages":"Pages 436-438"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linfoma difuso de células B grandes de colon: complejidades quirúrgicas en un tumor infrecuente 弥漫性大结肠B细胞淋巴瘤:罕见肿瘤的手术复杂性
IF 2
Revista de Gastroenterologia de Mexico Pub Date : 2026-07-01 Epub Date: 2026-02-16 DOI: 10.1016/j.rgmx.2026.01.002
K.J. Fuentes-Calvo, M.F. Ramos-Griera, D. Doniz Gómez-Llanos, F. Aguilar-Ruiz, O. Vergara-Fernández
{"title":"Linfoma difuso de células B grandes de colon: complejidades quirúrgicas en un tumor infrecuente","authors":"K.J. Fuentes-Calvo,&nbsp;M.F. Ramos-Griera,&nbsp;D. Doniz Gómez-Llanos,&nbsp;F. Aguilar-Ruiz,&nbsp;O. Vergara-Fernández","doi":"10.1016/j.rgmx.2026.01.002","DOIUrl":"10.1016/j.rgmx.2026.01.002","url":null,"abstract":"","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":"91 3","pages":"Pages 445-447"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Escala predictiva de mortalidad en enterocolitis neutropénica asociada a LMA: revisión sistemática de la literatura 与急性弛缓性麻痹相关的中性粒细胞性小肠结肠炎死亡率预测量表:系统文献综述
IF 2
Revista de Gastroenterologia de Mexico Pub Date : 2026-04-01 Epub Date: 2025-09-30 DOI: 10.1016/j.rgmx.2025.07.013
R. Zayas-Bórquez, J. Canto-Losa, M. García-Maldonado, N. Salgado-Nesme, O. Santes
{"title":"Escala predictiva de mortalidad en enterocolitis neutropénica asociada a LMA: revisión sistemática de la literatura","authors":"R. Zayas-Bórquez,&nbsp;J. Canto-Losa,&nbsp;M. García-Maldonado,&nbsp;N. Salgado-Nesme,&nbsp;O. Santes","doi":"10.1016/j.rgmx.2025.07.013","DOIUrl":"10.1016/j.rgmx.2025.07.013","url":null,"abstract":"<div><h3>Introduction and aims</h3><div>Neutropenic enterocolitis (NE) is a severe complication in immunocompromised patients, especially those with acute myeloid leukemia (AML) receiving intensive chemotherapy treatment. Despite medical advances, NE continues to be associated with a high mortality rate, particularly when its diagnosis and treatment are delayed. The present study aimed to identify the risk factors linked to mortality in patients with NE and develop a predictive scale for optimizing clinical decisions.</div></div><div><h3>Materials and methods</h3><div>A systematic review was conducted in accordance with the PRISMA 2020 guidelines and included 24 clinical studies (n<!--> <!-->=<!--> <!-->1,172). Factors associated with in-hospital mortality were identified through odds ratio (OR) and relative risk (RR), with a 95% confidence interval (CI), and bivariate statistical tests, such as the chi-square and Fisher's exact tests (p<!--> <!-->&lt;<!--> <!-->0.05). A predictive scale was constructed based on said factors. A meta-analysis was carried out, using the Der Simonian and Laird random effects model for evaluating granulocyte colony-stimulating factor (G-CSF) as a protective factor, with heterogeneity (I<sup>2</sup>) and leave-one-out sensitivity tests. Quality of evidence was evaluated using the GRADE system.</div></div><div><h3>Results</h3><div>The overall mortality rate was 23.6%. The identified predictors of greater mortality were profound neutropenia, comorbidities, concomitant infection, admission to the intensive care unit, late diagnosis, age ≥ 60 years, and absence of G-CSF use. The meta-analysis yielded a combined OR of 0.68 (95% CI 0.62-0.72; I<sup>2</sup> <!-->=<!--> <!-->0%) in favor of G-CSF use. Factors with no statistical significance or affected by indication bias, such as surgery or cytarabine, were excluded. The resulting scale stratifies patients into four risk categories, with estimated mortality rates of ≤ 10%, 11-30%, 31-50%, and<!--> <!-->&gt; 50%.</div></div><div><h3>Conclusion</h3><div>An exploratory mortality risk scale for patients with NE and AML, constructed from aggregate data and systematic evidence, is presented herein. Even though it yielded statistical robustness and clinical plausibility, the scale should not be employed for making clinical decisions until it has been prospectively validated in independent cohorts with multivariate adjustment.</div></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":"91 2","pages":"Pages 163-170"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148572114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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