Revista de Gastroenterologia de Mexico最新文献

{"title":"Inmunoexpresión de SOX9 en tumores primarios de carcinoma colorrectal con metástasis a ganglios linfáticos","authors":"","doi":"10.1016/j.rgmx.2024.01.004","DOIUrl":"10.1016/j.rgmx.2024.01.004","url":null,"abstract":"<div><h3>Introduction and aims</h3><p>Colorectal cancer is the most frequent malignant tumor of the digestive system. Its pathogeny is complex and involves the APC/β-catenin sequence. Lymph node metastases are a significant indicator for determining treatment and are a prognostic factor. SOX9 overexpression is related to oncogenic qualities and the capacity for metastasis. Our aim was to analyze SOX9 immunoexpression in primary colorectal cancer and lymph node metastasis status.</p></div><div><h3>Material and methods</h3><p>Seventy-nine available cases were divided into the group with lymph node metastasis (n<!--> <!-->=<!--> <!-->38) and the group without lymph node metastasis (n<!--> <!-->=<!--> <!-->41), evaluating their SOX9 expression. The IBM SPSS version 27 program in Spanish was utilized to carry out the statistical analysis, obtaining measures of central tendency, the kappa index, standard deviation, Wilcoxon Mann-Whitney nonparametric measurements, Spearman's correlation coefficient, and chi-square test and Student's t test values. SOX9 immunoexpression was evaluated through the mean-based H-score, with high immunoexpression as a score<!--> <!-->≥<!--> <!-->145 and low immunoexpression as a score<!--> <!-->≤<!--> <!-->144.</p></div><div><h3>Results</h3><p>A p<!--> <!-->=<!--> <!-->0.73 was obtained that was not statistically significant, regarding the relation of SOX9 expression in primary colorectal cancer to lymph node metastasis.</p></div><div><h3>Conclusions</h3><p>The absence or presence of lymph node metastasis was independent from SOX9 immunoexpression in primary colorectal cancer. However, due to the limited size of the population analyzed, further research is needed.</p></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0375090624000120/pdfft?md5=69b3a4b303b2499f4f30cdf2fc4fa026&pid=1-s2.0-S0375090624000120-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140405994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posicionamiento sobre manejo perioperatorio y riesgo quirúrgico en el paciente con cirrosis","authors":"","doi":"10.1016/j.rgmx.2024.05.001","DOIUrl":"10.1016/j.rgmx.2024.05.001","url":null,"abstract":"<div><h3>Introduction</h3><p>Management of the patient with cirrhosis of the liver that requires surgical treatment has been relatively unexplored. In Mexico, there is currently no formal stance or expert recommendations to guide clinical decision-making in this context.</p></div><div><h3>Aims</h3><p>The present position paper reviews the existing evidence on risks, prognoses, precautions, special care, and specific management or procedures for patients with cirrhosis that require surgical interventions or invasive procedures. Our aim is to provide recommendations by an expert panel, based on the best published evidence, and consequently ensure timely, quality, efficient, and low-risk care for this specific group of patients.</p></div><div><h3>Results</h3><p>Twenty-seven recommendations were developed that address preoperative considerations, intraoperative settings, and postoperative follow-up and care.</p></div><div><h3>Conclusions</h3><p>The assessment and care of patients with cirrhosis that require major surgical or invasive procedures should be overseen by a multidisciplinary team that includes the anesthesiologist, hepatologist, gastroenterologist, and clinical nutritionist. With respect to decompensated patients, a nephrology specialist may be required, given that kidney function is also a parameter involved in the prognosis of these patients.</p></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0375090624000594/pdfft?md5=a63e622295e5965b1aff94e2d4432495&pid=1-s2.0-S0375090624000594-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141410934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identificación de factores pronósticos para supervivencia en pacientes con adenocarcinoma gástrico metastásico en la población mexicana","authors":"","doi":"10.1016/j.rgmx.2023.07.008","DOIUrl":"10.1016/j.rgmx.2023.07.008","url":null,"abstract":"<div><h3>Introduction and aims</h3><p>Gastric adenocarcinoma is among the high-ranking tumors, with respect to frequency and mortality, worldwide. The inflammatory process and immune system activity are associated with oncologic control. Our aim was to identify whether the neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR), and other variables are prognostic factors for survival in patients with metastatic gastric cancer in a Mexican population.</p></div><div><h3>Material and methods</h3><p>Patients diagnosed with metastatic gastric adenocarcinoma, hospitalized within the time frame of December 2011 to 2021, were analyzed. The NLR, PLR, and albumin and hemoglobin levels obtained from blood samples were calculated. Functional status (ECOG and Karnofsky), sex, histology, and the presence of signet ring cells were also considered possible prognostic factors. Each factor's prognostic value for overall survival was determined through univariate and multivariate analyses.</p></div><div><h3>Results</h3><p>The study included 956 patients diagnosed with metastatic gastric cancer, of whom 494 (51.7%) were men and 462 (48.3%) were women. The main histologic finding was diffuse adenocarcinoma (n<!--> <!-->=<!--> <!-->619, 64.7%), followed by intestinal adenocarcinoma (n<!--> <!-->=<!--> <!-->293, 30.6%), and the presence of signet ring cells was found in 659 (68.9%) patients. Diagnostic laparoscopy was performed on 238 patients (24.9%) to confirm peritoneal carcinomatosis. The multivariate analysis showed that an NLR above 3.2 (HR 1.51, 95% CI 1.27-1.8; p<!--> <!-->&lt;<!--> <!-->0.001), albumin below 3.5<!--> <!-->g/dl (HR 1.25, 95% CI 1.06-1.47; p<!--> <!-->=<!--> <!-->0.006), and an ECOG performance status of 2 or higher (HR 1.39, 95% CI 1.10-1.76; p<!--> <!-->=<!--> <!-->0.005) were independent factors that predicted a lower survival rate, whereas a Karnofsky score above 70% (HR 0.69, 95% CI 0.53-0.91; p<!--> <!-->=<!--> <!-->0.008) was associated with a better survival rate. Lastly, the PLR was not statistically significant in the multivariate analysis.</p></div><div><h3>Conclusions</h3><p>The NLR, nutritional status assessed through albumin measurement, and functional status can act as independent prognostic survival factors in hospitalized Mexican patients diagnosed with metastatic gastric adenocarcinoma, and be taken into account during therapeutic decision-making.</p></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0375090623001167/pdfft?md5=294b23b5f9f1da2b8c6715cb71c8706c&pid=1-s2.0-S0375090623001167-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparación en los procedimientos endoscópicos antes y durante la pandemia del SARS-CoV-2 en un tercer nivel de atención","authors":"","doi":"10.1016/j.rgmx.2023.10.003","DOIUrl":"10.1016/j.rgmx.2023.10.003","url":null,"abstract":"<div><h3>Introduction</h3><p>SARS-CoV-2 emerged in 2019 and had a huge impact on the world. The area of endoscopy suffered great changes, causing a reduction in the number of procedures and its indications.</p></div><div><h3>Objective</h3><p>The aim of our study was to compare the quantity, indication, and type of procedures in 2019 with those in 2020.</p></div><div><h3>Method</h3><p>A retrospective, observational, analytic, and cross-sectional study was conducted, obtaining information from the endoscopy registry. The STROBE checklist was employed.</p></div><div><h3>Statistical analysis</h3><p>The quantitative variables were analyzed with descriptive statistics (measures of central tendency and dispersion) and the categorical variables with frequencies and percentages. The quantitative variables were compared, using the Student's t test/Mann-Whitney U test, and the categorical variables with contingency tables, using the Fisher's exact test.</p></div><div><h3>Results</h3><p>In 2019, a total of 277 procedures were performed, compared with 139 in 2020. Mean patient age was 98.53 months (61.46 SD) in 2019 and 77.02 months (59.81 SD) in 2020; 352 diagnostic procedures and 136 therapeutic procedures were carried out in 2019, compared with 51 diagnostic procedures and 88 therapeutic procedures in 2020. The number of diagnostic and therapeutic procedures were inverted (72.1% to 36.7% and 27.9% to 63.3%, respectively) (<em>P</em> <!-->&lt;<!--> <!-->.0001). Esophageal varices, upper gastrointestinal bleeding (UGIB), and foreign body extraction were the indications, in order of predominance in 2019, compared with foreign body extraction (<em>P</em> <!-->&lt;<!--> <!-->.05), UGIB, and esophageal varices in 2020. There were no differences regarding colonoscopy.</p></div><div><h3>Conclusion</h3><p>There was a clear difference in indication and type of procedure, with an increase in foreign body extraction in preschoolers.</p></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0375090624000077/pdfft?md5=d126e1463cf17372bd1d019b48634542&pid=1-s2.0-S0375090624000077-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140463210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Falla hepática aguda: manejo actual y pronóstico","authors":"","doi":"10.1016/j.rgmx.2024.05.005","DOIUrl":"10.1016/j.rgmx.2024.05.005","url":null,"abstract":"<div><p>Acute liver failure is a rare but serious syndrome, with an incidence of approximately 2,000 to 3,000 cases per year in North America. Its pathophysiology and clinical course vary, depending on the cause of the primary liver injury, and can lead to high morbidity and mortality or the need for liver transplantation, despite available therapies. This syndrome involves excessive activation of the immune system, with damage in other organs, contributing to its high mortality rate. The most accepted definition includes liver injury with hepatic encephalopathy and coagulopathy within the past 26 weeks in a patient with no previous liver disease. The main causes are paracetamol poisoning, viral hepatitis, and drug-induced liver injury, among others. Identifying the cause is crucial, given that it influences prognosis and treatment. Survival has improved with supportive measures, intensive therapy, complication prevention, and the use of medications, such as N-acetylcysteine. Liver transplantation is a curative option for nonresponders to medical treatment, but adequate evaluation of transplantation timing is vital for improving results. Factors such as patient age, underlying cause, and severity of organ failure influence the post-transplant outcomes and survival.</p></div>","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S037509062400065X/pdfft?md5=f9d7a233852a1339ad91c2ac062287d2&pid=1-s2.0-S037509062400065X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141692164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colangioscopia percutánea utilizando SpyGlass Discover para el manejo de coledocolitiasis difícil en anatomía alterada: reporte de caso","authors":"","doi":"10.1016/j.rgmx.2024.04.002","DOIUrl":"10.1016/j.rgmx.2024.04.002","url":null,"abstract":"","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0375090624000521/pdfft?md5=685af458c0fd83ce3d7b79e101c658c3&pid=1-s2.0-S0375090624000521-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141133449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pifia en manometría esofágica de alta resolución en pacientes con acalasia","authors":"","doi":"10.1016/j.rgmx.2024.04.005","DOIUrl":"10.1016/j.rgmx.2024.04.005","url":null,"abstract":"","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0375090624000557/pdfft?md5=a2deff68db18b3cfb2c974fde44ecaf8&pid=1-s2.0-S0375090624000557-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141140130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"El signo de la cuerda en la enfermedad de Crohn","authors":"","doi":"10.1016/j.rgmx.2024.04.006","DOIUrl":"10.1016/j.rgmx.2024.04.006","url":null,"abstract":"","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0375090624000569/pdfft?md5=3820afde601f2864e40111502454081e&pid=1-s2.0-S0375090624000569-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141959981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trasplante hepático o resección para el hepatocarcinoma temprano: más preguntas que respuestas","authors":"","doi":"10.1016/j.rgmx.2023.11.002","DOIUrl":"10.1016/j.rgmx.2023.11.002","url":null,"abstract":"","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S037509062300112X/pdfft?md5=6c577890d4e785362dcf0b9461f42191&pid=1-s2.0-S037509062300112X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139538016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perforación en yeyuno asociada a síndrome inflamatorio de reconstitución inmunologica por citomegalovirus: reporte de un caso","authors":"","doi":"10.1016/j.rgmx.2024.04.008","DOIUrl":"10.1016/j.rgmx.2024.04.008","url":null,"abstract":"","PeriodicalId":51767,"journal":{"name":"Revista de Gastroenterologia de Mexico","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0375090624000582/pdfft?md5=d45841d96dc172184db77a389612b658&pid=1-s2.0-S0375090624000582-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141959770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}