Case Reports in Cardiology最新文献

{"title":"Syndromic Congenital Heart Disease Diagnosed in Adulthood: A Reminder of the Phenotypic Variability of Alagille Syndrome.","authors":"Matthew K Campbell, Jessica Hallam, Samuel L Casella, Sangeeta Shah","doi":"10.1155/cric/5884548","DOIUrl":"10.1155/cric/5884548","url":null,"abstract":"<p><p>Alagille syndrome is a rare multisystemic genetic condition most commonly associated with neonatal liver disease. Variable expressivity is a defining feature of Alagille syndrome, resulting in a broad spectrum of phenotypic variation among individuals who meet the diagnostic criteria. We present an atypical case of cardiac-predominant Alagille syndrome diagnosed in adulthood after the detection of peripheral pulmonary stenosis on cardiac magnetic resonance imaging (CMR).</p>","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":"2026 ","pages":"5884548"},"PeriodicalIF":0.5,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12789812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensive Collateral Venous Circulation and Anatomic Remodeling in Chronic Deep Vein Thrombosis.","authors":"Demi Curbelo, Ian Lancaster, Alexander Yaylayan, Merrill Krolick","doi":"10.1155/cric/8841986","DOIUrl":"10.1155/cric/8841986","url":null,"abstract":"<p><p>Chronic deep venous thrombosis (DVT) can result in a significant venous outflow obstruction, often prompting the development of extensive compensatory mechanisms to maintain adequate circulation. We report a case of recurrent DVT, presenting with left lower extremity pain and edema. Venography revealed complete occlusion of the left common femoral vein with extensive collateral venous circulation. Given the presence of well-formed collaterals and clinical stability, the patient was treated conservatively with continued anticoagulation without additional invasive intervention. This case highlights the physiologic adaptation of collateral formation that can allow for conservative management in chronic DVT and contributes to a better understanding of management strategies for high-risk patients with recurrent thrombotic events.</p>","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":"2026 ","pages":"8841986"},"PeriodicalIF":0.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145953521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marked Sinus Bradycardia in a COVID-19 Patient.","authors":"Carlos Valladares, Adam Kaplan","doi":"10.1155/cric/4893066","DOIUrl":"10.1155/cric/4893066","url":null,"abstract":"<p><strong>Background: </strong>The presence of cardiac manifestations, including bradycardia, has been described as a manifestation of coronavirus disease 2019 (COVID-19). Our case report describes a case of sinus bradycardia secondary to possible sinus node dysfunction in an otherwise asymptomatic patient with COVID-19.</p><p><strong>Case presentation: </strong>We report the case of an unvaccinated 33-year-old female hospitalized due to bradycardia after 4 days of testing positive for COVID-19. She presented with a 1-day history of transitory lightheadedness and dizziness with no other associated symptoms. Sinus bradycardia was recorded on admission, heart rate 52/min that later dropped to 35/min on the second day of admission. Secondary causes of bradycardia were excluded based on the absence of relevant evidence from laboratory work-up and echocardiographic examination.</p><p><strong>Decision‐making: </strong>We recommend baseline ECG monitoring in hospitalized COVID-19 patients, regardless of disease severity, to assess for potential cardiac manifestations.</p><p><strong>Conclusion: </strong>Cardiac rhythm monitoring is an essential component of staying vigilant against potential complications. It raises the question of how physicians should respond to a patient with marked bradycardia and when should they intervene?</p>","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":"2025 ","pages":"4893066"},"PeriodicalIF":0.5,"publicationDate":"2025-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12750099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Venoarterial Extracorporeal Membrane Oxygenation as a Procedural Support Tool in Cardiovascular Instability: A Case Series.","authors":"Seonghyeon Bu","doi":"10.1155/cric/9598287","DOIUrl":"10.1155/cric/9598287","url":null,"abstract":"<p><p>The use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasing worldwide. Patients with cardiogenic shock were the first indication for VA-ECMO according to the Extracorporeal Life Support Organization (ELSO) guidelines. However, recent studies have shown that VA-ECMO is not beneficial in patients with cardiogenic shock. This report describes the case of three patients who presented with infarct-related cardiac arrest without cardiogenic shock and received VA-ECMO to support coronary intervention. These patients tolerated the treatment and showed a good prognosis at discharge. These cases describe the potential role of VA-ECMO as a supportive intervention in patients with infarct-related cardiac arrest without cardiogenic shock.</p>","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":"2025 ","pages":"9598287"},"PeriodicalIF":0.5,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12746534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145866521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomatic Premature Ventricular Contractions in the Context of Cardiac Memory Following Septal Accessory Pathway Ablation: A Case Report.","authors":"Manuel J Vogel, Jonas Herting, Moritz T Huttelmaier, Thomas H Fischer","doi":"10.1155/cric/1241417","DOIUrl":"10.1155/cric/1241417","url":null,"abstract":"<p><strong>Introduction: </strong>Wolff-Parkinson-White (WPW) syndrome is a congenital heart disorder marked by an accessory electrical pathway (AP) causing reentrant tachycardias. This report presents a case of WPW successfully treated with catheter ablation but followed by transient symptomatic premature ventricular contractions (PVCs).</p><p><strong>Case summary: </strong>A 27-year-old WPW patient was referred due to paroxysmal tachycardias. The baseline electrocardiogram confirmed ventricular pre-excitation, and the patient underwent radiofrequency ablation targeting a right septal AP. Some days later, the patient experienced palpitations distinct from preablation symptoms. A 24-h Holter ECG and exercise testing revealed frequent, monomorphic PVCs originating from the previously pre-excited region. Low-dose beta-blocker therapy alleviated symptoms, and there was no evidence of PVC recurrence after tapering temporary beta-blocker medication.</p><p><strong>Discussion: </strong>This case illustrates a new onset of PVC after ablation of septal AP in WPW syndrome. We postulate that transient electric instability due to AP-associated cardiac memory led to enhanced local automatic activity resulting in PVC.</p>","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":"2025 ","pages":"1241417"},"PeriodicalIF":0.5,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12723183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous Monitoring During Atrial Lead Screw-In, a Method to Reduce Atrial Lead Dislodgement.","authors":"Binbin Luo, Longfu Jiang, Di Lu, Lu Zhang","doi":"10.1155/cric/4932942","DOIUrl":"10.1155/cric/4932942","url":null,"abstract":"<p><p>The atrial lead is essential for atrial or dual-chamber pacing, requiring stable fixation to ensure reliable electrical thresholds and sensing. Despite advancements in lead designs, atrial screw-in leads still face a dislodgement rate of 0%-3.3%. This study introduces a novel technique for atrial lead fixation using real-time injury current monitoring, offering a promising method to minimize lead dislodgement and enhance clinical outcomes.</p>","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":"2025 ","pages":"4932942"},"PeriodicalIF":0.5,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12721743/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145821770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent Pulmonary Hypertension in Corrected Congenital Left Circumflex Artery to Coronary Sinus Fistula: A Case Report and Literature Review.","authors":"Nihar Jena, Tea Rrapo, Shubham Pahi, Jay Pradhan","doi":"10.1155/cric/6985938","DOIUrl":"10.1155/cric/6985938","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery fistulas (CAFs) are rare congenital anomalies, with the left circumflex artery to coronary sinus (LCx-CS) fistula representing an uncommon subtype. Pulmonary hypertension (PHTN) may arise as a consequence of large, unrepaired CAFs. While most patients experience improvement following surgical repair, there are instances where PHTN persists, necessitating ongoing monitoring and pharmacological intervention.</p><p><strong>Case description: </strong>We present the case of a middle-aged woman with no significant medical history who presented with dyspnea. She was found to have PHTN secondary to a large LCx-CS fistula. She underwent surgical ligation of the fistula. Postoperatively, the patient remained symptomatic, with elevated pulmonary arterial pressure persisting, prompting the initiation of triple therapy comprising macitentan, selexipag, and sildenafil. This therapeutic regimen significantly resolved her symptoms and improved her functional capacities.</p><p><strong>Discussion: </strong>This case highlights the hemodynamic implications associated with a long-standing LCx-CS fistula. Although congenital, such anomalies can remain asymptomatic for extended periods. The most likely hypothesis is that a large chronic fistula can cause irreversible histopathological changes to the pulmonary microvasculature, resulting in a \"point of no return\" and leading to persistent symptoms even after anatomical correction. In most reported scenarios, the surgical or interventional correction of CAF results in symptom resolution and hemodynamic improvement. However, the described case illustrates an atypical presentation, revealing the potential for sustained elevation of pulmonary arterial pressures. Consequently, this necessitates ongoing pharmacological management.</p><p><strong>Conclusion: </strong>While LCx-CS fistulas are infrequent and often asymptomatic, chronic fistula cases may result in various complications and symptomatic presentations. The case illustrates a rare case of persistent PHTN in a corrected LCx-CS fistula. Thorough follow-up, early diagnosis, and timely interventions, complemented by pharmacotherapy when necessary, are essential in managing these complex clinical scenarios.</p>","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":"2025 ","pages":"6985938"},"PeriodicalIF":0.5,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12688629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145726840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Septal Metastasis From Poorly Differentiated Colorectal Adenocarcinoma: A Rare Case Illustrating the Role of Multimodal Imaging and Multidisciplinary Management.","authors":"Ameer Odeh, Danish Saleh, Robert Bayer, Douglas R Johnston, Iman Imanirad, Mohamed Al-Kazaz","doi":"10.1155/cric/6626317","DOIUrl":"10.1155/cric/6626317","url":null,"abstract":"<p><strong>Background: </strong>Cardiac metastases from colorectal adenocarcinoma are rare and may present with varied or absent symptoms.</p><p><strong>Case summary: </strong>A middle-aged woman with recurrent colorectal adenocarcinoma presented with an infiltrating ventricular septal cardiac mass. Multimodal imaging, including PET-CT and cardiac MRI, was crucial for both identifying the lesion as a metastasis and for subsequent serial monitoring. Extensive cardiac involvement necessitated specialized surgical and radiation oncology expertise at a high-volume center, though extra-cardiac lesions led to deferring surgery or radiation as therapeutic options. Ultimately, lesion regression was achieved with intensive chemotherapy and immunotherapy targeting the primary malignancy.</p><p><strong>Discussion: </strong>To our knowledge, no prior cases have documented colorectal adenocarcinoma metastasizing to the interventricular septum with interatrial extension. Management of intracardiac metastases is complex and requires a multidisciplinary approach.</p><p><strong>Take home messages: </strong>Accurate diagnosis and characterization of cardiac masses requires a multimodal imaging approach, while effective management depends on a multidisciplinary strategy tailored to treatment goals and patient-specific factors. Surgical resection can be considered at high-volume centers but may be deferred in metastatic disease if it does not improve prognosis or symptoms. Factoring in the expected response to medical therapy is also important.</p>","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":"2025 ","pages":"6626317"},"PeriodicalIF":0.5,"publicationDate":"2025-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12682442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145709551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Dose Catheter-Directed Thrombolysis for Massive Pulmonary Embolism: A Case Report Highlighting Dosing Considerations in Asian Patients.","authors":"Zhongjian Tang, Yang Song, Min Zhang, Mengyan Li, Jingjing Shang, Aiya Shu, Kunkun Wang, Yun Lucy Lu","doi":"10.1155/cric/3210422","DOIUrl":"10.1155/cric/3210422","url":null,"abstract":"<p><p>Clinical management of massive pulmonary embolism is challenging when active hemorrhage, a contraindication to thrombolytics, is concurrently present. We describe a successful attempt in using low-dose catheter-directed thrombolysis (CDT) in a high-risk patient with absolute contraindications to systemic thrombolysis. A 69-year-old Asian female with cardiac arrest was brought to a resource-limited rural hospital. The patient underwent 50 min of cardiopulmonary resuscitation (CPR) before regaining the pulse but remained in cardiogenic shock. Computerized tomography (CT) of the chest found massive PE. The patient was found with multiple fractures and subarachnoid hemorrhage. Catheter-directed embolectomy was performed without clinical improvement. A low-dose CDT with alteplase was attempted by giving 5 mg over 2 h with a repeated session 24 h later for a total of 10 mg. The patient started improving, was extubated on Day 9, and transferred out of the ICU on Day 15. Low-dose CDT in massive PE could be lifesaving despite the presence of absolute alteplase contraindications. Patients with contraindications, a high risk of bleeding, or of Asian race may benefit more from the low-dose alteplase regimen.</p>","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":"2025 ","pages":"3210422"},"PeriodicalIF":0.5,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12681412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vein in Vain: A Case of Deep Vein Thrombosis Following the Use of the Mynx Closure Device.","authors":"Alexander Yaylayan, Vineet Madishetty, Kevin Schneider, Mohamed Tashani, Jesse Klein","doi":"10.1155/cric/8650666","DOIUrl":"10.1155/cric/8650666","url":null,"abstract":"<p><p>Vascular closure devices (VCDs) have significantly advanced catheter-based interventions by expediting hemostasis following arterial puncture. The Mynx closure device, which uses a sealant consisting of polyethylene glycol (PEG) to facilitate hemostasis, is a widely used tool for arterial closure. Despite their effectiveness, these devices are still associated with complications, including thrombosis and vessel occlusion, which warrant attention. We report a case involving a 58-year-old male with a complex medical history, including atrial flutter and nonischemic cardiomyopathy, who presented with right lower extremity pain following catheter ablation for atrial flutter. Hemostasis was effectively achieved by using the Mynx closure device. Despite successful recovery, the patient developed a DVT within the right lower extremity, involving the femoral and iliac veins which necessitated mechanical thrombectomy. While VCDs such as the Mynx closure device have shown superior benefits in reducing hemostasis time and improving patient comfort, instances of complications such as deep vein thrombosis and vessel occlusion have been reported. The potential for such complications suggests a need for proper training and careful monitoring to minimize risks.</p>","PeriodicalId":51760,"journal":{"name":"Case Reports in Cardiology","volume":"2025 ","pages":"8650666"},"PeriodicalIF":0.5,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12677988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145702517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}