International Journal of Rheumatology最新文献_第8页

The CEDAR Study: A Longitudinal Study of the Clinical Effects of Conventional DMARDs and Biologic DMARDs in Australian Rheumatology Practice. CEDAR研究:澳大利亚风湿病学实践中传统DMARDs和生物DMARDs临床效果的纵向研究。

IF 2.3

International Journal of Rheumatology Pub Date : 2017-01-01 Epub Date: 2017-05-23 DOI: 10.1155/2017/1201450

Lynden Roberts, Kathleen Tymms, Julien de Jager, Geoffrey Littlejohn, Hedley Griffiths, Dave Nicholls, Paul Bird, Jennifer Young, Julie Hill, Jane Zochling

{"title":"The CEDAR Study: A Longitudinal Study of the Clinical Effects of Conventional DMARDs and Biologic DMARDs in Australian Rheumatology Practice.","authors":"Lynden Roberts, Kathleen Tymms, Julien de Jager, Geoffrey Littlejohn, Hedley Griffiths, Dave Nicholls, Paul Bird, Jennifer Young, Julie Hill, Jane Zochling","doi":"10.1155/2017/1201450","DOIUrl":"https://doi.org/10.1155/2017/1201450","url":null,"abstract":"Objectives: To observe the choices of conventional disease modifying antirheumatic drugs (cDMARDs) and biologic DMARDs (bDMARDs) in the management of rheumatoid arthritis (RA) in Australian routine clinical practice, to assess treatment survival and determine the effect of cDMARDs/bDMARDs on disease activity.Methods: Routinely collected, deidentified clinical data was sourced from 20 Australian rheumatology practices. RA patients aged ≥18 years, who had received cDMARDs/bDMARDs and a recorded subsequent visit, were included. A linear mixed model was used to determine the change over time and the percentage reduction in disease activity was summarized.Results: 12,526 RA patients were included: 72% females, mean age 62 years. cDMARDs and bDMARDs were used in 92% and 30% of patients, respectively. The most commonly prescribed cDMARD was methotrexate (76% patients); median time to stopping treatment was 337 months [95% CI: 279-ND]. Etanercept was the most commonly prescribed bDMARD (12% patients); median time to stopping treatment was 79 months [95% CI: 57-93]. Of 5,341 patients with a first change in medication (cDMARD or bDMARD), 87% had therapy escalation and 13% deescalation. Reduction in DAS28-ESR, 6-month post-DMARDs initiation ranged from 3%, adalimumab, to 14%, leflunomide and tocilizumab.Conclusions: In this large Australian cohort of unselected community RA patients, the choices of cDMARDs/bDMARDs are aligned with current international guidelines.","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":"2017 ","pages":"1201450"},"PeriodicalIF":2.3,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1201450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35103949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis. 日本类风湿关节炎患者中需要住院治疗的感染的发生率和危险因素，包括肺囊虫肺炎

IF 2.3

International Journal of Rheumatology Pub Date : 2017-01-01 Epub Date: 2017-10-18 DOI: 10.1155/2017/6730812

Atsushi Hashimoto, Shiori Suto, Kouichiro Horie, Hidefumi Fukuda, Shinichi Nogi, Kanako Iwata, Hirotaka Tsuno, Hideki Ogihara, Misato Kawakami, Akiko Komiya, Hiroshi Furukawa, Toshihiro Matsui, Shigeto Tohma

{"title":"Incidence and Risk Factors for Infections Requiring Hospitalization, Including Pneumocystis Pneumonia, in Japanese Patients with Rheumatoid Arthritis.","authors":"Atsushi Hashimoto, Shiori Suto, Kouichiro Horie, Hidefumi Fukuda, Shinichi Nogi, Kanako Iwata, Hirotaka Tsuno, Hideki Ogihara, Misato Kawakami, Akiko Komiya, Hiroshi Furukawa, Toshihiro Matsui, Shigeto Tohma","doi":"10.1155/2017/6730812","DOIUrl":"https://doi.org/10.1155/2017/6730812","url":null,"abstract":"Objective: Rheumatoid arthritis (RA) may be complicated by different infections, but risk factors for these are not fully elucidated. Here, we assessed the incidence of and risk factors for infections requiring hospitalization (IRH) including pneumocystis pneumonia (PCP) in patients with RA.Methods: We retrospectively surveyed all RA patients treated at our hospital from 2009 to 2013, for whom data were available on demographic features, medications, comorbidities, and severity of RA. Multivariate logistic regression analysis was applied to calculate adjusted odds ratios (ORs) for factors associated with the occurrence of IRH.Results: In a total of 9210 patient-years (2688 patients), there were 373 IRH (3.7/100 patient-years). Respiratory tract infections were most frequent (n = 154, and additionally 16 PCP), followed by urinary tract infections (n = 50). Significant factors for PCP included higher age (≥70 years; OR 3.5), male sex (6.6), underlying lung disease (3.0), use of corticosteroids (4.8), and use of biologics (5.4). Use of methotrexate (5.7) was positively associated with PCP but negatively with total infections (0.7). Additionally, functional disorders and higher RA disease activity were also related to total infections.Conclusions: Risk factors for infection should be taken into account when deciding treatment for the individual RA patient.","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":"2017 ","pages":"6730812"},"PeriodicalIF":2.3,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6730812","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35290132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: "The COMORA Study". 15个国家类风湿关节炎患者维生素D状况的评估及其与疾病活动度的关系:“COMORA研究”

IF 2.3

International Journal of Rheumatology Pub Date : 2017-01-01 Epub Date: 2017-06-01 DOI: 10.1155/2017/5491676

Najia Hajjaj-Hassouni, Nada Mawani, Fadoua Allali, Hanan Rkain, Kenza Hassouni, Ihsane Hmamouchi, Maxime Dougados

{"title":"Evaluation of Vitamin D Status in Rheumatoid Arthritis and Its Association with Disease Activity across 15 Countries: \"The COMORA Study\".","authors":"Najia Hajjaj-Hassouni, Nada Mawani, Fadoua Allali, Hanan Rkain, Kenza Hassouni, Ihsane Hmamouchi, Maxime Dougados","doi":"10.1155/2017/5491676","DOIUrl":"https://doi.org/10.1155/2017/5491676","url":null,"abstract":"The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients' RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average of vitamin D serum dosage was 27.3 ng/mL ± 15.1 [0.1-151]. Status of vitamin D was insufficient in 54.6% and deficient in 8.5% of patients. 43% of RA patients were supplemented with vitamin D and absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency (p < 0.001). Finally, our study shows that the status of low levels of vitamin D is common in RA in different countries and under different latitudes. Absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency. Low levels of vitamin D were associated with patients characteristics (age, BMI, and educational level), RA (disease activity and corticosteroid dosage), and comorbidities (lung disease and osteoporosis therapy). This suggests the need for a particular therapeutic strategy to improve vitamin D status in RA patients.","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":"2017 ","pages":"5491676"},"PeriodicalIF":2.3,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/5491676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35123758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 46

Effect of Curcuma xanthorrhiza Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D₃ towards Disease Activity (SLEDAI), IL-6, and TGF-β1 Serum. 补充姜黄对低维生素D系统性红斑狼疮患者给予维生素D3对疾病活动性(SLEDAI)、IL-6、TGF-β1血清的影响

IF 2.3

International Journal of Rheumatology Pub Date : 2017-01-01 Epub Date: 2017-12-28 DOI: 10.1155/2017/7687053

C Singgih Wahono, Cameleia Diah Setyorini, Handono Kalim, Nurdiana Nurdiana, Kusworini Handono

{"title":"Effect of Curcuma xanthorrhiza Supplementation on Systemic Lupus Erythematosus Patients with Hypovitamin D Which Were Given Vitamin D3 towards Disease Activity (SLEDAI), IL-6, and TGF-β1 Serum.","authors":"C Singgih Wahono, Cameleia Diah Setyorini, Handono Kalim, Nurdiana Nurdiana, Kusworini Handono","doi":"10.1155/2017/7687053","DOIUrl":"https://doi.org/10.1155/2017/7687053","url":null,"abstract":"Background: Curcumin contained in Curcuma xanthorrhiza is an immunomodulator that has similar biological effect as vitamin D. Combination of curcumin and vitamin D3 is expected to work synergistically.Objective: To determine the effect of Curcuma xanthorrhiza supplementation on vitamin D3 administration to SLEDAI, IL-6, and TGF-β1 serum in SLE patients with hypovitamin D.Methods: This was a double-blind RCT conducted in Saiful Anwar Hospital, Malang, in January 2016-March 2017. Subjects were SLE active (SLEDAI > 3) with levels of 25(OH)D3 ≤ 30 ng/ml and divided into two groups: those receiving cholecalciferol 3 × 400 IU and placebo 3 × 1 tablets (group I) and those receiving 3 × 400 IU cholecalciferol and Curcuma xanthorrhiza 3 × 20 mg for 3 months (group II). SLEDAI, levels of vitamin D, IL-6, and TGF-β1 in serum were evaluated before and after the treatment.Results: There were no significant differences in SLEDAI reduction, decreased serum levels of IL-6, and increased levels of TGF-β1 serum among groups after the treatment. Decreased levels of serum IL-6 have a positive correlation with SLEDAI reduction. Conclusion. Curcuma xanthorrhiza supplementation on vitamin D3 had no effects on SLEDAI and serum levels of IL-6 and TGF-β1. This clinical trial is registered with NCT03155477.","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":"2017 ","pages":"7687053"},"PeriodicalIF":2.3,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7687053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35831492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Review of Current Immunologic Therapies for Hidradenitis Suppurativa. 当前治疗湿疹的免疫疗法综述

IF 2.3

International Journal of Rheumatology Pub Date : 2017-01-01 Epub Date: 2017-08-20 DOI: 10.1155/2017/8018192

Victoria K Shanmugam, Nadia Meher Zaman, Sean McNish, Faye N Hant

{"title":"Review of Current Immunologic Therapies for Hidradenitis Suppurativa.","authors":"Victoria K Shanmugam, Nadia Meher Zaman, Sean McNish, Faye N Hant","doi":"10.1155/2017/8018192","DOIUrl":"10.1155/2017/8018192","url":null,"abstract":"Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of apocrine gland-bearing skin which affects approximately 1-4% of the population. The disease is more common in women and patients of African American descent and approximately one-third of patients report a family history. Obesity and smoking are known risk factors, but associations with other immune disorders, especially inflammatory bowel disease, are also recognized. The pathogenesis of HS is poorly understood and host innate or adaptive immune response, defective keratinocyte function, and the microbial environment in the hair follicle and apocrine gland have all been postulated to play a role in disease activity. While surgical interventions can be helpful to reduce disease burden, there is a high recurrence rate. Increasingly, data supports targeted immune therapy for HS, and longitudinal studies suggest benefit from these agents, both when used alone and as an adjunct to surgical treatments. The purpose of this review is to outline the current data supporting use of targeted immune therapy in HS management.","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":"2017 ","pages":"8018192"},"PeriodicalIF":2.3,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35407246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Nonradiographic Axial Spondyloarthritis, the Radiographic Axial Spondyloarthritis, and Ankylosing Spondylitis: The Tangled Skein of Rheumatology. 非影像学的中轴性脊柱炎、影像学的中轴性脊柱炎和强直性脊柱炎:风湿病学的纠结。

IF 2.3

International Journal of Rheumatology Pub Date : 2017-01-01 Epub Date: 2017-05-07 DOI: 10.1155/2017/1824794

Anand N Malaviya, Roopa Rawat, Neha Agrawal, Nilesh S Patil

{"title":"The Nonradiographic Axial Spondyloarthritis, the Radiographic Axial Spondyloarthritis, and Ankylosing Spondylitis: The Tangled Skein of Rheumatology.","authors":"Anand N Malaviya, Roopa Rawat, Neha Agrawal, Nilesh S Patil","doi":"10.1155/2017/1824794","DOIUrl":"https://doi.org/10.1155/2017/1824794","url":null,"abstract":"Since 1984 the diagnosis of ankylosing spondylitis (AS) has been based upon the modified New York (mNY) criteria with mandatory presence of radiographic sacroiliitis, without which the diagnosis is not tenable. However, it may take years or decades for radiographic sacroiliitis to develop delaying the diagnosis for long periods. It did not matter in the past because no effective treatment was available. However, with the availability of a highly effective treatment, namely, tumour necrosis factor-α inhibitors (TNFi), the issue of early diagnosis of AS acquired an urgency. The Assessment of SpondyloArthritis International Society (ASAS) classification criteria published in 2009 was a significant step towards this goal. These criteria described an early stage of the disease where sacroiliitis was demonstrable only on MRI but not on standard radiograph. Therefore, this stage of the disease was labelled \"nonradiographic axial SpA\" (nr-axSpA). But questions have been raised if, in search of early diagnosis, specificity was compromised. The Federal Drug Administration (FDA, USA) withheld approval for the use of TNFi in patients with nr-axSpA because of issues related to the specificity of these criteria. This review attempts to clarify some of these aspects of the nr-axSpA-AS relationship and also tries to answer the question whether ASAS classifiable radiographic axial spondyloarthritis (r-axSpA) term can be interchangeably used with the term AS.","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":"2017 ","pages":"1824794"},"PeriodicalIF":2.3,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1824794","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35037527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Validation of Administrative Osteoarthritis Diagnosis Using a Clinical and Radiological Population-Based Cohort 基于临床和放射学人群队列的行政性骨关节炎诊断的验证

IF 2.3

International Journal of Rheumatology Pub Date : 2016-12-29 DOI: 10.1155/2016/6475318

M. M. Rahman, Jacek A. Kopec, C. Goldsmith, A. Anis, J. Cibere

{"title":"Validation of Administrative Osteoarthritis Diagnosis Using a Clinical and Radiological Population-Based Cohort","authors":"M. M. Rahman, Jacek A. Kopec, C. Goldsmith, A. Anis, J. Cibere","doi":"10.1155/2016/6475318","DOIUrl":"https://doi.org/10.1155/2016/6475318","url":null,"abstract":"Objectives. The validity of administrative osteoarthritis (OA) diagnosis in British Columbia, Canada, was examined against X-rays, magnetic resonance imaging (MRI), self-report, and the American College of Rheumatology criteria. Methods. During 2002–2005, 171 randomly selected subjects with knee pain aged 40–79 years underwent clinical assessment for OA in the knee, hip, and hands. Their administrative health records were linked during 1991–2004, in which OA was defined in two ways: (AOA1) at least one physician's diagnosis or hospital admission and (AOA2) at least two physician's diagnoses in two years or one hospital admission. Sensitivity, specificity, and predictive values were compared using four reference standards. Results. The mean age was 59 years and 51% were men. The proportion of OA varied from 56.3 to 89.7% among men and 77.4 to 96.4% among women according to reference standards. Sensitivity and specificity varied from 21 to 57% and 75 to 100%, respectively, and PPVs varied from 82 to 100%. For MRI assessment, the PPV of AOA2 was 100%. Higher sensitivity was observed in AOA1 than AOA2 and the reverse was true for specificity and PPV. Conclusions. The validity of administrative OA in British Columbia varied due to case definitions and reference standards. AOA2 is more suitable for identifying OA cases for research using this Canadian database.","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":"55 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2016-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/6475318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64480596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Corrigendum to “An Insight into Methods and Practices in Hip Arthroplasty in Patients with Rheumatoid Arthritis” “类风湿关节炎患者髋关节置换术的方法和实践”的勘误表

IF 2.3

International Journal of Rheumatology Pub Date : 2016-12-27 DOI: 10.1155/2016/1741420

M. S. Mosleh-Shirazi, M. Ibrahim, P. Pastides, Wasim Khan, H. Rahman, L. Jahangiri

引用次数: 0

Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading 骨关节炎中的免疫介质:在临床影像学分级较高的骨关节炎患者中，髌下脂肪垫浸润的CD8+ T细胞增加

IF 2.3

International Journal of Rheumatology Pub Date : 2016-12-14 DOI: 10.1155/2016/9525724

Jirun Apinun, P. Sengprasert, P. Yuktanandana, S. Ngarmukos, A. Tanavalee, Rangsima Reantragoon

{"title":"Immune Mediators in Osteoarthritis: Infrapatellar Fat Pad-Infiltrating CD8+ T Cells Are Increased in Osteoarthritic Patients with Higher Clinical Radiographic Grading","authors":"Jirun Apinun, P. Sengprasert, P. Yuktanandana, S. Ngarmukos, A. Tanavalee, Rangsima Reantragoon","doi":"10.1155/2016/9525724","DOIUrl":"https://doi.org/10.1155/2016/9525724","url":null,"abstract":"Osteoarthritis is a condition of joint failure characterized by many pathologic changes of joint-surrounding tissues. Many evidences suggest the role of both innate and adaptive immunity that interplay, resulting either in initiation or in progression of osteoarthritis. Adaptive immune cells, in particular T cells, have been demonstrated to play a role in the development of OA in animal models. However, the underlying mechanism is yet unclear. Our aim was to correlate the frequency and phenotype of tissue-infiltrating T cells in the synovial tissue and infrapatellar fat pad with radiographic grading. Our results show that CD8+ T cells are increased in osteoarthritic patients with higher radiographic grading. When peripheral blood CD8+ T cells were examined, we show that CD8+ T cells possess a significantly higher level of activation than its CD4+ T cell counterpart (P < 0.0001). Our results suggest a role for CD8+ T cells and recruitment of these activated circulating peripheral blood CD8+ T cells to the knee triggering local inflammation within the knee joint.","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":"99 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2016-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/9525724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64619466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever 埃及家族性地中海热患儿血清淀粉样蛋白A水平

IF 2.3

International Journal of Rheumatology Pub Date : 2016-12-13 DOI: 10.1155/2016/7354018

Hala M Lofty, H. Marzouk, Y. Farag, M. Nabih, Iman Khalifa, Noha Mostafa, A. Salah, L. Rashed, Kamal El Garf

{"title":"Serum Amyloid A Level in Egyptian Children with Familial Mediterranean Fever","authors":"Hala M Lofty, H. Marzouk, Y. Farag, M. Nabih, Iman Khalifa, Noha Mostafa, A. Salah, L. Rashed, Kamal El Garf","doi":"10.1155/2016/7354018","DOIUrl":"https://doi.org/10.1155/2016/7354018","url":null,"abstract":"Background and Objectives. SAA is an acute-phase reactant detected during an FMF attack or other inflammatory conditions. High SAA levels may increase the risk of amyloidosis. The aim of the study is to measure the serum amyloid A (SAA) level in a group of Egyptian children with familial Mediterranean fever (FMF) and study its various correlates, if any. Methods. The study enrolled seventy-one children with FMF. Results. SAA level was high in 78.9% of the studied patients with a mean of 81.62 ± 31.6 mg/L, and CRP was positive in 31% of patients. There was no significant releation between SAA level and any demographic or clinical manifestation. High SAA was more frequent in V726A allele (16.9%) followed by M694V allele (12.3%). Elevated SAA levels were more frequent in patients on low colchicine doses. Forty-five percent (45%) of patients have low adherence to colchicine therapy. Interpretation and Conclusion. High SAA levels were detected two weeks after last FMF attack in a large percentage of Egyptian FMF children. This indicates that subclinical inflammation continues during attack-free periods, and SAA could be used as a marker of it.","PeriodicalId":51715,"journal":{"name":"International Journal of Rheumatology","volume":"2016 1","pages":""},"PeriodicalIF":2.3,"publicationDate":"2016-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2016/7354018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64517374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16