{"title":"Nucleoporin 43 inhibits NF-κB pathway by targeting TRAF6 in miiuy croaker, Miichthys miiuy","authors":"Wenxin Li, Yan Xu, Qi Li, Tianjun Xu, Yuena Sun","doi":"10.1016/j.cirep.2024.200148","DOIUrl":"https://doi.org/10.1016/j.cirep.2024.200148","url":null,"abstract":"Tumor necrosis factor receptor-associated factor 6 (TRAF6) serves as a critical factor in the initiation of the NF-κB pathway and holds significance in modulating the inflammatory response. However, the regulatory mechanism of TRAF6 in teleost fish is poorly understood. We demonstrate Miichthys miiuy nucleoporin 43 (mm-nup43), a member of the nuclear pore complex (NPC), is a negative regulator of the NF-κB pathway and inhibits the expression of inflammatory cytokines. Mechanistically, mm-nup43 interacts with TRAF6 and inhibits it via the ubiquitin-proteasome pathway. Meanwhile, mm-nup43 decreased p65 phosphorylation, thereby negatively regulating NF-κB signaling. In summary, these results classify that mm-nup43 inhibits the TRAF6-mediated NF-κB pathway and prevents excessive inflammation.","PeriodicalId":516937,"journal":{"name":"Comparative Immunology Reports","volume":"6 1","pages":"200148-200148"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Borland, C. Riesenbach, U. Shandilya, M.A. Chiasson, N.A. Karrow, D. Huyben
{"title":"Growth performance, hepatic gene expression, and plasma biochemistry of rainbow trout fed full-fat meal, defatted meal, oil and chitin from black soldier flies","authors":"M. Borland, C. Riesenbach, U. Shandilya, M.A. Chiasson, N.A. Karrow, D. Huyben","doi":"10.1016/j.cirep.2024.200149","DOIUrl":"https://doi.org/10.1016/j.cirep.2024.200149","url":null,"abstract":"","PeriodicalId":516937,"journal":{"name":"Comparative Immunology Reports","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141143970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura A. Carvalho, S. Whyte, S. Purcell, Tyson Hay, Richard G. Taylor, Rachel Balder, Nellie Gagné, S. Dalvin, Mark D Fast
{"title":"The impact of functional feed on Atlantic salmon (Salmo salar) systemic immune response to high and low levels of sea lice infection (Lepeophtheirus salmonis) and co-infection with infectious salmon anemia virus","authors":"Laura A. Carvalho, S. Whyte, S. Purcell, Tyson Hay, Richard G. Taylor, Rachel Balder, Nellie Gagné, S. Dalvin, Mark D Fast","doi":"10.1016/j.cirep.2024.200147","DOIUrl":"https://doi.org/10.1016/j.cirep.2024.200147","url":null,"abstract":"","PeriodicalId":516937,"journal":{"name":"Comparative Immunology Reports","volume":"226 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141039751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacinta Agius, Danielle Ackerly, Travis Beddoe, Karla J. Helbig
{"title":"Analysis of the presence of anti-viral innate immune pathways in the Australian Haliotis laevigata.","authors":"Jacinta Agius, Danielle Ackerly, Travis Beddoe, Karla J. Helbig","doi":"10.1016/j.cirep.2024.200145","DOIUrl":"https://doi.org/10.1016/j.cirep.2024.200145","url":null,"abstract":"","PeriodicalId":516937,"journal":{"name":"Comparative Immunology Reports","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141058108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linnea K. Andersen, Jason W. Abernathy, Bradley D. Farmer, Miles D. Lange, Matthew E. McEntire, Steven D. Rawles
{"title":"Gene expression profiles of white bass (Morone chrysops) and hybrid striped bass (M. chrysops x M. saxatilis) gill tissue following Flavobacterium covae infection","authors":"Linnea K. Andersen, Jason W. Abernathy, Bradley D. Farmer, Miles D. Lange, Matthew E. McEntire, Steven D. Rawles","doi":"10.1016/j.cirep.2024.200144","DOIUrl":"https://doi.org/10.1016/j.cirep.2024.200144","url":null,"abstract":"","PeriodicalId":516937,"journal":{"name":"Comparative Immunology Reports","volume":"286 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140782975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. K. Leet, Catherine A. Richter, Rachel A. Claunch, Robert W. Gale, D. Tillitt, Luke R. Iwanowicz
{"title":"Immunomodulation in adult largemouth bass (Micropterus salmoides) exposed to a model estrogen or mixture of endocrine disrupting contaminants during early gonadal recrudescence","authors":"J. K. Leet, Catherine A. Richter, Rachel A. Claunch, Robert W. Gale, D. Tillitt, Luke R. Iwanowicz","doi":"10.1016/j.cirep.2024.200140","DOIUrl":"https://doi.org/10.1016/j.cirep.2024.200140","url":null,"abstract":"","PeriodicalId":516937,"journal":{"name":"Comparative Immunology Reports","volume":"66 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139965902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}