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A randomized clinical trial: Efficacy of group-based acceptance and commitment therapy program for breast cancer patients with high fear of progression. 随机临床试验：以小组为基础的接受与承诺治疗计划对高度恐惧病情恶化的乳腺癌患者的疗效。

Psycho-Oncology Pub Date : 2024-04-01 DOI: 10.1002/pon.6339

Fatemeh Hassani Alimolk, F. McDonald, Mohammad Asghari-Jafarabadi, F. Ahmadi, Saeedeh Zenoozian, M. Lashkari, Pandora Patterson

{"title":"A randomized clinical trial: Efficacy of group-based acceptance and commitment therapy program for breast cancer patients with high fear of progression.","authors":"Fatemeh Hassani Alimolk, F. McDonald, Mohammad Asghari-Jafarabadi, F. Ahmadi, Saeedeh Zenoozian, M. Lashkari, Pandora Patterson","doi":"10.1002/pon.6339","DOIUrl":"https://doi.org/10.1002/pon.6339","url":null,"abstract":"BACKGROUND\u0000Fear of progression (FOP) is a common and significant concern among cancer patients, encompassing worries about cancer progression during active treatment. Elevated levels of FOP can be dysfunctional. This study aims to assess the efficacy of an Acceptance and Commitment Therapy (ACT)-based intervention on FOP, anxiety sensitivity (AS), and quality of life (QOL) in breast cancer patients.\u0000\u0000\u0000METHODS\u0000A clinical trial was conducted involving 80 stage I-III active-treatment breast cancer patients with a score greater than 34 on the Fear of Progression Questionnaire-Short Form scale. These patients were randomly assigned in a 1:1 ratio to either an intervention group, which received weekly 70-min sessions of 5-ACT-bsed group-therapy, or a control group that received usual treatment. Variables including FOP, AS, QOL, and ACT-related factors were assessed using ASQ, QLQ-C30, Cognitive Fusion Questionnaire, and Acceptance and Action Questionnaire-II at three time points: baseline, post-intervention, and 3-month follow-up. The efficacy of the intervention was evaluated using mixed model analysis across all time-points.\u0000\u0000\u0000RESULTS\u0000The fidelity and acceptability of the ACT-based manual were confirmed using significant methods. A significant reduction in FOP was observed only in the ACT group at post-intervention (P-valueACT < 0.001; Cohen dACT = 1.099). Furthermore, the ACT group demonstrated a more significant reduction in FOP at follow-up. Furthermore, all secondary and ACT-related variables, except for the physical symptoms subscale, showed significant improvement in the ACT group compared to the control group.\u0000\u0000\u0000CONCLUSIONS\u0000Our ACT-based manual showed promise for reducing FOP, AS, and improving QOL, and ACT-related variables in breast cancer patients 3 months following the intervention.","PeriodicalId":516935,"journal":{"name":"Psycho-Oncology","volume":"117 1","pages":"e6339"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140778039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cognitive impairment in cervical cancer survivors—Exploring the discrepancy between subjective and objective assessment 宫颈癌幸存者的认知障碍--探索主观和客观评估之间的差异

Psycho-Oncology Pub Date : 2024-02-01 DOI: 10.1002/pon.6300

E. Areklett, S. Andersson, E. Fagereng, K. Bruheim, J. Stubberud, K. Lindemann

{"title":"Cognitive impairment in cervical cancer survivors—Exploring the discrepancy between subjective and objective assessment","authors":"E. Areklett, S. Andersson, E. Fagereng, K. Bruheim, J. Stubberud, K. Lindemann","doi":"10.1002/pon.6300","DOIUrl":"https://doi.org/10.1002/pon.6300","url":null,"abstract":"Cancer‐related cognitive impairment has severe implications for the quality of life and societal participation of cervical cancer survivors (CCS). However, there is no research on the association between subjective and objective cognitive impairment (CI) in cervical cancer. This cross‐sectional study aimed to examine the frequency and severity of objective CI in CCS reporting significant subjective CI and explore the discrepancy between subjective and objective CI.Sixty‐five CCS reporting significant subjective CI, defined as 1.5 SD below the normative mean, underwent neuropsychological (NP) assessment covering attention, verbal memory, processing speed, verbal fluency, and executive functions. CCS were compared to healthy age‐matched controls (n = 74). A subjective versus objective discrepancy score was calculated based on the standardized scores within each group.The CCS group performed significantly poorer across all NP tests compared to healthy controls (all p‐values <0.001) and 81.5% had scores below cut‐off as defined by the International Cognition and Cancer Task Force. However, compared to published normative data, most CCS performed within the clinically normal range. Processing speed and verbal memory were the most affected cognitive domains. By calculating a discrepancy score, both groups on average displayed a quite accurate concordance between subjective and objective cognitive functioning.Although CI is evident in CCS, our results confirm that objective and subjective CI represent different constructs and highlight the limitations of normative data. Differentiating subjective and objective CI is important when tailoring effective interventions in the survivorship care of CCS.","PeriodicalId":516935,"journal":{"name":"Psycho-Oncology","volume":"27 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139897639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of aerobic exercise on neurocognitive function in postmenopausal women receiving endocrine therapy for breast cancer: The Exercise Program in Cancer and Cognition randomized controlled trial 有氧运动对接受乳腺癌内分泌治疗的绝经后妇女神经认知功能的影响：癌症与认知锻炼计划随机对照试验

Psycho-Oncology Pub Date : 2024-01-29 DOI: 10.1002/pon.6298

Catherine M. Bender, S. Sereika, Amanda L. Gentry, Cheryl Cuglewski, J. Duquette, George Grove, Meredith H Cummings, Myeong‐ga Cho, A. Brufsky, Priscilla McAuliffe, R. Budway, Emilia J. Diego, Steven Evans, Margaret Rosenzweig, Anna L. Marsland, Yvette P. Conley, Kirk Erickson

{"title":"Effects of aerobic exercise on neurocognitive function in postmenopausal women receiving endocrine therapy for breast cancer: The Exercise Program in Cancer and Cognition randomized controlled trial","authors":"Catherine M. Bender, S. Sereika, Amanda L. Gentry, Cheryl Cuglewski, J. Duquette, George Grove, Meredith H Cummings, Myeong‐ga Cho, A. Brufsky, Priscilla McAuliffe, R. Budway, Emilia J. Diego, Steven Evans, Margaret Rosenzweig, Anna L. Marsland, Yvette P. Conley, Kirk Erickson","doi":"10.1002/pon.6298","DOIUrl":"https://doi.org/10.1002/pon.6298","url":null,"abstract":"The Exercise Program in Cancer and Cognition Study was a randomized controlled trial designed to determine whether 6 months of moderate‐intensity aerobic exercise improves neurocognitive function in women with breast cancer (BC) receiving endocrine therapy (ET).Postmenopausal women with hormone receptor+, early‐stage BC, within two years post‐primary therapy were randomized to the exercise intervention (six months, ≥150 min of moderate‐intensity aerobic exercise/week) or usual care control condition. Outcomes were assessed at pre‐randomization and after intervention completion. Groups were compared using linear mixed‐effects modeling.Participants (N = 153) were = 62.09 ± 8.27 years old, with stage I BC (64.1%) and a median of 4.7 months post‐diagnosis. We found a group‐by‐time interaction (p = 0.041) and a trend for the main effect of time (p = 0.11) for processing speed with improved performance in the exercise group and no change in the controls. Similar main effects of time were observed for learning and memory (p = 0.024) and working memory (p = 0.01). Better intervention adherence was associated with improved processing speed (p = 0.017).Six months of moderate‐intensity aerobic exercise improves processing speed in postmenopausal women with BC receiving ET who initiate exercise within 2 years of completing primary therapy (surgery +/− chemotherapy). This is the first large‐scale study to examine the effects of aerobic exercise on neurocognitive function in women with BC. Additional research is needed to address the long‐term effects of aerobic exercise on cognitive function.","PeriodicalId":516935,"journal":{"name":"Psycho-Oncology","volume":"25 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140488043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0