Zhonghua shao shang yu chuang mian xiu fu za zhi最新文献

{"title":"[Role and mechanism of infrared thermography in early identification of necrosis risk in random-pattern flaps of mice].","authors":"X Q Jiang, J Xu, X W Ling, F M Cai, H Chen, J Xiao","doi":"10.3760/cma.j.cn501225-20241118-00453","DOIUrl":"10.3760/cma.j.cn501225-20241118-00453","url":null,"abstract":"<p><p><b>Objective:</b> To investigate the role and mechanism of infrared thermography (IRT) in early identification of necrosis risk in random-pattern flaps (RPFs) of mice. <b>Methods:</b> This study was an experimental study with a grouped design. A RPF model was established on the dorsum of 92 male C57BL/6J mice aged 6-8 weeks. The flap was divided into three equal zones (zones Ⅰ, Ⅱ, and Ⅲ) from the caudal to the cephalic end. The relative temperatures (RTs, the difference between the target zones and the normal control zone) of the three zones were measured using an infrared thermal imager at postoperative day (POD) 0 (immediately), 3, and 7. At POD 3 and 7, receiver operating characteristic (ROC) curves were used to evaluate the predictive efficacy of the RT of flap zone Ⅱ for flap necrosis and to determine the optimal cutoff values. Based on the RT of flap zone Ⅱ at POD 3, mice were divided into >-0.1 ℃ group and ≤-0.1 ℃ group; based on the RT of flap zone Ⅱ at POD 7, mice were divided into >0.1 ℃ group and ≤0.1 ℃ group. The survival rate of flaps was calculated for the first two groups of mice at POD 3 and for the latter two groups of mice at POD 7. Laser Doppler perfusion imaging was used to measure blood perfusion volume of flaps in the above groups at the corresponding time points. At POD 3, the tissue of flap zone Ⅱ from >-0.1 ℃ and ≤-0.1 ℃ groups of mice was collected for transcriptomic sequencing to screen for differentially expressed genes (DEGs) with significantly differential expression, for immunofluorescence staining to calculate the ratios of inducible nitric oxide synthase (iNOS)/CD68 and arginase 1 (ARG1)/CD68, for immunohistochemical staining to detect the expression of C-C motif chemokine ligand 2 (CCL2), for dihydroethidium (DHE) staining to detect the expression of DHE, for real-time fluorescence quantitative reverse transcription polymerase chain reaction to measure the mRNA expressions of tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-10, and for Western blotting to detect the protein expressions of CD68, iNOS, ARG1, heme oxygenase-1 (HO-1), and superoxide dismutase 1 (SOD1). The sample size was three for the DEGs screening and protein expression detecting experiments, and 4 for the remaining experiments. <b>Results:</b> From POD 0 to 7, RTs of flap zones Ⅰ and Ⅱ showed an increasing trend, while RTs in flap zone Ⅲ rose initially and then decreased. At POD 3 and 7, the areas under the ROC curves of the RT of flap zone Ⅱ for predicting flap necrosis were 0.82 and 0.85, respectively (with 95% <i>CI</i>s of 0.72-0.93 and 0.78-0.93, respectively), with optimal cutoff values of -0.1 and 0.1 ℃, respectively. At POD 3, there were no statistically significant differences in the survival rate or blood perfusion volume of flaps between ≤-0.1 ℃ group and >-0.1 ℃ group of mice (<i>P</i>>0.05). At POD 7, the survival rate (<i>t</i>=4.19, <i>P</i><0.05) and blood perfusion volume (<i>t</i>=5.58, <i>P</i><0.05) of fla","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"42 8","pages":"767-776"},"PeriodicalIF":0.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13522919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148908376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Summary of the 21^st Chinese Conference on Burns and Wound Repair].","authors":"Y H Bu, G P Liang, X K Yang, Z Zheng, G X Luo","doi":"10.3760/cma.j.cn501225-20260612-00236","DOIUrl":"10.3760/cma.j.cn501225-20260612-00236","url":null,"abstract":"<p><p>The 21^st Chinese Conference on Burns and Wound Repair was successfully held in the historic city of Xi'an from May 28^th to 30^th, 2026, bringing together over 800 participants from across the country for this academic event. The conference featured one main venue and six parallel thematic sub-forums and invited over 300 renowned experts and scholars from China and abroad to engage in in-depth academic exchanges and intellectual dialogues over three days around key topics such as severe burn care, acute and chronic wound management, scar prevention and treatment, rehabilitation and nursing, and youth innovation. The conference showcased the latest breakthroughs and cutting-edge achievements in burn medicine and wound repair fields in China, enhanced the capabilities and standards in critical injury management, complex wound repair, and comprehensive scar prevention and treatment. The conference thereby effectively promoted the high-quality development of burn care and wound repair in China.</p>","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"42 7","pages":"700-702"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Performance of PHMB-surface mesoporous silica composite material and its effect on infected full-thickness skin defect wounds in rats].","authors":"Y M Zhu, J Jin, W W Wang","doi":"10.3760/cma.j.cn501225-20250830-00373","DOIUrl":"10.3760/cma.j.cn501225-20250830-00373","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the performance of polyhexamethylene biguanide hydrochloride (PHMB)-surface mesoporous silica composite material (hereinafter referred to as the composite material) and its effect on infected full-thickness skin defect wounds in rats. &lt;b&gt;Methods:&lt;/b&gt; This study was an experimental study including group design, factorial design, and repeated measures design. The composite material with a 1:1 mass ratio of PHMB to surface mesoporous silica and good biocompatibility was prepared by rotary evaporation method. The &lt;i&gt;in vitro&lt;/i&gt; release of PHMB from the composite material was detected by continuous quantitative measurement. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of PHMB and the composite material against &lt;i&gt;Staphylococcus aureus&lt;/i&gt; ATCC 6538 and &lt;i&gt;Escherichia coli&lt;/i&gt; ATCC 35150 were detected by broth microdilution method. The continuous bactericidal duration of PHMB and the composite material against the above-mentioned two types of bacteria was detected by continuous bacterial addition assay. The resistance of the above-mentioned two types of bacteria to PHMB and the composite material was detected by sub-lethal concentration induction assay. The sample size for the above experiments was 3. Forty-five female Sprague-Dawley rats aged 10-12 weeks were divided into routine dressing change group, PHMB group, and composite material group by random number table method, with 15 rats in each group. After preparing infected full-thickness skin defect wounds on the back of all rats, the wounds of rats in routine dressing change group, PHMB group, and composite material group were rinsed and dressed with normal saline, PHMB solution and composite material dispersion with a final PHMB mass fraction of 0.100%, respectively. The wound healing rates were calculated, the wound infection status was observed, and the wound tissue bacterial load was detected by the plate counting method at post injury day (PID) 6, 12, and 18, respectively. &lt;b&gt;Results:&lt;/b&gt; The composite material could continuously release PHMB for &gt;144 h. For both &lt;i&gt;Staphylococcus aureus&lt;/i&gt; and &lt;i&gt;Escherichia coli&lt;/i&gt;, the MICs of the composite material were lower than those of PHMB, but the MBCs of both materials against two bacteria were identical. The continuous bactericidal duration of PHMB against &lt;i&gt;Staphylococcus aureus&lt;/i&gt; and &lt;i&gt;Escherichia coli&lt;/i&gt; was both 3 d, and the continuous bactericidal duration of the composite material against &lt;i&gt;Staphylococcus aureus&lt;/i&gt; and &lt;i&gt;Escherichia coli&lt;/i&gt; was both 6 d. &lt;i&gt;Staphylococcus aureus&lt;/i&gt; and &lt;i&gt;Escherichia coli&lt;/i&gt; exhibited resistance to composite materials significantly later than to PHMB. The wound healing rates of rats in composite material group at PID 6, 12, and 18 were significantly higher than those in routine dressing change group and PHMB group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). At PID 6, 12, and 18, no infection occurred in the wounds of rats in composite materi","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"42 7","pages":"621-630"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects and mechanisms of PIT on wound healing of full-thickness skin defects in diabetic mice].","authors":"Y G Zong, W Q Huang, Z Zhang, Y Peng","doi":"10.3760/cma.j.cn501225-20260127-00049","DOIUrl":"10.3760/cma.j.cn501225-20260127-00049","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the effects and mechanisms of polyvinyl alcohol/ionic liquid-tannic acid composite hydrogel (PIT) on wound healing of full-thickness skin defects in diabetic mice. &lt;b&gt;Methods:&lt;/b&gt; This study was an experimental research involving grouped design and repeated measurements. An ionic hydrogel matrix crosslinked by polyvinyl alcohol-4-(1H)-vinylimidazole-1-methylene benzoic acid and oxidized hyaluronic acid was prepared, and tannic acid was loaded via Cu&lt;sup&gt;2+&lt;/sup&gt; chelation to construct PIT. A 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution was prepared and reacted respectively with tannic acid and PIT for 24 hours. An ultraviolet spectrophotometer was used to detect the DPPH radical scavenging rate. According to the random number table method (the same grouping method below), mouse macrophage RAW264.7 cells were divided into a phosphate buffered saline (PBS) group cultured with PBS, as well as a hydrogen peroxide group and a PIT group, in which cells were first treated with hydrogen peroxide for 12 hours and then respectively cultured under routine condition and with PIT. After 24 hours of culture, the fluorescent probe method was adopted to detect the intracellular reactive oxygen species (ROS) level. &lt;i&gt;Escherichia coli&lt;/i&gt; ATCC 25922, &lt;i&gt;Staphylococcus aureus&lt;/i&gt; ATCC 25923, methicillin-resistant &lt;i&gt;Staphylococcus aureus&lt;/i&gt; (MRSA) BNCC 337371, and human umbilical vein endothelial cells (HUVECs) were collected and all divided into PBS group, tannic acid (TA) group, and PIT group, which were cultured with PBS, TA solution, and PIT, respectively. After 12 hours of bacterial culture, the plate counting method was used to count bacterial colonies; after 24 hours of cell culture, the tube formation assay was performed to measure the total tube length, the number of branching nodes, and the number of branches. The sample size of all the above experiments was 3. Eighteen 8-week-old male Kunming mice were selected and divided into PBS group, TA group, and PIT group (with 6 mice in each group) to establish a full-thickness skin defect wound model of diabetes (with one wound in each mouse). At post injury day (PID) 0 (immediately), the wounds of mice in PBS group, TA group, and PIT group were treated respectively with PBS, TA solution, and PIT by topical application, and then the dressings were changed daily. The wound healing status was observed at PID 0, 4, 8, and 12, and the wound healing rates at PID 4, 8, and 12 were calculated. At PID 12, wound tissue was harvested. Hematoxylin-eosin staining was performed to observe the status of wound re-epithelialization and to measure the thickness of newly formed epithelium. Masson staining was performed to observe the deposition of collagen fibers in wounds and to calculate the proportion of collagen fiber-positive area. &lt;b&gt;Results:&lt;/b&gt; After 24 hours of reaction, the DPPH radical scavenging rate of PIT was significantly higher than that of TA (&lt;i&gt;t&lt;/i&gt;=16.35, &lt;i&gt;P&lt;/i&gt;&lt;0.0","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"42 7","pages":"631-640"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Bidirectional two-sample MR analysis of causal relationships between human inflammatory proteins and HS and keloids].","authors":"S S Wang, K Xiao, H T Xiao, D W Han, J Zhang, L Wang, Y C Li","doi":"10.3760/cma.j.cn501225-20250117-00025","DOIUrl":"10.3760/cma.j.cn501225-20250117-00025","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To explore the causal relationships between human inflammatory proteins and hypertrophic scars (HS) and keloids. &lt;b&gt;Methods:&lt;/b&gt; This study was conducted based on bidirectional two-sample Mendelian randomization (MR) analysis. Data of human inflammatory proteins, HS, and keloids were acquired from genome-wide association study database. The inverse variance weighted (IVW) method was adopted to evaluate the causal relationships between 91 kinds of human inflammatory proteins and HS and keloids, i.e., a forward MR analysis. For the above associations, Cochran's Q test was used to assess heterogeneity, MR-Egger regression and MR-PRESSO outlier tests were performed to evaluate horizontal pleiotropy, and the leave-one-out method was applied to analyze the robustness of the results. The IVW method was also used to evaluate whether there was a reverse causal relationship between HS, keloids and inflammatory proteins screened out by aforementioned forward MR analysis. &lt;b&gt;Results:&lt;/b&gt; CD6, leukemia inhibitory factor (LIF), tumor necrosis factor ligand superfamily member 12 (TNFSF12), programmed death-ligand 1 (PD-L1), interleukin-17C (IL-17C), LIF receptor (LIFR), osteoprotegerin (OPG), and fibroblast growth factor 23 (FGF23) had significant causal relationships with HS (with &lt;i&gt;OR&lt;/i&gt;s of 1.365, 0.506, 1.567, 1.683, 0.621, 1.375, 0.623, and 0.553, respectively, 95% &lt;i&gt;CI&lt;/i&gt;s of 1.100-1.693, 0.289-0.887, 1.081-2.273, 1.090-2.599, 0.408-0.947, 1.025-1.845, 0.402-0.966, and 0.315-0.971, respectively, &lt;i&gt;P&lt;/i&gt;&lt;0.05). Among them, CD6, TNFSF12, PD-L1, and LIFR were risk factors for HS, while LIF, IL-17C, OPG, and FGF23 were protective factors for HS. CD5, IL-10 receptor subunit alpha (IL-10RA), IL-5, LIF, and OPG had significant causal relationships with keloids (with &lt;i&gt;OR&lt;/i&gt;s of 0.744, 1.303, 0.686, 0.603, and 0.715, respectively, 95% &lt;i&gt;CI&lt;/i&gt;s of 0.573-0.965, 1.024-1.660, 0.472-0.996, 0.431-0.842, and 0.553-0.924, respectively, &lt;i&gt;P&lt;/i&gt;&lt;0.05). Among them, IL-10RA was a risk factor for keloids, whereas CD5, IL-5, LIF, and OPG were protective factors for keloids. No significant heterogeneity or horizontal pleiotropy was observed in the above associations (&lt;i&gt;P&lt;/i&gt;&gt;0.05), and the robustness of the results was not driven by any single nucleotide polymorphism. Significant reverse causal relationships existed between HS and TNFSF12 and LIFR of the 8 inflammatory proteins which had significant causal relationships with HS screened out by aforementioned forward MR analysis (with &lt;i&gt;OR&lt;/i&gt;s of 0.972 and 0.968, respectively, 95% &lt;i&gt;CI&lt;/i&gt;s of 0.949-0.997 and 0.942-0.994, respectively, &lt;i&gt;P&lt;/i&gt;&lt;0.05). No reverse causal relationship was found between keloids and the 5 inflammatory proteins which had significant causal relationships with keloids screened out by aforementioned forward MR analysis (&lt;i&gt;P&lt;/i&gt;&gt;0.05). &lt;b&gt;Conclusions:&lt;/b&gt; CD6, TNFSF12, PD-L1, and LIFR may increase the risk of HS, while LIF, IL-17C, OPG, and FGF23 may decrease the ris","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"42 7","pages":"669-678"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Interpretation of the 2025 <i>American Burn Association Clinical Practice Guideline on blood product transfusion in burn care</i>].","authors":"L L Sun, L Ding, L C Zhang, S D Duan, Y F Jin, W J Liu","doi":"10.3760/cma.j.cn501225-20251210-00516","DOIUrl":"10.3760/cma.j.cn501225-20251210-00516","url":null,"abstract":"<p><p>The <i>American Burn Association Clinical Practice Guideline on blood product transfusion in burn care</i> was released in July 2025. Based on the PICO (Population, Intervention, Comparison, Outcome) framework and available evidence, the guideline provided evidence-based recommendations for blood product transfusion issues during hospitalization of adult burn patients, covering the management of transfusion indications, viscoelastic testing, the use of erythropoietin and tranexamic acid, and blood product transfusion strategies, etc. This article interpreted the key points of the guideline to facilitate their understanding and application by clinical medical professionals.</p>","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"42 7","pages":"694-699"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects and mechanisms of cerium-myricetin nanosystem on wound healing in rats with full-thickness burns].","authors":"T Wang, J F Teng, C Hu, L Y Wan, W Zhang, X Y Bai, J Deng, G X Luo","doi":"10.3760/cma.j.cn501225-20260312-00101","DOIUrl":"10.3760/cma.j.cn501225-20260312-00101","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the effects and mechanisms of cerium-myricetin nanosystem (Ce-MYR) on wound healing in rats with full-thickness burns. &lt;b&gt;Methods:&lt;/b&gt; This study was an experimental study with a grouped design and repeated measurement design. Ce-MYR was prepared by coordination self-assembly and characterized. Mouse RAW264.7 cells were divided into control group cultured normally, hydrogen peroxide group treated with hydrogen peroxide, and low Ce-MYR group, medium Ce-MYR group, and high Ce-MYR group which were first exposed to hydrogen peroxide and subsequently treated with Ce-MYR at final mass concentrations of 5, 10, and 20 μg/mL, respectively. After 24 h of culture, intracellular reactive oxygen species (ROS) levels were detected using the fluorescent probe method. Mouse bone marrow-derived macrophages (BMDMs) were divided into control group cultured normally, lipopolysaccharide (LPS) group treated with LPS, and Ce-MYR group treated with LPS combined with Ce-MYR. After 24 h of culture, the percentages of CD86- and CD206-positive areas in cells were calculated after immunofluorescence staining. Additional mouse BMDMs were divided into the LPS group and the Ce-MYR group, as described above. After 24 h of culture, the protein expressions of heme oxygenase-1 (HO-1), arginase-1 (Arg-1), inducible nitric oxide synthase (iNOS), and NOD-like receptor family pyrin domain-containing protein 3 (NLRP3) in cells were detected by Western blotting. The sample size in all the above experiments was 4. Ten 6-week-old male Sprague-Dawley rats were used to establish four full-thickness burn wounds on the back of each rat, which were divided into phosphate-buffered saline (PBS) group and Ce-MYR group according to the random number table method, with 5 rats in each group. PBS or Ce-MYR was subcutaneously injected at the wound margin at post-injury days 0 (immediately), 3, and 6, respectively. The percentages of residual wound area were calculated at post-injury days 3, 7, 14, and 21. At post-injury day 21, the wound tissue of rats was collected and the number of CD31-positive blood vessels was counted after immunohistochemical staining, the percentages of CD86- and CD206-positive areas were calculated after immunofluorescence staining, and the levels of interleukin-6 (IL-6), IL-1β, and tumor necrosis factor-α (TNF-α) were measured by enzyme-linked immunosorbent assay. &lt;b&gt;Results:&lt;/b&gt; After 24 h of culture, the ROS level in RAW264.7 cells in hydrogen peroxide group was significantly higher than that in control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05); the ROS level in RAW264.7 cells in medium Ce-MYR group was significantly lower than that in low Ce-MYR group (&lt;i&gt;P&lt;/i&gt;&lt;0.05) and significantly higher than that in high Ce-MYR group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). After 24 h of culture, the percentage of CD86-positive area in BMDMs in Ce-MYR group was significantly lower than that in LPS group (&lt;i&gt;P&lt;/i&gt;&lt;0.05) and significantly higher than that in control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05); the","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"42 7","pages":"611-620"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Value of shear wave elastography in the early diagnosis of DPN in patients with type 2 diabetes mellitus].","authors":"Y J Zhang, M Y Tang, Y Jian, X P Wu, L H Ma, S L Cai, C L Deng, Z R Wei","doi":"10.3760/cma.j.cn501225-20241230-00513","DOIUrl":"10.3760/cma.j.cn501225-20241230-00513","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the value of shear wave elastography (SWE) in the early diagnosis of diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus. &lt;b&gt;Methods:&lt;/b&gt; This study was a diagnostic case-control study. From May 2021 to October 2022, 68 patients with type 2 diabetes mellitus who met the inclusion criteria were admitted to the Department of Burns and Plastic Surgery of Affiliated Hospital of Zunyi Medical University, including 45 males and 23 females, aged (57±10) years. According to whether the DPN was present, the patients were divided into DPN group (38 patients) and non-DPN group (30 patients). During the same period, 30 healthy volunteers who underwent physical examinations at the health examination center of the hospital were recruited as healthy control group, including 19 males and 11 females, aged (56±10) years. Cross-sectional areas of the bilateral common peroneal nerves and tibial nerves measured by a color Doppler ultrasonography system in two-dimensional ultrasonography mode, and the stiffness of the bilateral common peroneal nerves and tibial nerves measured in SWE mode were compared between volunteers in healthy control group and two groups of patients at admission. Independent risk factors for the development of DPN were screened in the three groups of participants. Receiver operating characteristic curves were used to evaluate the diagnostic value of common peroneal nerve stiffness, common peroneal nerve cross-sectional area, tibial nerve stiffness, and tibial nerve cross-sectional area for DPN in two groups of patients. The correlations of common peroneal nerve stiffness and common peroneal nerve cross-sectional area with the Toronto clinical scoring system (TCSS) score were analyzed in patients of DPN group. &lt;b&gt;Results:&lt;/b&gt; At admission, the cross-sectional areas of the bilateral common peroneal nerves of patients in DPN group were significantly larger than those of patients in non-DPN group and volunteers in healthy control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05); there was no statistically significant difference in the cross-sectional area of the bilateral tibial nerves between volunteers in healthy control group and two groups of patients (&lt;i&gt;P&lt;/i&gt;&gt;0.05). At admission, the stiffness of the bilateral tibial nerves and common peroneal nerves of patients in both non-DPN group and DPN group was significantly greater than that of volunteers in healthy control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05); the stiffness of the left tibial nerve and the bilateral common peroneal nerves of patients was significantly greater in DPN group than in non-DPN group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The results of multivariable ordinal logistic regression analysis showed that common peroneal nerve stiffness, tibial nerve stiffness, and common peroneal nerve cross-sectional area were all independent risk factors for the development of DPN among the participants in the three groups (with &lt;i&gt;OR&lt;/i&gt;s of 0.91, 0.93, and 0.75, respectively, 95% &lt;i&gt;CI&lt;/i&gt;s ","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"42 7","pages":"649-658"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research progress on the role of calcitonin gene-related peptide in the repair of diabetic wounds].","authors":"X Y Wang, Q Tan","doi":"10.3760/cma.j.cn501225-20250215-00063","DOIUrl":"10.3760/cma.j.cn501225-20250215-00063","url":null,"abstract":"<p><p>Diabetic wounds are a severe complication of diabetes, which can lead to amputation or even mortality in severe cases. While normal wound healing consists of four phases: hemostasis, inflammation, proliferation, and remodeling, diabetic wounds tend to become chronic and refractory primarily due to a prolonged inflammatory phase. In diabetic wounds, insufficient synthesis and release of endogenous calcitonin gene-related peptide (CGRP) is a critical upstream mechanism underlying the disrupted neuro-immune communication, the persistent inflammation, and the arrested wound healing process. In contrast to pure skin defect wounds, where CGRP is rapidly upregulated after injury, CGRP remains persistently low in diabetic wound tissue, consequently failing to drive macrophage polarization towards the M2 phenotype or promote vascular maturation and collagen fiber deposition in the later phase of inflammation. In the early inflammatory phase, CGRP exerts pro-inflammatory effects by enhancing angiogenesis and modulating macrophage polarization. In the late inflammatory phase, CGRP upregulates thrombospondin-1, promotes neutrophil apoptosis and phagocytic clearance, thereby inhibiting excessive inflammatory response and shifting the wound microenvironment from a pro-inflammatory state to a pro-reparative state. Restoring CGRP signaling reconstructs the neuroimmunomodulation axis and improves wound repair while relieving diabetic neuropathic pain. Engineered CGRP combined with intelligent delivery systems offers promising prospects for diabetic wound therapy. However, large-scale clinical trials are still required to validate its clinical efficacy and safety. This paper systematically analyzes the mechanisms and application strategies of CGRP in facilitating diabetic wound repair, which can provide a theoretical basis and innovative strategies for clinical management.</p>","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"42 7","pages":"687-693"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Meta-analysis of the effects of PDL combined with fractional carbon dioxide laser in the treatment of hypertrophic scars in children].","authors":"J Wu, H M Zhang, R Liu, N X Zhang, R T Cui","doi":"10.3760/cma.j.cn501225-20241224-00502","DOIUrl":"10.3760/cma.j.cn501225-20241224-00502","url":null,"abstract":"<p><p><b>Objective:</b> To evaluate the effects of pulsed dye laser (PDL) combined with fractional carbon dioxide laser in the treatment of hypertrophic scars (HSs) in children. <b>Methods:</b> This study was a meta-analysis. Databases including PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform, and VIP Chinese Journal Service Platform were retrieved to obtain the publicly published retrospective and prospective studies on the effects of PDL combined with fractional carbon dioxide laser for pediatric HS from the establishment of each database to October 31, 2024. The outcome indexes included the total score of the patient and observer scar assessment scale (POSAS) and laser treatment-related adverse reactions. Stata version 16.0 software was used to conduct a meta-analysis. <b>Results:</b> A total of 7 studies were included, involving 348 children with HSs. Meta-analysis results showed that the total POSAS scores in HS children who received PDL combined with fractional carbon dioxide laser treatment were significantly lower than those before treatment (with a standardized mean difference of -7.76, a 95% <i>CI</i> of -10.91 to-4.61, <i>P</i><0.05). Subgroup analysis results suggested that geographic distribution, scar duration (divided into ≤3 months group and >3 months group), intervention measures, and fractional carbon dioxide laser energy parameters might be sources of heterogeneity for the total POSAS score. The incidence of adverse reactions of PDL combined with fractional carbon dioxide laser for pediatric HS was 3.50% (with a 95% <i>CI</i> of 1.60% to 6.00%, <i>P</i><0.05). There was no publication bias in the total POSAS score, its subgroup analyses (including geographic distribution, scar duration, intervention measures, fractional carbon dioxide laser energy parameters, and assessor), or adverse reactions related to laser treatment (<i>P</i>>0.05). <b>Conclusions:</b> PDL combined with fractional carbon dioxide laser is beneficial for the recovery of pediatric HS, with a low rate of adverse reactions and a favorable safety profile. For pediatric HS, the early intervention window within 3 months after scar formation should be prioritized, and a regimen combining low-energy fractional carbon dioxide laser flexibly with PDL should be adopted to achieve better therapeutic outcomes.</p>","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"42 7","pages":"679-686"},"PeriodicalIF":0.0,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13416978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148671945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}