Zhonghua shao shang yu chuang mian xiu fu za zhi最新文献

{"title":"[Application of iceberg theory in the diagnosis and treatment of refractory wounds at the surgical site after craniotomy].","authors":"P H Zhang, Y K Zhang, P F Liang","doi":"10.3760/cma.j.cn501225-20250119-00028","DOIUrl":"10.3760/cma.j.cn501225-20250119-00028","url":null,"abstract":"<p><p>After craniotomy, the surgical site is prone to develop refractory wounds, which seriously affects the patient's quality of life and significantly increases the medical cost. Clinical studies indicate that the pathogenic factors of such wounds are extremely diverse, their formation mechanism is complex, and their clinical treatment is extremely difficult. In this paper, iceberg analysis is applied to the diagnosis and treatment of refractory wounds after craniotomy. Based on domestic and international literature and clinical practice, combined with preoperative image examination results and intraoperative exploration findings, we provided an in-depth discussion on the causes of wound formation, comprehensively analyzed the pathogenic factors affecting wound healing, and shared the clinical diagnosis and treatment experience in this aspect. Based on the iceberg theory, we propose precise debridement measures and targeted effective repair strategies for this type of refractory wounds.</p>","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"41 6","pages":"509-515"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical effects of extracorporeal shock wave combined with complex decongestive therapy in the treatment of lower limb lymphedema after cervical cancer surgery].","authors":"J P Zhou, Y Y Lin, M F Zhu, X X Situ, J Wang","doi":"10.3760/cma.j.cn501225-20250205-00051","DOIUrl":"10.3760/cma.j.cn501225-20250205-00051","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To explore the clinical effects of extracorporeal shock wave therapy (ESWT) combined with complex decongestive therapy (CDT) in the treatment of lower limb lymphedema after cervical cancer surgery. &lt;b&gt;Methods:&lt;/b&gt; This study was a prospective randomized controlled trial. From April 2023 to December 2024, 64 patients were admitted to the Department of Oncology Rehabilitation of Nan'ao People's Hospital of Dapeng New District of Shenzhen. All patients were female, aged 33-75 years. The patients were divided into control group treated with CDT alone and combined treatment group treated with ESWT and CDT according to the random number table method, with 32 patients in each group. Four patients withdrew in the research process, and 30 patients were included in each group finally. Before treatment and at the end of 4 weeks of treatment (hereinafter referred to as after treatment), the skin stiffness was measured using a portable MyotonPRO device at the superficial projection position of vastus lateralis, vastus medialis, vastus intermedius, medial gastrocnemius, and lateral gastrocnemius to reflect the degree of skin fibrosis of lower limb, the circumferences were measured at the mid-knee, 10 cm and 20 cm above the superior patellar border, and the mid-ankle, 10 cm and 20 cm below the inferior patellar border to reflect the severity degree of edema of lower limb, the life quality was scored using the simplified Chinese version of the lower limb lymphedema functioning, disability, and health questionnaire (Lymph-ICF-LL), and the pain intensity was scored using the visual analogue scale (VAS). The differences of the above indexes were calculated between before and after treatment. &lt;b&gt;Results:&lt;/b&gt; The skin stiffness at the superficial projection position of vastus lateralis, vastus medialis, vastus intermedius, medial gastrocnemius, and lateral gastrocnemius of patients in combined treatment group after treatment was significantly smaller than that in control group (with &lt;i&gt;t&lt;/i&gt; values of 2.78, 2.04, 3.12, 2.01, and 2.35, respectively, &lt;i&gt;P&lt;/i&gt;&lt;0.05). The differences in skin stiffness between before and after treatment at the superficial projection position of the above-mentioned muscles of patients in combined treatment group was (65±23), (24±8), (25±8), (65±27), and (69±34) N/m, respectively, which were significantly larger than (49±23), (16±19), (8±9), (45±39), and (43±42) N/m in control group (with &lt;i&gt;t&lt;/i&gt; values of -2.75 -2.35, -7.47, -2.33, and -2.64, respectively, &lt;i&gt;P&lt;/i&gt;&lt;0.05), and the mean differences between groups (95% confidence intervals) were 16 (5 to 28), 9 (1 to 17), 17 (12 to 21), 20 (3 to 36), and 26 (4 to 49) N/m, respectively. The circumferences at 10 cm and 20 cm below the inferior patellar border, mid-knee, and 10 cm and 20 cm above the superior patellar border of patients in combined treatment group after treatment were significantly smaller than those in control group (with &lt;i&gt;t&lt;/i&gt; values of -2.41, -2.49","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"41 6","pages":"543-551"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Repair methods for refractory head wounds involving intracranial structures and their clinical effectiveness].","authors":"M N Wang, P F Liang, C L Bi, M T Huang, Z Y He, P H Zhang, J Zhou, J Z Zeng, S Lan, J F Liu","doi":"10.3760/cma.j.cn501225-20250106-00008","DOIUrl":"10.3760/cma.j.cn501225-20250106-00008","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the repair methods for refractory head wounds involving intracranial structures and their clinical effectiveness. &lt;b&gt;Methods:&lt;/b&gt; This study was a retrospective observational study. From September 2020 to July 2024, 68 patients with refractory head wounds involving intracranial structures who met the inclusion criteria were admitted to the Department of Burns and Plastic Surgery of Xiangya Hospital of Central South University (hereinafter referred to as our hospital) and were co-managed with neurosurgeons from our hospital. Among them, 38 were male and 30 were female, aged 1 to 76 years. Based on the causes of difficult wound healing, the refractory head wounds involving intracranial structures were classified into 5 categories: simple tissue defect wounds, simple infectious wounds, implant-related wounds, wounds communicating with paranasal sinuses, and radiation-damaged wounds. Corresponding management plans were adopted according to the wound condition. After wound bed preparation was completed, according to factors such as wound location, size, blood supply condition, need for soft tissue filling, and the patient's general condition, and also following the principle of minimizing damage, patients with no obvious scalp soft tissue defect were sutured directly. For patients with large defects that could not be sutured directly (with wound area of 8 cm×3 cm to 28 cm×13 cm), the most suitable tissue flaps (including pedicled scalp flaps and free tissue flaps) were designed to repair the wounds. The donor site wounds of scalp flaps were directly sutured or repaired by full-thickness skin grafting and the donor site wounds of free tissue flaps were directly sutured. Before surgery, the types of refractory wounds and the microbial culture results of wound exudate specimens were recorded. During surgery, the wound repair methods, types of free tissue flaps, recipient vessels, and vascular anastomosis methods between donor and recipient sites were recorded. After surgery, the recovery of the head wounds and the tissue flap donor sites was observed. The recipient site appearance, blood supply, wound recurrence, and subsequent management were followed up. &lt;b&gt;Results:&lt;/b&gt; Among 68 patients, 2 cases had simple tissue defect wounds, 15 cases had simple infectious wounds, 43 cases had implant-related wounds, 4 cases had wounds communicating with paranasal sinuses, and 4 cases had radiation-damaged wounds. Before surgery, the microbial culture results of wound exudate specimens were positive in 28 cases. After wound bed preparation was completed, the wounds of 17 patients were sutured directly, the wounds of 31 patients were repaired with pedicled scalp flap transfer, and the wounds of 20 patients were repaired with free tissue flap transplantation. Of the 20 patients who underwent free tissue flap transplantation for wound repair, 12 patients had the superficial temporal arteries and veins as the recipient vessels and ","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"41 6","pages":"525-533"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Influence and mechanism of extracellular vesicles derived from human dermal papilla cells on skin fibrosis in mice].","authors":"Y W Wang, F Y Cai, A Shi, Y C Kang, R M Zhao, Z H Hu, X Y Di, Y Liu","doi":"10.3760/cma.j.cn501225-20240925-00348","DOIUrl":"10.3760/cma.j.cn501225-20240925-00348","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To explore the influence and mechanism of extracellular vesicles (EVs) derived from human dermal papilla cells (hDPCs), i. e. hDPC-EVs on skin fibrosis in mice. &lt;b&gt;Methods:&lt;/b&gt; This study was an experimental research. One hundred discarded hair follicle units from 2 male patients aged 25 years and 40 years who underwent hair transplantation surgery at the Second Hospital of Lanzhou University in September 2024 were collected, and primary hDPCs were extracted and successfully identified. After hDPCs of passage 3 to 5 were taken and cultured, the hDPC-EVs were extracted and successfully identified. The expression of microRNA-182-5p (miRNA-182-5p) in hDPCs and hDPC-EVs was detected by real-time fluorescence quantitative reverse transcription polymerase chain reaction (RT-PCR, &lt;i&gt;n&lt;/i&gt;=4). Thirty 6-week-old male C57BL/6J mice were taken and injected intradermal bleomycin for 4 weeks to establish mouse skin fibrosis models. Six mice after modeling were selected according to the random number table method (the same grouping method applied hereafter), and another 6 healthy untreated 6-week-old male C57BL/6J mice were taken. The protein expression of transforming growth factor β&lt;sub&gt;1&lt;/sub&gt; (TGF-β&lt;sub&gt;1&lt;/sub&gt;) in normal skin tissue and fibrotic skin tissue of mice was detected by Western blotting (&lt;i&gt;n&lt;/i&gt;=3). The remaining 24 mice after modeling were divided into phosphate buffered solution (PBS)+miRNA mimic control group, EV+miRNA mimic control group, EV+miRNA inhibitor group, and miRNA mimic group (&lt;i&gt;n&lt;/i&gt;=6). Two weeks after injection of the reagents corresponding to the group names, the protein expressions of α-smooth muscle actin (α-SMA) and type Ⅰ collagen in fibrotic skin tissue was detected by Western blotting (&lt;i&gt;n&lt;/i&gt;=3), and the expression of miRNA-182-5p and the mRNA expression of TGF-β&lt;sub&gt;1&lt;/sub&gt; in fibrotic skin tissue was detected by real-time fluorescence quantitative RT-PCR (&lt;i&gt;n&lt;/i&gt;=4). Human hypertrophic scar fibroblasts (HSFs) were taken and divided into miRNA-182-5p mimic+wild-type TGF-β&lt;sub&gt;1&lt;/sub&gt; group, miRNA-182-5p control+wild-type TGF-β&lt;sub&gt;1&lt;/sub&gt; group, miRNA-182-5p mimic+mutant-type TGF-β&lt;sub&gt;1&lt;/sub&gt; group, and miRNA-182-5p control+mutant-type TGF-β&lt;sub&gt;1&lt;/sub&gt; group. Cells in each group were transfected with the corresponding plasmids and cultured for 36 h. Double luciferase reporter gene assay was performed to detect the interaction between miRNA-182-5p and TGF-β&lt;sub&gt;1&lt;/sub&gt; (denoted as relative luciferase activity, &lt;i&gt;n&lt;/i&gt;=5). &lt;b&gt;Results:&lt;/b&gt; The expression of miRNA-182-5p in hDPC-EVs was significantly higher than that in hDPCs (&lt;i&gt;t&lt;/i&gt;=5.48, &lt;i&gt;P&lt;/i&gt;&lt;0.05). Compared with that in normal skin tissue of mice, the protein expression of TGF-β&lt;sub&gt;1&lt;/sub&gt; was increased in fibrotic skin tissue of mice. After 2 weeks of treatment, compared with those in PBS+miRNA mimic control group, the protein expressions of α-SMA and type Ⅰ collagen in the fibrotic skin tissue of mice in EV+miRNA mimic control gro","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"41 6","pages":"559-568"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the misdiagnosis causes and treatment strategies for burns combined with alcohol withdrawal syndrome].","authors":"X Z Shang, M X Ding, G A Lin, C Wang, Z C Lin, D S Hu, S Li, J S Meng, R Xiao","doi":"10.3760/cma.j.cn501225-20240604-00211","DOIUrl":"10.3760/cma.j.cn501225-20240604-00211","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the misdiagnosis causes and treatment strategies for burns combined with alcohol withdrawal syndrome (AWS). &lt;b&gt;Methods:&lt;/b&gt; This study was a retrospective observational study. From January 2014 to December 2023, 334 male burn patients aged 29-90 (53±11) years and combined with alcohol dependence were admitted to the PLA Burn Center of the 990&lt;sup&gt;th&lt;/sup&gt; Hospital of Joint Logistics Support Force. Patients were divided into AWS group (29 cases) and non-AWS group (305 cases) based on whether AWS developed or not. The misdiagnosis causes and treatment outcomes of AWS of patients in AWS group were analyzed. The total burn surface area, full-thickness burn area, burn index, hospitalization day, and mortality were compared between patients in the two groups. The 334 patients were further stratified by burn severity into mild-moderate burn patients (306 cases), severe burn patients (11 cases), and critically severe burn patients (17 cases), and the correlation between AWS incidence and burn severity in patients with burns combined with alcohol dependence was analyzed. &lt;b&gt;Results:&lt;/b&gt; The misdiagnosis causes of AWS in AWS group of patients were primarily insufficient clinician awareness of AWS (48.3%, 14/29) and then overlapping symptoms between AWS and burn-related complications, such as shock, electrolyte imbalance, stress-induced mental disorders, and epilepsy (51.7%, 15/29), which influenced judgement of the clinicians. After active treatment, the AWS symptoms alleviated obviously or disappeared in 27 patients, while 2 patients died of multiple organ failure. Compared with those in non-AWS group, the total burn surface area, full-thickness burn area, burn index, and hospitalization day of patients in AWS group were significantly increased (with &lt;i&gt;Z&lt;/i&gt; values of -8.35, -6.98, -8.32, and -4.56, respectively, &lt;i&gt;P&lt;/i&gt;&lt;0.05). The mortality of patients in AWS group was 6.9% (2/29), which was significantly higher than 0.7% (2/305) in non-AWS group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). The AWS incidences of patients with mild-moderate burn, severe burn, and critically severe burn were 4/306, 8/11, and 17/17, respectively, and the AWS incidences of burn patients combined with alcohol dependence had strongly positive correlation with burn severity (&lt;i&gt;r&lt;/i&gt;=0.87, &lt;i&gt;P&lt;/i&gt;&lt;0.05). &lt;b&gt;Conclusions:&lt;/b&gt; The AWS incidence in burn patients is low, and its incidence is closely correlated with burn severity, predominantly affecting males over 40 years old with prolonged alcohol use and severe burns. The AWS symptoms appear later and are easily masked by symptoms of burn complications, making it easy to misdiagnose or even miss the diagnosis. Therefore, clinicians should strengthen the screening of alcohol drinking history in male severe burn patients over 40 years old, and consult with physicians of relevant disciplines in a timely manner to ensure early diagnosis and intervention to reduce the risks of misdiagnosis or missed diagnosis and to impr","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"41 6","pages":"587-593"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Research advances on the mechanism and clinical application of cold atmospheric plasma in promoting wound healing].","authors":"Z Y Zhao, C H Cai, H Liu, S W Liu, X G Wang","doi":"10.3760/cma.j.cn501225-20241117-00448","DOIUrl":"10.3760/cma.j.cn501225-20241117-00448","url":null,"abstract":"<p><p>Wound healing is a complex biological process involving multiple stages, including hemostasis, inflammation, proliferation, and remodeling. Cold atmospheric plasma (CAP), as an efficient, non-invasive, and innovative therapy for wound care, has significant application prospects in this field. It has been demonstrated that CAP can promote wound cell proliferation and reduce microbial load on wounds through various mechanisms. Through a comprehensive analysis of recent domestic and international literature on the biological effects of CAP, this paper reviews how CAP promotes the repair of acute and chronic wounds from the perspectives of mechanism and clinical application and the research progress in the application methods of CAP in recent years.</p>","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"41 6","pages":"604-608"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Analysis of the number, type, and functional heterogeneity of senescent cells in the radiation-induced skin wounds in mice].","authors":"Y Chen, Z Cheng, L Ma, C M Shi","doi":"10.3760/cma.j.cn501225-20240604-00209","DOIUrl":"10.3760/cma.j.cn501225-20240604-00209","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the number, type, and functional heterogeneity of senescent cells in the radiation-induced skin wounds in mice. &lt;b&gt;Methods:&lt;/b&gt; The study was an experimental study. Forty male p16-diphtheria toxin receptor-tdTomato (p16&lt;sup&gt;DTR/Tom&lt;/sup&gt;) transgenic mice aged 6-8 weeks, which could be used to trace senescent cells, were divided into 35 Gy group and 50 Gy group (with 20 mice in each group) according to the random number table method, and 35 or 50 Gy X-ray irradiation was applied to the skin of the right hind limb of the mice to establish 3 or 4 degree of radiation-induced skin injury model, respectively. The positive area percentage of senescent cells in the wound tissue of mice in two groups was detected before irradiation and at 10, 20, and 30 d after irradiation; at 10 d after irradiation, the co-localization of endothelial cells (ECs), mononuclear macrophages (MMs), keratinocytes (KCs), fibroblasts (Fbs) and senescent cells in the wound tissue of mice in 50 Gy group was observed by immunofluorescence method. Nine male p16&lt;sup&gt;DTR/Tom&lt;/sup&gt; transgenic mice aged 6-8 weeks were divided into unirradiated group without any treatment and 35 Gy group and 50 Gy group with the same treatment as above (with 3 mice in each group) according to the random number table method. The wound tissue of mice in 35 Gy group and 50 Gy group at 10 d after irradiation and the normal skin tissue of mice in unirradiated group at the corresponding time point was taken, and the senescence percentages of KCs, Fbs, ECs, and MMs were detected by flow cytometry. Bioinformatics analysis was performed on publicly available single-cell transcriptome sequencing data from normal skin tissue of healthy rats (setting as control group) and mixed wound tissue of rats for 7 and 14 d after irradiation with 30 Gy electron beams (setting as irradiated group), and the two groups of cells were subjected to senescence assessment to screen for senescent cells, the correlation between the expression profiles of senescence-associated secretory phenotypes (SASPs) of various types of senescent cells in irradiated group was analyzed, and the differentially expressed genes (DEGs) with significantly differential expression between the senescent cells in irradiated group and the corresponding normal cells in control group were screened for gene ontology (GO) enrichment analysis. &lt;b&gt;Results:&lt;/b&gt; The positive area percentage of senescent cells in the wound tissue of mice in 50 Gy group was significantly higher than that in 35 Gy group at 20 and 30 d after irradiation (with &lt;i&gt;t&lt;/i&gt; values of -5.56 and -5.48, respectively, &lt;i&gt;P&lt;/i&gt;&lt;0.05). ECs, MMs, KCs, and Fbs co-localized with senescent cells in the wound tissue of mice in 50 Gy group at 10 d after irradiation. The senescence percentages of KCs, Fbs, ECs, and MMs in the wound tissue of mice in 50 Gy group at 10 d after irradiation were (21.07±9.49)%, (16.10±3.27)%, (16.90±5.29)%, and (34.13±8.76)%, respectively, ","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"41 6","pages":"577-586"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Effects of acellular allogeneic dermis combined with autologous split-thickness skin grafts in repairing deep burn wounds in head, face, neck, and torso in children].","authors":"J L Zhang, S H Liu, D Y Wang, M J Jiang, W G Xie, M M Xi","doi":"10.3760/cma.j.cn501225-20240615-00231","DOIUrl":"10.3760/cma.j.cn501225-20240615-00231","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To analyze the effects of acellular allogeneic dermis combined with autologous split-thickness skin grafts in repairing deep burn wounds in head, face, neck, and torso in children. &lt;b&gt;Methods:&lt;/b&gt; This study was a historical control study. Thirty children who were admitted to Tongren Hospital of Wuhan University & Wuhan Third Hospital (hereinafter referred to as our hospital) from January 2013 to May 2018 and underwent autologous split-thickness skin grafting alone for repairing deep burn wounds were selected as control group, including 15 males and 15 females, aged from 7 months to 13 years. Thirty-one children who were admitted to our hospital from June 2018 to May 2021 and underwent acellular allogeneic dermis combined with autologous split-thickness skin grafting for repairing deep burn wounds were selected as observation group, including 17 males and 14 females, aged 6 months to 13 years. The wound healing time of children in the two groups was recorded, the survival rates of skin grafts on 15 d after operation were calculated, and the incidences of adverse reactions such as pain and pruritus after wound healing were calculated. One year after operation, the Vancouver scar scale (VSS) was used to score the scars in the grafted area in the two groups of children in terms of color, thickness, softness, and vascular distribution, and the total VSS score was calculated; the satisfaction of one family member of children with the curative effect was investigated by using the efficacy satisfaction questionnaire developed by our hospital, and the satisfaction rate was calculated. &lt;b&gt;Results:&lt;/b&gt; The wound healing time of children in control group was significantly shorter than that in observation group (&lt;i&gt;t&lt;/i&gt;=8.86, &lt;i&gt;P&lt;/i&gt;&lt;0.05). There were no statistically significant differences in the survival rates of skin grafts on 15 d after operation, and the incidences of pain and pruritus after wound healing in children between the two groups (&lt;i&gt;P&lt;/i&gt;&gt;0.05). One year after operation, the scores of thickness, softness, color, and vascular distribution and the total score of VSS of scars in the skin grafting areas in children in observation group were 1 (0, 1), 2 (1, 2), 1 (0, 1), 1 (0, 1), and 4 (3, 5), which were significantly lower than 3 (2,4), 3 (3, 4), 2 (2, 3), 2 (2, 3), and 11 (10, 12), respectively in control group (with &lt;i&gt;Z&lt;/i&gt; values of 6.20, 6.10, 6.42, 6.16, and 6.73, respectively, &lt;i&gt;P&lt;/i&gt;&lt;0.05). One year after operation, the satisfaction rate with the curative effect of one family member of children in observation group was 96.77% (30/31), which was significantly higher than 76.67% (23/30) in control group (&lt;i&gt;P&lt;/i&gt;&lt;0.05). &lt;b&gt;Conclusions:&lt;/b&gt; Acellular allogeneic dermis combined with autologous split-thickness skin grafts for repairing deep burn wounds in head, face, neck, and torso in children can improve the wound healing quality, alleviate scar, and increase the satisfaction degree of children's family members. ","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"41 6","pages":"569-576"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Clinical efficacy of vascularized lymph node transfer combined with lymphatico-venous anastomosis in treating unilateral upper limb lymphedema after radical mastectomy for breast cancer].","authors":"Z C Chen, J Z Chen, X K Wu, S E Xiao, H Li, B H Wu, C L Deng","doi":"10.3760/cma.j.cn501225-20250228-00105","DOIUrl":"10.3760/cma.j.cn501225-20250228-00105","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the clinical efficacy of vascularized lymph node transfer (VLNT) combined with lymphatico-venous anastomosis (LVA) in treating unilateral upper limb lymphedema after radical mastectomy for breast cancer. &lt;b&gt;Methods:&lt;/b&gt; This study was a retrospective cohort study. Forty female patients aged 35-75 years with unilateral upper limb lymphedema after radical mastectomy for breast cancer who met the inclusion criteria were admitted to the Affiliated Hospital of Zunyi Medical University from April 2021 to January 2024. Based on the treatment method, patients were divided into LVA group (18 cases) who underwent LVA treatment only and VLNT+LVA group (22 cases) who underwent VLNT combined with LVA treatment. The volumes of the affected limbs in both groups of patients were measured before treatment and 3, 6, and 12 months after treatment. The differences in affected limb volumes at each time point before and after treatment (i.e., the volume differences of affected limbs at each time point after treatment) were calculated. Analysis of covariance (ANCOVA) was used to control the influence of confounding factors such as baseline data on the volume differences of affected limbs at each time point after treatment. The quality of life was assessed using the Lymphedema Quality of Life Questionnaire before treatment and 12 months after treatment. During the follow-up period, the occurrence of infectious complications in patients of both groups were monitored. Ultrasonography or radionuclide imaging was performed 12 months after treatment to evaluate the survival of lymph nodes in patients in VLNT+LVA group. &lt;b&gt;Results:&lt;/b&gt; The volume differences of affected limbs in patients in VLNT+LVA group 6 and 12 months after treatment were (521±193) and (694±355) cm³, respectively, which were significantly greater than (377±92) and (452±229) cm³ in LVA group (with mean differences of 144 and 242 cm³, respectively, 95% confidence intervals of 44-244 and 46-438 cm³, respectively, &lt;i&gt;t&lt;/i&gt; values of 2.90 and 2.49, respectively, both &lt;i&gt;P&lt;/i&gt; values &lt;0.05). ANCOVA showed that after adjusting for baseline data, the volume difference of affected limb of patients in VLNT+LVA group 6 and 12 months after treatment were significantly greater than those in LVA group (with &lt;i&gt;F&lt;/i&gt; values of 6.52 and 5.26, respectively, &lt;i&gt;P&lt;/i&gt;&lt;0.05). Twelve months after treatment, the quality of life scores of patients in LVA group and VLNT+LVA group were 8 (4, 9) and 7 (4, 9), respectively, which were significantly higher than 6 (3, 7) and 5 (2, 7) before treatment (with &lt;i&gt;Z&lt;/i&gt; values of -2.97 and -3.46, respectively, both &lt;i&gt;P&lt;/i&gt; values &lt;0.05). However, there was no statistically significant difference in quality of life score of patients between the two groups 12 months after treatment (&lt;i&gt;P&lt;/i&gt;&gt;0.05). During the 12-month post-treatment follow-up, patients in neither group developed infectious complications such as erysipelas, cellulitis, or lymphangitis. ","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"41 6","pages":"534-542"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Multi-omics Mendelian randomization study on the causality between non-ionizing radiation and facial aging].","authors":"Z C He, Y X Shang, X P Xu, C Y Jia, Y P Wang","doi":"10.3760/cma.j.cn501225-20240830-00320","DOIUrl":"10.3760/cma.j.cn501225-20240830-00320","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Objective:&lt;/b&gt; To investigate the causality between non-ionizing radiation and facial aging, and to identify potential genes associated with facial aging. &lt;b&gt;Methods:&lt;/b&gt; This study employed a method of analysis based on multiple Mendelian randomization (MR). Genome-wide association study data of non-ionizing radiation (FinnGen database, &lt;i&gt;n&lt;/i&gt;=218 281) and facial aging (UK Biobank database, &lt;i&gt;n&lt;/i&gt;=423 999) were retrieved. Single nucleotide polymorphisms (SNPs) were used as instrumental variables, with a significance threshold (&lt;i&gt;P&lt;/i&gt;&lt;5×10&lt;sup&gt;-6&lt;/sup&gt;) applied and further linkage disequilibrium analysis performed to select SNPs associated with non-ionizing radiation. Two-sample MR (TSMR) analysis was conducted to assess the causality between non-ionizing radiation and facial aging, using inverse variance weighting (IVW) method as the primary analytical method and supplementing with MR-Egger regression, weighted median, weighted mode, and simple mode methods for validation. For the selected non-ionizing radiation-associated SNPs, heterogeneity was tested by Cochran &lt;i&gt;Q&lt;/i&gt; test, horizontal pleiotropy was assessed by the MR-Egger intercept test and MR-PRESSO test, and robustness was evaluated via leave-one-out analysis. Multivariable MR (MVMR) analysis was performed to adjust for confounding factors affecting facial aging including smoking frequency, blood alcohol concentration, exercise frequency, body mass index, and systolic and diastolic blood pressure. Summary-data-based MR (SMR) analysis using expression quantitative trait loci (eQTL) data was conducted to screen candidate genes of facial aging, which were then validated by TSMR analysis. Protein quantitative trait loci (pQTL) and methylation quantitative trait loci (mQTL) data were analyzed by TSMR analysis to examine the causal role of &lt;i&gt;MED1&lt;/i&gt; gene with facial aging from multi-omics aspect. The genetic association of &lt;i&gt;MED1&lt;/i&gt; gene with facial aging was verified by colocalization analysis (posterior probability H4&gt;50%). &lt;b&gt;Results:&lt;/b&gt; Twenty non-ionizing radiation-related SNPs that reached the significance threshold were screened out, with &lt;i&gt;F&lt;/i&gt; values being all &gt;10. IVW analysis demonstrated a positive causality between non-ionizing radiation and facial aging (with odds ratio of 1.02, with 95% confidence interval of 1.01-1.02, &lt;i&gt;P&lt;/i&gt;&lt;0.05). The analysis results of MR-Egger regression, weighted median, simple mode method, and weighted mode method (with odds ratios of 1.02, 1.02, 1.01, and 1.01, respectively, with 95% confidence intervals of 1.01-1.03, 1.01-1.02, 0.99-1.02, respectively, &lt;i&gt;P&lt;/i&gt;&lt;0.05) were consistent with IVW method. For these 20 non-ionizing radiation-related SNPs, Cochran &lt;i&gt;Q&lt;/i&gt; test under IVW method and MR-Egger showed no significant heterogeneity (with &lt;i&gt;Q&lt;/i&gt; values of 23.20 and 22.59, respectively, &lt;i&gt;P&lt;/i&gt;&gt;0.05); the MR-Egger intercept test (with intercept absolute value of 0.01, with standard error of 0.01, &lt;i&gt;P&lt;/i&gt;&gt;0.05) and MR-PRESS","PeriodicalId":516861,"journal":{"name":"Zhonghua shao shang yu chuang mian xiu fu za zhi","volume":"41 6","pages":"594-603"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12242939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}