Problems of Particularly Dangerous Infections最新文献

{"title":"Analysis and Forecast of the Spread of Particularly Dangerous Mycoses around the World","authors":"A. Lipnitsky, N. Polovets, A. A. Murugova, A. V. Toporkov","doi":"10.21055/0370-1069-2023-4-16-23","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-4-16-23","url":null,"abstract":"The literature review presents an analysis of publications over the past five years on the global distribution of particularly dangerous (endemic) mycoses: coccidioidomycosis, histoplasmosis, blastomycosis, paracoccidioidomycosis. The causative agents of these mycoses are dimorphic micromycetes, which can cause a severe course of the disease, even death. These fungi exist in specific ecological niches, but in recent years there have been many reports of them occurring outside of regions of traditionally known endemicity. There are potential causes for these changes, such as global factors (climate change, migration) and extensive use of immunosuppressive drugs. Climate warming may provide favorable conditions for the growth of Coccidioides spp. in new areas, while prolonged dry spells and subsequent dust storms result in increased incidence of coccidioidomycosis in already established endemic areas. Currently, there is an assumption that not only the soil, but also rodents are the primary reservoir of Coccidioides in the external environment. Histoplasmosis is endemic in the countries of the Americas, but the extent of spread of the causative agents has not been fully defined. In Latin America, histoplasmosis is one of the most common infections in HIV-infected people, with a high mortality rate. Many epidemiological data on blastomycosis come from North America, with less information from Africa and Asia. Cases of endemic mycoses in immunocompetent travelers are usually diagnosed incorrectly, due to the absence of specific symptoms. There is also a risk of reactivation of infection in persons with acquired immunosuppression, even after a long period of time. Isolation of pathogens from environmental objects using conventional cultural methods is difficult, while the introduction of molecular-genetic studies will supplement the knowledge about the epidemiology of these mycoses.","PeriodicalId":516710,"journal":{"name":"Problems of Particularly Dangerous Infections","volume":"29 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140513090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Efficacy of Different Schemes for Using Recombinant Vector Vaccines against Ebola Fever, Based on Vaccinia Virus, MVA Strain","authors":"L. F. Stovba, O. V. Chukhralya, D. Pavel'ev, N. K. Chernikova, S. Borisevich","doi":"10.21055/0370-1069-2023-4-24-31","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-4-24-31","url":null,"abstract":"The aim of this review was to investigate the use of the vaccines based on vaccinia virus, MVA stain, and adenovirus vectors for the prevention of Ebola virus disease. The recombinant MVA strains expressing antigen determinants of Filoviridae family representatives were assessed as possible candidates for vaccine preparations. Application of this virus as a vaccine vector is conditioned by the absence of herd immunity to smallpox and its safety for healthy adult volunteers, children, adolescents, individuals suffering from tuberculosis, persons aged 56–80 years, people with diagnosed atopic dermatitis, AIDS. Furthermore, immunization with the vaccine on the basis of vaccinia virus, MVA strain, does not cause complications associated with cardiovascular diseases. Preclinical trials on immunogenicity and protective efficiency were carried out on immune-competent and immune-compromised mice; guinea pigs adapted to Ebola virus; rhesus macaques and cynomolgus monkeys. Presented are the results of experiments on the creation of vaccines expressing either only viral glycoprotein or viral glycoprotein and structural protein Vp40. Given that Ebola fever and other filovirus infection outbreaks are hard to predict, multivalent vaccines that would be able to provide protection against all filovirus species were designed. Clinical trials on simultaneous use of the vaccines based on recombinant adenovirus vectors and MVA strain showed more pronounced safety of vaccines on the basis of recombinant MVA strain. Studies of humoral and T-cell immune responses have revealed that this vector is more suitable for booster vaccination in case of heterologous prime/booster immunization scheme. Vaccination regimens for forming strong durable immune responses have been analyzed. Epidemiological modeling provided evidence that preventive immunization leading to long-term immunity in healthy population in areas of high epidemic risk will be of greater benefit in terms of controlling future outbreaks compared to ring immunization that was effective during smallpox eradication campaign. Increased immunity level, induced by prime/booster vaccination, persisting for a long period of time, will have an advantage over accelerated ring immunization; when the duration of protection is more significant than the speed it is formed at.","PeriodicalId":516710,"journal":{"name":"Problems of Particularly Dangerous Infections","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chukotka as a Portal for the Rabies Introduction into Kamchatka (Systematic Review)","authors":"A. D. Botvinkin, I. D. Zarva, S. A. Chupin, A. V. Mel’nikov, I. V. Mel’tsov","doi":"10.21055/0370-1069-2023-4-6-15","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-4-6-15","url":null,"abstract":"The aim of this review was to assess the peculiarities of distribution and epidemiological risk of rabies in the extreme northeast of Asia. The systematic review was prepared through synthesizing publications on rabies over 1860–2022 (n=22) and previously unpublished data for 2009–2023. From the late 19th century until the 1980s, rabies epizootics were consistently observed in Chukotka and Kamchatka. A correlation was found between the time of occurrence of rabies in those territories with a lag period of 1–2 years (r=0.349; p=0.054). In 2009–2023, 24 animal rabies cases were confirmed in Chukotka; rabies has not been registered in Kamchatka since 1981. Until 1982, 5 confirmed human rabies cases were described in Chukotka, as well as 4 lethal cases presumably due to rabies (Chukotka – 3, Kamchatka – 1). The similarity of the spatial distribution of epizootics in different periods of time was established. Rabies was detected mainly in the area of the permanent polar fox (Vulpes lagopus) habitation, in the coastal tundra from the mouth of the Kolyma River to the Anadyr Gulf. Outside this territory (the valleys of the Anadyr and Penzhina Rivers, the Kamchatka Peninsula), rabies was reported in red foxes (Vulpes vulpes). At present, the importance of the polar fox in the spread of rabies in Chukotka has decreased, while the significance of the red fox has increased substantially. Due to vaccination, rabies among dogs is recorded sporadically. Rabies virus isolates from Chukotka belong to the Arctic genetic lineage (Arctic-3 group), which has a circumpolar distribution. The possibility of independent circulation of the rabies virus in the Kamchatka Peninsula is doubtful because of the limited size of the red fox population. Based on the mapping, possible directions for the introduction of rabies to Kamchatka from Chukotka have been identified. Barrier oral rabies vaccination of foxes is recommended during the years of high abundance of red and polar foxes in Chukotka.","PeriodicalId":516710,"journal":{"name":"Problems of Particularly Dangerous Infections","volume":"26 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Historical Aspects of Bioterrorism: Factors Determining the Possibility of Using Pathogenic Biological Agents as Biological Weapons","authors":"M. A. Yudin, A. S. Bogacheva, A. L. Buzmakova, A. V. Potapova, A. V. Romanova, D. O. Kalyakina, V. V. Shilov","doi":"10.21055/0370-1069-2023-4-32-41","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-4-32-41","url":null,"abstract":"Every year, the number of potentially life-threatening pathogenic biological agents (PBAs) is rapidly growing, which are represented by viruses, bacteria, rickettsia, chlamydia, protozoa, fungi, genetically engineered constructs and modified microorganisms, prions and toxins. The use of PBAs for the purpose of destroying society, the economic resources of the country, deteriorating the quality of food and water supplies, intimidating the population, provoking internal unrest, destabilizing government, and creating economic, socio-psychological and environmental crises is nothing more than biological terrorism. The numerous international agreements, treaties and protocols that have been developed and ratified to date, limiting the production and use of weapons of mass destruction, do not guarantee the elimination of the risks of illegal acquisition and use of biologically active substances by terrorist organizations, which does not exclude the possibility of committing acts of bioterrorism. In this regard, the preservation and strengthening of administrative-legal, medical-biological, sanitary-epidemiological, veterinary and phytosanitary and other measures should form the basis of the state policy of the Russian Federation to counter the use and spread of PBAs.","PeriodicalId":516710,"journal":{"name":"Problems of Particularly Dangerous Infections","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern Diagnostic Technologies in the Study of the Field Material Collected from the Natural Plague Foci of the Kyrgyz Republic in 2023","authors":"S. Berdiev, G. A. Eroshenko, A. N. Balykova, N. T. Usenbaev, N. Kebekbaeva, A. Dzhaparova, Zh. Mukanmetesen uulu, D. Zhumashov, A. S. Razhapbaeva, A. M. Yuldasheva, E. G. Oglodin, A. D. Katyshev, A. A. Kuznetsov, A. V. Fadeeva, V. V. Kutyrev","doi":"10.21055/0370-1069-2023-4-50-61","DOIUrl":"https://doi.org/10.21055/0370-1069-2023-4-50-61","url":null,"abstract":"The aim of the work was to analyze the results of investigating the field material obtained from natural plague foci of the Kyrgyz Republic (KR) in 2023, using modern diagnostic technologies.Materials and methods. 1435 biological samples from the Tien Shan, Alai and Talas high-mountain foci of the Kyrgyz Republic were studied using conventional methods of laboratory diagnosis of plague: microbiological, immunological, biological; as well as modern molecular-genetic methods. Testing of the obtained samples for the presence of plague pathogen DNA was carried out using RT-PCR; and the presence of antibodies to the plague microbe was detected by enzyme-linked immunosorbent assay (ELISA). Molecular identification of Yersinia pestis strains according to their appurtenance to subspecies, biovars, and phylogenetic lineages was performed by RT-PCR using the method of identifying single-nucleotide substitutions based on the analysis of melting curves of products.Results and discussion. An approach to the molecular identification of Y. pestis strains from plague foci of the KR has been developed and validated through identifying singlenucleotide substitutions using the analysis of product melting curves (HMR-analysis) with a set of designed primers. It has been established that Y. pestis strains isolated in the Sarydzhaz autonomous focus of the Tien Shan high-mountain focus belong to the biovar antiqua of the main subspecies, phylogenetic branch 0.ANT5. The phylogenetic relation of Y. pestis strains isolated in 2023 was studied based on genome-wide SNP analysis. Areas of epizootic activity in Eastern Alai have been identified. The data obtained indicate the sustained activation of plague foci in the KR. Areas of the territory of the KR that are promising for paleogenomic research are also discussed.","PeriodicalId":516710,"journal":{"name":"Problems of Particularly Dangerous Infections","volume":"11 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140512818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}