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Molecular Therapy: Oncology最新文献

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BRAF V600E in a Preclinical Model of Pleomorphic Xanthoastrocytoma (PXA): Analysis of the Tumor Microenvironment and Immune Cell Infiltration dynamics in vivo. BRAF V600E 在多形性黄细胞瘤 (PXA) 临床前模型中的应用：体内肿瘤微环境和免疫细胞浸润动态分析
Molecular Therapy: Oncology Pub Date : 2024-04-01 DOI: 10.1016/j.omton.2024.200808
Alessandro Canella, Matthew Nazzaro, M. Artomov, Lakshmi Prakruthi Rao Venkata, Diana Thomas, Justin Lyberger, Aleksandr Ukhatov, Yao Lulu Xing, Katherine Miller, Gregory K Behbehani, N. Amankulor, Claudia K. Petritsch, P. Rajappa
{"title":"BRAF V600E in a Preclinical Model of Pleomorphic Xanthoastrocytoma (PXA): Analysis of the Tumor Microenvironment and Immune Cell Infiltration dynamics in vivo.","authors":"Alessandro Canella, Matthew Nazzaro, M. Artomov, Lakshmi Prakruthi Rao Venkata, Diana Thomas, Justin Lyberger, Aleksandr Ukhatov, Yao Lulu Xing, Katherine Miller, Gregory K Behbehani, N. Amankulor, Claudia K. Petritsch, P. Rajappa","doi":"10.1016/j.omton.2024.200808","DOIUrl":"https://doi.org/10.1016/j.omton.2024.200808","url":null,"abstract":"","PeriodicalId":516670,"journal":{"name":"Molecular Therapy: Oncology","volume":"66 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140769823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of necroptosis in multinucleated giant cells induced by conditionally-replicating syncytial oHSV in co-cultures of cancer cells and non-cancerous cells 在癌细胞和非癌细胞的共培养物中，条件性复制的合胞卵母细胞瘤病毒诱导多核巨细胞发生坏死
Molecular Therapy: Oncology Pub Date : 2024-04-01 DOI: 10.1016/j.omton.2024.200803
Takuma Suzuki, Hiroaki Uchida
{"title":"Induction of necroptosis in multinucleated giant cells induced by conditionally-replicating syncytial oHSV in co-cultures of cancer cells and non-cancerous cells","authors":"Takuma Suzuki, Hiroaki Uchida","doi":"10.1016/j.omton.2024.200803","DOIUrl":"https://doi.org/10.1016/j.omton.2024.200803","url":null,"abstract":"","PeriodicalId":516670,"journal":{"name":"Molecular Therapy: Oncology","volume":"133 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140781354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced Therapeutic Efficacy for Glioblastoma Immunotherapy with a New Generation Oncolytic Herpes Simplex Virus Armed with Anti-PD-1 Antibody and IL-12 新一代肿瘤溶解性单纯疱疹病毒与抗 PD-1 抗体和 IL-12 共同增强胶质母细胞瘤免疫疗法的疗效
Molecular Therapy: Oncology Pub Date : 2024-04-01 DOI: 10.1016/j.omton.2024.200799
Lei Wang, Xusha Zhou, Xiaoqing Chen, Yuanyuan Liu, Yue Huang, Yuan Cheng, Peigen Ren, Jing Zhao, G. Zhou
{"title":"Enhanced Therapeutic Efficacy for Glioblastoma Immunotherapy with a New Generation Oncolytic Herpes Simplex Virus Armed with Anti-PD-1 Antibody and IL-12","authors":"Lei Wang, Xusha Zhou, Xiaoqing Chen, Yuanyuan Liu, Yue Huang, Yuan Cheng, Peigen Ren, Jing Zhao, G. Zhou","doi":"10.1016/j.omton.2024.200799","DOIUrl":"https://doi.org/10.1016/j.omton.2024.200799","url":null,"abstract":"","PeriodicalId":516670,"journal":{"name":"Molecular Therapy: Oncology","volume":"268 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140773358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harnessing Exosomes as a Platform for Drug Delivery in Breast Cancer: A Systematic Review for In Vivo and In Vitro Studies 利用外泌体作为乳腺癌给药平台：体内和体外研究系统综述
Molecular Therapy: Oncology Pub Date : 2024-04-01 DOI: 10.1016/j.omton.2024.200800
Abdulwahab Teflischi Gharavi, Saeed Irian, A. Niknejad, K. Parang, Mona Salimi
{"title":"Harnessing Exosomes as a Platform for Drug Delivery in Breast Cancer: A Systematic Review for In Vivo and In Vitro Studies","authors":"Abdulwahab Teflischi Gharavi, Saeed Irian, A. Niknejad, K. Parang, Mona Salimi","doi":"10.1016/j.omton.2024.200800","DOIUrl":"https://doi.org/10.1016/j.omton.2024.200800","url":null,"abstract":"","PeriodicalId":516670,"journal":{"name":"Molecular Therapy: Oncology","volume":"138 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140761791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional remodeling of intraperitoneal macrophages by oncolytic adenovirus restores anti-tumor immunity for peritoneal metastasis of gastric cancer 溶瘤腺病毒对腹腔巨噬细胞的功能重塑可恢复胃癌腹膜转移的抗肿瘤免疫力
Molecular Therapy: Oncology Pub Date : 2024-04-01 DOI: 10.1016/j.omton.2024.200806
Motoyasu Tabuchi, Satoru Kikuchi, H. Tazawa, Tomohiro Okura, Toshihiro Ogawa, Ema Mitsui, Yuta Une, Shinji Kuroda, Hiroki Sato, K. Noma, S. Kagawa, Toshiaki Ohara, Junko Ohtsuka, Rieko Ohki, Y. Urata, Toshiyoshi Fujiwara
{"title":"Functional remodeling of intraperitoneal macrophages by oncolytic adenovirus restores anti-tumor immunity for peritoneal metastasis of gastric cancer","authors":"Motoyasu Tabuchi, Satoru Kikuchi, H. Tazawa, Tomohiro Okura, Toshihiro Ogawa, Ema Mitsui, Yuta Une, Shinji Kuroda, Hiroki Sato, K. Noma, S. Kagawa, Toshiaki Ohara, Junko Ohtsuka, Rieko Ohki, Y. Urata, Toshiyoshi Fujiwara","doi":"10.1016/j.omton.2024.200806","DOIUrl":"https://doi.org/10.1016/j.omton.2024.200806","url":null,"abstract":"","PeriodicalId":516670,"journal":{"name":"Molecular Therapy: Oncology","volume":"79 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140770280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The heterogeneous sensitivity of pediatric brain tumors to different oncolytic viruses is predicted by unique gene expression profiles 独特的基因表达谱预测了小儿脑肿瘤对不同溶瘤病毒的不同敏感性
Molecular Therapy: Oncology Pub Date : 2024-04-01 DOI: 10.1016/j.omton.2024.200804
Konstantinos Vazaios, Εftychia Stavrakaki, L. Vogelezang, Jie Ju, Piotr Waranecki, Dennis S. Metselaar, M. Meel, Vera Kemp, B.G. Van Den Hoogen, R.C. Hoeben, E. Chiocca, W. Goins, Andrew Stubbs, Yunlei Li, Marta M. Alonso, F. Calkoen, E. Hulleman, J. van der Lugt, M. Lamfers
{"title":"The heterogeneous sensitivity of pediatric brain tumors to different oncolytic viruses is predicted by unique gene expression profiles","authors":"Konstantinos Vazaios, Εftychia Stavrakaki, L. Vogelezang, Jie Ju, Piotr Waranecki, Dennis S. Metselaar, M. Meel, Vera Kemp, B.G. Van Den Hoogen, R.C. Hoeben, E. Chiocca, W. Goins, Andrew Stubbs, Yunlei Li, Marta M. Alonso, F. Calkoen, E. Hulleman, J. van der Lugt, M. Lamfers","doi":"10.1016/j.omton.2024.200804","DOIUrl":"https://doi.org/10.1016/j.omton.2024.200804","url":null,"abstract":"","PeriodicalId":516670,"journal":{"name":"Molecular Therapy: Oncology","volume":"238 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeted treatment of chondrosarcoma with a bacteriophage-based particle delivering a secreted tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) 用噬菌体颗粒递送分泌型肿瘤坏死因子相关凋亡诱导配体（TRAIL）靶向治疗软骨肉瘤
Molecular Therapy: Oncology Pub Date : 2024-04-01 DOI: 10.1016/j.omton.2024.200805
Aitthiphon Chongchai, K. Bentayebi, Grace Chu, Wenqing Yan, Sajee Waramit, Thanyaluck Phitak, P. Kongtawelert, P. Pothacharoen, Keittisak Suwan, Amin Hajitou
{"title":"Targeted treatment of chondrosarcoma with a bacteriophage-based particle delivering a secreted tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)","authors":"Aitthiphon Chongchai, K. Bentayebi, Grace Chu, Wenqing Yan, Sajee Waramit, Thanyaluck Phitak, P. Kongtawelert, P. Pothacharoen, Keittisak Suwan, Amin Hajitou","doi":"10.1016/j.omton.2024.200805","DOIUrl":"https://doi.org/10.1016/j.omton.2024.200805","url":null,"abstract":"","PeriodicalId":516670,"journal":{"name":"Molecular Therapy: Oncology","volume":"32 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140765887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bortezomib facilitates the TRAIL-mediated killing of resistant rhabdomyosarcoma by ErbB2/ Her2-targeted CAR-NK-92 cells via upregulation of DR5 硼替佐米通过上调 DR5 促进 ErbB2/ Her2 靶向 CAR-NK-92 细胞在 TRAIL 介导下杀死耐药横纹肌肉瘤
Molecular Therapy: Oncology Pub Date : 2024-04-01 DOI: 10.1016/j.omton.2024.200802
C. Heim, L. Hartig, N. Weinelt, Laura M. Moser, E. Salzmann‐Manrique, M. Merker, Winfried S. Wels, Torsten Tonn, Peter Bader, J. Klusmann, Sjoerd J. L. van Wijk, E. Rettinger
{"title":"Bortezomib facilitates the TRAIL-mediated killing of resistant rhabdomyosarcoma by ErbB2/ Her2-targeted CAR-NK-92 cells via upregulation of DR5","authors":"C. Heim, L. Hartig, N. Weinelt, Laura M. Moser, E. Salzmann‐Manrique, M. Merker, Winfried S. Wels, Torsten Tonn, Peter Bader, J. Klusmann, Sjoerd J. L. van Wijk, E. Rettinger","doi":"10.1016/j.omton.2024.200802","DOIUrl":"https://doi.org/10.1016/j.omton.2024.200802","url":null,"abstract":"","PeriodicalId":516670,"journal":{"name":"Molecular Therapy: Oncology","volume":"479 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140759586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oncolytic virus V937 in combination with PD-1 blockade therapy to target immunologically quiescent liver and colorectal cancer 肿瘤溶解病毒 V937 与 PD-1 阻断疗法相结合，靶向免疫静止期肝癌和结直肠癌
Molecular Therapy: Oncology Pub Date : 2024-04-01 DOI: 10.1016/j.omton.2024.200807
Thai Q. Tran, Jeff Grein, Mohammed Selman, L. Annamalai, J. Yearley, W. Blumenschein, S. Sadekova, Alissa A. Chackerian, Uyen Phan, Janica C. Wong
{"title":"Oncolytic virus V937 in combination with PD-1 blockade therapy to target immunologically quiescent liver and colorectal cancer","authors":"Thai Q. Tran, Jeff Grein, Mohammed Selman, L. Annamalai, J. Yearley, W. Blumenschein, S. Sadekova, Alissa A. Chackerian, Uyen Phan, Janica C. Wong","doi":"10.1016/j.omton.2024.200807","DOIUrl":"https://doi.org/10.1016/j.omton.2024.200807","url":null,"abstract":"","PeriodicalId":516670,"journal":{"name":"Molecular Therapy: Oncology","volume":"69 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140796964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The 15th International Oncolytic Virotherapy Conference: Clinical successes point to a brighter future for cancer treatment 第 15 届国际溶瘤病毒疗法大会：临床成功预示着癌症治疗的美好未来
Molecular Therapy: Oncology Pub Date : 2024-03-01 DOI: 10.1016/j.omton.2024.200774
J. Rajwani, Danyel Evseev, Esha S. Kaul, Douglas J. Mahoney
{"title":"The 15th International Oncolytic Virotherapy Conference: Clinical successes point to a brighter future for cancer treatment","authors":"J. Rajwani, Danyel Evseev, Esha S. Kaul, Douglas J. Mahoney","doi":"10.1016/j.omton.2024.200774","DOIUrl":"https://doi.org/10.1016/j.omton.2024.200774","url":null,"abstract":"","PeriodicalId":516670,"journal":{"name":"Molecular Therapy: Oncology","volume":"87 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140086947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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