The Open AIDS Journal最新文献

{"title":"Trends in the Treatment of Anemia Using Recombinant Human Erythropoietin in Patients with HIV Infection.","authors":"Patrick S Sullivan,&nbsp;Debra L Hanson,&nbsp;James T Richardson,&nbsp;John T Brooks","doi":"10.2174/1874613601105010113","DOIUrl":"https://doi.org/10.2174/1874613601105010113","url":null,"abstract":"<p><strong>Background: </strong>Treating anemia with erythropoietin (EPO) to hemoglobin (Hb) endpoints >11 g/dL may increase risk of serious adverse cardiovascular events.</p><p><strong>Methods: </strong>We used medical records data (1996-2003 from the Adolescent Spectrum of HIV Disease Project [ASD] and 1996-2006 from the HIV Outpatient Study [HOPS]) to describe EPO prescription patterns for mildly, moderately, or severely anemic HIV-infected patients. We calculated proportions prescribed EPO and treated to Hb>12 g/dL, and tested for trends over time. We calculated median hemoglobin at first EPO prescription, and described temporal changes using linear regression.</p><p><strong>Results: </strong>Among 37,395 patients in ASD and 7,005 patients in HOPS, EPO prescription increased over time for moderately anemic patients; for patients with severe anemia, EPO prescription increased only among ASD patients. Hb at EPO prescription decreased over time in ASD patients (median=8.5 g/dL), but not in HOPS patients (median 9.5 g/dL). Percentage of EPO-treated patients with post-treatment Hb>12 g/dL was 18.3% in ASD and stable, and was 56.7% in HOPS and increased over time (p = 0.03).</p><p><strong>Conclusions: </strong>Through 2006, EPO prescription increased over time for patients with moderate or severe anemia. Many patients treated with EPO had post-treatment Hb>12 g/dL. Based on 2011 FDA recommendations, changes in previous prescription practices will be needed.</p>","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"5 ","pages":"113-8"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ab/7b/TOAIDJ-5-113.PMC3257553.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30393485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Early Sero-Conversion HIV Infection Using the INSTI HIV-1 Antibody Point-of-Care Test.","authors":"Darrel Cook,&nbsp;Mark Gilbert,&nbsp;Lillo Difrancesco,&nbsp;Mel Krajden","doi":"10.2174/1874613601004010176","DOIUrl":"https://doi.org/10.2174/1874613601004010176","url":null,"abstract":"<p><p>We compared the INSTI(TM) HIV-1 Antibody Point-of-Care (POC) Test to laboratory-based tests for detection of early sero-conversion (i.e. acute) HIV infections. Fifty-three (53) individuals with early HIV infection, (i.e. 3(rd) generation anti-HIV EIA non-reactive or reactive, HIV-1 Western Blot non-reactive or indeterminate and HIV-1 p24 antigen reactive) were tested by INSTI(TM). The INSTI(TM) test was reactive for 34/49 (sensitivity 69.4%; 95% confidence interval 54.6-81.8%) early-infected individuals whose laboratory-based 3(rd) generation HIV EIA test was reactive. Four (4) were non-reactive by both the laboratory-based EIA and INSTI(TM )tests, but were p24 antigen reactive. The INSTI(TM )POC test performs well compared with other POC tests for the detection of early sero-conversion HIV infection, but it may miss 20% to 30% of those detected by laboratory-based 3(rd) generation anti-HIV tests. Both POC and laboratory-based anti-HIV tests will fail to detect a proportion of infected individuals in the first weeks after infection.</p>","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"4 ","pages":"176-9"},"PeriodicalIF":0.0,"publicationDate":"2010-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874613601004010176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29791871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Microcapillary Flow Cytometry for Community-Based CD4+ T Lymphocyte Enumeration in Remote Burkina Faso.","authors":"Cybèle A Renault,&nbsp;Arouna Traore,&nbsp;Rhoderick N Machekano,&nbsp;Dennis M Israelski","doi":"10.2174/1874613601004010171","DOIUrl":"https://doi.org/10.2174/1874613601004010171","url":null,"abstract":"<p><strong>Background: </strong>CD4+ T lymphocyte enumeration plays a critical role in the initiation and monitoring of HIV-infected patients on antiretroviral therapy. There is an urgent need for low-cost CD4+ enumeration technologies, particularly for use in dry, dusty climates characteristic of many small cities in Sub-Saharan Africa.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>Blood samples from 98 HIV-infected patients followed in a community HIV clinic in Ouahigouya, Burkina Faso were obtained for routine CD4+ T lymphocyte count monitoring. The blood samples were divided into two aliquots, on which parallel CD4+ measurements were performed using microcapillary (Guava EasyCD4) and dedicated (Becton Dickinson FACSCount) CD4+ enumeration systems. Spearman rank correlation coefficient was calculated, and the sensitivity, specificity and positive predictive value (PPV) for EasyCD4 <200 cells/µL were determined compared to the reference standard FACSCount CD4 <200 cells/µL.</p><p><strong>Results: </strong>Mean CD4 counts for the EasyCD4 and FACSCount were 313.75 cells/µL and 303.47 cells/µL, respectively. The Spearman rank correlation coefficient was 0.92 (p<0.001). Median values using EasyCD4 were higher than those with the FACSCount (p=0.004). For a CD4<350 cells/uL, sensitivity of the EasyCD4 was 93.9% (95%CI 85.2-98.3%), specificity was 90.6% (95% CI 75.0-98.0%), and PPV was 95.4% (95%CI 87.1-99.0%).</p><p><strong>Conclusion: </strong>Use of the EasyCD4 system was feasible and highly accurate in the harsh conditions of this remote city in Sub-Saharan Africa, demonstrating acceptable sensitivity and specificity compared to a standard operating system. Microcapillary flow cytometry offers a cost-effective alternative for community-based, point-of-care CD4+ testing and could play a substantial role in scaling up HIV care in remote, resource-limited settings.</p>","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"4 ","pages":"171-5"},"PeriodicalIF":0.0,"publicationDate":"2010-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8e/a7/TOAIDJ-4-171.PMC3023948.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29613335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Abacavir/Lamivudine/Zidovudine Plus Tenofovir in HBV/HIV-1 Coinfected Adults: 48-Week Data.","authors":"Allan E Rodriguez,&nbsp;Edwin Dejesus,&nbsp;Vanessa Williams,&nbsp;David Irlbeck,&nbsp;Lisa Ross,&nbsp;Belinda Ha,&nbsp;Charles T Lancaster","doi":"10.2174/1874613601004010167","DOIUrl":"https://doi.org/10.2174/1874613601004010167","url":null,"abstract":"<p><p>In HBV/HIV-coinfected patients, the risk of end-stage liver disease and death is increased. This open-label, prospective, pilot study evaluated abacavir/lamivudine/zidovudine twice daily plus tenofovir once daily in HBV/HIV-coinfected antiretroviral-naïve subjects. Nine adults (8 males) enrolled, with baseline mean HIV-1 RNA = 4.5 log(10) copies/mL, HBV DNA = 9.0 log(10) copies/mL, and median CD4 count =158 cells/mm(3). No subject had baseline ALT >5x ULN.SIX SUBJECTS COMPLETED THE STUDY: 1 withdrew due to non-treatment-related toxoplasmosis and 2 were lost-to-follow-up. At week 48, 100% (6/6) of remaining subjects had ≥2 log(10) decrease in HBV DNA, and 100% (6/6) and 83% (5/6) had HIV-1 RNA <400 and <50 copies/mL, respectively. Median change from baseline in CD4 count was 157 cells/mm(3). One subject experienced treatment-related grade 3 leukopenia. These results demonstrate that abacavir/lamivudine/zidovudine and tenofovir were well tolerated with sustained HIV-1 and HBV antiviral activity through 48 weeks in HBV/HIV-coinfected, antiretroviral-naïve subjects.</p>","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"4 ","pages":"167-70"},"PeriodicalIF":0.0,"publicationDate":"2010-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/76/TOAIDJ-4-167.PMC3023942.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29613931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Maternal HIV-1 Status and Antiretroviral Drugs on Haematological Profiles of South African Infants in Early Life.","authors":"Diana B Schramm,&nbsp;Fiona Anthony,&nbsp;Busani Mathebula,&nbsp;Gayle Sherman,&nbsp;Ashraf Coovadia,&nbsp;Glenda E Gray,&nbsp;Louise Kuhn,&nbsp;Caroline T Tiemessen","doi":"10.2174/1874613601004010156","DOIUrl":"https://doi.org/10.2174/1874613601004010156","url":null,"abstract":"<p><p>Maternal HIV-1 status and antiretroviral drug exposure may influence the haematological profiles of infants. We recruited infants from 118 uninfected control women and from 483 HIV-1 infected women who received no antiretroviral drugs (n=28), or received single-dose Nevirapine (sdNVP) (n=424) or triple-drug combination therapy (n=31) to reduce HIV-1 transmission. Blood was drawn from infants within 24 hours of delivery or 6-12 weeks post-delivery and full blood counts performed using a fully automated AcT-5-diff haematology analyser and reference controls. Exposed uninfected (EU; no NVP) differed from control infants only in having lower basophil counts and percentages. In all infant groups, leukocyte profiles showed characteristic quantitative changes with age in the first 6 weeks of life. HIV-1 infected infants displayed by 6 weeks elevations in white blood cells, lymphocyte, monocyte and basophil counts, and monocyte and basophil percentages, when compared to EU infants. At birth EU NVP-treated infants exhibited elevated monocyte percentages and counts and basophil counts that did not persist at 6 weeks. Interestingly, EU newborns of mothers with high CD4 counts (> 500 cells/μl) that had taken sdNVP had significantly elevated white blood cell, monocyte and basophil counts when compared to newborn infants of mothers with similar CD4 counts that had not taken sdNVP; this was not evident in infants of mothers with CD4 counts <200 cells/μl. These previously undescribed features may affect immune response capability in early life and clinical consequences of such changes need to be further investigated.</p>","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"4 ","pages":"156-65"},"PeriodicalIF":0.0,"publicationDate":"2010-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/de/cd/TOAIDJ-4-156.PMC3024568.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29618073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV Patient Characteristics that Affect Adherence to Exercise Programmes: An Observational Study.","authors":"Andrea Petróczi,&nbsp;Kim Hawkins,&nbsp;Gareth Jones,&nbsp;Declan P Naughton","doi":"10.2174/1874613601004010148","DOIUrl":"https://doi.org/10.2174/1874613601004010148","url":null,"abstract":"<p><strong>Background: </strong>Benefits of exercise for HIV-infected persons have been documented, although in clinical practice, diminished adherence to exercise limits the effectiveness of this auxiliary treatment. Exercise intervention studies carry the caveat that the results are limited to volunteers with good compliance and completion profiles.</p><p><strong>Objectives: </strong>This study aimed to identify characteristics contributing to adherence vs non-adherence to prescribed supervised 10-week 75-minute aerobic and progressive resistance exercise programme in a clinical setting that requires twice-weekly attendance at the physiotherapy gym.</p><p><strong>Study design: </strong>This observational study was comprised of 11 males and 11 females, physician-assessed, HIV seropositive patients referred to exercise programmes in a tertiary multi-disciplinary outpatient service for HIV patients at an urban Teaching Hospital in London (UK). Measurements taken prior to the exercise programme were used as dependent variables and include CD4 count, fitness level, flexibility and perceived physical-, emotional-, functional- and psychological- well-being. Attendance records were categorised into a dichotomous independent variable of adherence based on a natural break that occurred at 8/20 attended sessions.</p><p><strong>Results: </strong>Prior-to-treatment differences in perceived physical, functional and psychological well-being exist between adherent and non-adherent patients, but no differences were found in age, CD4 count or fitness level. Perceived well-being explained 55.7% of the variances in attendance. Gender and reason for referral appear to be independent of adherence, whereas ethnicity may play an influential role.</p><p><strong>Conclusion: </strong>Perceived well-being appears to differentiate between adherent and non-adherent patients. Further studies are required to investigate other psychological characteristics and barriers to maintaining exercise.</p>","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"4 ","pages":"148-55"},"PeriodicalIF":0.0,"publicationDate":"2010-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/33/0e/TOAIDJ-4-148.PMC2944991.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29305511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a Text Messaging Risk Reduction Intervention for Methamphetamine-Using MSM: Research Note.","authors":"Cathy J Reback,&nbsp;Deborah Ling,&nbsp;Steven Shoptaw,&nbsp;Jane Rohde","doi":"10.2174/1874613601004030116","DOIUrl":"https://doi.org/10.2174/1874613601004030116","url":null,"abstract":"<p><p>Men who have sex with men (MSM) who use methamphetamine experience high risks for HIV infection due to sexual transmission behaviors often engaged in when under the influence of methamphetamine. Methamphetamine-using MSM use various forms of information technology (IT) communication such as instant messaging, social networking sites, and websites to facilitate a sexual and/or drug \"hook up.\" Given the acceptability of IT communication in their daily lives, an IT intervention represents an appropriate strategy to reach and intervene with out-of-treatment, methamphetamine-using MSM. The aim of this study was to conduct formative work to develop a text messaging intervention to reduce methamphetamine use and high-risk sexual behaviors among out-of-treatment MSM, which involved conducting focus groups, community partners' meetings, and a pre-test intervention. These activities culminated in the development of a two-week, text-messaging intervention that delivered real-time electronic correspondence based on the behavioral change theories of Social Support Theory, Health Belief Model, and Social Cognitive Theory. The focus groups, community meetings, and pre-test were used to identify the IT communication device, the text messages that best support risk reduction and healthier behavioral choices, and logo, flyer and website development. The input and feedback from the target population and community partners were critical to the successful development of a culturally appropriate intervention. The knowledge gleaned from the formative work of this study will be vitally helpful in designing future IT studies.</p>","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"4 ","pages":"116-22"},"PeriodicalIF":0.0,"publicationDate":"2010-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f8/2d/TOAIDJ-4-116.PMC2905770.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29145099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing innovative intervention approaches for methamphetamine-using men who have sex with men not currently in drug treatment.","authors":"Gordon Mansergh,&nbsp;Mahnaz R Charania,&nbsp;David Purcell","doi":"10.2174/1874613601004030103","DOIUrl":"https://doi.org/10.2174/1874613601004030103","url":null,"abstract":"Men who have sex with men (MSM) continue to be disproportionately affected by HIV and AIDS. The U.S. Centers for Disease Control and Prevention (CDC) estimates that MSM account for 48% of all men living with HIV and 53% of all new HIV infections in the United States in 2007 [1], and the number of incident cases among MSM continue to increase in the U.S. while incidence has been flat or declining for other risk groups [2]. Further, MSM are at elevated risk for HIV infection throughout the world [3]. \u0000 \u0000Several U.S. studies [4-6] suggest that unprotected anal sex accounts for the acquisition of most HIV infections among MSM, and situational factors play an important role in understanding sexual risk taking. One such factor is the use of methamphetamine during sex. Methamphetamine, a central nervous system stimulant, has been consistently linked to unprotected anal sex among MSM [7] as well as to acquisition of HIV [8]. Methamphetamine use has distinct, long lasting cognitive effects that can lead to sexual disinhibition and impaired judgment, and is often associated with poor adherence to medication regimens [9-11]. Methamphetamine-using MSM are up to 4 times more likely to engage in unprotected anal sex, compared to substance-using MSM who do not use methamphetamine [10]. \u0000 \u0000In a longitudinal study of more than 4000 HIV-negative MSM, Koblin and her colleagues found that prospectively, methamphetamine was an independent risk factor for HIV seroconversion [8]. HIV-positive MSM who use methamphetamine (compared to MSM who do not) are also more susceptible to acquiring other STDs and possibly infecting their sexual partners because methamphetamine also functions as an immunosuppressive drug that decreases CD4 levels while increasing viral load [12]. \u0000 \u0000Although several reviews and summaries have highlighted the efficacy of HIV behavioral interventions for MSM [13-15], CDC has only identified a small number of evidence-based interventions for MSM that reduce sexual risk behavior and none target substance-using men [16]. Behavioral HIV prevention may be particularly challenging for substance-using MSM due to competing physical and emotional needs [17], as well as direct and indirect effects of methamphetamine use. Prior studies have reported on a successful intensive drug treatment model for methamphetamine users to reduce drug use and related harms [18]. In addition, a study of methamphetamine-using MSM found four different treatment-based approaches that successfully reduced sexual risk behavior and methamphetamine use from baseline, but there were no difference between groups in sexual risk reduction [19]. Thus, there remains a need for researchers to develop, implement, and evaluate the efficacy of behavioral HIV prevention interventions for substance-using MSM. \u0000 \u0000In 2006, the CDC Division of HIV/AIDS Prevention announced a scientific initiative to fund formative research and pilot testing of four interventions for methamphetamine-using MSM not cur","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"4 ","pages":"103-4"},"PeriodicalIF":0.0,"publicationDate":"2010-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/5d/TOAIDJ-4-103.PMC2905768.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29137292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adaptation of a Couple-Based HIV Intervention for Methamphetamine-Involved African American Men who have Sex with Men.","authors":"Elwin Wu,&nbsp;Nabila El-Bassel,&nbsp;L Donald McVinney,&nbsp;Yves-Michel Fontaine,&nbsp;Leona Hess","doi":"10.2174/1874613601004030123","DOIUrl":"https://doi.org/10.2174/1874613601004030123","url":null,"abstract":"<p><p>In the U.S., incidence of HIV infection among men who have sex with men (MSM) has steadily increased since the 1990s. This points to a need for innovation to address both emerging trends as well as longer-standing disparities in HIV risk and transmission among MSM, such as the elevated rates of HIV/STIs among African American MSM and methamphetamine users. While couple-based sexual risk reduction interventions are a promising avenue to reduce HIV/STI transmission, prior research has been almost exclusively with heterosexual couples. We sought to adapt an existing, evidence-based intervention-originally developed and tested with heterosexual couples-for a new target population consisting of African American MSM in a longer-term same-sex relationship where at least one partner uses methamphetamine. The adaptation process primarily drew from data obtained from a series of focus groups with 8 couples from the target population. Attention is given to the methods used to overcome challenges faced in this adaptation process: limited time, a lead investigator who is phenotypically different from the target population, a dearth of descriptive information on the experiences and worldviews among the target population, and a concomitant lack of topical experts. We also describe a visualization tool used to ensure that the adaptation process promotes and maintains adherence to the theory that guides the intervention and behavior change. The process culminated with an intervention adapted for the new target population as well as preliminary indications that a couple-based sexual-risk reduction intervention for African American, methamphetamine-involved male couples is feasible and attractive.</p>","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"4 ","pages":"123-31"},"PeriodicalIF":0.0,"publicationDate":"2010-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/82/6f/TOAIDJ-4-123.PMC2908928.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29143237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward a Better Understanding of Non-Addicted, Methamphetamine-Using, Men who Have Sex with Men (MSM) in Atlanta.","authors":"Brian J Dew","doi":"10.2174/1874613601004030141","DOIUrl":"https://doi.org/10.2174/1874613601004030141","url":null,"abstract":"Methamphetamine use has increasingly become linked with sexual risk behaviors among men have sex with men (MSM). Yet, the majority of research has been done with methamphetamine dependent MSM or with samples in which addiction to the substance was not evaluated. Furthermore, research with methamphetamine-using MSM in the Southern U.S. is lacking. In this study, focus groups and in-depth interviews were conducted in order to understand the motives, context, and other facilitators and barriers of methamphetamine use among non-addicted MSM residing in Atlanta. Participants included 30 non-addicted, methamphetamine-using MSM and 16 local mental and public health officials. Findings from the first of this two-phase formative research project will result in the initial development of a community-tested, culturally-specific social marketing campaign and an individual-based intervention based in HIV-testing facilities.","PeriodicalId":515834,"journal":{"name":"The Open AIDS Journal","volume":"4 ","pages":"141-7"},"PeriodicalIF":0.0,"publicationDate":"2010-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/1874613601004030141","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29143235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}