Chinese Journal of Traumatology最新文献

{"title":"Advances in mesenchymal stem cells therapy for tendinopathies","authors":"Xu-Feng Mao,&nbsp;Xi-Qian Zhang,&nbsp;Zhe-Yu Yao,&nbsp;Hai-Jiao Mao","doi":"10.1016/j.cjtee.2023.11.002","DOIUrl":"10.1016/j.cjtee.2023.11.002","url":null,"abstract":"<div><p>Tendinopathies are chronic diseases of an unknown etiology and associated with inflammation. Mesenchymal stem cells (MSCs) have emerged as a viable therapeutic option to combat the pathological progression of tendinopathies, not only because of their potential for multidirectional differentiation and self-renewal, but also their excellent immunomodulatory properties. The immunomodulatory effects of MSCs are increasingly being recognized as playing a crucial role in the treatment of tendinopathies, with MSCs being pivotal in regulating the inflammatory microenvironment by modulating the immune response, ultimately contributing to improved tissue repair. This review will discuss the current knowledge regarding the application of MSCs in tendinopathy treatments through the modulation of the immune response.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 1","pages":"Pages 11-17"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127523001165/pdfft?md5=761790d72f00a614dc7dc988f07e3116&pid=1-s2.0-S1008127523001165-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135664800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcitonin gene-related peptide inhibits neuronal apoptosis in heatstroke rats via PKA/p-CREB pathway","authors":"Jie Zhu ,&nbsp;Ya-Hong Chen ,&nbsp;Jing-Jing Ji ,&nbsp;Cheng-Xiang Lu ,&nbsp;Zhi-Feng Liu","doi":"10.1016/j.cjtee.2023.06.002","DOIUrl":"10.1016/j.cjtee.2023.06.002","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;p&gt;The incidence of heatstroke (HS) is not particularly high; however, once it occurs, the consequences are serious. It is reported that calcitonin gene-related peptide (CGRP) is protective against brain injury in HS rats, but detailed molecular mechanisms need to be further investigated. In this study, we further explored whether CGRP inhibited neuronal apoptosis in HS rats via protein kinase A (PKA)/p-cAMP response element-binding protein (p-CREB) pathway.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;p&gt;We established a HS rat model in a pre-warmed artificial climate chamber with a temperature of (35.5 ± 0.5) °C and a relative humidity of 60% ± 5%. Heatstress was stopped once core body temperature reaches above 41 °C. A total of 25 rats were randomly divided into 5 groups with 5 animals each: control group, HS group, HS+CGRP group, HS+CGRP antagonist (CGRP8-37) group, and HS+CGRP+PKA/p-CREB pathway blocker (H89) group. A bolus injection of CGRP was administered to each rat in HS+CGRP group, CGRP8-37 (antagonist of CGRP) in HS+CGRP8-37 group, and CGRP with H89 in HS+CGRP+H89 group. Electroencephalograms were recorded and the serum concentration of S100B, neuron-specific enolase (NSE), neuron apoptosis, activated caspase-3 and CGRP expression, as well as pathological morphology of brain tissue were detected at 2 h, 6 h, and 24 h after HS &lt;em&gt;in vivo&lt;/em&gt;. The expression of PKA, p-CREB, and Bcl-2 in rat neurons were also detected at 2 h after HS &lt;em&gt;in vitro&lt;/em&gt;. Exogenous CGRP, CGRP8-37, or H89 were used to determine whether CGRP plays a protective role in brain injury via PKA/p-CREB pathway. The unpaired &lt;em&gt;t&lt;/em&gt;-test was used between the 2 samples, and the mean ± SD was used for multiple samples. Double-tailed &lt;em&gt;p&lt;/em&gt; &lt; 0.05 was considered statistically significant.&lt;/p&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;p&gt;Electroencephalogram showed significant alteration of θ (54.50 ± 11.51 &lt;em&gt;vs.&lt;/em&gt; 31.30 ± 8.71, &lt;em&gt;F&lt;/em&gt; = 6.790, &lt;em&gt;p&lt;/em&gt; = 0.005) and α wave (16.60 ± 3.21 &lt;em&gt;vs.&lt;/em&gt; 35.40 ± 11.28, &lt;em&gt;F&lt;/em&gt; = 4.549, &lt;em&gt;p&lt;/em&gt; = 0.020) in HS group compared to the control group 2 h after HS. The results of triphosphate gap terminal labeling (TUNEL) showed that the neuronal apoptosis of HS rats was increased in the cortex (9.67 ± 3.16 &lt;em&gt;vs.&lt;/em&gt; 1.80 ± 1.10, &lt;em&gt;F&lt;/em&gt; = 11.002, &lt;em&gt;p&lt;/em&gt; = 0.001) and hippocampus (15.73 ± 8.92 &lt;em&gt;vs.&lt;/em&gt; 2.00 ± 1.00, &lt;em&gt;F&lt;/em&gt; = 4.089, &lt;em&gt;p&lt;/em&gt; = 0.028), the expression of activated caspase-3 was increased in the cortex (61.76 ± 25.13 &lt;em&gt;vs.&lt;/em&gt; 19.57 ± 17.88, &lt;em&gt;F&lt;/em&gt; = 5.695, &lt;em&gt;p&lt;/em&gt; = 0.009) and hippocampus (58.60 ± 23.30 &lt;em&gt;vs.&lt;/em&gt; 17.80 ± 17.62, &lt;em&gt;F&lt;/em&gt; = 4.628, &lt;em&gt;p&lt;/em&gt; = 0.019); meanwhile the expression of serum NSE (5.77 ± 1.78 &lt;em&gt;vs.&lt;/em&gt; 2.35 ± 0.56, &lt;em&gt;F&lt;/em&gt; = 5.174, &lt;em&gt;p&lt;/em&gt; = 0.013) and S100B (2.86 ± 0.69 &lt;em&gt;vs.&lt;/em&gt; 1.35 ± 0.34, &lt;em&gt;F&lt;/em&gt; = 10.982, &lt;em&gt;p&lt;/em&gt; = 0.001) were increased significantly under HS. Exogenous CGRP decreased the concentrations of NSE and S100B, ","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 1","pages":"Pages 18-26"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127523000500/pdfft?md5=182ab4d1fd2aa99930f931f262651db9&pid=1-s2.0-S1008127523000500-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9820168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ABCB1 gene polymorphisms rs1128503, rs2032582, rs4148738 with anemia in patients receiving dabigatran after total knee arthroplasty","authors":"Alina Kasimova ,&nbsp;Dmitry Labutin ,&nbsp;Anton Gvozdetsky ,&nbsp;Svetlana Bozhkova","doi":"10.1016/j.cjtee.2023.06.003","DOIUrl":"10.1016/j.cjtee.2023.06.003","url":null,"abstract":"<div><h3>Purpose</h3><p>Dabigatran is usually prescribed in recommended doses without monitoring of the blood coagulation for the prevention of venous thromboembolism after joint arthroplasty. ABCB1 is a key gene in the metabolism of dabigatran etexilate. Its allele variants are likely to play a pivotal role in the occurrence of hemorrhagic complications.</p></div><div><h3>Methods</h3><p>The prospective study included 127 patients with primary knee osteoarthritis undergoing total knee arthroplasty. Patients with anemia and coagulation disorders, elevated transaminase and creatinine levels as well as already receiving anticoagulant and antiplatelet therapy were excluded from the study. The association of ABCB1 gene polymorphisms rs1128503, rs2032582, rs4148738 with anemia as the outcome of dabigatran therapy was evaluated by single-nucleotide polymorphism analysis with a real-time polymerase chain reaction assay and laboratory blood tests. The beta regression model was used to predict the effect of polymorphisms on the studied laboratory markers. The probability of the type 1 error (<em>p</em>) was less than 0.05 was considered statistically significant. BenjaminiHochberg was used to correct for significance levels in multiple hypothesis tests. All calculations were performed using Rprogramming language v3.6.3.</p></div><div><h3>Results</h3><p>For all polymorphisms there was no association with the level of platelets, protein, creatinine, alanine transaminase, prothrombin, international normalized ratio, activated partial thromboplastin time and fibrinogen. Carriers of rs1128503 (TT) had a significant decrease of hematocrit (<em>p</em> = 0.001), red blood count and hemoglobin (<em>p</em> = 0.015) while receiving dabigatran therapy during the postoperative period compared to the CC, CT. Carriers of rs2032582 (TT) had a significant decrease of hematocrit (<em>p</em> = 0.001), red blood count and hemoglobin (<em>p</em> = 0.006) while receiving dabigatran therapy during the postoperative period compared to the GG, GT phenotypes. These differences were not observed in carriers of rs4148738.</p></div><div><h3>Conclusion</h3><p>It might be necessary to reconsider thromboprophylaxis with dabigatran in carriers of rs1128503 (TT) or rs2032582 (TT) polymorphisms in favor of other new oral anticoagulants. The long-term implication of these findings would be the reduction of bleeding complications after total joint arthroplasty.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 1","pages":"Pages 27-33"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127523000640/pdfft?md5=ebb1ffd04b83c70f3a1642d7007f9741&pid=1-s2.0-S1008127523000640-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9820167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic lumbar hernia: A systematic review of the literature","authors":"Ioannis Tsouknidas ,&nbsp;Nikolaos Tasis ,&nbsp;Maria Ioanna Antonopoulou ,&nbsp;Vasileios Acheimastos ,&nbsp;Dimitrios K. Manatakis","doi":"10.1016/j.cjtee.2023.05.006","DOIUrl":"10.1016/j.cjtee.2023.05.006","url":null,"abstract":"<div><h3>Purpose</h3><p>Traumatic lumbar hernia (TLH) constitutes a protrusion of content through a defect in the posterior abdominal wall, as a result of injury. This rare entity has been described in limited number of cases.</p></div><div><h3>Methods</h3><p>A systematic review of the literature was performed according to the meta-analysis of observational studies in epidemiology guidelines. The English literature from 1990 until 2021 was reviewed, using PubMed, EMBASE and Google Scholar bibliographic databases, to identify case reports and case series with patients that were diagnosed with TLH. For each eligible study, demographics, clinical presentation, hernia characteristics, preoperative imaging investigations, operation details, and postoperative data were extracted for assessment. Statistical analysis was performed on SPSS, version 20.0.</p></div><div><h3>Results</h3><p>A total of 62 studies were included for review, with 164 patients with TLH. Mean age was (42.6 ± 14.3) years (47.6% males, 31.1% females, gender not specified in 35 cases). Mean diameter of hernia neck was (6.3 ± 3.1) cm, while the triangles of Petit and Grynfeltt were affected in 74.5% and 14.6%, respectively. Patients diagnosed in the emergency setting account for 54.2%, with CT scan establishing diagnosis in all but one case (97.7%). A delayed diagnosis was made in 45.8%, at a mean 1 year following trauma. Flank bulging (82.8%) and chronic back pain (34.3%) were the most frequent symptoms. In both delayed and acute group, open surgery (63.6% and 92.3%, respectively) was the preferred surgical approach. Postoperative complications were reported in 11.4% of acute and 15.0% of delayed patients. Hernia recurrence was 7%.</p></div><div><h3>Conclusions</h3><p>TLH is uncommon with 164 cases described since 1990. CT scan is the gold standard in diagnosis. Open surgery is generally the preferred approach, particularly in the emergency setting. Acute TLH can be treated either by primary suture repair or mesh, depending on the local conditions, whereas delayed cases usually require a mesh.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 1","pages":"Pages 53-57"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127523000482/pdfft?md5=45727d8ab0e438a8a90cb9900ddfa21e&pid=1-s2.0-S1008127523000482-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9890922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The expression mechanism of programmed cell death 1 ligand 1 and its role in immunomodulatory ability of mesenchymal stem cells","authors":"Zhuo Chen ,&nbsp;Meng-Wei Yao ,&nbsp;Xiang Ao ,&nbsp;Qing-Jia Gong ,&nbsp;Yi Yang ,&nbsp;Jin-Xia Liu ,&nbsp;Qi-Zhou Lian ,&nbsp;Xiang Xu ,&nbsp;Ling-Jing Zuo","doi":"10.1016/j.cjtee.2023.11.003","DOIUrl":"10.1016/j.cjtee.2023.11.003","url":null,"abstract":"<div><p>Programmed cell death 1 ligand 1 (PD-L1) is an important immunosuppressive molecule, which inhibits the function of T cells and other immune cells by binding to the receptor programmed cell death-1. The PD-L1 expression disorder plays an important role in the occurrence, development, and treatment of sepsis or other inflammatory diseases, and has become an important target for the treatment of these diseases. Mesenchymal stem cells (MSCs) are a kind of pluripotent stem cells with multiple differentiation potential. In recent years, MSCs have been found to have a strong immunosuppressive ability and are used to treat various inflammatory insults caused by hyperimmune diseases. Moreover, PD-L1 is deeply involved in the immunosuppressive events of MSCs and plays an important role in the treatment of various diseases. In this review, we will summarize the main regulatory mechanism of PD-L1 expression, and discuss various biological functions of PD-L1 in the immune regulation of MSCs.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 1","pages":"Pages 1-10"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127523001190/pdfft?md5=6cf9f266fbec518657032f702055e69a&pid=1-s2.0-S1008127523001190-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of overlay differentially expressed genes in both rats and goats with blast lung injury through comparative transcriptomics","authors":"Hong Wang,&nbsp;Jun-Hong Gao,&nbsp;Xiao-Lin Fan,&nbsp;Qing Lu,&nbsp;Liang Li,&nbsp;Ning Ma,&nbsp;Qi Wang,&nbsp;Yu-Hao Zhang","doi":"10.1016/j.cjtee.2023.11.005","DOIUrl":"10.1016/j.cjtee.2023.11.005","url":null,"abstract":"<div><h3>Purpose</h3><p>To identify the potential target genes of blast lung injury (BLI) for the diagnosis and treatment.</p></div><div><h3>Methods</h3><p>This is an experimental study. The BLI models in rats and goats were established by conducting a fuel-air explosive power test in an unobstructed environment, which was subsequently validated through hematoxylin-eosin staining. Transcriptome sequencing was performed on lung tissues from both goats and rats. Differentially expressed genes were identified using the criteria of <em>q</em> ≤ 0.05 and |log₂ fold change| ≥ 1. Following that, enrichment analyses were conducted for gene ontology and the Kyoto Encyclopedia of Genes and Genomes pathways. The potential target genes were further confirmed through quantitative real-time polymerase chain reaction and enzyme linked immunosorbent assay.</p></div><div><h3>Results</h3><p>Observations through microscopy unveiled the presence of reddish edema fluid, erythrocytes, and instances of focal or patchy bleeding within the alveolar cavity. Transcriptome sequencing analysis identified a total of 83 differentially expressed genes in both rats and goats. Notably, 49 genes exhibited a consistent expression pattern, with 38 genes displaying up-regulation and 11 genes demonstrating down-regulation. Enrichment analysis highlighted the potential involvement of the interleukin-17 signaling pathway and vascular smooth muscle contraction pathway in the underlying mechanism of BLI. Furthermore, the experimental findings in both goats and rats demonstrated a strong association between BLI and several key genes, including anterior gradient 2, ankyrin repeat domain 65, bactericidal/permeability-increasing fold containing family A member 1, bactericidal/permeability-increasing fold containing family B member 1, and keratin 4, which exhibited up-regulation.</p></div><div><h3>Conclusions</h3><p>Anterior gradient 2, ankyrin repeat domain 65, bactericidal/permeability-increasing fold containing family A member 1, bactericidal/permeability-increasing fold containing family B member 1, and keratin 4 hold potential as target genes for the prognosis, diagnosis, and treatment of BLI.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 1","pages":"Pages 34-41"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S100812752300127X/pdfft?md5=5fc2dfd50210c390c167561bbddb6041&pid=1-s2.0-S100812752300127X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of ultrasonography in predicting the outcomes of simple long bone fractures treated by closed intramedullary nail fixation","authors":"Tilak Rommel Pinto, Chiranjeevi Srinivasa Gowda, A. Braggs, Kiyana Mirza, Aravinda Hegde K","doi":"10.1016/j.cjtee.2023.11.007","DOIUrl":"https://doi.org/10.1016/j.cjtee.2023.11.007","url":null,"abstract":"","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"2 1","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139022719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of green channel for stroke patients on treatment of severe aneurysmal subarachnoid hemorrhage","authors":"Xue-Jiao Wang ,&nbsp;Yu Deng ,&nbsp;Xiao-Qing Li ,&nbsp;Feng-Feng Jiang ,&nbsp;Wen-Yan Jia ,&nbsp;He-Chun Zhang ,&nbsp;Feng-Ying Chen ,&nbsp;Bai-Yun Liu","doi":"10.1016/j.cjtee.2023.11.004","DOIUrl":"10.1016/j.cjtee.2023.11.004","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Purpose&lt;/h3&gt;&lt;div&gt;To explore the effect of green channel for stroke patients on the treatment of severe aneurysmal subarachnoid hemorrhage.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;This is a retrospective case-control study. The clinical data of patients with severe aneurysmal subarachnoid hemorrhage admitted to the emergency department of our hospital from January 2015 to June 2022 were retrospectively analyzed. Patients diagnosed with subarachnoid hemorrhage, confirmed intracranial aneurysm by preoperative CT angiography or digital subtraction, graded Hunt-Hess grade III, IV, and V, &lt; 72 h from the onset to the time of consultation received surgical treatment in our hospital were included in this study. Patients with serious underlying diseases, such as heart, liver, kidney diseases, or malignant tumors, traumatic subarachnoid hemorrhage, previous history of cerebral hemorrhage, and incomplete data were excluded. The control group included patients with severe aneurysmal subarachnoid hemorrhage admitted from January 2015 to December 2018 before the establishment of the green channel for stroke patients, and the observation group included patients with severe aneurysmal subarachnoid hemorrhage admitted from January 2019 to June 2022 after the establishment of the green channel. The control group received routine treatment in the emergency department; the observation group received improved treatment of green channel for stroke patients. Gender, age, Hunt-Hess grade on admission, modified Rankin scale (mRS) on admission, aneurysm location, aneurysm size and whether accompanied by intracerebral hemorrhage, the time from onset to emergency department, the time from emergency department to vascular diagnostic examination, the time from onset to surgery, the time from emergency department to surgery, the time from hospital admission to surgery, length of hospital stay, complications, treatment effect were analyzed and compared between the 2 groups. SPSS 23.0 software was utilized to conduct comparisons between the 2 groups. The &lt;em&gt;t&lt;/em&gt;-test, Chi-square test, or Mann-Whitney &lt;em&gt;U&lt;/em&gt; test was chosen based on the data type. Statistical significance was established when &lt;em&gt;p&lt;/em&gt; &lt; 0.05.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 71 patients were included in this study, of whom 37 were in the control group and 34 were in the observation group. There were no statistical differences in age, gender, Hunt-Hess grade, mRS scores, aneurysm location, aneurysm size, intracerebral hemorrhage, the time from onset to emergency department, length of hospital stay, complications between the observation group and the control group (all &lt;em&gt;p&lt;/em&gt; &gt; 0.05). The time (min) from visit to vascular diagnostic test (60.50 &lt;em&gt;vs&lt;/em&gt;. 120.00, &lt;em&gt;p&lt;/em&gt; = 0.027), the time (min) from onset to surgery (1792.00 &lt;em&gt;vs&lt;/em&gt;. 2868.00, &lt;em&gt;p&lt;/em&gt; = 0.023), the time (min) from emergency department to surgery (1568.50 &lt;em&gt;vs&lt;/em&gt;. 2778.00, &lt;em&gt;p&lt;/em&gt; = 0.016","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 6","pages":"Pages 328-333"},"PeriodicalIF":1.8,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138832952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Road traffic mortality in Zunyi city, China: A 10 - year data analysis (2013-2022).","authors":"Tian-Jing Sun, Xiao-Fei Huang, Fang-Ke Xie, Ji Zhang, Xu-Heng Jiang, An-Yong Yu","doi":"10.1016/j.cjtee.2023.09.007","DOIUrl":"https://doi.org/10.1016/j.cjtee.2023.09.007","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to examine the pattern of motorization and the mortality rate related to road traffic crashes in Zunyi (a city in northern Guizhou province of China) from 2013 to 2022, and to identify the epidemiological characteristics of these crashes with to provide insights that could help improve road safety.</p><p><strong>Methods: </strong>Data were obtained from the Zunyi traffic management data platform, and the mortality rates were calculated. We deployed various analytical methods, including descriptive analysis, Chi-square test or Fisher's exact test of categorical variable, circular distribution map analysis, and Rayleigh test to characterize the traits of road traffic crashes in the region.</p><p><strong>Results: </strong>During the 10-year study period, 7488 people died due to road traffic accidents, with males accounting for 70.4% and females 29.6% (χ² = 101.97, p < 0.001). The mortality rate increased from 7.80 deaths per 100,000 people in 2013 to 10.70 deaths per 100,000 people in 2016, but then decreased to 9.54 deaths per 100,000 people in 2019. A notable finding was that the death rate per 10,000 vehicles declined from 16.09 deaths per 10,000 vehicles in 2013 to 5.48 deaths per 10,000 vehicles in 2022. The study also found that vulnerable road users represented nearly half (48.76%) of all accident fatalities, and unlicensed or inexperienced driving contributed significantly to the occurrence of road traffic accidents.</p><p><strong>Conclusion: </strong>Although the number of road traffic accidents in Zunyi has decreased, there are still some critical issues that need to be addressed, particularly for vulnerable road users and unlicensed drivers. Our results highlight the need of targeted interventions to address the specific risk factors of road traffic crashes, particularly those affecting vulnerable road users and drivers without sufficient experience or license.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of curettage vs. trephination technique for harvesting anterior iliac crest bone graft: A cadaveric study.","authors":"Albert Cakar, Omer Faruk Egerci, Fırat Dogruoz, Ersin Tasatan, Serra Ozturk, Muzaffer Sindel, Ozkan Kose","doi":"10.1016/j.cjtee.2023.10.007","DOIUrl":"https://doi.org/10.1016/j.cjtee.2023.10.007","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this cadaveric study was to compare the volume and weight of bone graft harvested using the curettage vs. the trephination technique from the anterior iliac crest.</p><p><strong>Methods: </strong>Embalmed cadavers were studied in this experimental research. The right hemipelvis of each cadaver was used for the trephine bone harvesting technique, whereas the left hemipelvis was used for the conventional curettage technique. The weight and the volume of the harvested bone were measured and statistically compared between the 2 sides. The Wilcoxon Signed-Rank test was employed to compare the graft volume and weight obtained from the right and left sides of the hemipelvis.</p><p><strong>Results: </strong>Ten embalmed adult cadavers were used in this study. All subjects were Caucasian males with a mean age of 59.8 years (range 44 - 73 years) at the time of death. A total of 81 cylindrical bone grafts were harvested from the right iliac crest. In 9 out of 81 (11.1 %), the cortex of the ilium was penetrated by the chisel. The mean weight of the bone graft harvested with the trephine technique (26.97 ± 2.32) g was heavier than the curettage technique (23.74 ± 2.09) g (p = 0.007). Similarly, the volume of the bone graft was higher in the trephine technique (8.40 ± 0.84) cm³ compared to the curettage technique (6.60 ± 1.26) cm³ (p = 0.011). The trephination technique lasted a mean of (12.76 ± 1.87) min (range 10.30-16.10 min), while the curettage technique lasted a mean of (14.53 ± 0.89) min (range 13.50-16.00 min) (p = 0.028).</p><p><strong>Conclusion: </strong>Harvesting anterior iliac crest bone graft with the trephine technique provides a higher bone volume and weight than the conventional curettage technique. The trephine technique might be advocated over the curettage technique, especially when a large amount of autologous bone graft is required. However, a meticulous harvesting technique should be followed to prevent complications, particularly the three-dimensional anatomy should be kept in mind, and the depth of trephination should be well-controlled.</p><p><strong>Clinical trial registration: </strong>Institutional Review Board registration: 2022/499.</p>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}