Zhi Fu , Yi Chang , Tao Xiong , Wen-Kai Gao , Kui Li , Yu Liu
{"title":"A study on the application of diffuse axonal multi-axis general evaluation for brain injury assessment in small overlap barrier crash test","authors":"Zhi Fu , Yi Chang , Tao Xiong , Wen-Kai Gao , Kui Li , Yu Liu","doi":"10.1016/j.cjtee.2024.04.005","DOIUrl":"10.1016/j.cjtee.2024.04.005","url":null,"abstract":"<div><h3>Purpose</h3><p>Head injury criterion (HIC) companied by a rotation-based metric was widely believed to be helpful for head injury prediction in road traffic accidents. Recently, the Euro-New Car Assessment Program utilized a newly developed metric called diffuse axonal multi-axis general evaluation (DAMAGE) to explain test device for human occupant restraint (THOR) head injury, which demonstrated excellent ability in capturing concussions and diffuse axonal injuries. However, there is still a lack of comprehensive understanding regarding the effectiveness of using DAMAGE for Hybrid Ⅲ 50th percentile male dummy (H50th) head injury assessment. The objective of this study is to determine whether the DAMAGE could capture the risk of H50th brain injury during small overlap barrier tests.</p></div><div><h3>Methods</h3><p>To achieve this objective, a total of 24 vehicle crash loading curves were collected as input data for the multi-body simulation. Two commercially available mathematical dynamic models, namely H50th and THOR, were utilized to investigate the differences in head injury response. Subsequently, a decision method known as simple additive weighting was employed to establish a comprehensive brain injury metric by incorporating the weighted HIC and either DAMAGE or brain injury criterion. Furthermore, 35 sets of vehicle crash test data were used to analyze these brain injury metrics.</p></div><div><h3>Results</h3><p>The rotational displacement of the THOR head is significantly greater than that of the H50th head. The maximum linear and rotational head accelerations experienced by H50th and THOR models were (544.6 ± 341.7) m/s<sup>2</sup>, (2468.2 ± 1309.4) rad/s<sup>2</sup> and (715.2 ± 332.8) m/s<sup>2</sup>, (3778.7 ± 1660.6) rad/s<sup>2</sup>, respectively. Under the same loading condition during small overlap barrier (SOB) tests, THOR exhibits a higher risk of head injury compared to the H50th model. It was observed that the overall head injury response during the small overlap left test condition is greater than that during the small overlap right test. Additionally, an equation was formulated to establish the necessary relationship between the DAMAGE values of THOR and H50th.</p></div><div><h3>Conclusion</h3><p>If H50th rather than THOR is employed as an evaluation tool in SOB crash tests, newly designed vehicles are more likely to achieve superior performance scores. According to the current injury curve for DAMAGE and brain injury criterion, it is highly recommended that HIC along with DAMAGE was prioritized for brain injury assessment in SOB tests.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 4","pages":"Pages 200-210"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127524000567/pdfft?md5=b4bde7a09029508e141e4f70f8e1e473&pid=1-s2.0-S1008127524000567-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jin-Ming Wang , Zheng-Dong Li , Chang-Sheng Cai , Ying Fan , Xin-Biao Liao , Fu Zhang , Jian-Hua Zhang , Dong-Hua Zou
{"title":"Parametric analysis of craniocerebral injury mechanism in pedestrian traffic accidents based on finite element methods","authors":"Jin-Ming Wang , Zheng-Dong Li , Chang-Sheng Cai , Ying Fan , Xin-Biao Liao , Fu Zhang , Jian-Hua Zhang , Dong-Hua Zou","doi":"10.1016/j.cjtee.2024.03.010","DOIUrl":"10.1016/j.cjtee.2024.03.010","url":null,"abstract":"<div><h3>Purpose</h3><p>The toughest challenge in pedestrian traffic accident identification lies in ascertaining injury manners. This study aimed to systematically simulate and parameterize 3 types of craniocerebral injury including impact injury, fall injury, and run-over injury, to compare the injury response outcomes of different injury manners.</p></div><div><h3>Methods</h3><p>Based on the total human model for safety (THUMS) and its enhanced human model THUMS-hollow structures, a total of 84 simulations with 3 injury manners, different loading directions, and loading velocities were conducted. Von Mises stress, intracranial pressure, maximum principal strain, cumulative strain damage measure, shear stress, and cranial strain were employed to analyze the injury response of all areas of the brain. To examine the association between injury conditions and injury consequences, correlation analysis, principal component analysis, linear regression, and stepwise linear regression were utilized.</p></div><div><h3>Results</h3><p>There is a significant correlation observed between each criterion of skull and brain injury (<em>p</em> < 0.01 in all Pearson correlation analysis results). A 2-phase increase of cranio-cerebral stress and strain as impact speed increases. In high-speed impact (> 40 km/h), the Von Mises stress on the skull was with a high possibility exceed the threshold for skull fracture (100 MPa). When falling and making temporal and occipital contact with the ground, the opposite side of the impacted area experiences higher frequency stress concentration than contact at other conditions. Run-over injuries tend to have a more comprehensive craniocerebral injury, with greater overall deformation due to more adequate kinetic energy conduction. The mean value of maximum principal strain of brain and Von Mises stress of cranium at run-over condition are 1.39 and 403.8 MPa, while they were 1.31, 94.11 MPa and 0.64, 120.5 MPa for the impact and fall conditions, respectively. The impact velocity also plays a significant role in craniocerebral injury in impact and fall loading conditions (the <em>p</em> of all <em>F</em>-test < 0.05). A regression equation of the craniocerebral injury manners in pedestrian accidents was established.</p></div><div><h3>Conclusion</h3><p>The study distinguished the craniocerebral injuries caused in different manners, elucidated the biomechanical mechanisms of craniocerebral injury, and provided a biomechanical foundation for the identification of craniocerebral injury in legal contexts.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 4","pages":"Pages 187-199"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127524000373/pdfft?md5=309100d796ac1ba84d8ff60342705222&pid=1-s2.0-S1008127524000373-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140407941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Teng-Fei Tian , Fu-Hao Mo , Hao-Yang Su , Can Huang , Hui Zhao , Jun Liu , Bo Shang , Kui Li , Jin-Long Qiu
{"title":"Investigation on vehicle occupant dummy applicability for under-foot impact loading conditions","authors":"Teng-Fei Tian , Fu-Hao Mo , Hao-Yang Su , Can Huang , Hui Zhao , Jun Liu , Bo Shang , Kui Li , Jin-Long Qiu","doi":"10.1016/j.cjtee.2024.02.002","DOIUrl":"10.1016/j.cjtee.2024.02.002","url":null,"abstract":"<div><h3>Purpose</h3><p>Under-foot impact loadings can cause serious lower limb injuries in many activities, such as automobile collisions and underbody explosions to military vehicles. The present study aims to compare the biomechanical responses of the mainstream vehicle occupant dummies with the human body lower limb model and analyze their robustness and applicability for assessing lower limb injury risk in under-foot impact loading environments.</p></div><div><h3>Methods</h3><p>The Hybrid III model, the test device for human occupant restraint (THOR) model, and a hybrid human body model with the human active lower limb model were adopted for under-foot impact analysis regarding different impact velocities and initial lower limb postures.</p></div><div><h3>Results</h3><p>The results show that the 2 dummy models have larger peak tibial axial force and higher sensitivity to the impact velocities and initial postures than the human lower limb model. In particular, the Hybrid III dummy model presented extremely larger peak tibial axial forces than the human lower limb model. In the case of minimal difference in tibial axial force, Hybrid III's tibial axial force (7.5 KN) is still 312.5% that of human active lower limb's (2.4 KN). Even with closer peak tibial axial force values, the biomechanical response curve shapes of the THOR model show significant differences from the human lower limb model.</p></div><div><h3>Conclusion</h3><p>Based on the present results, the Hybrid III dummy cannot be used to evaluate the lower limb injury risk in under-foot loading environments. In contrast, potential improvement in ankle biofidelity and related soft tissues of the THOR dummy can be implemented in the future for better applicability.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 4","pages":"Pages 235-241"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127524000087/pdfft?md5=7df9e04a6fbbb8a1426d0c4b99381dcc&pid=1-s2.0-S1008127524000087-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140463576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Guide for Authors BM I to V","authors":"","doi":"10.1016/S1008-1275(24)00071-3","DOIUrl":"https://doi.org/10.1016/S1008-1275(24)00071-3","url":null,"abstract":"","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 4","pages":"Pages I-V"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127524000713/pdfft?md5=f6d584fd1c82188a406034bf78db3d31&pid=1-s2.0-S1008127524000713-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mozhgan Seif , Sedigheh Edalat , Ali Majidpour Azad Shirazi , Somayeh Alipouri , Mohsen Bayati
{"title":"Prediction of the burden of road traffic injuries in Iran by 2030: Prevalence, death, and disability-adjusted life years","authors":"Mozhgan Seif , Sedigheh Edalat , Ali Majidpour Azad Shirazi , Somayeh Alipouri , Mohsen Bayati","doi":"10.1016/j.cjtee.2024.02.004","DOIUrl":"10.1016/j.cjtee.2024.02.004","url":null,"abstract":"<div><h3>Purpose</h3><p>Road traffic accidents pose a global challenge with substantial human and economic costs. Iran experiences a high incidence of road traffic injuries, leading to a significant burden on society. This study aims to predict the future burden of road traffic injuries in Iran until 2030, providing valuable insights for policy-making and interventions to improve road safety and reduce the associated human and economic costs.</p></div><div><h3>Methods</h3><p>This analytical study utilized time series models, specifically autoregressive integrated moving average (ARIMA) and artificial neural networks (ANNs), to predict the burden of road traffic accidents by analyzing past data to identify patterns and trends in Iran until 2030. The required data related to prevalence, death, and disability-adjusted life years (DALYs) rates were collected from the Institute for Health Metrics and Evaluation database and analyzed using R software and relevant modeling and statistical analysis packages.</p></div><div><h3>Results</h3><p>Both prediction models, ARIMA and ANNs indicate that the prevalence rates (per 100,000) of all road traffic injuries, except for motorcyclist road injuries which have an almost flat trend, remaining at around 430, increase by 2030. Based on estimations of both models, the rates of death and DALYs due to motor vehicle and pedestrian road traffic injuries decrease. For motor vehicle road injuries, estimated trends decrease to approximately 520 DALYs and 10 deaths. Also, for pedestrian road injuries these rates reached approximately 300 DALYs and 6 deaths, according to the models. For cyclists and other road traffic injuries, the predicted DALY rates by the ANN model increase to almost 50 and 8, while predictions conducted by the ARIMA model show a static trend, remaining at 40 and approximately 6.5. Moreover, these rates for the prediction of death rate by the ANN model increased to 0.6 and 0.1, while predictions conducted by the ARIMA model show a static trend, remaining at 0.43 and 0.07. According to the ANN model, the predicted rates of DALY and death for motorcyclists decrease to 100 and approximately 2.7, respectively. On the other hand, predictions made by the ARIMA model show a static trend, with rates remaining at 200 and approximately 3.2, respectively.</p></div><div><h3>Conclusion</h3><p>The prevalence of road traffic injuries is predicted to increase, while the death and DALY rates of road traffic injuries show different patterns. Effective intervention programs and safety measures are necessary to prevent and reduce road traffic accidents. Different interventions should be designed and implemented specifically for different groups of pedestrians, cyclists, motorcyclists, and motor vehicle drivers.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 4","pages":"Pages 242-248"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127524000105/pdfft?md5=883a4eb2de840eae416c51c81af87db8&pid=1-s2.0-S1008127524000105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Management of proximal tibial stress fracture associated with advanced knee osteoarthritis: A systematic review","authors":"Mukesh Kumar Saini , Mahendra Singh , Devendra Singh , Prem Manohar Seervi , Pera Jayavardhan Reddy , Neelam Ramana Reddy","doi":"10.1016/j.cjtee.2023.07.002","DOIUrl":"10.1016/j.cjtee.2023.07.002","url":null,"abstract":"<div><h3>Purpose</h3><p>Tibial stress fracture associated with knee osteoarthritis is an unusual and difficult clinical scenario. There is no clear existing treatment guideline for this uncommon clinical disease. The aim of this study is to review the impact of various treatment options for patients with advanced knee osteoarthritis associated with proximal tibial stress fracture.</p></div><div><h3>Methods</h3><p>The study was performed using the databases of PubMed and Scopus. Methodological index for non-randomized studies score was used to evaluate the included studies’ bias. The concluded data included the treatment approach, reported outcome measure, and time to fracture union. The literature search was started in December 2021 and accomplished in January 2022. A narrative description of the different methods and comparison of their results were done.</p></div><div><h3>Results</h3><p>Out of total assessed 69 studies, 9 studies were included in our review. The commonest treatment approach used was total knee arthroplasty by long tibial stem extension. The mean preoperative knee society score and knee functional score were 30.62 and 23.17, respectively. The mean postoperative knee society knee score was 86.87, while the functional score was 83.52. The average reported time to achieve fracture union was 4 months (a range of 2.07 – 5.50 months).</p></div><div><h3>Conclusion</h3><p>The optimal clinical outcome for treating either acute or mobile tibial stress fracture in patients with advanced knee osteoarthritis can be achieved with long stem total knee arthroplasty. However, due to heterogeneity of data, comparison of different treatment options for chronic proximal tibial stress fracture mal-union/non-union coexisting with knee osteoarthritic and such inferences need to be judged cautiously.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 3","pages":"Pages 147-152"},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127523000688/pdfft?md5=6c2fb0167b3060a7d30f923a033415c7&pid=1-s2.0-S1008127523000688-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9995002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeting the adenosine A2A receptor for neuroprotection and cognitive improvement in traumatic brain injury and Parkinson's disease","authors":"Yan Zhao , Yuan-Guo Zhou , Jiang-Fan Chen","doi":"10.1016/j.cjtee.2023.08.003","DOIUrl":"10.1016/j.cjtee.2023.08.003","url":null,"abstract":"<div><p>Adenosine exerts its dual functions of homeostasis and neuromodulation in the brain by acting at mainly 2 G-protein coupled receptors, called A<sub>1</sub> and A<sub>2A</sub> receptors. The adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>R) antagonists have been clinically pursued for the last 2 decades, leading to final approval of the istradefylline, an A<sub>2A</sub>R antagonist, for the treatment of OFF-Parkinson's disease (PD) patients. The approval paves the way to develop novel therapeutic methods for A<sub>2A</sub>R antagonists to address 2 major unmet medical needs in PD and traumatic brain injury (TBI), namely neuroprotection or improving cognition. In this review, we first consider the evidence for aberrantly increased adenosine signaling in PD and TBI and the sufficiency of the increased A<sub>2A</sub>R signaling to trigger neurotoxicity and cognitive impairment. We further discuss the increasing preclinical data on the reversal of cognitive deficits in PD and TBI by A<sub>2A</sub>R antagonists through control of degenerative proteins and synaptotoxicity, and on protection against TBI and PD pathologies by A<sub>2A</sub>R antagonists through control of neuroinflammation. Moreover, we provide the supporting evidence from multiple human prospective epidemiological studies which revealed an inverse relation between the consumption of caffeine and the risk of developing PD and cognitive decline in aging population and Alzheimer's disease patients. Collectively, the convergence of clinical, epidemiological and experimental evidence supports the validity of A<sub>2A</sub>R as a new therapeutic target and facilitates the design of A<sub>2A</sub>R antagonists in clinical trials for disease-modifying and cognitive benefit in PD and <span>TBI</span> patients.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 3","pages":"Pages 125-133"},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127523000871/pdfft?md5=6cf1f4c93f01db18a5fb0b1c521fa670&pid=1-s2.0-S1008127523000871-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10535215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Post-discharge follow-up of patients with spine trauma in the National Spinal Cord Injury Registry of Iran during the COVID-19 pandemic: Challenges and lessons learned","authors":"Zahra Azadmanjir , Moein Khormali , Mohsen Sadeghi-Naini , Vali Baigi , Habibollah Pirnejad , Mohammad Dashtkoohi , Zahra Ghodsi , Seyed Behnam Jazayeri , Aidin Shakeri , Mahdi Mohammadzadeh , Laleh Bagheri , Mohammad-Sajjad Lotfi , Salman Daliri , Amir Azarhomayoun , Homayoun Sadeghi-Bazargani , Gerard O'reilly , Vafa Rahimi-Movaghar","doi":"10.1016/j.cjtee.2023.10.005","DOIUrl":"10.1016/j.cjtee.2023.10.005","url":null,"abstract":"<div><h3>Purpose</h3><p>The purpose of the National Spinal Cord Injury Registry of Iran (NSCIR-IR) is to create an infrastructure to assess the quality of care for spine trauma and in this study, we aim to investigate whether the NSCIR-IR successfully provides necessary post-discharge follow-up data for these patients.</p></div><div><h3>Methods</h3><p>An observational prospective study was conducted from April 11, 2021 to April 22, 2022 in 8 centers enrolled in NSCIR-IR, respectively Arak, Rasht, Urmia, Shahroud, Yazd, Kashan, Tabriz, and Tehran. Patients were classified into 3 groups based on their need for care resources, respectively: (1) non-spinal cord injury (SCI) patients without surgery (group 1), (2) non-SCI patients with surgery (group 2), and (3) SCI patients (group 3). The assessment tool was a self-designed questionnaire to evaluate the care quality in 3 phases: pre-hospital, in-hospital, and post-hospital. The data from the first 2 phases were collected through the registry. The post-hospital data were collected by conducting follow-up assessments. Telephone follow-ups were conducted for groups 1 and 2 (non-SCI patients), while group 3 (SCI patients) had a face-to-face visit. This study took place during the COVID-19 pandemic. Data on age and time interval from injury to follow-up were expressed as mean ± standard deviation (SD) and response rate and follow-up loss as a percentage.</p></div><div><h3>Results</h3><p>Altogether 1538 telephone follow-up records related to 1292 patients were registered in the NSCIR-IR. Of the total calls, 918 (71.05%) were related to successful follow-ups, but 38 cases died and thus were excluded from data analysis. In the end, post-hospital data from 880 patients alive were gathered. The success rate of follow-ups by telephone for groups 1 and 2 was 73.38% and 67.05% respectively, compared to 66.67% by face-to-face visits for group 3, which was very hard during the COVID-19 pandemic. The data completion rate after discharge ranged from 48% – 100%, 22% – 100% and 29% – 100% for groups 1 – 3.</p></div><div><h3>Conclusions</h3><p>To improve patient accessibility, NSCIR-IR should take measures during data gathering to increase the accuracy of registered contact information. Regarding the loss to follow-ups of SCI patients, NSCIR-IR should find strategies for remote assessment or motivate them to participate in follow-ups through, for example, providing transportation facilities or financial support.</p></div>","PeriodicalId":51555,"journal":{"name":"Chinese Journal of Traumatology","volume":"27 3","pages":"Pages 173-179"},"PeriodicalIF":2.1,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1008127523001153/pdfft?md5=013ac9d4d6faae18f79cbcd2c71e60fb&pid=1-s2.0-S1008127523001153-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135614557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}