Environmental Analysis Health and Toxicology最新文献_第2页

Phytochemical evaluation, embryotoxic, and teratogenic effects of Buwakan (Decalobanthus peltatus (L.) A.R.Simões & Staples) leaf extracts on duck embryo Buwakan（Decalobanthus peltatus (L.) A.R.Simões & Staples）叶提取物对鸭胚胎的植物化学评估、胚胎毒性和致畸作用

Environmental Analysis Health and Toxicology Pub Date : 2024-02-27 DOI: 10.5620/eaht.2024004

Merrah Joy Blaye. Subebe, Josephine C. Ogaro, Melanie L. Dayon, M. M. E. Manting, Aki Murashima, Akiko Omori, Jaime Q. Guihawan, M. Uy, Ahmad Reza F. Mazahery, M. Villacorte-Tabelin

{"title":"Phytochemical evaluation, embryotoxic, and teratogenic effects of Buwakan (Decalobanthus peltatus (L.) A.R.Simões & Staples) leaf extracts on duck embryo","authors":"Merrah Joy Blaye. Subebe, Josephine C. Ogaro, Melanie L. Dayon, M. M. E. Manting, Aki Murashima, Akiko Omori, Jaime Q. Guihawan, M. Uy, Ahmad Reza F. Mazahery, M. Villacorte-Tabelin","doi":"10.5620/eaht.2024004","DOIUrl":"https://doi.org/10.5620/eaht.2024004","url":null,"abstract":"Decalobanthus peltatus is a woody vine that is commonly utilized in traditional Southeast Asian medicinal preparations. Despite the documented therapeutic uses of D. peltatus, there is hardly any information regarding its toxic effects on its consumers. In this study, crude leaf extracts (aqueous, methanol, ethyl acetate, and hexane) from D. peltatus were prepared and evaluated for their embryotoxicity and teratogenic effects. Phytochemical screening of bioactive compounds from the plants showed the presence of alkaloids, flavonoids, saponins, steroids, and tannins. In addition, investigations on the toxicity of the crude leaf extracts were determined using brine shrimp lethality assay, in which the LC50 was calculated. Results showed that the ethyl acetate leaf extract was the most toxic among the crude leaf extracts, with an LC50 of 14.54 ppm. Based on this result, ethyl acetate leaf extract was treated on duck embryos, and the alteration of vascular branching patterns in the chorioallantoic membrane was quantified. Gross morphological and histological analysis of the skin tissues from the treated duck embryos were also examined. We found significant reduction of primary and tertiary vessel diameters in the duck embryos treated with ethyl acetate leaf extracts in both concentrations compared to the control group. Treated duck embryos exhibited gross malformations, growth retardation, and hemorrhages on the external body surfaces at 1000 ppm. Histopathological analysis of the skin tissues from the 14-day-old treated duck embryos showed a reduced number of feather follicles compared to the control group. These results suggest that D. peltatus crude leaf extracts present risks when taken in significant dosages and comprehensive toxicity testing on therapeutic herbs should be performed to ensure their safety on the consumers.","PeriodicalId":515414,"journal":{"name":"Environmental Analysis Health and Toxicology","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140425172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decision support model to assess pesticide safeness toward environment 评估农药对环境安全性的决策支持模型

Environmental Analysis Health and Toxicology Pub Date : 2024-02-14 DOI: 10.5620/eaht.2024003

Ariel Peaceo Gunawan, D. N. Utama

{"title":"Decision support model to assess pesticide safeness toward environment","authors":"Ariel Peaceo Gunawan, D. N. Utama","doi":"10.5620/eaht.2024003","DOIUrl":"https://doi.org/10.5620/eaht.2024003","url":null,"abstract":"For farmers around the world to protect crops from disturbing pests, it is common to use pesticides to ward off the growth of pests or even eliminate them. Even though pesticides are seen as a good thing for protecting crops, there is one thing that mustn’t be forgotten the origin of the pesticide itself is a toxin compound that is dangerous if used irresponsibly. The main concern of this study is excessive use of pesticides may cause serious consequences to the ecosystem and environment through the accumulation of pesticide residue by irresponsible farmers. To minimize the effects of pesticide residues, the selection of the type of pesticide needs to be considered which type may not be harmful to the environment's health even though accumulation happens. Therefore, in this study, a fuzzy-based computational model assessor was built to measure the safety level of pesticides toward the environment. The fuzzy model was created with consideration of several parameters related to pesticide behaviors, its effects on beneficial organisms, and its persistence in the environment. The method used for this study includes literature reviewing, fuzzification, statistical approach, expert knowledge sharing, and quantitative analysis. The model created in this study can assist in a more accurate and realistic method of selecting better pesticide options that will be used by farmers. To ensure the validity of the model, verifying and validating the formula and pesticide result assessment were done with related literature articles. In this study, from 10 types of pesticides used as a sample, dodine, and iprodione pesticides are the best option for protecting crops with a safety level of 7.36, and abamectin, dimethoate, chorpyrifos, and methidathion are not safe options for farming use because of its potential of harming the environment.","PeriodicalId":515414,"journal":{"name":"Environmental Analysis Health and Toxicology","volume":"674 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139839197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decision support model to assess pesticide safeness toward environment 评估农药对环境安全性的决策支持模型

Environmental Analysis Health and Toxicology Pub Date : 2024-02-14 DOI: 10.5620/eaht.2024003

Ariel Peaceo Gunawan, D. N. Utama

{"title":"Decision support model to assess pesticide safeness toward environment","authors":"Ariel Peaceo Gunawan, D. N. Utama","doi":"10.5620/eaht.2024003","DOIUrl":"https://doi.org/10.5620/eaht.2024003","url":null,"abstract":"For farmers around the world to protect crops from disturbing pests, it is common to use pesticides to ward off the growth of pests or even eliminate them. Even though pesticides are seen as a good thing for protecting crops, there is one thing that mustn’t be forgotten the origin of the pesticide itself is a toxin compound that is dangerous if used irresponsibly. The main concern of this study is excessive use of pesticides may cause serious consequences to the ecosystem and environment through the accumulation of pesticide residue by irresponsible farmers. To minimize the effects of pesticide residues, the selection of the type of pesticide needs to be considered which type may not be harmful to the environment's health even though accumulation happens. Therefore, in this study, a fuzzy-based computational model assessor was built to measure the safety level of pesticides toward the environment. The fuzzy model was created with consideration of several parameters related to pesticide behaviors, its effects on beneficial organisms, and its persistence in the environment. The method used for this study includes literature reviewing, fuzzification, statistical approach, expert knowledge sharing, and quantitative analysis. The model created in this study can assist in a more accurate and realistic method of selecting better pesticide options that will be used by farmers. To ensure the validity of the model, verifying and validating the formula and pesticide result assessment were done with related literature articles. In this study, from 10 types of pesticides used as a sample, dodine, and iprodione pesticides are the best option for protecting crops with a safety level of 7.36, and abamectin, dimethoate, chorpyrifos, and methidathion are not safe options for farming use because of its potential of harming the environment.","PeriodicalId":515414,"journal":{"name":"Environmental Analysis Health and Toxicology","volume":"60 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139779248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of pesticide residue content in fruits and vegetables from Lagos, Nigeria 尼日利亚拉各斯水果和蔬菜中农药残留量的测定

Environmental Analysis Health and Toxicology Pub Date : 2024-02-07 DOI: 10.5620/eaht.2024002

Tosin Oluwoyo, Kumsal Kocadal, Ş. Saygi, D. Battal

{"title":"Determination of pesticide residue content in fruits and vegetables from Lagos, Nigeria","authors":"Tosin Oluwoyo, Kumsal Kocadal, Ş. Saygi, D. Battal","doi":"10.5620/eaht.2024002","DOIUrl":"https://doi.org/10.5620/eaht.2024002","url":null,"abstract":"Developing countries like Nigeria are increasingly employing pesticides to boost the productivity of their agriculture and food supply, despite the fact that doing so poses a health risk to the general populace. The purpose of this study was to assess pesticide residue levels in Lagos, Nigeria. A total of 18 samples from three neighbourhood markets were collected, and they were then examined for the presence of organochlorine (Endosulfan I, Pentachlorophenol, Heptachlor epoxide, and Endosulfan II) and organophosphate (Dichlorvos, Dimethoate, Phorate, and methyl parathion) residues. During the pre-treatment, the multi-residue Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS citrate) method with the addition of acetonitrile was used, and then samples were analysed using GC-MS. All of the samples contained dichlorvos, but the orange sample's concentration was below the limit of quantification, making quantification impossible. Dimethoate concentrations were below MRLs except waterleaf sample. With a concentration of 0.043 μg/mL, Waterleaf had the highest quantity of dimethoate in the sample. The findings of this study indicate that in order to safeguard the health of consumers, it is necessary to closely monitor organochlorine and organophosphate use nationwide, along with other related pesticides, and to test for pesticide residues in food products.","PeriodicalId":515414,"journal":{"name":"Environmental Analysis Health and Toxicology","volume":"29 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139797662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of pesticide residue content in fruits and vegetables from Lagos, Nigeria 尼日利亚拉各斯水果和蔬菜中农药残留量的测定

Environmental Analysis Health and Toxicology Pub Date : 2024-02-07 DOI: 10.5620/eaht.2024002

Tosin Oluwoyo, Kumsal Kocadal, Ş. Saygi, D. Battal

{"title":"Determination of pesticide residue content in fruits and vegetables from Lagos, Nigeria","authors":"Tosin Oluwoyo, Kumsal Kocadal, Ş. Saygi, D. Battal","doi":"10.5620/eaht.2024002","DOIUrl":"https://doi.org/10.5620/eaht.2024002","url":null,"abstract":"Developing countries like Nigeria are increasingly employing pesticides to boost the productivity of their agriculture and food supply, despite the fact that doing so poses a health risk to the general populace. The purpose of this study was to assess pesticide residue levels in Lagos, Nigeria. A total of 18 samples from three neighbourhood markets were collected, and they were then examined for the presence of organochlorine (Endosulfan I, Pentachlorophenol, Heptachlor epoxide, and Endosulfan II) and organophosphate (Dichlorvos, Dimethoate, Phorate, and methyl parathion) residues. During the pre-treatment, the multi-residue Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS citrate) method with the addition of acetonitrile was used, and then samples were analysed using GC-MS. All of the samples contained dichlorvos, but the orange sample's concentration was below the limit of quantification, making quantification impossible. Dimethoate concentrations were below MRLs except waterleaf sample. With a concentration of 0.043 μg/mL, Waterleaf had the highest quantity of dimethoate in the sample. The findings of this study indicate that in order to safeguard the health of consumers, it is necessary to closely monitor organochlorine and organophosphate use nationwide, along with other related pesticides, and to test for pesticide residues in food products.","PeriodicalId":515414,"journal":{"name":"Environmental Analysis Health and Toxicology","volume":"272 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139857769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anticancer potency of Egyptian venom snakes on MCF-7 and HepG2 carcinoma cells 埃及毒蛇对 MCF-7 和 HepG2 癌细胞的抗癌作用

Environmental Analysis Health and Toxicology Pub Date : 2024-01-10 DOI: 10.5620/eaht.2024001

Sherif Abdallah, Khaled Y. Abdel-Halim, Abeer Alm-Eldeen

{"title":"Anticancer potency of Egyptian venom snakes on MCF-7 and HepG2 carcinoma cells","authors":"Sherif Abdallah, Khaled Y. Abdel-Halim, Abeer Alm-Eldeen","doi":"10.5620/eaht.2024001","DOIUrl":"https://doi.org/10.5620/eaht.2024001","url":null,"abstract":"Breast and hepatic cancers are the leading incidences in the globe occurring of the human sufferings from various cancers. Snake venoms have been reported to provide effective therapeutic agents. The current study investigates the anticancer potency of Egyptian venoms snakes on two cells: breast cancer cells (MCF-7) and hepato-cancer cells (HepG2) (In vitro assay). The examined venoms were more potent on MCF-7 than HepG2 cells. Their inhibition % on MCF-7 ranged from 71.47 to 99.02% with medium inhibition concentrations (IC50s): 3.48, 3.60, 3.70, 4.33, and 4.49 μg/ml for venoms: Echis pyramid (E.H), Cerastes vipera (C.V), Naja haje (N.H), Echis coloratus (E.C), and Cerastes cerastes (C.C), respectively. The values of IC50s on HepG2 were 4.32, 17.77, 59.72, 63.75, and 217.90 μg/ml for toxins: E.C, E.P, C.V, C.C, and N.H, respectively. Some biomarkers were conducted to investigate the apoptotic effects of toxins into the cells. Increasing profiles of lactate dehydrogenase (LDH) activity and levels of glutathione content (GSH) and malodialdhyde (MDA) as well as repairment of DNA indicated such these actions. So, more reliable investigations on these venoms were needed to provide intelligent therapeutic agent for cancer treatment.","PeriodicalId":515414,"journal":{"name":"Environmental Analysis Health and Toxicology","volume":"66 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139441038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0