Review of Clinical Pharmacology and Pharmacokinetics - International Edition最新文献_第3页

Impact of residence on the association between benzo[a]pyrene-DNA adduct levels and CYP1B1 gene polymorphisms in breast cancer patients 居住地对乳腺癌患者苯并[a]芘-DNA 加合物水平与 CYP1B1 基因多态性之间关系的影响

Review of Clinical Pharmacology and Pharmacokinetics - International Edition Pub Date : 2024-05-05 DOI: 10.61873/jlre4978

Ali Hussein Shakir Al-Jailawi, H. A. Al-Hindy, Hayder O. Hashim

{"title":"Impact of residence on the association between benzo[a]pyrene-DNA adduct levels and CYP1B1 gene polymorphisms in breast cancer patients","authors":"Ali Hussein Shakir Al-Jailawi, H. A. Al-Hindy, Hayder O. Hashim","doi":"10.61873/jlre4978","DOIUrl":"https://doi.org/10.61873/jlre4978","url":null,"abstract":"Globally, breast cancer is the primary cause of cancer-related death, and rising incidence rates are anticipated. Im¬proving illness prevention and treatment strategies requires a better understanding of the interactions occurring be¬tween genetic variables, environmental exposures, and disease pathogenesis. This study investigated the impact of residence on the association between benzo[a]pyrene-DNA adduct levels and CYP1B1 gene polymorphisms in breast cancer patients. In brief, 58 female breast cancer patients in Babylon, Iraq were recruited as subjects of this cross-sectional study. We gathered clinical information (including residency, age, age at diagnosis, and haematological markers), and by using molecular and biochemical methods, the CYP1B1 polymorphisms and the benzo[a]pyrene-DNA adduct levels were assessed. Among the different types of breast cancer, there was no apparent association between the residence and CYP1B1 polymorphisms. However, the amounts of benzo[a]pyrene-DNA adduct varied according to where a patient lived, with urban residents showing higher concentrations than rural residents. Benzo[a]pyrene-DNA adduct levels were shown to be correlated with specific polymorphisms in the CYP1B1 gene. Our study highlights the intricate connections between environmental exposures, genetic variables, and place of res¬idency in the aetiology of breast cancer. Variations in quantities of benzo[a]pyrene-DNA adducts imply possible func¬tions for environmental carcinogens, although no substantial correlation was found between genetic polymorphisms and the place of residence.","PeriodicalId":515365,"journal":{"name":"Review of Clinical Pharmacology and Pharmacokinetics - International Edition","volume":"25 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beneficial effect of Alhagi maurorum on rats submitted to sulfadimidine-induced kidney injury Alhagi maurorum 对磺胺脒引起的肾损伤大鼠的益处

Review of Clinical Pharmacology and Pharmacokinetics - International Edition Pub Date : 2024-05-05 DOI: 10.61873/hnkr5864

Nada Mahdi Alkhafaji, Hussein Jasim Alharbi

{"title":"Beneficial effect of Alhagi maurorum on rats submitted to sulfadimidine-induced kidney injury","authors":"Nada Mahdi Alkhafaji, Hussein Jasim Alharbi","doi":"10.61873/hnkr5864","DOIUrl":"https://doi.org/10.61873/hnkr5864","url":null,"abstract":"Alhagi maurorum is one of the many plants that have proven effectiveness in folklore medicine and that are still utilized to treat disease or disorders, thanks to their phytochemical compounds and other secondary metabolites. Sulfadimidine, chemical known as 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzene-sulfonamide, is an antibacterial drug that has side-effects on organs such as the kidney. In this study, the unwanted acute effect of this sulfonamide and of its metabolites was recorded in the form of rat interstitial nephritis and as an increase in creatinine and blood urea nitrogen (BUN) levels. Results showed a significant (P<0.05) decrease in BUN levels in rat groups treated with the ethanolic extract of Alhagi maurorum as a therapy, but there were no significant differences ob¬served in terms of the creatinine levels in these groups. The undertaken histological study revealed an almost normal histological appearance of the kidneys in the two groups of rats that were treated with the plant extract as a therapy after the damage that occurred as a result of the drug injection (interstitial nephritis, infiltration lympho¬cytes, and mild tubular atrophy). Our study suggests a potential benefit from natural plants in the treatment of drug-related adverse effects.","PeriodicalId":515365,"journal":{"name":"Review of Clinical Pharmacology and Pharmacokinetics - International Edition","volume":"342 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical analysis and antibacterial activity of the Achillea millefolium extract 蓍草提取物的化学分析和抗菌活性

Review of Clinical Pharmacology and Pharmacokinetics - International Edition Pub Date : 2024-05-05 DOI: 10.61873/cgwa5841

Walaa Jubair Sabbar, Raghad S. Mouhamad, Ibrahim A. Murad, E. E. Al-Abodi

引用次数: 0

Real-world data on the effectiveness of the meloxicam and pridinol combination for musculoskeletal pain 美洛昔康和普利迭醇联合疗法治疗肌肉骨骼疼痛疗效的真实世界数据

Review of Clinical Pharmacology and Pharmacokinetics - International Edition Pub Date : 2024-05-05 DOI: 10.61873/kmkm8961

Marwan Mahtook, Maiss Saadi, Saifan Alhameedawi, Noor M. Obaid, Khulood Alsaraf

{"title":"Real-world data on the effectiveness of the meloxicam and pridinol combination for musculoskeletal pain","authors":"Marwan Mahtook, Maiss Saadi, Saifan Alhameedawi, Noor M. Obaid, Khulood Alsaraf","doi":"10.61873/kmkm8961","DOIUrl":"https://doi.org/10.61873/kmkm8961","url":null,"abstract":"Musculoskeletal pain includes several types of discomfort associated with the skeletal system. Pharmaceutically, pridinol was developed in order to relax muscles. No empirical data exist to support the effectiveness of using meloxicam in combination therapy for the treatment of musculoskeletal pain. This study compared pridinol and meloxicam for musculoskeletal pain. The current observational study assessed a total of 82 patients. The study’s participants were divided into three groups: the “meloxicam” group, the “pridinol” group, and the “meloxicam + pridinol” group. Pain levels were measured before and four weeks after giving the drug, by using a visual analogue scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). We employed a Kruskal-Wallis test in order to evaluate the variations in pain measurement among the groups. The three groups’ VAS and WOMAC scores did not differ before the drug administration. The “meloxicam + pridinol” treatment resulted in significant pain relief based on VAS and WOMAC scores at 1, 2, and 4 weeks (as compared to other groups; p<0.05). At 4 weeks, the VAS and WOMAC ratings exhibited no significant pain relief in the “meloxicam” group when compared to the “pridinol” group. The meloxicam-pridinol combination proved efficacious for musculoskeletal pain, and is recom¬mended for its therapy.","PeriodicalId":515365,"journal":{"name":"Review of Clinical Pharmacology and Pharmacokinetics - International Edition","volume":"44 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Theoretical calculations and molecular modelling of isoindoline compounds as anticonvulsant agents 作为抗惊厥剂的异吲哚啉化合物的理论计算和分子建模

Review of Clinical Pharmacology and Pharmacokinetics - International Edition Pub Date : 2024-05-05 DOI: 10.61873/afgh8682

Raniah Hameed Chalawi, M. Ezzat

{"title":"Theoretical calculations and molecular modelling of isoindoline compounds as anticonvulsant agents","authors":"Raniah Hameed Chalawi, M. Ezzat","doi":"10.61873/afgh8682","DOIUrl":"https://doi.org/10.61873/afgh8682","url":null,"abstract":"The lack of safe and effective antiepileptic drugs is a persistent issue that could be addressed through the repurposing or further development of commonly available drugs. Due to high accuracy, low effort, and high cost, it is best to begin the search for alternative treatments with a theoretical chemical study. Isoindoline derivatives, their ΔG, and their molecular docking were subjected to the molecular level theory. Having a ΔG of -4.9, compound A1 demonstrated a unique activity against protein 1OHV (4-aminobutyrate-aminotransferase; from pig), while the same compound demonstrated distinct activity against protein 3F8E (coumarins as suicide carbonic anhydrase inhibitors) with a ΔG of -4.533. Moreover, compound A3 exhibited a unique activity against protein 6KZP (calcium channel-ligand) with a ΔG of -7.597. The undertaken DFT analysis determined the highest occupied molecular orbital (HOMO), the least unoc¬cupied molecular orbital (LUMO), and the HOMO-LUMO gap values for the studied derivatives (compound A1: -0.202, -0.091, and -0.111 eV; compound A3: -0.228, -0.102, and -0.126 eV, respectively). The ionization potential, the soft¬ness, the hardness, and other chemical properties of these compounds were subsequently computed. Drug likeness predictions were employed in order to show that the compounds adhered to Lipinski’s rule. Our results indicate that the molecular mass, log P, as well as the hydrogen bonding donors and acceptors of the herein assessed isoindoline compounds fall within acceptable ranges.","PeriodicalId":515365,"journal":{"name":"Review of Clinical Pharmacology and Pharmacokinetics - International Edition","volume":"23 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141012034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Susceptibility to antibiotics and virulence profiling of Proteus mirabilis among foodstuff 食品中神奇变形杆菌对抗生素的敏感性和毒力谱分析

Review of Clinical Pharmacology and Pharmacokinetics - International Edition Pub Date : 2024-05-05 DOI: 10.61873/gspt1121

S. Jabuk, Anmar M. K. Al-Maamori, R. Hussian, Zahraa M. Al-Taee

引用次数: 0

Network pharmacology and molecular docking reveal the mechanisms of action of Panax notoginseng against post-COVID-19 thromboembolism 网络药理学和分子对接揭示了三七抗 COVID-19 后血栓栓塞的作用机制

Review of Clinical Pharmacology and Pharmacokinetics - International Edition Pub Date : 2024-05-05 DOI: 10.61873/dtfa3974

Shouli Yuan, Ismael Obaidi, Tao Zhang, Maria Pigott, Shibo Jiang, Helen Sheridan, Junying Liu

{"title":"Network pharmacology and molecular docking reveal the mechanisms of action of Panax notoginseng against post-COVID-19 thromboembolism","authors":"Shouli Yuan, Ismael Obaidi, Tao Zhang, Maria Pigott, Shibo Jiang, Helen Sheridan, Junying Liu","doi":"10.61873/dtfa3974","DOIUrl":"https://doi.org/10.61873/dtfa3974","url":null,"abstract":"Panax notoginseng (PNGS) is a potent folk therapy for blood-related diseases. However, further research is required to fully elucidate the mechanisms of its pharmacological activities and to explore its therapeutic potential for treating thromboembolism (TE) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study aimed at analysing the molecular mechanisms of PNGS and at clarifying their potential role in treating TE induced by COVID-19, by employing network pharmacology and molecular docking. To this end, a network pharmacological ap¬proach was combined with expression profiling by high-throughput sequencing of GSE156701 so as to elucidate the compound constituents of PNGS for treating TE caused by SARS-CoV-2 at a systemic level. Protein-protein interac¬tion network, Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes analyses were employed in order to decipher the associated drug-target interactions. The integration of these results suggested that five targets, including the angiotensin-converting enzyme (ACE), the coagulation factor III (F3), interleukin-1 beta (IL-1β), the mitogen-activated protein kinase 1 (MAPK1), and the plasminogen activator inhibitor-1 (SERPINE1), represent major genes involved in thromboembolism. The data suggest that PNGS exerts collective therapeutic effects against TE caused by SARS-CoV-2, and provides a theoretical basis for further laboratory study of the active drug-like ingredients and the potential mechanisms of PNGS in TE treatment.","PeriodicalId":515365,"journal":{"name":"Review of Clinical Pharmacology and Pharmacokinetics - International Edition","volume":"248 2‐8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141012837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular study of KRAS mutations in Iraqi patients with gastrointestinal tract cancer 伊拉克胃肠道癌症患者 KRAS 基因突变的分子研究

Review of Clinical Pharmacology and Pharmacokinetics - International Edition Pub Date : 2024-05-05 DOI: 10.61873/uuxz2461

Hajir B. Aljaryan, A. K. Al-Shamari, T. H. Al-Ameedy, Amal Talib Al Sa’ady, Samir Azzat Malik Hussain

{"title":"Molecular study of KRAS mutations in Iraqi patients with gastrointestinal tract cancer","authors":"Hajir B. Aljaryan, A. K. Al-Shamari, T. H. Al-Ameedy, Amal Talib Al Sa’ady, Samir Azzat Malik Hussain","doi":"10.61873/uuxz2461","DOIUrl":"https://doi.org/10.61873/uuxz2461","url":null,"abstract":"Gastrointestinal cancers, including stomach, liver, oesophageal, pancreatic, and colorectal cancers, represent more than a quarter of all cancers. Many abnormal gene expressions and dysregulated signalling pathways have been found in human cancer. Cancer often has activating mutations of the KRAS (Kirsten rat sarcoma virus) oncogene. Fifty blood samples from gastrointestinal cancer patients were gathered from the Merjan Teaching Hospital in Babylon, Iraq, and were used for a case-control study in the Oncology Center. According to the results, the most common cancers were found in the colon (29%), followed by the liver (27%), pancreas (19%), stomach (13%), and other (12%). In this work, we evaluated the distribution of KRAS mutations across the gastrointestinal tract. Sequencing data re¬vealed a significant regional difference in the frequency of KRAS mutations, while the alignment results revealed the presence of six variations in the analysed samples when compared with the referring reference DNA sequences. Six highly interesting nucleic acid polymorphisms were detected in the investigated samples. When combined with addi¬tional carcinogenic markers such as the patient sex, age, consistent molecular subtypes, and tumour stage, KRAS mutation is not the deterministic carcinogenic factor for gastrointestinal malignancies.","PeriodicalId":515365,"journal":{"name":"Review of Clinical Pharmacology and Pharmacokinetics - International Edition","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial activity of the alcoholic extract of berberine against Staphylococcus aureus isolated from burn and wound infections 小檗碱酒精提取物对从烧伤和伤口感染中分离出的金黄色葡萄球菌的抗菌活性

Review of Clinical Pharmacology and Pharmacokinetics - International Edition Pub Date : 2024-05-05 DOI: 10.61873/fmpt5825

Ola Abbas Khdhair, Y. Jassim, Noor Abed Alreda Alkremy, T. H. Al-Ameedy

引用次数: 0

Evaluation of the active compound and antibacterial activity of a Salvia rosmarinus extract against pathogenic bacteria 评估丹参提取物的活性化合物和对病原菌的抗菌活性

Review of Clinical Pharmacology and Pharmacokinetics - International Edition Pub Date : 2024-05-05 DOI: 10.61873/ixyc6187

Lubna Abdul Muttalib Al-Shalah, Huda Abbas Mohammed, Alaa Rasheed Omran, A. Althahab, F. Abd

引用次数: 0