伊拉克胃肠道癌症患者 KRAS 基因突变的分子研究

Hajir B. Aljaryan, A. K. Al-Shamari, T. H. Al-Ameedy, Amal Talib Al Sa’ady, Samir Azzat Malik Hussain
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引用次数: 0

摘要

胃肠道癌症,包括胃癌、肝癌、食道癌、胰腺癌和结肠直肠癌,占所有癌症的四分之一以上。在人类癌症中发现了许多异常的基因表达和失调的信号通路。癌症通常具有 KRAS(克氏鼠肉瘤病毒)癌基因的激活突变。我们从伊拉克巴比伦的 Merjan 教学医院收集了 50 份胃肠道癌症患者的血液样本,用于肿瘤中心的病例对照研究。结果显示,最常见的癌症是结肠癌(29%),其次是肝癌(27%)、胰腺癌(19%)、胃癌(13%)和其他癌症(12%)。在这项工作中,我们评估了KRAS突变在胃肠道中的分布情况。测序数据显示,KRAS突变的频率存在显著的区域差异,而比对结果显示,与参考DNA序列相比,分析样本中存在六种变异。在调查样本中发现了六种非常有趣的核酸多态性。当与其他致癌标志物如患者性别、年龄、一致的分子亚型和肿瘤分期相结合时,KRAS突变并不是胃肠道恶性肿瘤的决定性致癌因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular study of KRAS mutations in Iraqi patients with gastrointestinal tract cancer
Gastrointestinal cancers, including stomach, liver, oesophageal, pancreatic, and colorectal cancers, represent more than a quarter of all cancers. Many abnormal gene expressions and dysregulated signalling pathways have been found in human cancer. Cancer often has activating mutations of the KRAS (Kirsten rat sarcoma virus) oncogene. Fifty blood samples from gastrointestinal cancer patients were gathered from the Merjan Teaching Hospital in Babylon, Iraq, and were used for a case-control study in the Oncology Center. According to the results, the most common cancers were found in the colon (29%), followed by the liver (27%), pancreas (19%), stomach (13%), and other (12%). In this work, we evaluated the distribution of KRAS mutations across the gastrointestinal tract. Sequencing data re¬vealed a significant regional difference in the frequency of KRAS mutations, while the alignment results revealed the presence of six variations in the analysed samples when compared with the referring reference DNA sequences. Six highly interesting nucleic acid polymorphisms were detected in the investigated samples. When combined with addi¬tional carcinogenic markers such as the patient sex, age, consistent molecular subtypes, and tumour stage, KRAS mutation is not the deterministic carcinogenic factor for gastrointestinal malignancies.
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