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Levetiracetam effect on adult-onset temporal lobe epilepsy with positive voltage-gated potassium channel antibody. 左乙拉西坦对电压门控钾通道抗体阳性成人发病颞叶癫痫的影响。
IF 2.9
The Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2015-01-01 DOI: 10.1176/appi.neuropsych.13070158
Wei Wang, Hong-Bo Zheng, Jing Xiao, Lei Chen, Dong Zhou
{"title":"Levetiracetam effect on adult-onset temporal lobe epilepsy with positive voltage-gated potassium channel antibody.","authors":"Wei Wang,&nbsp;Hong-Bo Zheng,&nbsp;Jing Xiao,&nbsp;Lei Chen,&nbsp;Dong Zhou","doi":"10.1176/appi.neuropsych.13070158","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13070158","url":null,"abstract":"<p><p>Temporal lobe epilepsy is considered to be the most frequent of all epileptic syndromes. Recently, several retrospective studies suggest that limbic encephalitis (LE) may be a cause for adult onset unexplained seizure disorders in patients. This report describes two cases of adult onset epilepsy with voltage-gated potassium channel antibodies (VGKC-abs)-associated LE that responded well to levetiracetam (LEV). As demonstrated by these two cases and reviewing previous reports, we propose that the therapeutic regimen for VGKC-abs associated seizures still needs to be determined and LEV may be effective in treating this kind of disorders. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e100-6"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13070158","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32751587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Neurological and psychiatric findings of marchiafava-bignami disease in a nonalcoholic diabetic patient with high blood glucose levels. 非酒精性糖尿病高血糖患者marchiafava-bignami病的神经学和精神病学表现
IF 2.9
The Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2015-01-01 DOI: 10.1176/appi.neuropsych.14030056
Ozden Kilinc, Damla Ozbek, Esra Ozkan, Ipek Midi
{"title":"Neurological and psychiatric findings of marchiafava-bignami disease in a nonalcoholic diabetic patient with high blood glucose levels.","authors":"Ozden Kilinc,&nbsp;Damla Ozbek,&nbsp;Esra Ozkan,&nbsp;Ipek Midi","doi":"10.1176/appi.neuropsych.14030056","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.14030056","url":null,"abstract":"","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e149-50"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.14030056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33135191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Unusual Case of Sporadic Creutzfeldt-Jakob Disease Subtype VV1. 散发性克雅氏病VV1亚型罕见病例。
IF 2.9
The Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2015-01-01 DOI: 10.1176/appi.neuropsych.14070160
Timothy P Wuerz, Alberto Bizzi, Brian S Appleby
{"title":"Unusual Case of Sporadic Creutzfeldt-Jakob Disease Subtype VV1.","authors":"Timothy P Wuerz,&nbsp;Alberto Bizzi,&nbsp;Brian S Appleby","doi":"10.1176/appi.neuropsych.14070160","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.14070160","url":null,"abstract":"","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e172-3"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.14070160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33140922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
GIPR Gene Polymorphism and Weight Gain in Patients With Schizophrenia Treated With Olanzapine. 奥氮平治疗精神分裂症患者的GIPR基因多态性与体重增加
IF 2.9
The Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2015-01-01 DOI: 10.1176/appi.neuropsych.13120389
Shin Ono, Yutaro Suzuki, Naoki Fukui, Kazushi Sawamura, Takuro Sugai, Junzo Watanabe, Nobuto Tsuneyama, Toshiyuki Someya
{"title":"GIPR Gene Polymorphism and Weight Gain in Patients With Schizophrenia Treated With Olanzapine.","authors":"Shin Ono,&nbsp;Yutaro Suzuki,&nbsp;Naoki Fukui,&nbsp;Kazushi Sawamura,&nbsp;Takuro Sugai,&nbsp;Junzo Watanabe,&nbsp;Nobuto Tsuneyama,&nbsp;Toshiyuki Someya","doi":"10.1176/appi.neuropsych.13120389","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13120389","url":null,"abstract":"<p><p>Association between gastric inhibitory polypeptide receptor polymorphism, rs10423928, and body mass index in olanzapine-treated schizophrenia was examined. Body mass index change for the A/T+A/A genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"162-4"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13120389","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32751614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Reduced telomere length in neurodegenerative disorders may suggest shared biology. 神经退行性疾病的端粒长度减少可能提示共享生物学。
IF 2.9
The Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2015-01-01 Epub Date: 2014-12-26 DOI: 10.1176/appi.neuropsych.13100240
Lakshmi Narayanan Kota, Srikala Bharath, Meera Purushottam, Nagaraj S Moily, Palanimuthu Thangaraju Sivakumar, Mathew Varghese, Pramod Kumar Pal, Sanjeev Jain
{"title":"Reduced telomere length in neurodegenerative disorders may suggest shared biology.","authors":"Lakshmi Narayanan Kota,&nbsp;Srikala Bharath,&nbsp;Meera Purushottam,&nbsp;Nagaraj S Moily,&nbsp;Palanimuthu Thangaraju Sivakumar,&nbsp;Mathew Varghese,&nbsp;Pramod Kumar Pal,&nbsp;Sanjeev Jain","doi":"10.1176/appi.neuropsych.13100240","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13100240","url":null,"abstract":"<p><p>Early cell death is a feature of neurodegenerative disorders. Telomere shortening is related to premature cellular senescence and could be a marker for cellular pathology in neurological diseases. Relative telomere length in dementia (N=70), Huntington's disease (N=35), ataxia telangiectasia (N=9), and age-group matched control samples (N=105) was measured as relative telomere copy/single copy gene ratios. Individuals with Huntington's disease had the lowest relative telomere copy/single copy gene ratio (0.21), followed by ataxia telangiectasia (0.31) and dementia (0.48). The younger control group had the highest relative telomere copy/single copy gene ratio (1.07). The reduced telomere length could be indicative of shared biological pathways across these disorders contributing to cellular senescence. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e92-6"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13100240","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32935224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 36
Genes, brains, and behavior: imaging genetics for neuropsychiatric disorders. 基因、大脑和行为:神经精神疾病的成像遗传学。
IF 2.9
The Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2015-01-01 Epub Date: 2015-03-09 DOI: 10.1176/appi.neuropsych.13080185
Ayla Arslan
{"title":"Genes, brains, and behavior: imaging genetics for neuropsychiatric disorders.","authors":"Ayla Arslan","doi":"10.1176/appi.neuropsych.13080185","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13080185","url":null,"abstract":"<p><p>The majority of neuropsychiatric disorders show a strong degree of heritability, yet little is known about molecular factors involved in the pathophysiology of diseases like schizophrenia. After a brief historical introduction into the current understanding of neuropsychiatric disorders, the aim of this study is to discuss imaging genetics as a strategy to explore the pathophysiology of neuropsychiatric disorders. The candidate gene approach of imaging genetics is used for validation/replication studies of genes, whereas the hypothesis-free, noncandidate gene approach appears to be a tool for gene discovery. Besides, integration of environmental factors into neuroimaging begins to converge on neuroimaging studies of genetic variation. In the light of data from other avenues such as animal experimentation, these developments show a model of interdisciplinary research, which may lead to identifying markers for neuropsychiatric disorders. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"81-92"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13080185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33113308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Reversible mirror clock drawing after acute right frontoparietal lobe infarct. 急性右额顶叶梗死后的可逆镜像时钟图。
IF 2.9
The Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2015-01-01 DOI: 10.1176/appi.neuropsych.14020044
Yu-Wen Cheng, Chi-Cheng Yang, Sung-Chun Tang, Jiann-Shing Jeng
{"title":"Reversible mirror clock drawing after acute right frontoparietal lobe infarct.","authors":"Yu-Wen Cheng,&nbsp;Chi-Cheng Yang,&nbsp;Sung-Chun Tang,&nbsp;Jiann-Shing Jeng","doi":"10.1176/appi.neuropsych.14020044","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.14020044","url":null,"abstract":"","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e156-7"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.14020044","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33135195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Posttraumatic panhypopituitarism with depression. 创伤后垂体功能减退伴抑郁症。
IF 2.9
The Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2015-01-01 DOI: 10.1176/appi.neuropsych.14030052
Manjeet Singh Bhatia, Priyanka Gautam, Anubhav Rathi, Jaswinder Kaur, Shruti Srivastava
{"title":"Posttraumatic panhypopituitarism with depression.","authors":"Manjeet Singh Bhatia,&nbsp;Priyanka Gautam,&nbsp;Anubhav Rathi,&nbsp;Jaswinder Kaur,&nbsp;Shruti Srivastava","doi":"10.1176/appi.neuropsych.14030052","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.14030052","url":null,"abstract":"To the Editor: Hypopituitarism, also known as Simmonds’ disease, occurs most commonly from pituitary tumors and a head injury, though a fracture of the base of the skull is considered a rare cause. Traumatic brain injury leads to significant disability and endocrine dysfunction in approximately 59% of patients. Its signs and symptoms overlap with the neurological and psychiatric sequelae so often misdiagnosed. Alterations in circulating levels of hormones occur hours or days after trauma, may represent adaptive responses to injury, and are influenced by the type of injury and therapy in the acute phase of injury Endocrine manifestations of hypopituitarism reveal deficiencies of specific hormones leading to hypoadrenocorticotropinemia, hypothyroidism, and hypogonadism. Deficiency in corticotropin levels is characterized by decreased levels of adrenal androgens and decreased production of cortisol. Acute loss of adrenal function is a medical emergency and may lead to hypotension and death if not treated. Signs and symptoms of corticotropin deficiency include myalgias, arthralgias, fatigue, headache, weight loss, anorexia, nausea, vomiting, abdominal pain, altered mentation or altered consciousness, dry wrinkled skin, loss of axillary and pubic hair, anemia, and impaired gluconeogenesis. Studies have implied that pituitary dysfunction can be diagnosed years after the initial insult.","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e158"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.14030052","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33135196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Attention improves after clinical improvement in acutely depressed adolescents. 急性抑郁青少年临床改善后注意力改善。
IF 2.9
The Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2015-01-01 Epub Date: 2014-10-31 DOI: 10.1176/appi.neuropsych.13120372
Yuval Bloch, Shai Aviram, Yoram Braw, Hila Z Gvirts, Liron Rabany, Garry Walter
{"title":"Attention improves after clinical improvement in acutely depressed adolescents.","authors":"Yuval Bloch,&nbsp;Shai Aviram,&nbsp;Yoram Braw,&nbsp;Hila Z Gvirts,&nbsp;Liron Rabany,&nbsp;Garry Walter","doi":"10.1176/appi.neuropsych.13120372","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13120372","url":null,"abstract":"<p><p>In recently depressed adolescents, attention and emotional reactivity improved significantly compared with baseline. Working memory did not improve. This supports the position that, in adolescent depression, attention is state dependent compared with other executive functions that are trait dependent. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"153-6"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13120372","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32618745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Mental health diagnoses and health care utilization in persons with dementia, Parkinson's disease, and stroke. 痴呆症、帕金森病和中风患者的心理健康诊断和医疗保健利用
IF 2.9
The Journal of Neuropsychiatry and Clinical Neurosciences Pub Date : 2015-01-01 Epub Date: 2014-12-26 DOI: 10.1176/appi.neuropsych.13110333
Jessica Calleo, Amber B Amspoker, Laura Marsh, Mark E Kunik
{"title":"Mental health diagnoses and health care utilization in persons with dementia, Parkinson's disease, and stroke.","authors":"Jessica Calleo,&nbsp;Amber B Amspoker,&nbsp;Laura Marsh,&nbsp;Mark E Kunik","doi":"10.1176/appi.neuropsych.13110333","DOIUrl":"https://doi.org/10.1176/appi.neuropsych.13110333","url":null,"abstract":"<p><p>In late life, neurological disturbances, depression, and anxiety frequently complicate the clinical presentation but are often undertreated. An administrative database of 3,034 male veterans, age 55 years and older, with a diagnosis of dementia, Parkinson's disease, or stroke was examined for the prevalence of mood and anxiety disorders and mental health service use. Those with more than one of these neurological diagnoses were most likely to have a comorbid depressive or anxiety disorder. The majority of patients with anxiety and depression were prescribed antidepressants. Mental health specialty visits were less frequent than medication treatment overall but most common for those with dementia only. These data suggest that specialty mental health care remains a significant unmet need for individuals with neurological disorders complicated by depression and anxiety. </p>","PeriodicalId":514751,"journal":{"name":"The Journal of Neuropsychiatry and Clinical Neurosciences","volume":" ","pages":"e117-21"},"PeriodicalIF":2.9,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1176/appi.neuropsych.13110333","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32935225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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