Canadian Journal of Public Health-Revue Canadienne De Sante Publique最新文献

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Spatial patterns of Mental Health Act apprehensions in Toronto, Canada, 2014-2022. 2014-2022 年加拿大多伦多《精神健康法案》逮捕的空间模式。
IF 2.9 4区 医学
Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-12-01 Epub Date: 2024-07-25 DOI: 10.17269/s41997-024-00912-7
Amber Gillespie, Jillian Stringer, Olaf Berke
{"title":"Spatial patterns of Mental Health Act apprehensions in Toronto, Canada, 2014-2022.","authors":"Amber Gillespie, Jillian Stringer, Olaf Berke","doi":"10.17269/s41997-024-00912-7","DOIUrl":"10.17269/s41997-024-00912-7","url":null,"abstract":"<p><strong>Objectives: </strong>This research examines the temporal rates and spatial patterns of police-involved Mental Health Act (MHA) apprehensions in Toronto, Canada, from 2014 to 2022. Building from the work of Toronto Police Services (TPS), the goal of this research is to deepen our understanding of MHA apprehensions and provide insights which may be used to guide local mental health reform efforts.</p><p><strong>Methods: </strong>Using data collected by TPS, an exploratory, descriptive analysis of spatial patterns of MHA apprehension events between 2014 and 2022 at the neighbourhood level was conducted. To identify high-rate clusters, we used a discrete Poisson model in SaTScan, with a circular moving window. Primary and secondary clusters with a relative risk of 1.5 or greater are reported.</p><p><strong>Results: </strong>From 2014 to 2022, 93,932 MHA apprehensions occurred in Toronto. Apprehension rates were found to vary substantially between neighbourhoods, with approximately 91% of Toronto's 140 neighbourhoods experiencing a net positive increase in rates during the study period after adjusting for population growth. Repeated spatial cluster analysis for each year revealed a range of 4 to 7 clusters annually, with the downtown core consistently emerging as an area of elevated risk (RR range 1.58-1.99).</p><p><strong>Conclusion: </strong>Rising MHA apprehensions within Toronto highlight the pressing need to confront the city's intensifying mental health needs. These findings offer valuable insights into the patterns and nature of police-involved MHA apprehensions, outline reproducible analysis methods that can be used by others, and support targeted evaluation, expansion, and implementation of downstream initiatives to improve mental health responses.</p>","PeriodicalId":51407,"journal":{"name":"Canadian Journal of Public Health-Revue Canadienne De Sante Publique","volume":" ","pages":"862-879"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occupational patterns of opioid-related harms comparing a cohort of formerly injured workers to the general population in Ontario, Canada. 阿片类药物相关伤害的职业模式,将加拿大安大略省曾受过伤害的工人群组与普通人群进行比较。
IF 2.9 4区 医学
Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-12-01 Epub Date: 2024-04-24 DOI: 10.17269/s41997-024-00882-w
Nancy Carnide, Gregory Feng, Chaojie Song, Paul A Demers, Jill S MacLeod, Jeavana Sritharan
{"title":"Occupational patterns of opioid-related harms comparing a cohort of formerly injured workers to the general population in Ontario, Canada.","authors":"Nancy Carnide, Gregory Feng, Chaojie Song, Paul A Demers, Jill S MacLeod, Jeavana Sritharan","doi":"10.17269/s41997-024-00882-w","DOIUrl":"10.17269/s41997-024-00882-w","url":null,"abstract":"<p><strong>Objectives: </strong>The role of work-related injuries as a risk factor for opioid-related harms has been hypothesized, but little data exist to support this relationship. The objective was to compare the incidence of opioid-related harms among a cohort of formerly injured workers to the general population in Ontario, Canada.</p><p><strong>Methods: </strong>Workers' compensation claimants (1983-2019) were linked to emergency department (ED) and hospitalization records (2006-2020). Incident rates of opioid-related poisonings and mental and behavioural disorders were estimated among 1.7 million workers and in the general population. Standardized incidence ratios (SIRs) and 95% confidence intervals (CI) were calculated, adjusting for age, sex, year, and region.</p><p><strong>Results: </strong>Compared to the general population, opioid-related poisonings among this group of formerly injured workers were elevated in both ED (SIR = 2.41, 95% CI = 2.37-2.45) and hospitalization records (SIR = 1.54, 95% CI = 1.50-1.59). Opioid-related mental and behavioural disorders were also elevated compared to the general population (ED visits: SIR = 1.86, 95% CI = 1.83-1.89; hospitalizations: SIR = 1.42, 95% CI = 1.38-1.47). Most occupations and industries had higher risks of harm compared to the general population, particularly construction, materials handling, processing (mineral, metal, chemical), and machining and related occupations. Teaching occupations displayed decreased risks of harm.</p><p><strong>Conclusion: </strong>Findings support the hypothesis that work-related injuries have a role as a preventable risk factor for opioid-related harms. Strategies aimed at primary prevention of occupational injuries and secondary prevention of work disability and long-term opioid use are warranted.</p>","PeriodicalId":51407,"journal":{"name":"Canadian Journal of Public Health-Revue Canadienne De Sante Publique","volume":" ","pages":"851-861"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Childcare use and the social-emotional and behavioural outcomes of late-preterm and early-term born children at age 5: An analysis of the All Our Families longitudinal cohort. 托儿服务的使用与早产儿和晚产儿 5 岁时的社会情感和行为结果:对 "我们所有的家庭"(All Our Families)纵向队列的分析。
IF 2.9 4区 医学
Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-12-01 Epub Date: 2024-07-24 DOI: 10.17269/s41997-024-00908-3
Nikki Stephenson, Suzanne Tough, Carly McMorris, Tyler Williamson, Sheila McDonald, Amy Metcalfe
{"title":"Childcare use and the social-emotional and behavioural outcomes of late-preterm and early-term born children at age 5: An analysis of the All Our Families longitudinal cohort.","authors":"Nikki Stephenson, Suzanne Tough, Carly McMorris, Tyler Williamson, Sheila McDonald, Amy Metcalfe","doi":"10.17269/s41997-024-00908-3","DOIUrl":"10.17269/s41997-024-00908-3","url":null,"abstract":"<p><strong>Objectives: </strong>Gestational age at birth (GA) shows an inverse gradient of risk with social-emotional and behavioural outcomes among children born late preterm (≥ 34 and < 37 weeks) and early term (≥ 37 and < 39 weeks). Childcare has the potential to influence this association. This study aimed to estimate the association between GA and social-emotional/behavioural problems among children born between ≥ 34 and < 41 weeks gestation, determine whether this association was modified by childcare use, and describe the relationship between childcare and behavioural and social-emotional functioning at age 5.</p><p><strong>Methods: </strong>Using data from the All Our Families cohort (n = 1324), logistic regression models were used to model the association between GA and social-emotional/behavioural problems (BASC-2 composite scales at age 5). Models were fit with interaction terms between GA and childcare variables (amount, multiplicity, and type of childcare at age 3) to assess effect modification.</p><p><strong>Results: </strong>GA showed no significant associations with social-emotional/behavioural problems at age 5, though the type of childcare significantly modified the association between GA and externalizing and internalizing problems. Neither the number of hours spent in childcare (amount) nor the number of childcare arrangements used (multiplicity) modified the association between GA and social-emotional/behavioural problems. However, multiplicity was associated with externalizing behavioural problems (aOR = 2.09, 95% CI 1.14‒3.83).</p><p><strong>Conclusion: </strong>This study found no significant association between GA and social-emotional/behavioural problems at age 5, though childcare type modified this association. Factors such as using multiple childcare arrangements to meet families' childcare needs have the potential to influence a child's social-emotional and behavioural functioning at age 5.</p>","PeriodicalId":51407,"journal":{"name":"Canadian Journal of Public Health-Revue Canadienne De Sante Publique","volume":" ","pages":"980-991"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sociodemographic factors associated with vaccine hesitancy in the South Asian community in Canada. 加拿大南亚社区中与疫苗犹豫不决有关的社会人口因素。
IF 2.9 4区 医学
Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-12-01 Epub Date: 2024-05-07 DOI: 10.17269/s41997-024-00885-7
Baanu Manoharan, Rosain Stennett, Russell J de Souza, Shrikant I Bangdiwala, Dipika Desai, Sujane Kandasamy, Farah Khan, Zainab Khan, Scott A Lear, Lawrence Loh, Rochelle Nocos, Karleen M Schulze, Gita Wahi, Sonia S Anand
{"title":"Sociodemographic factors associated with vaccine hesitancy in the South Asian community in Canada.","authors":"Baanu Manoharan, Rosain Stennett, Russell J de Souza, Shrikant I Bangdiwala, Dipika Desai, Sujane Kandasamy, Farah Khan, Zainab Khan, Scott A Lear, Lawrence Loh, Rochelle Nocos, Karleen M Schulze, Gita Wahi, Sonia S Anand","doi":"10.17269/s41997-024-00885-7","DOIUrl":"10.17269/s41997-024-00885-7","url":null,"abstract":"<p><strong>Objective: </strong>South Asians represent the largest non-white ethnic group in Canada and were disproportionately impacted by the COVID-19 pandemic. We sought to determine the factors associated with vaccine hesitancy in South Asian Canadians.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of vaccine hesitancy using data collected at the baseline assessment of a prospective cohort study, COVID CommUNITY South Asian. Participants (18 + years) were recruited from the Greater Toronto and Hamilton Area in Ontario (ON) and the Greater Vancouver Area in British Columbia (BC) between April and November 2021. Demographic characteristics and vaccine attitudes measured by the Vaccine Attitudes Examination (VAX) scale were collected. Each item is scored on a 6-point Likert scale, and higher scores reflect greater hesitancy. A multivariable linear mixed effects model was used to identify sociodemographic factors associated with vaccine hesitancy, adjusting for multiple covariates.</p><p><strong>Results: </strong>A total of 1496 self-identified South Asians (52% female) were analyzed (mean age = 38.5 years; standard deviation (SD): 15.3). The mean VAX score was 3.2, SD: 0.8 [range: 1.0‒6.0]. Factors associated with vaccine hesitancy included: time since immigration (p = 0.04), previous COVID-19 infection (p < 0.001), marital status (p < 0.001), living in a multigenerational household (p = 0.03), age (p = 0.02), education (p < 0.001), and employment status (p = 0.001).</p><p><strong>Conclusion: </strong>Among South Asians living in ON and BC, time since immigration, prior COVID-19 infection, marital status, living in a multigenerational household, age, education, and employment status were associated with vaccine hesitancy. This information can be used to address vaccine hesitancy in the South Asian population in future COVID-19 waves or pandemics.</p>","PeriodicalId":51407,"journal":{"name":"Canadian Journal of Public Health-Revue Canadienne De Sante Publique","volume":" ","pages":"924-935"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transitioning to a guaranteed annual income and the impact on activities of daily living in older adults: Evidence from public pensions in Canada using the CLSA. 向保证年收入过渡及其对老年人日常生活活动的影响:加拿大公共养老金使用 CLSA 提供的证据。
IF 2.9 4区 医学
Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-12-01 Epub Date: 2024-04-22 DOI: 10.17269/s41997-024-00875-9
Laura J Jiménez, Daniel J Dutton
{"title":"Transitioning to a guaranteed annual income and the impact on activities of daily living in older adults: Evidence from public pensions in Canada using the CLSA.","authors":"Laura J Jiménez, Daniel J Dutton","doi":"10.17269/s41997-024-00875-9","DOIUrl":"10.17269/s41997-024-00875-9","url":null,"abstract":"<p><strong>Objective: </strong>Statistically model the likelihood of changes in the activities of daily living (ADLs) over time for three groups of older adults: those on a pension at all time periods, those never on a pension, and those who transition onto a public pension.</p><p><strong>Methods: </strong>Our study used data from the Canadian Longitudinal Study on Aging (CLSA), a large national survey. We used data from baseline (2010-2015) and the first follow-up wave (2015-2018). We used logistic regression to model the likelihood of ADL changes in males and females by pension receipt status, controlling for several potential confounders and allowing for the impact of public pensions to be modified by baseline income.</p><p><strong>Results: </strong>The magnitudes of the estimates indicated that those who transition to a public pension are less likely to report ADL degradation and more likely to report ADL improvement compared to those with no public pension. In the lowest baseline income group, those who transitioned onto a pension at follow-up had a 15% (male) or 11% (female) lower likelihood of reporting degraded ADL scores compared to those not receiving a pension at follow-up. Those who transitioned onto a pension in the lowest income group were more likely to report an improved ADL score at follow-up.</p><p><strong>Conclusion: </strong>Our results could provide evidence for the potential health benefits of more comprehensive guaranteed annual income programs beyond the pension program. The penalty of being low-income was mitigated by the stability of the pension income in terms of ADL improvement or degradation.</p>","PeriodicalId":51407,"journal":{"name":"Canadian Journal of Public Health-Revue Canadienne De Sante Publique","volume":" ","pages":"903-912"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140869523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gaining influence: Developing a Healthy Public Policy Unit at Vancouver Coastal Health. 获得影响力:在温哥华沿岸卫生局建立健康公共政策部门。
IF 2.9 4区 医学
Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-12-01 Epub Date: 2024-07-25 DOI: 10.17269/s41997-024-00921-6
Wes Regan, Melinda Markey, Juan Solorzano, Mark Lysyshyn
{"title":"Gaining influence: Developing a Healthy Public Policy Unit at Vancouver Coastal Health.","authors":"Wes Regan, Melinda Markey, Juan Solorzano, Mark Lysyshyn","doi":"10.17269/s41997-024-00921-6","DOIUrl":"10.17269/s41997-024-00921-6","url":null,"abstract":"<p><strong>Setting: </strong>Regional Public Health Unit (Office of the Chief MHO, Vancouver Coastal Health Authority, BC, Canada).</p><p><strong>Intervention: </strong>Recognizing the need to invest resources that strategically move public health work \"upstream\" where policies and investments can shape the determinants of health, the Office of the Chief MHO for Vancouver Coastal Health embarked on a process in 2019 to develop a population health team designed to engage in Healthy Public Policy (HPP) and Health in All Policies (HiAP) approaches to health promotion. The mission and design of this unit was informed by internal and external research and engagement which continued even through the COVID-19 pandemic.</p><p><strong>Outcomes: </strong>In the fall of 2022, this new unit, the first of its kind in British Columbia, was launched. In 2023, it embarked on strategic planning, engaged in key public policy processes, and implemented priority areas of work to help advance healthy public policy in the region, including the development of processes, tools, and practices to support a more systematic and rigorous approach to this emerging area of public health practice.</p><p><strong>Implications: </strong>The creation of this new Healthy Public Policy Unit invites discussion within Canada's public health community on the issue of resource allocation to support upstream interventions seeking to build the capacity and effectiveness of HPP and HiAP approaches.</p>","PeriodicalId":51407,"journal":{"name":"Canadian Journal of Public Health-Revue Canadienne De Sante Publique","volume":" ","pages":"964-969"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141767944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology and biostatistics in Canada: Learning from the past to innovate the future. 加拿大的流行病学和生物统计学:学习过去,创新未来。
IF 2.9 4区 医学
Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-12-01 DOI: 10.17269/s41997-024-00978-3
Hilary K Brown, Paul Villeneuve, Nazeem Muhajarine
{"title":"Epidemiology and biostatistics in Canada: Learning from the past to innovate the future.","authors":"Hilary K Brown, Paul Villeneuve, Nazeem Muhajarine","doi":"10.17269/s41997-024-00978-3","DOIUrl":"10.17269/s41997-024-00978-3","url":null,"abstract":"","PeriodicalId":51407,"journal":{"name":"Canadian Journal of Public Health-Revue Canadienne De Sante Publique","volume":" ","pages":"835-838"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142632376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Routine vaccine uptake in school-aged autistic and non-autistic youth: A linked database study. 学龄自闭症和非自闭症青少年的常规疫苗接种情况:链接数据库研究。
IF 2.9 4区 医学
Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-12-01 Epub Date: 2024-09-25 DOI: 10.17269/s41997-024-00937-y
Linda Dodds, Christopher Filliter, Leslie Anne Campbell, Noni E MacDonald, Sarah Shea, Eve Dubé, Isabel M Smith, Azar Mehrabadi, Jillian H Filliter
{"title":"Routine vaccine uptake in school-aged autistic and non-autistic youth: A linked database study.","authors":"Linda Dodds, Christopher Filliter, Leslie Anne Campbell, Noni E MacDonald, Sarah Shea, Eve Dubé, Isabel M Smith, Azar Mehrabadi, Jillian H Filliter","doi":"10.17269/s41997-024-00937-y","DOIUrl":"10.17269/s41997-024-00937-y","url":null,"abstract":"<p><strong>Objectives: </strong>This study was conducted to determine whether school-aged autistic youth received routine vaccines at a lower rate than their non-autistic peers.</p><p><strong>Methods: </strong>In Nova Scotia (NS), Canada, vaccines routinely delivered in early adolescence are administered to Grade 7 students through a school-based Public Health vaccination program. NS youth eligible to receive Grade 7 vaccinations between 2011 and 2017 were included in this study. Autism spectrum disorder (ASD) diagnoses were determined from administrative health data. Rates of receipt of any Grade 7 vaccine and of individual vaccines were compared between autistic and non-autistic youth. Subgroup analyses included comparing Grade 7 vaccine receipt between autistic youth and their non-autistic siblings and early childhood vaccine receipt between autistic and non-autistic cohorts.</p><p><strong>Results: </strong>The rates of receipt of any vaccine were 73% among 916 autistic youth and 82% among 49,599 non-autistic youth (adjusted relative risk = 0.91; 95% confidence interval = 0.87-0.95). Similar results were found for individual vaccines. Subgroup analyses revealed lower rates of Grade 7 vaccine receipt among autistic youth compared to among their non-autistic siblings. Rates of early childhood vaccine receipt did not differ between autistic and non-autistic cohorts.</p><p><strong>Conclusion: </strong>Autistic youth were under-vaccinated compared to their non-autistic peers for Grade 7 vaccinations. Lower vaccination rates in autistic youth than in their non-autistic siblings suggest that setting-related factors may contribute more to the under-vaccination of autistic youth than parental vaccine hesitancy. Barriers to vaccine uptake for school-aged autistic youth, including those unique to school-based vaccination programs, must be explored and addressed.</p>","PeriodicalId":51407,"journal":{"name":"Canadian Journal of Public Health-Revue Canadienne De Sante Publique","volume":" ","pages":"992-1001"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11644134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term serological response and boostability of intradermal rabies immunization: A retrospective chart review. 皮内狂犬病免疫接种的长期血清反应和可增强性:回顾性病历审查。
IF 2.9 4区 医学
Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-11-26 DOI: 10.17269/s41997-024-00968-5
Eileen J Burnett, Rachel J Mcpherson, Joshua P Aquin, Ka Yan Xu, Pierre J Plourde
{"title":"Long-term serological response and boostability of intradermal rabies immunization: A retrospective chart review.","authors":"Eileen J Burnett, Rachel J Mcpherson, Joshua P Aquin, Ka Yan Xu, Pierre J Plourde","doi":"10.17269/s41997-024-00968-5","DOIUrl":"https://doi.org/10.17269/s41997-024-00968-5","url":null,"abstract":"<p><strong>Objectives: </strong>Rabies vaccines in Canada are currently labeled for intramuscular use only; however, intradermal vaccine administration may be equally effective. This study aims to assess the immediate and long-term (≥ 2 years) serological response and boostability of intradermal administration of rabies vaccine for pre-exposure prophylaxis.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted using data from electronic medical records at the Winnipeg Regional Health Authority Travel Health & Tropical Medicine Services Clinic. Individuals ≥ 18 years of age at time of vaccination who received at least 3 × 0.1 mL doses of intradermal rabies vaccine were included. All charts were reviewed to extract post-primary immunization and post-booster serology results, and t-tests were conducted to evaluate seroprotection (defined as serology ≥ 0.5 IU/mL).</p><p><strong>Results: </strong>A total of 324 individuals received an intradermal rabies primary pre-exposure vaccination series with follow-up serology within 90 days. Seroprotection was observed in 96% (GMT = 3.36 IU/mL, 95% CI 3.07-3.68). Of these, 68 had serology results 1.8-2.5 years later, with seroprotection declining to 44% (GMT = 0.52 IU/mL, 95% CI 0.41-0.65). However, 100% seroprotection was observed in those who received an intradermal booster dose at ≥ 2 years with follow-up serology (n = 20, GMT = 4.7 IU/mL, 95% CI 3.7-6.2).</p><p><strong>Conclusion: </strong>Intradermal administration of a primary pre-exposure rabies vaccine series demonstrates a strong serological response. While titers decline over time, the robust serological response demonstrated after a single intradermal booster vaccine dose suggests that a strong anamnestic immune response was maintained. This finding supports existing evidence that intradermal administration of rabies vaccines can be used effectively for rabies pre-exposure and post-exposure prophylaxis.</p>","PeriodicalId":51407,"journal":{"name":"Canadian Journal of Public Health-Revue Canadienne De Sante Publique","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with self-rated health in Black Canadians: A cross-sectional study. 加拿大黑人自评健康的相关因素:一项横断面研究。
IF 2.9 4区 医学
Canadian Journal of Public Health-Revue Canadienne De Sante Publique Pub Date : 2024-11-26 DOI: 10.17269/s41997-024-00973-8
Sheila A Boamah, Roger Antabe, Shamara Baidoobonso, Josephine Etowa, Pascal Djiadeu, Clemence Ongolo-Zogo, Winston Husbands, Lawrence Mbuagbaw
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